检索结果-南通市图书馆

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： pascal j.Goldschmidt-Clermont Aisha Khan George jimsheleishvili patricia Graham Adriana Brooks Risset Silvera Alexander j.p.Goldschmidt Damien D.pearse W.Dalton Dietrich Allan D.Levi james D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami project to Cure paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Ethnicity, politics, and the Marginalization of Women and Children in j. p. Clark＇s The Wives Revolt and Ahmed Yerima＇s Little Drops

在线全文

学校读者我要写书评

暂无评论

journal of Literature and Art Studies 2012年第4期2卷 464-470页

作者： sola Fosudo Lagos State University Lagos Nigeria

Ethnic sentiments are usually dictated by political and socio-economic factors and they derive from manipulation of minority interests and groups who are in the face of discrimination and marginalization jostle for attention and relevance within a geopolitical setting in a society. Most often, such political situation which promotes domination by one group and socio-economic subordination of another, usually results in ethnic crisis which arises from, and also leads to serious suspicion, anger, civil unrest, and sometimes war. It is not in doubt, that in times of ethno-political crisis and war, women and children are the main victims as they account for an estimated 80% of refugees and displaced persons worldwide. It is in view of this that this paper examines the politics of ethnic conflicts and discusses some of its painful outcomes, such as marginalization and dehumanization of women and children. The essay uses j. p. Clark＇s The Wives Revolt （1991） and Ahmed Yerima＇s Little Drops （2009） for illustration to point out the importance of democratic principles and increased representation of woman in governance and advocating against discriminatory policies in respect of women and children.

关键词： ethnicity politics marginalization civil unrest democratic principles

Monogamous nature of symmetric N-qubit states of the W class: Concurrence and negativity tangle

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese physics B 2015年第11期24卷 85-91页

作者： p.j.Geetha K.o.Yashodamma Sudha Department of physics Kuvempu University Inspire Institute Inc.

Using Majorana representation of symmetric N-qubit pure states, we have examined the monogamous nature of the family of states with two-distinct spinors, the W class of states. We have evaluated the N-concurrence tangle and showed that all the states in this family have vanishing concurrence tangle. The negativity tangle for the W class of states is shown to be non-zero, illustrating the fact that the concurrence tangle is always lesser than or equal to the negativity tangle in a pure N-qubit state.

关键词： monogamy of quantum entanglement Majorana representation of symmetric pure states concur-rence tangle negativity tangle

Numerical Simulation of the Tip Aerodynamics and Acoustics Test

在线全文

学校读者我要写书评

暂无评论

journal of Thermal Science 2016年第2期25卷 153-160页

作者： F Tejero E p Doerffer o Szulc j L Cross The Szwalski Institute of Fluid-Flow Machinery Polish Academy of Sciences. Fiszera 14 80-231 Gdansk Poland NASA Ames Research Center (retired) Moffett Field CA USA

The application of an efficient flow control system on helicopter rotor blades may lead to improved aerodynamic performance. Recently, our invention of Rod Vortex Generators(RVGs) has been analyzed for helicopter rotor blades in hover with success. As a step forward, the study has been extended to forward flight conditions. For this reason, a validation of the numerical modelling for a reference helicopter rotor(without flow control) is needed. The article presents a study of the flow-field of the AH-1G helicopter rotor in low-, medium- and high-speed forward flight. The CFD code FLoWer from DLR has proven to be a suitable tool for the aerodynamic analysis of the two-bladed rotor without any artificial wake modelling. It solves the URANS equations with LEA(Linear Explicit Algebraic stress) k-ω model using the chimera overlapping grids technique. Validation of the numerical model uses comparison with the detailed flight test data gathered by Cross j. L. and Watts M. E. during the Tip Aerodynamics and Acoustics Test(TAAT) conducted at NASA in 1981. Satisfactory agreements for all speed regimes and a presence of significant flow separation in high-speed forward flight suggest a possible benefit from the future implementation of RVGs. The numerical results based on the URANS approach are presented not only for a popular, low-speed case commonly used in rotorcraft community for CFD codes validation but preferably for medium- and high-speed test conditions that have not been published to date.

关键词： AH-1G TAAT helicopter rotor forward flight chimera overlapping grid

VARIoUS NoTIoNS oF oRTHoGoNALITY IN NoRMED SpACES

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Scientia 2013年第5期33卷 1387-1397页

作者： N.B.oKELo j.o.AGURE p.o.oLECHE School of Mathematics and Actuarial Science Jaramogi Oginga Odinga University of Science and Technology School of Mathematics Statistics and Actuarial Science Maseno University

In this paper, we present various notions and aspects of orthogonality in normed spaces. Characterizations and generalizations of orthogonality are also consid- ered. Results on orthogonality of the range and the kern... 详细信息

关键词： orthogonality normed space elementary operator

Electrochemical studies on interplay of mineralogical variation and particle size on bioleaching low grade complex sulphide ores

在线全文

学校读者我要写书评

暂无评论

中国有色金属学会会刊：英文版 2009年第5期19卷 1312-1325页

作者： p.A.oLUBAMBI j.H.poTGIETER S.NDLoVU j.o.BoRoDE Department of Chemical and Metallurgical Engineering Tshwane University of TechnologyPretoriaSouth Africa Chemistry and Materials Division School of BiologyChemistry and Health SciencesManchester Metropolitan UniversityUK School of Chemical and Metallurgical Engineering University of the WitwatersrandJohannesburgSouth Africa Department of Metallurgical and Materials Engineering Federal University of TechnologyAkureNigeria

The interplay of mineralogical variation and mineral phase distribution within varying particle sizes on the dissolution behaviour of a low grade complex sulphide ore was investigated through bioleaching experiments and electrochemical technique. Investigations were carried out utilizing mineralogical data on the variations in mineral and phase distribution within particle sizes of ophilic cultures of Acidithiobacillus ferrooxidans,Acidithiobacillus thiooxidans and Leptospirillum *** behaviour was studied using particulate electrodes from the four varying particle sizes and from massive electrodes prepared from the two major sulphide mineral rich phases(sphalerite-rich and galena-rich)and a complex mineralogical phase of the bulk *** studies reveal the highest recoveries at a particle size of 75μm,while electrochemical investigations reveal the highest dissolution at particle size of 106μ*** results show that sphalerite rich phase has the highest dissolution rate while galena-rich complex phase has the *** studies confirm the highest bacterial attack at the sphalerite-rich *** discrepancies between the dissolutions within particle sizes obtained from bioleaching experiments and electrochemical studies are consistent with and attributed both to the physical and mineralogical *** behaviour is influenced and controlled by galvanic interaction resulting from mineralogical variation, while bioleaching behaviour is influenced by mineralogical variation as well as physical effect of particle size.

关键词：复杂硫化矿化学研究颗粒大小低品位浸出用电互作矿物

Role of ore mineralogy in optimizing conditions for bioleaching low-grade complex sulphide ores

在线全文

学校读者我要写书评

暂无评论

中国有色金属学会会刊：英文版 2008年第5期18卷 1234-1246页

作者： p.A.oLUBAMBI S.NDLoVU j.H.poTGIETER j.o.BoRoDE School of Chemical and Metallurgical Engineering University of the Witwatersrand Department of Metallurgical and Materials Engineering Federal University of Technology

The role that ore mineralogy plays in understanding and optimizing the conditions favouring the bioleaching of complex sulphide ore containing high amounts of siderite was studied using mixed cultures of mesophilic bacteria,with emphasis on zinc,lead and copper *** influencing parameters investigated include particle size,stirring speed,volume of inoculum,pulp density,and *** results show that the mixed mesophilic cultures can extract about two and a half times the amount of zinc than copper over an equivalent period of *** highest zinc and copper recoveries of 89.2% and 36.4% respectively are obtained at particle size of 75 μm,stirring speed of 150 r/min,pulp density of 10% (w/v),12% (v/v) inoculum concentration,and a pH of *** in elemental composition within different particle sizes resulting from the mineralogy of the ore account for the bioleaching behaviour at varying particle *** dissolution at varying pulp density,volume of inoculum,solution pH and the low solution potential observed are also influenced by ore mineralogy.

关键词：硫化物矿石矿石矿物学生物浸取加工参数

Microstructural Features of Spray-Deposited Immiscible Bearing Alloys Al-43Sn and Al-7Sn-1.3Cu-1.3Ni

在线全文

学校读者我要写书评

暂无评论

journal of Materials Science & Technology 2003年第5期19卷 437-443页

作者： o.p.pandey Thapar Institute of Engineering & Technology Deemed University Patiala-147004 India

Two commercial grade aluminum based immiscible bearing alloys were spray-deposited using convergent-divergent type of nozzle. The processing parameters for spray-deposition were adjusted in such a way that most of the droplets arrived on the deposition substrate in either liquid or semi-liquid state. The microstructural features of spray-formed and as-cast alloys are compared. In spray-formed alloys equiaxed grains were observed. The cell boundaries and intercellular regions were observed to be decorated with sub-micron sized particles whereas in normal casting the second phase was observed to be segregated along grain boundaries. The morphology and distribution of second phase were observed to have similarity with those in over-spread and atomized powders produced under similar processing conditions. The microstructural features observed with variation in spray conditions are discussed in detail.

关键词： Spray deposition Immiscible bearing alloys Microstructure Atomization

Modelling the smart farm

在线全文

学校读者我要写书评

暂无评论

Information processing in Agriculture 2017年第3期4卷 179-187页

作者： Michael j.o’Grady Gregory M.p.o’Hare School of Computer Science University College DublinBelfieldDublin 4Ireland Earth Institute University College DublinBelfieldDublin 4Ireland

Smart farming envisages the harnessing of Information and Communication Technologies as an enabler of more efficient,productive,and profitable farming *** technologies do not suffice on their own;rather they must be judiciously combined to deliver meaningful information in near ***-support tools incorporating models of disparate farming activities,either on their own or in combination with other models,offer one popular approach;exemplars include GpFARM,ApSIM,GRAZpLAN amongst many *** models tend to be generic in nature and their adoption by individual farmers is *** technologies offer an opportunity to remedy this situation;farm-specific models that can reflect near real-time events become tractable using such *** on the development,and application of farm-specific models is at a very early *** paper thus presents an overview of models within the farming enterprise;it then reviews the state-of the art in smart technologies that promise to enable a new generation of enterprise-specific models that will underpin future smart farming enterprises.

关键词： Smart agriculture Modelling Sensing Internet of things