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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

Germination of chenopodium Album in Response to Microwave Plasma Treatment

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Plasma Science and Technology 2008年第4期10卷 506-511页

作者： Bo■ena ER Vitězslav STRA■K Michal ER■ Milan TIcH■ Petr PATENKA Institute of Systems Biology and Ecology Academy of Sciences of the Czech RepublicNa Sádkách 7CZ-370 05eské BudějoviceCzech Republic University of South Bohemia in eské Budějovice Department of PhysicsJeronymova 10CZ-371 15 eské BudějoviceCzech Republic charles University in Prague Faculty of Mathematics and PhysicsV Holeovikách 2CZ-180 00 Praha 8Czech Republic University of South Bohemia in eské Budějovice Department of PhysicsJeronymova 10 CZ-371 15 eské BudějoviceCzech Republic Technical University of LiberecDepartment of Material SciencesHáIkova 6CZ-461 17 Liberec iCzech Republic

The seeds of Lamb＇s Quarters （chenopodium album agg.） were stimulated by low- pressure discharge. The tested seeds were exposed to plasma discharge for different time durations （from 6 minutes to 48 minutes）. Germination tests were performed under specified laboratory conditions during seven days in five identical and completely independent experiments. Significant differences between the control and plasma-treated seeds were observed. The treated seeds showed structural changes on the surface of the seat coat. They germinated faster and their sprout accretion on the first day of seed germination was longer. Germination rate for the untreated seeds was 15% while it increased approximately three times （max 55%） for seeds treated by plasma from 12 minutes to 48 minutes.

关键词： early growth germination Lamb's Quarters seed enhancement stimulation surfatron discharge

Mechanism and Kinetic of Free Radical Reactions for Propane Using theoretical calculations

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Journal of chemistry and chemical Engineering 2012年第6期6卷 563-573页

作者： Abbas A- Ali drea Nadia Izet Department of chemistry College of Science Babylon University post box No.4 Hilla-lraq Department of chemistry College of Education for Girls AL-Kufa University Al Najafe-lraq

Quantum calculation method has been used to understand and investigate the free radical reactions of propane with hydroxyl radical in vacuum through modem quantum mechanics that is package on hyperchem 8.02 program. Optimized structures and structural reactivates have been studied through bond stability and angles using DFT calculation based on the basis set 6-31G＊. Energetic properties have been calculated like total energy, Gibbs free energy, entropy, heat of formation, and rate constant for all chemical species that＇s participate in the suggested reaction mechanism. Reaction mechanism and rate determining step had been suggested according to calculation of energy barrier values, and compares between the suggested competitive reactions for each probable reaction step. Suggested structures and the probable transition states have been studied.

关键词： Free radicals reaction mechanism theoretical chemistry quantum mechanics rate determining step.

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Probiotic treatment of inflammatory bowel disease:Its extent and intensity

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World Journal of Immunology 2022年第2期12卷 15-24页

作者： Saheli Biswas ena Ray Banerjee Department of Zoology University of CalcuttaKolkata 700019West BengalIndia

Free radicals(reactive oxygen species,superoxides and hydroxyl radicals)lead to the development of oxidative stress because of imbalance in the amount of *** development of oxidative stress leads to chronic diseases in *** instability in the antioxidant activities and accumulation of oxidative stress due to free radicals may occur in diseases like inflammatory bowel disease(IBD).Antioxidants are substances that inhibit or delay the mechanism of oxidation of molecules mediated by free radicals and also transform into lesseractive *** are defined as live microorganisms that show beneficial effects on inflamed intestine and balance the inflammatory immune responses in the *** strains have been reported to scavenge hydroxyl radicals and superoxide anions that are abundantly produced during oxidative *** most widely studied probiotic strains are Streptococcus,Bifidobacterium and *** cultured in broth have shown some amount of antioxidant *** milk and soy milk,which possess starter microorganisms(probiotics),tends to increase the antioxidant activities *** review aims to discuss the in vivo and in vitro antioxidant activities of specific probiotics with various assays with respect to IBD.

关键词： Oxidative stress Inflammatory bowel disease Probiotics Therapy Antioxidative activity

Exploring research on ecotechnology through artificial intelligence and bibliometric maps

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Environmental Science and Ecotechnology 2024年第5期21卷 405-412页

作者： Ricardo Ruiz-Sanchez Ricardo Arencibia-Jorge Julia Tagüena Jose Luis Jimenez-Andrade Humberto carrillo-calvet Unidad Profesional Interdisciplinaria de Ingeniería Palenque(UPIIP) Instituto Politecnico NacionalPalenqueChiapasCP 29960Mexico complexity Sciences center National Autonomous University of MexicoCircuito Centro Cultural s/nCoyoacan04510Mexico CityMexico Institute of Renewable Energies(IER) National Autonomous University of MexicoPriv.Xochicalco s/nCol.CentroTemixcoMorelosCP 62580Mexico Faculty of Sciences National Autonomous University of MexicoCircuito Centro Cultural s/nCoyoacan04510Mexico CityMexico

Ecotechnology,quintessential for crafting sustainable socio-environmental strategies,remains tantalizingly *** analysis,steered by the nuances of machine learning and augmented by bibliometric insights,delineates the expansive terrain of this domain,elucidates pivotal research themes and conundrums,and discerns the vanguard nations in this ***,we deftly connect our discoveries to the United Nations'2030 Sustainable Development Goals,thereby accentuating the profound societal ramifications of ecotechnology.

关键词： Ecotechnologies Bibliometrics Sustainable development goals Network analysis SOM neural networks

Exploring the relationship between gut microbial ecology and inflammatory disease:An insight into health and immune function

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World Journal of Immunology 2024年第1期14卷 1-16页

作者： Akashlina Marik Saheli Biswas ena Ray Banerjee Department of Zoology University of CalcuttaKolkata 700019West BengalIndia

The immune system,host brain development,and general metabolism are all influenced by the gut *** make up the majority of the gut microbiota in *** mouse has been the most often used animal model in preclinical biological *** mice,Firmicutes and clostridiales are *** the other hand,Bacteroidaceae,Prevotellaceae,and Firmicutes are commonly found in *** this review,we performed a detailed study by focusing on a comparison between human and murine gut microbiomes,role of the microbiome and their secreted metabolites in regulating gut immunity to maintain homeostasis,and changes in the microbial composition in the dysbiotic state.

关键词： Gut microbiome Immunity Inflammatory Bowel disease Diabetes Dysbiosis