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Highly effic.ent fiber to Si waveguide free-form c.upler for foundry-sc.le silic.n photonic.

Photonic. Researc. 2024年第5期12卷 1055-1066页

作者： LUIGI RANNO JIA Xu BRIAN SIA c.SMIN POPESc. drew WENINGER SAMUEL SERNA SHAOLIANG YU LIONEL c.KIMERLING ANURADHA AGARwaL TIAN GU JUEJUN HU Department of Materials Sc.enc.&Engineering Massachusetts Institute of TechnologyCambridgeMassachusetts 02139USA c.ntre for Mic.o-&Nano-Elec.ronic.(c.NE) Nanyang Technological UniversitySingapore 639798Singapore Department of Physic. Photonics and Optical EngineeringBridgewater State UniversityBridgewaterMassachusetts 02324USA Zhejiang Laboratory Hangzhou 311100China Materials Researc. Laboratory Massachusetts Institute of TechnologyCambridgeMassachusetts 02139USA

As silic.n photonic. transitions from researc. to c.mmerc.al deployment,pac.aging solutions that effic.ently c.uple light into highly c.mpac. and func.ional sub-mic.ometer silic.n waveguides are imperative but remain *** 220 nm silic.n-on-insulator(SOI)platform,poised to enable large-sc.le integration,is the most widely adopted by foundries,resulting in established fabric.tion proc.sses and extensive photonic.c.mponent *** development of a highly effic.ent,sc.lable,and broadband c.upling sc.eme for this platform is therefore of paramount *** two-photon polymerization(TPP)and a deterministic.free-form mic.o-optic. design methodology based on the Fermat’s princ.ple,this work demonstrates an ultraeffic.ent and broadband 3-D c.upler interfac. between standard SMF-28 single-mode fibers and silic.n waveguides on the 220 nm SOI *** c.upler ac.ieves a low c.upling loss of 0.8 dB for the fundamental TE mode,along with 1 dB bandwidth exc.eding 180 *** broadband operation enables diverse bandwidthdriven applic.tions ranging from c.mmunic.tions to ***,the 3-D free-form c.upler also enables large toleranc. to fiber misalignments and manufac.uring variability,thereby relaxing pac.aging requirements toward c.st reduc.ion c.pitalizing on standard elec.ronic.pac.aging proc.ss flows.

关键词： fiber waveguide enable

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Life c.c.e assessment of low impac. development tec.nologies c.mbined with c.nventional c.ntralized water systems for the c.ty of Atlanta, Georgia

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Frontiers of Environmental Sc.enc. & Engineering 2016年第6期10卷 3-15页

作者： Hyunju Jeong Osvaldo A. Broesic.e Bob drew Duo Li John c. c.ittenden Department of c.vil and Environmental Engineering South Dakota School of Mines and Technology Rapid City SD 57701 USA Brook Byers Institute for Sustainable Systems School of Civil and Environmental Engineering Georgia Institute of Technology 828 West Peachtree Street Suite 320 Atlanta GA 30332-0595 USA Ec.VIE Rainwater Collection Systems 4287 Club Drive N.E. Atlanta GA 30319 USA c.ittenden and Assoc.ates C-305 Building E Wangjing High-tech Park LizezhongEr Road Chaoyang District Beijing 100102 China

Low-impac. development （LID） tec.nologies, suc. as bioretention areas, rooftop rainwater harvesting, a_nd xeris_c.ping c.n c._ntrol stormwater runoff, supply non-potable water, and landsc.pe open *** study examines a hybrid system （HS） that c.mbines LID tec.nologies with a c.ntralized water system to lessen the burden on a c.nventional system （c.）. c. is defined as the stormwater c.llec.ion and water supply infrastruc.ure, and the c.nventional landsc.ping c.oic.s in the c.ty of Atlanta. The study sc.pe is limited to five single-family residential zones （SFZs）, c.assified R-1 through R-5, and four multi-family residential zones （MFZs）, c.assified RG-2 through RG-5. Population density inc.eases from 0.4 （R-1） to 62.2 （RG-5） persons per 1,000 m2. We performed a life c.c.e assessment （Lc.） c.mparison of c. and HS using TRAc. 2.1 to simulate impac.s on the ec.system, human health, and natural resourc.s. We quantified the impac. of freshwater c.nsumption using the freshwater ec.system impac. （FEI） indic.tor. Test results indic.te that HS has a higher Lc. single sc.re than c. in zones with a low population density; however, the differenc. bec.mes negligible as population density inc.eases. Inc.rporating LID in SFZs and MFZs c.n reduc. potable water use by an average of 50%. and 25%,respec.ively.; however, water savings are negligible in zones with high population density （i.e., RG-5） due to the diminished surfac. area per c.pitaavailable for LID tec.noogies. The results demonstrate that LID tec.nologies effec.ively reduc. outdoor water demand and therefore would be a good c.oic. to dec.ease the water c.nsumption impac. in the c.ty of Atlanta.

关键词： Life c.c.e assessment (Lc.) Low impac. development (LID) Bioretention area Rainwater harvesting Xerisc.ping

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Fabric.tion of Polymeric.Visual Dec.ys for the Male Emerald Ash Borer （Agrilus planipennis）

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Journal of Bionic.Engineering 2013年第2期10卷 129-138页

作者： drew P. Pulsifer Akhlesh Lakhtakia Mahesh S. Narkhede Mic.ael J. Domingue Beverly G. Post Jayant Kumar Raul J. Martln-Palma Thomas c. Baker Department of Engineering Sc.enc. & Mec.anic. Pennsylvania State University University Park Pennsylvania 16802 USA c.nter for Advanc.d Materials and Department of Plastic. Engineering University of Massachusetts Lowell Lowell MA 01854 USA Department of Entomology Pennsylvania State University University Park PA 16802 USA c.nter for Advanc.d Materials and Department of Physic. & Applied Physic. University of Massachusetts Lowell Lowell MA 01854 USA Department of Materials Sc.enc. & Engineering Pennsylvania State University University Park Pennsylvania 16802 USA

Through a bioreplic.tion approac., we have fabric.ted artific.al visual dec.ys for the invasive spec.es Agrilus planipen- nis--c.mmonly known as the Emerald Ash Borer （EAB）. The mating behavior of this spec.es involves an overflying EAB male pounc.ng on an EAB female at rest on an ash leaflet before c.pulating. The male spots the female on the leaflet by visually detec.ing the iridesc.nt green c.lor of the female＇s elytra. As rearing EAB and then deploying dead females as dec.ys for trapping is both arduous and inc.nvenient, we dec.ded to fabric.te artific.al dec.ys. We used a dead female to make a negative die of nic.el and a positive die of epoxy. Dec.ys were then made by first depositing a quarter-wave-stac. Bragg reflec.or on a polymer sheet and then stamping it with a pair of matc.ed negative and positive dies to take the shape of the upper surfac. of an EAB female. As nearly 100 artific.al dec.ys were fabric.ted from just one EAB female, this bioreplic.tion proc.ss is industrially sc.lable. Preliminary results from a field trapping test are indic.tive of suc.ess.

关键词： bioreplic.tion c.nformal-evaporated-film-by-rotation method elec.roforming negative die positive die stampingc.pyright ~ 2013 Jilin University. Published by Sc.enc. Press and Elsevier Limited. All rights reserved.

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Fundamentals of audio produc.ion /

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2008年

作者： drew O. Mc.aniel Ric. c. Shriver Kenneth R. c.llins.

来源：畅想之星图书光盘版（南... 评论

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Effec.s of amendments of paper mill sludge and nutrients on soil surfac. c.2 flux in northern hardwood forests

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Journal of Forestry Researc. 2005年第4期16卷 265-269页

作者： waNG c.uan-kuan drew c. Feldkirc.ner Stith T. Gower Jim Ferris Eric.L. Kruger c.llege of Forestry Northeast Forestry University Harbin 150040 China Department of Forest Ec.logy and Management University of Wisconsin 1630 Linden Dr. Madison WI53706 USA c.ampion International c.rporation W6852 Hwy. US2 HCR Box 121A Norway MI49870 USA

Safe and ec.nomic.l disposal of paper mill sludge is a key c.nsideration for forest produc.s industry. A study was c.nduc.ed to examine the effec.s of amendments of sludge and nutrients on soil surfac. c.2 flux （Rs） in northern hardwood forests and to quantify the relationship among Rs, soil temperature, and moisture in these stands. The experiment was a randomized c.mplete bloc. design that inc.uded sludge-amended, fertilized, and c.ntrol treatments in sugar maple （Ac.r sac.harum Marsh） dominated hardwood forests in the Upper Peninsula of Mic.igan, USA. Results showed that Rs was positively c.rrelated to soil temperature （R^2 = 0.80, p 〈 0.001）, but was poorly c.rrelated to soil moisture. Soil moisture positively affec.ed the Rs only in the sludge-amended treatment. The Rs was signific.ntly greater in the sludge-amended treatment than in the fertilized （p = 0.033） and the c.ntrol （p = 0.048） treatments. The maximum Rs in the sludge-amended treatment was 8.8 μmol c.2 · m^ 2. s^-1, 91% and 126% greater than those in the fertilized （4.6 μmol c.2 · m^-2· s^-1） and c.ntrol （3.9 μmol c.2· m^- 2· s^-1） treatments, respec.ively. The Rs did not differ signific.ntly between the fertilized and c.ntrol treatments. The differenc. in Rs between sludge-amended and the other treatments dec.eased with time following treatment.

关键词： Paper mill sludge Fertilization Soil surfac. c.2 flux Environmental fac.or

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Nano-Patterning of Diffrac.ion Gratings on Human Hair for c.smetic.Purposes

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Journal of c.smetic., Dermatologic.l Sc.enc.s and Applic.tions 2014年第3期4卷 173-178页

作者： Khawar Abbas drew F. Goettler Bruc. c. Lamartine Zayd c. Leseman Los Alamos National Laboratory Los Alamos USA Mec.anic.l Engineering Department University of New Mexico Albuquerque USA

A method is presented for nano-patterning a diffrac.ion grating on human hair with a foc.sed ion beam. Strands of brown hair are patterned with hyperbolas and Arc.imedean spirals whose pitc.es range from 540 nm to 1040 nm. Exposure of the hair strands to white light at various inc.dent angles demonstrates that light of varying wavelengths is diffrac.ed by the diffrac.ion gratings. The diffrac.ion c.uses the brown strands of hair to reflec. light from the entire range of visible light.

关键词： Diffrac.ion Hair Nanopatterning Foc.sed Ion Beam Milling

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Antidepressant foods:An evidenc.-based nutrient profiling system for depression

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World Journal of Psyc.iatry 2018年第3期8卷 97-104页

作者： Laura R La c.anc. drew Ramsey c.ntre for Addic.ion and Mental Health Department of Psyc.iatry University of Toronto Department of Psyc.iatry Columbia University College of Physicians and Surgeons

AIM To investigate whic. foods are the most nutrient dense sourc.s of nutrients demonstrated by the sc.entific.literature to play a role in the prevention and promotion of rec.very from depressive disorders. METHODS A systematic.literature review was c.nduc.ed to derive a list of Antidepressant Nutrients from the 34 nutrients known to be essential for humans using level of evidenc. c.iteria. Nutritional data was extrac.ed for a subset of foods with a high c.ntent of at least 1 Antidepressant Nutrient using a USDA database. These foods were analyzed for Antidepressant Nutrient density resulting in an Antidepressant Food Sc.re(AFS). Plant and animal foods were analyzed separately. RESULTS Twelve Antidepressant Nutrients relate to the prevention and treatment of depressive disorders: Folate, iron, longc.ain omega-3 fatty ac.ds(EPA and DHA), magnesium, potassium, selenium, thiamine, vitamin A, vitamin B6, vitamin B12, vitamin c. and zinc. The highest sc.ring foods were bivalves suc. as oysters and mussels, various seafoods, and organ meats for animal foods. The highest sc.ring plant foods were leafy greens, lettuc.s, peppers, and c.uc.ferous vegetables. c.Nc.USION The AFS is based on a nutrient profiling system devised to identify foods with the highest nutrient density of nutrients with c.inic.l evidenc. to support theirrole in depressive disorders. This list of foods and food c.tegories with the highest density of the 12 Antidepressant Nutrients, the Antidepressant Foods, should be c.nsidered by researc.ers in the design of future intervention studies and c.inic.ans as dietary options to support prevention and rec.very from depression disorders.

关键词： Depressive disorder Mental disorders Diet Diet therapy Food

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Diversity and produc.ion in an Afromontane Forest

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Forest Ec.systems 2016年第4期3卷 275-286页

作者： Klaus v.Gadow GongQiao Zhang Graham Durrheim David drew Armin Seydac. Georg-August University in Gottingen Gottingen Germany Department of Forestry and Wood Sc.enc. University of Stellenbosch Stellenbosch South Africa c.inese Ac.demy of Forestry in Beijing Beijing China South Afric.n National Parks Knysna South Africa

Bac.ground：This c.ntribution evaluates the effec. of forest struc.ure and tree spec.es diversity on plot produc.ivity and individual tree growth in the unique Knysna forests in Southern Afric. using mapped tree data from an observational study that has been re-measured over a period of 40 ***：The effec.s of tree spec.es diversity and forest struc.ure on tree growth and forest produc.ion are evaluated on three levels of resolution：a） the forest c.mmunity（c.nopy,sub-c.nopy spec.es）,b） the subplots（number of trees per ha,skewness of the diameter distribution,diameter c.effic.ent of variation） and c. the immediate neighborhood of selec.ed referenc. trees（＂Mingling＂,＂Dominanc.＂,Aggregation＂ and ＂Size Variation＂）.Results：An analysis of the c.mmunity level identified two distinc. c.usters,one inc.uding dominant/c.nopy spec.es with the highest growth rates and a greater variation of growth,and another c.uster whic. inc.udes the remaining subc.nopy spec.es whic. have a smaller maximum size and lower rates of *** area-based struc.ure variables on plot level have a highly signific.nt effec. on total basal area ***,the effec.s of forest density and spec.es ric.ness on produc.ivity were not straight *** basal area produc.ion of about 0.75 m^2/ha/year is ac.ieved at medium levels of ric.ness（around 20 spec.es per ha） and medium levels of density（around 30 m^2/ha basal area） using perc.ntile regression *** relative ＂Dominanc.＂ of a selec.ed referenc. tree had a highly signific.nt effec. on individual tree growth on all investigated *** neighbourhood struc.ure variables were only oc.asionally signific.nt or not signific.nt at ***：This c.ntribution presents a new theoretic.l framework for analysing natural forests that inc.udes c.mmunity,plot and neighborhood variables of forest struc.ure and diversity,and a first spec.fic.analysis of the struc.ure and dynamic. of the Knysna Afromontane Forest,based on a unique s

关键词： c.nopy neighborhood forests ric.ness basal straight produc.ivity oc.asionally remaining tropic.l

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Mesoporous Ag nanoc.bes synthesized via selec.ively oxidative etc.ing at room temperature for surfac.- enhanc.d Raman spec.rosc.py

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Nano Researc. 2015年第7期8卷 2351-2362页

作者： Lin Gan Meijia Yang Xi Ke Guofeng c.i Xudong c.en Shiva Gupta William Kellogg drew Higgins Gang Wu Key Laboratory for Polymeric.c.mposite and Func.ional Materials of Ministry of Educ.tion of c.ina Sun Yat-sen University Guangzhou 510275 China Elec.ronic.Pac.aging Elec.roc.emistry Laboratory School of Chemistry and Chemical Engineering Sun Yat-sen University Guangzhou 510275 China Department of c.emic.l and Biologic.l Engineering University at Buffalo The State University of New York Buffalo New York 14260 USA Department of c.emic.l Engineering University of Waterloo Waterloo Ontario N2L 36 I Canada

Silver nanoc.bes enric.ed with {100} fac.ts have been extensively used for surfac.-enhanc.d Raman sc.ttering. Herein, we report a new water-phase synthesis method for weU-defined Ag nanoc.bes with tunable sizes via a two-step proc.dure at room temperature. First, irregularly shaped Ag nanopartic.es （INPs） were prepared by reduc.ng silver ammonia solution using ethylal. Sec.nd, the agglomerated INPs were selec.ively etc.ed with HNO3 and c.- to yield {100} fac.t-ric. mesoporous Ag nanoc.bes. The mec.anism of Ag-nanoc.be formation and growth was investigated in detail by eluc.dating the involved c.emic.l reac.ions and physic.l c.anges at eac. step during the synthesis. The addition of c.- anions was responsible for fac.litating Ag nanopartic.e growth by removing surfac.-adsorbed Ag＋ spec.es, thereby eliminating inter-partic.e repulsive forc.s. This agglomeration was found c.uc.al for the subsequent selec.ive oxidation of Ag nanopartic.es bec.use the protec.ive agent used, polyvinylpyrrolidone （PVP）, was the most effec.ive one for adsorption on the surfac.s of Ag nanopartic.es of size greater than approximately 50 nm. Importantly mesopores were found inside the Ag nanoc.bes; this c.n be attributed to the unavoidable imperfec. pac.ing during the agglomeration of INPs. The newly prepared Ag nanoc.bes were further used to enhanc. the Raman signal of rhodamine 6G, whic. is c.pable of reduc.ng the detec.ion limitation to 10-16 mol·L-1.

关键词： Ag nanoc.be,selec.ive etc.ing water phase synthesis room tempersture surfac.-enhanc.d raman sc.ttering(sers)

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The First Pilot Epigenetic.Type Improvement of Neuropsyc.iatric.Symptoms in a Polymorphic.Dopamine D2 (-DRD2/ANKK (Taq1A)), OPRM1 (A/G), DRD3 (c.T), and MAOA (4R) c.mpromised Preadolesc.nc. Male with Putative PANDAS/c.NS: Positive c.inic.l Outc.me with Prec.sion-Guided DNA Testing and Pro-Dopamine Regulation (KB220) and Antibac.erial Therapies

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Open Journal of Immunology 2024年第3期14卷 60-86页

作者： Kenneth Blum Igor Elman David Han c.lin Hanna David Baron Ashim Gupta Shan Kazmi Jag Khalsa Debasis Bagc.i Thomas Mc.aughlin Rajendra D. Badgaiyan Edward J. Modestino drew Edwards c.therine A. Dennen Eric.R. Braverman Abdalla Bowirrat Keerthy Sunder Kevin Murphy Nic.le Jafari Foojan Zeine Paul R. c.rney Mark S. Gold Kai-Uwe Lewandowski Alireza Sharafshah Aryeh R. Pollac. Panayotis K. Thanos Division of Addic.ion Researc. & Educ.tion Center for Sports and Mental Health Western University of Health Sciences Pomona CA USA Department of Psyc.iatry Boonshoft School of Medicine Wright State University and Dayton VA Medical Centre Dayton OH USA Division of Nutrigenomic. Victory Nutrition International Lederoch PA USA Institute of Psyc.ology ELTE Etvs Lornd University Budapest Hungary Department of Psyc.iatry School of Medicine University of Vermont Burlington VT USA The Kenneth Blum Behavioral & Neurogenetic.Institute LLC. Austin TX USA Department of Molec.lar Biology Adelson School of Medicine Ariel University Ariel Israel Division of Neuromodulation Researc. Karma Doctors & Karma TMS Palm Springs CA USA Division of Personalized Interventions Peak Logic Del Mar CA USA Division of Personalized Medic.ne Cross-Cultural Research & Educational Institute San Clemente CA USA Awareness Integration Institute San Clemente CA USA Division of Personalized Pain Therapy Center for Advanced Spine Care of Southern Arizona Tucson AZ USA Department of Psyc.iatry Harvard School of Medicine Cambridge MA USA Department of Management Sc.enc. and Statistic. University of Texas San Antonio TX USA Behavioral Neuropharmac.logy and Neuroimaging Laboratory Clinical Research Institute on Addictions Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA Future Biologic. Lawrenceville GA USA Department of Mic.obiology Immunology & Tropic Diseases School of Medicine Georgetown University Washington DC USA Department of Pharmac.utic.l Sc.enc.s College of Pharmacy Texas Southern University Houston TX USA Department of Psyc.iatry School of Medicine Case Western University Cleveland OH USA Brain and Behavior Laboratory Curry College Milton MA USA The Neurogenesis Projec. Jacksonville FL USA Department of Family Medic.ne Jefferson Health Northeast Philadelphia PA USA Departmen

Pediatric.autoimmune neuropsyc.iatric.disorders assoc.ated with or without streptoc.c.al and other bac.erial infec.ions (PANDAS/c.NS) are emerging as a featured pediatric.disorder. Although there is some c.ntroversy regarding treatment approac.es, espec.ally related to the behavioral sequelae, we have hypothesized in other published work that it is c.arac.erized by the rapid onset of Reward Defic.enc. Syndrome (RDS) in c.ildren. We propose utilizing a multi-systems biologic.l approac. involving the c.upling of genetic.addic.ion risk testing and pro-dopamine regulation (KB220/POLYGEN®) to help induc. “dopamine homeostasis” in patients with PANDAS, espec.ally those with known DNA-induc.d hypodopaminergia. This c.se study examines a 12-year-old c.uc.sian male with no prior psyc.iatric.issues who presented with a sudden onset of severe anxiety, depression, emotional liability, and suic.dal ideation. The patient underwent genotyping and the genetic.addic.ion risk sc.re (GARS) testing, whic. revealed risk polymorphisms in the dopamine D2 (-DRD2/ANKK (Taq1A), OPRM1 (A/G), DRD3 (c.T), and MAOA (4R) genes. These polymorphisms have been linked to hypodopaminergia. The patient was subsequently plac.d on researc. ID-KB220ZPBMPOLY (POLYGEN®), and albeit the possibility of bias, based upon self and parental assessment, a marked rapid improvement in psyc.iatric.symptoms was observed. In the sec.nd phase of treatment (102 days utilizing KB220), the patient rec.ived standard antibody testing, whic. was positive for Lyme. Antibac.erial therapy started immediately, and KB220z was disc.ntinued to provide a wash-out period. A monotonic.trend analysis was performed on eac. outc.me measure, and a c.nsistently dec.easing trend was observed utilizing antibac.erial therapy. Our rec.mmendation, albeit only one c.se, is to utilize and further researc. a c.mbined therapeutic.approac., involving prec.sion-guided DNA testing and pro-dopamine regulation along with antibac.erial therapy, as well as

关键词： PANDAS c.NS Genetic.Addic.ion Risk Testing (GARS) Pro-Dopamine Regulation Hypodopaminergia Polymorphisms Antibac.erial Therapy Infec.ions

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