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Albumin-bound paclitaxel as new treatment for metastatic cholangiocarcinoma: A case report

World Journal of Clinical Oncology 2020年第10期11卷 844-853页

作者： Roberto Martin Huertas Raquel fuentes-Mateos Juan Jose serrano Domingo Elena Corral de la Fuente Mercedes Rodríguez-Garrote Medical Oncology Department Hospital Universitario Ramon y CajalMadrid 28034Spain

BACKGROUND Cholangiocarcinomas are rare and very aggressive *** patients have advanced-stage or unresectable disease at presentation,and the systemic therapies have limited ***-bound paclitaxel(nab-paclitaxel)is a solvent-free taxane that has been approved for the treatment of some cancers such as breast,non-small cell lung and pancreatic cancer,however it has not been applied to treat *** have both preclinical and clinical evidence of the efficacy of nab-paclitaxel in cholangiocarcinoma,yet no phase 3 trials have been *** sUMMARY A 63-year-old man was diagnosed in December 2016 with stage III B intrahepatic *** was performed,followed by adjuvant chemotherapy treatment with capecitabine and gemcitabine;although,the gemcitabine was suspended due to allergic reaction after two *** April 2019,metastatic cholangiocarcinoma relapse was diagnosed,and a first-line treatment with FOLFOX scheme was *** cycles were administered,producing an initial clinical improvement and decrease in blood tumor marker *** and serological progression was noted in september *** a second-line treatment,FOLFIRI was not recommended due to risk of worsening the patient’s tumor-related diarrhea.A combination therapy with gemcitabine was not feasible,as the patient had previously suffered from an allergic reaction to this *** decided to use nab-paclitaxel as a second-line treatment,and four cycles were *** clinical and serological responses were observed,and a radiological mixed response was also *** Advanced cholangiocarcinoma could be treated with nab-paclitaxel monotherapy,which should be studied in combination with other types of treatment(chemotherapy,fibroblast growth factor receptor inhibitors).

关键词： Cholangiocarcinoma Chemotherapy Albumin-bound paclitaxel Case report Metastatic Clinical trial

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Toxicity to repeated dose of the humanized monoclonal antibody R3,during six months by intravenous route in Cercopithecus aethiops sabaeus monkeys.

Toxicity to repeated dose of the humanized monoclonal antibo...

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第十五届国际药理学大会

作者： Arteaga M.E. Hernández O. Hernández J. González C. subirós N fuentes D Casacó A Charro L Barredo A Centro Nacional para la Producción de Animales de Laboratorio.（CENPALAB） Cuba Centro Nacional para la Producción de Animales de Laboratorio.（CENPALAB） Cuba Centro Nacional para la Producción de Animales de Laboratorio.（CENPALAB） Cuba Centro Nacional para la Producción de Animales de Laboratorio.（CENPALAB） Cuba Centro Nacional para la Producción de Animales de Laboratorio.（CENPALAB） Cuba Centro Nacional para la Producción de Animales de Laboratorio.（CENPALAB） Cuba Centro de Inmunologiá Molecular （CIM） Centro de Neurociencias Centro Nacional de Investigaciones Científicas （ CNIC ） Cento de Investigaciones Médico Quirúrgicas （CMEQ）

＜正＞ The humanized monoclonal antibody R3 （mAb h - R3）,is a product destined to the treatment in human patients by intravenous route, to diminish or eliminate malignant cell transformations associated to the Epidermal Growth factor receptor overexpression. The objective was to evaluate the toxicity of the mAb h - R3 administration by intravenous route to18 Cercopithecus aethiops sabaeus monkeys during six months. Three experimental groups were utilized: group Control, and two groups treated to low and high dose of 2.85 and 28.57 （mg/Kg） respectively. Deaths were not observed, the body weight had a significant increase for weeks, there were not toxic effects in the Haemotological and Biochemical parameters. In the electrocardiography registrations, it was observed a light increment of the cardiac frequency in treated animals. There were neither neurotoxic effects on the studied variables nor macro and microscopic lesions in the skin.

关键词： Toxicity Cercopithecus aethiops sabaeus. monkeys monoclonal antibody

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Determination of Radioactive Contaminant <sup>137sup>Cs (Fission Product) and Comparison with Natural <sup>40sup>K Present in Mexican strawberries

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Journal of Geoscience and Environment Protection 2022年第7期10卷 257-265页

作者： Fridda Concepción fuentes Gama Juan Manuel Navarrete Tejero Aleja.dro Ramírez Chávez Miguel Ángel Zúñiga Pérez Department of Inorganic and Nuclear Chemistry Faculty of Chemistry National Autonomous University of Mexico Mexico City Mexico

several previous papers have been published about radioactive contamination in Mexican soil, marine sediments and foodstuffs. Ever since, results have been according to expectation, mainly consisting of natural isotopes in small concentration. Continuous research leads with the surprising finding of fission product sup>137sup>Cs (tsub>1/2sub> = 30 years) in strawberries produced in different states, about 2000 km away from each other. Never before, such contaminant has been observed in foodstuffs, produced in this country. The aim of this work is to report the presence of sup>137sup>Cs in Mexican strawberries and compare the activity of such contaminant with the natural radioactivity of sup>40sup>K (tsub>1/2sub> = 1.28 × 10sup>9sup> years), through gamma spectrometry. Eventually, the specific activity of sup>137sup>Cs observed in samples FM4, FM5 and FBC is respectively 0.7, 0.8 and 0.3 Bq/kg. The limits established in CODEX-sTAN-193-1995 for sup>137sup>Cs are 1000 Bq/kg, so all samples meet the recommendation. It’s presence now in vegetables result with enough interest to be known and considered in the near future to measure the possible effect that radioactive contamination could reach after nearly 80 years from second world war, where no nuclear test has been performed, nuclear accident occurred, neither nuclear weapon has ever been used.

关键词： Radioactive Contamination

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卷尾猴的卵泡生长发育及排卵的超声监测

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中国实验动物学报 2007年第1期15卷 25-29,I0004页

作者：唐东红 Maria Aleja.dra fuentes Priego Maria Elena Ortiz 叶尤松代解杰中国医学科学院中国协和医科大学医学生物学研究所昆明650118 智利医学生殖研究中心

目的建立卷尾猴正常月经周期卵泡生长发育变化规律及排卵的超声监测（ultrasound examination，Us）技术。方法采用阴道细胞涂片及超声监测技术，对5只卷尾猴连续3个周期检查阴道细胞变化，对卵泡生长发育进行超声监测。结果阴道脱落细... 详细信息

目的建立卷尾猴正常月经周期卵泡生长发育变化规律及排卵的超声监测（ultrasound examination，Us）技术。方法采用阴道细胞涂片及超声监测技术，对5只卷尾猴连续3个周期检查阴道细胞变化，对卵泡生长发育进行超声监测。结果阴道脱落细胞在生殖周期内呈周期性变化。月经周期为（21．13±2）d。阴道细胞学涂片显示卷尾猴的月经周期分为以下各期：月经期（menstrual phase，M）、滤泡期（follicular phase，F）、排卵前期（preovulation phase，Co），黄体期（luteal phase，L）。Us技术在滤泡期及排卵前期可观测到直径约3～9min的优势卵泡（dominant follicle，DF）的生长过程。当DF较前一天至少小10％，轮廓不规则，回声较以前强，阴道细胞涂片显示淋巴细胞出现，提示排卵已发生，黄体开始形成。结论B型超声技术能实时监测卷尾猴的卵泡生长发育过程，预知优势卵泡排卵时间。

关键词：卷尾猴 B超卵泡生长发育排卵

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利用地理信息系统数据库分析钉螺空间区域的分布

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中华预防医学杂志 1999年第6期33卷 343-345页

作者：周晓农 TK Kristensen 洪青标孙乐平 M fuentes JB Malone 江苏省血吸虫病防治研究所无锡市214064 DanishBilharziasisLaboratoryCharlottenlund Denmark schoolofVeterinaryMedicineMfuentes JBMalone

目的　利用地理信息系统（ＧＩＳ）数据库分析中国大陆钉螺的空间区域分布。方法　收集中国九省３４个种群钉螺等位基因实验所得的种群遗传变异资料以及钉螺易感性实验资料，建立数据库。以世界数字地图为背景，在ＡｒｃＶｉｅｗ３．... 详细信息

目的　利用地理信息系统（ＧＩＳ）数据库分析中国大陆钉螺的空间区域分布。方法　收集中国九省３４个种群钉螺等位基因实验所得的种群遗传变异资料以及钉螺易感性实验资料，建立数据库。以世界数字地图为背景，在ＡｒｃＶｉｅｗ３．０ａ软件上与钉螺的遗传变异和易感性数据库相联。采用ＡｒｃＶｉｅｗ空间分析和ＧＩＳ重叠分析功能进行区域划分。收集１９９５年ＡＶＨＲＲＮＤＶＩ卫星图像组合成流行季节的卫星图像，并重叠各种群钉螺的杂合指数、多态位点百分率和血吸虫感染率分布图，进行图像分类。结果　空间分析结果，将钉螺遗传杂合性指数、多态位点百分率和钉螺感染率的分布图，划分成西部和东部二大区域，各区域内有各种类型。三层分布图与ＡＶＨＲＲＮＤＶＩ卫星图像重叠分析后，显示出西部四川、西部云南、中部江湖洲滩和东南部沿海４个明显不同的区域。结论　首次运用ＧＩＳ分析种群遗传学资料，佐证了中国大陆钉螺种群结构为分裂亚群结构，并可区分出多个亚种的理论。

关键词：钉螺空间区域分布地理信息系统

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Immunotherapy in triple-negative breast cancer:A literature review and new advances

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World Journal of Clinical Oncology 2022年第3期13卷 219-236页

作者： Guillermo Arturo valencia Patricia Rioja Zaida Morante Rossana Ruiz Hugo fuentes Carlos A Castaneda Tatiana Vidaurre silvia Neciosup Henry L Gomez Department of Medical Oncology Instituto Nacional de Enfermedades NeoplásicasLima 15036Peru

Triple-negative breast cancer(TNBC)is a highly complex,heterogeneous disease and historically has limited treatment *** has a high probability of disease recurrence and rapid disease progression despite adequate systemic *** has emerged as an important alternative in the management of this malignancy,showing an impact on progression-free survival and overall survival in selected *** this review we focused on immunotherapy and its current relevance in the management of TNBC,including various scenarios(metastatic and early-neoadjuvant,adjuvant-),new advances in this subtype and the research of potential predictive biomarkers of response to treatment.

关键词： Triple-negative breast cancer Early disease Immunotherapy Biomarkers Metastatic disease

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Contribution of Different Agronomic Practices and the Fungus Beauveria bassiana on the Coffee Berry Borer

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Journal of Life sciences 2013年第9期7卷 980-992页

作者： Alberto Fernandez Turro Ernesto Castafieda Hidalgo Francisco simon Ricardo Everton Kort Kamp Fernandes Juana Iris Duran Cos Odisa Baque fuentes Universidad de Guantanamo UG Km 212 Carretera a Santiago de Cuba Guantanamo 95100 Cuba Instituto Tecnologico del valle de Oaxaca. Ex Hacienda de Nazareno Xoxocotlan Oaxaca 71230 Mexico Ministerio de la Agricultura. Laboratorio Provincial de sanidad Vegetal de santiago de Cuba Carretera a Siboney Santiago de Cuba Cuba Federal University of Goias UFG Carretera 235 Sector Universitario Goiania 74605-050 Brasil

The research was carried out to study the effect of varying certain ecological conditions in the coffee through the implementation of different agronomic practices such as regulation of the shade, ground cover and rehabilitation of plantations on the populations of the coffee berry borer Hypothenemus hampei Ferrari （Coleoptera： Curculionidae）, it was also evaluated the influence of these conditions in the introduction and transfer of new variants of application of the fungus Beauveria bassiana （Balsamo） Vuillemin. The results showed that the pest damage was lower under a system of sustainable coffee, designed after the restoration of the population density of coffee, conducting systematic pruning and plant health, sanitation of the forest, shade management to double stratum with scattered light intensity of 60-70% and a combination of systems of denominated handling of weeds （strip weeding - Ring weeding）, it was found that under these conditions the technical effectiveness of the fungus B. bassiana was higher compared with applications made in the trees less enlightened, being more advantageous to spray the foliage four times with a frequency of 40 days from 60 days to peak flowering with positive economic indicators even when used as single biological control strategy against the coffee berry borer.

关键词： Coffee berry borer coffee plantation management Beauveria bassiana

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资源枯竭全球最大产铜国遭遇大减产

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商业周刊（中文版） 2023年第10期 29-31页

作者： James Attwood valentina fuentes 孟洁冰(译) 不详

2010年,安德烈·索加雷特(a.drésougarret)作为总工程师,营救了33名被困在井下701米处长达两个多月的智利矿工,赢得全球赞誉。现在,作为智利国家铜业公司(Codelco)的首席执行官,他必须尝试完成另一项艰难的壮举:将这家全球头号铜生产... 详细信息

2010年,安德烈·索加雷特(a.drésougarret)作为总工程师,营救了33名被困在井下701米处长达两个多月的智利矿工,赢得全球赞誉。现在,作为智利国家铜业公司(Codelco)的首席执行官,他必须尝试完成另一项艰难的壮举:将这家全球头号铜生产商从目前的困境中解救出来。

关键词：铜业公司首席执行官安德烈资源枯竭智利生产商

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门多萨中央公园

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新建筑 2015年第6期 83-84页

作者： Daniel Becker Claudio Ferrari Oscar fuentes 宋玮 EMBT中国地区

城市的文化体验给予门多萨市一种独特的观感,这样的体验是由遍布于历史事件的网络所构成。这就是经由时间积累形成下来的场所意义不应被低估的原因。也许在许多方面这一观点已经过时,但是该公司仍然坚持用非量产的方式,关注除城市铁路... 详细信息

城市的文化体验给予门多萨市一种独特的观感,这样的体验是由遍布于历史事件的网络所构成。这就是经由时间积累形成下来的场所意义不应被低估的原因。也许在许多方面这一观点已经过时,但是该公司仍然坚持用非量产的方式,关注除城市铁路交通发展之外的其他不确定性因素。

关键词：中央公园不确定性因素城市铁路历史事件交通发展场所

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Implications of Klotho in vascular health and disease

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World Journal of Cardiology 2014年第12期6卷 1262-1269页

作者： Ernesto Martín-Núez Javier Donate-Correa Mercedes Muros-de-fuentes Carmen Mora-Fernández Juan F Navarro-González Research Unit University Hospital Nuestra Se?ora de Candelaria 38010 Santa Cruz de Tenerife Spain Clinical Analysis service and Research Unit University Hospital Nuestra Se ora de Candelaria 38010 Santa Cruz de Tenerife Spain Nephrology service and Research Unit University Hospital Nuestra Se ora de Candelaria 38010 Santa Cruz de Tenerife Spain

Cardiovascular disease(CVD) is a prevalent condition in general population and the first cause of death overall. Klotho, a pleiotropic protein related to longevity that acts as a co-receptor of the fibroblast growth factor 23, has been proposed as a key regulator of the development of CVD. In the few clinical studies made, it has been observed a relationship between low levels of soluble Klotho and the occurrence and severity of CVD, as well as a reduction of cardiovascular risk when they are high. Also, different polymorphisms of human Klotho gene have been related to the incidence of cardiovascular events. Moreover, several experimental studies indicate that this protein acts in the maintenance of vascular homeostasis. Klotho improves endothelial dysfunction through promotion of NO production and mediates antiinflammatory and anti-aging effects such as suppression of adhesion molecules expression, attenuation of nuclear factor-kappa B or inhibition of Wnt signaling. Furthermore,this protein is related to the attenuation of vascular calcification as well as prevention of cardiac hypertrophy. The expression of this protein in the vascular wall implies a new scenario for the treatment of vascular disorders. The purpose of this review is to provide an overview of the relationship between the Klotho protein and CVD, in addition to its role in the maintenance of functional vascular integrity.

关键词： Klotho Cardiovascular disease vascular health Aging Endothelial dysfunction vascular calcification

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