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Bioinformatics analysis and experimental validation of cystathionine-gamma-lyase as a potential prognosis biomarker in hepatocellular carcinoma

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BIOCELL 2024年第3期48卷 463-471页

作者： YANAN ma SHANSHAN WANG HUIGUO DING Department of Gastroenterology and Hepatology Beijing You’an Hospital Affiliated with Capital Medical UniversityBeijing100069China Beijing Institute of Hepatology Beijing You’an Hospital Affiliated with Capital Medical UniversityBeijing100069China

Background:Hepatocellular carcinoma(HCC)is a common malignant tumor with poor prognosis and high mortality *** cystathionine-gamma-lyase(CSE)plays an important role in the development of multiple tumors,the clinical implication and potential mechanisms of CSE in HCC development remain ***:In our study,the CSE expression in HCC was analyzed in Gene Expression Omnibus(GEO)and The Cancer Genome Atlas(TCGA)datasets and further conﬁrmed by RT-qPCR and immunohistochemistry assays in HCC ***,the associations between CSE expression and HCC malignancy as well as survival were analyzed in GSE14520 and validated in HCC ***,the biological functions of CSE in HCC cells was assessed by CCK-8,ﬂow cytometry and Western ***:Lower transcriptional and proteomic CSE expressions were found in HCC tissues in contrast to adjacent normal *** CSE mRNA expression was signiﬁcantly associated with advanced clinicopathological features and poor outcomes in HCC patients from public database and our *** univariate and multivariate analyses of GSE14520 data showed that CSE expression was an independent prognostic indicator for the overall survival(OS)and recurrence-free survival(RFS)of HCC *** vitro experiments further explained that CSE might trigger HCC cell apoptosis by ***:In summary,the present study identiﬁed the relationship between CSE expression and HCC malignancy as well as OS and RFS,indicating that CSE might be a potential prognostic biomarker and a novel therapeutic target for HCC.

关键词： Hepatocellular carcinoma Cystathionine-gamma-lyase Hydrogen sulfide Prognosis Apoptosis

Microed as a powerful technique for the structure determination of complex porous materials

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Chinese Journal of Structural Chemistry 2024年第3期43卷 41-54页

作者： Chao ma Cong Lin Jian Li State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityKowloonHong Kong China

Porous materials have garnered significant attention in recent *** the intrinsic relationship between their structures and properties requires precise knowledge of their atomic ***-crystal X-ray diffraction(SCXRD)has traditionally been the primary method for elucidating such structures,but it demands large,high-quality crystals,often exceeding 5μm in *** growth of these crystals can be a time-consuming process,especially for one-and two-dimensional *** explore structures at the nanoscale,Microed(microcrystal electron diffraction(ed))offers unprecedented insights into the realm of *** revolutionary technique enables researchers to uncover intricate details within nanoscale structures,promising to reshape our fundamental understanding of *** this review,we delve into the applications of Microed in the study of various porous materials,including zeolites,metal-organic frameworks(MOFs),and covalent organic frameworks(COFs).We emphasize the pivotal role of Microed in nanomaterial characterization,enabling precise crystallographic analysis and phase identification.

关键词： Atomic structure Microed Porous materials Three-dimensional electron diffraction

Appendiceal bleeding caused by vascular malformation: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2457-2462页

作者： Qin ma Jin-Jie Du Department of General Surgery Fuling Hospital Affiliated to Chongqing UniversityChongqing 408000China Department of Geriatrics Fuling Hospital Affiliated to Chongqing UniversityChongqing 408000China

BACKGROUND Acute lower gastrointestinal bleeding(LGIB)is a common occurrence in clinical ***,appendiceal bleeding is an extremely rare condition that can easily be overlooked and *** preoperative detection of appen-diceal bleeding often poses challenges due to the lack of related guidelines and consensus,resulting in controversial treatment *** SUMmaRY We presented a case of a 33-year-old female who complained of hematochezia that had lasted for 1 *** revealed continuous bleeding in the appen-diceal orifice.A laparoscopic appendectomy was performed immediately,and a pulsating blood vessel was observed in the mesangium of the appendix,accor-dingly,active bleeding into the appendicular lumen was *** examination revealed numerous hyperplastic vessels in the appendiceal mucosa and dilated capillary *** The preoperative detection of appendiceal bleeding is often challenging,colo-noscopy is extremely important,bowel preparation is not routinely recommend-ed for patients with acute LGIB or only low-dose bowel preparation is *** appendectomy is the most appropriate treatment for appendiceal bleeding.

关键词： Lower gastrointestinal bleeding Appendiceal bleeding Colonoscopy Vas-cular malformation Laparoscopic appendectomy Case report

In Vitro Propagation and Artificial Seed Production of Fritillaria cirrhosa D. Don, an Endangered Medicinal Plant

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Phyton-International Journal of Experimental Botany 2024年第6期93卷 1297-1310页

作者： Qian Tao Guiqi Han Bujin ma Hongmei Jia Can Zhao Wenshang Li Zhuyun Yan Chengdu University of Traditional Chinese Medicine State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest ChinaChengdu610000China

Fritillaria cirrhosa ***(Liliaceae)is an endangered perennial bulbous plant and its dry bulb is a valuable med-icinal material with antitussive and expectorant ***,lack of resources and expensive prices make it difﬁcult to meet clinical *** study presents a regeneration system aimed at overcoming the challenge of inadequate supply in ***,focusing on:(1)callus induction,(2)bulblets and adventitious bud induction,and(3)artiﬁcial seed *** development was achieved in 84.93%on Murashige and Skoog(MS)medium fortiﬁed with 1.0 mg·L^(-1) *** optimal medium for callus differentiation into regenerated bulb-lets was MS medium supplemented with 1.0 mg·L^(-1)6-benzyladenine(6-BA)and 0.2 mg·L^(-1)α-naphthaleneacetic acid(NAA).Subsequently,bulblets and adventitious buds were induced from regenerated bulblet sections cul-tured on MS medium fortiﬁed with 0.3 mg·L^(-1)6-BA+1.0 mg·L^(-1)2,4-dichlorophenoxyacetic acid(2,4-D),2.0 mg·L^(-1)6-BA+0.5 mg·L^(-1),and the induction rates were 88.17%and 84.24%,*** regenerated bulblets were transplanted into a substrate of humus soil,river sand,and pearlite(1:1:1)after low-temperature *** germination rate was 42.80%after culture for 30 *** bulblets were used for encap-sulations in liquid MS medium containing 3%sucrose(w/v)+0.5 mg·L^(-1) NAA+2.0 mg·L^(-1)6-BA+3%sodium alginate(w/v)with a 10 min exposure to 2%CaCl_(2).Under non-aseptic conditions,the germination rate reached 81.67%,while the rooting rate was 20.56%after 45 *** capsule added 1.0 g·L^(-1) carbendazim and 1.0 g·L^(-1) activated carbon was the best component of artiﬁcial *** study successfully established an efﬁcient regen-eration system for the rapid propagation of ***,involving in vitro bulblet regeneration and artiﬁcial seed *** method introduces a novel approach for efﬁcient breeding and germplasm preservation,making it suitable for large-scale industrial resou

关键词： Artiﬁcial seed callus induction Fritillaria cirrhosa organogenesis plant propagation

When LoRa meets distributed machine learning to optimize the network connectivity for green and intelligent transportation system

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Green Energy and Intelligent Transportation 2024年第3期3卷 24-41页

作者： malak Abid Ali Khan Hongbin ma Arshad Farhad Asad Mujeeb Imran Khan Mirani Muhammad Hamza National Key Lab of Autonomous Intelligent Unmanned Systems School of AutomationBeijing Institute of TechnologyBeijing 100081China Department of Computer Science Namal UniversityPakistan Department of Electrical Engineering Tsinghua UniversityBeijing 100084China Faculty of Information Technology Beijing University of TechnologyBeijing 100124China School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China

LoRa technology contributes to green energy by enabling efficient,long-range communication for the Internet of Things(IoT).This paper addresses the challenges related to coverage range in outdoor monitoring systems utilizing LoRa,where the network performance is affected by the density of gateways(GWs)and end devices(eds),as well as environmental *** mitigate interference,data throughput losses,and high-power consumption,the proposed spreading factor(SF)and hybrid(data rate|SF)models dynamically adjust the transmission *** orchestration of concurrent data modifications within the network server(NS)is crucial for uninterrupted communication between GWs and eds,especially in monitoring electric vehicle(EV)stations to reduce traffic congestion and *** K-means and density-based spatial clustering of applications with noise(DBSCAN)algorithms optimizes ed allocation,averts data congestion,and improves the signal-tointerference noise ratio(SINR).These methods ensure seamless information reception by meticulously allocated eds across various GW *** estimate the free-space losses(FSL),a log-distance path loss model(log-PL)is *** various bandwidths(BWs),bidirectional communications,and duty cycles(DCs)helps to prevent saturation,thus prolonging the operational lifespan of *** findings reveal a notable packet rejection rate(PRR)of 0%for the DBSCAN(hybrid model).In contrast,the K-means exhibits a PRR ranging from 5%(hybrid model)to 35.29%(SF model)for the ten GWs ***,the network saturation is reduced to 10.185%and 9.503%,respectively,highlighting an improvement in the average efficiency of slotted ALOHA(91.1%)and pure ALOHA(90.7%).These enhancements increase the lifespan of eds to 15,465.27 days.

关键词： DBSCAN Green transportation Hybrid model Intelligent transportation K-means

Identi?cation and Analysis of the Intermediates from Photodegradation of 3,3′-diamino-4,4′-azoxyfurazan (DAAF)by SERS and HPLC–MS/MS

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Journal of Analysis and Testing 2024年第3期8卷 351-360页

作者： Qi Wu Zhenqi Zhang Wenxu Zheng Juan Li Nan ma Rui Li Bo Yang Weimiao Wang Xiaodong Li Meikun Fan Faculty of Geosciences and Environmental Engineering Southwest Jiaotong University Institute of Chemical materials China Academy of Engineering Physics College of materials and Energy South China Agricultural University Southwest University of Science and Technology

Understanding the structural changes and degradation mechanisms of organic pollutants is critical in environmental *** this work, a xenon lamp was used as an analog light source to simulate the eff ect of sunlight on 3,3′-diamino-4,4′-azoxyfurazan (DAAF) in aqueous solution. Combining high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC–MS/MS), surface-enhanced Raman spectroscopy (SERS) with density functional theory (DFT), the degradation intermediates and mechanisms of DAAF were investigated. The sequential breakdown of the–NH 2and–O–N=bonds, followed by the removal of atomic O from–N=N(O)–, was emphasized and investigated using two-dimensional correlation spectroscopy (2D-COS) and SERS spectra. Three intermediates with mass-to-charge ratios (m/z) 181, 251 and180 were identifi ed and characterized by integrating experimental SERS data with DFT-calculated Raman spectra based on structures hypothesized from MS spectra. The fi ndings from HPLC–MS and SERS not only corroborate each other but also provide a foundation for a detailed examination of the DAAF degradation process.

关键词： DAAF High-performance liquid chromatography coupled with tandem mass spectrometry (HPLC–MS/MS) Photodegradation products Reaction pathways Surface-enhanced Raman spectroscopy (SERS)

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基于情境引擎的车载导航交互设计研究

汽车工程 2024年第1期46卷 18-28页

作者：马钧柏玥同济大学汽车学院上海200092 同济大学设计创意学院上海200092

针对车载导航模式单一、无法根据情境差异动态改变交互策略导致用户体验不足的问题,本文提出了一种支持根据不同情境自适应车载导航交互策略的情境引擎模型。结合以用户为中心的设计流程(UCD)与情境感知理论,定义了汽车人机交互情境,并... 详细信息

针对车载导航模式单一、无法根据情境差异动态改变交互策略导致用户体验不足的问题,本文提出了一种支持根据不同情境自适应车载导航交互策略的情境引擎模型。结合以用户为中心的设计流程(UCD)与情境感知理论,定义了汽车人机交互情境,并通过对典型驾驶用户进行跟车调研,提取关键情境要素,阐述了导航情境下情境引擎模型的自适应交互策略及原理,将用户对不同信息的需求程度映射至交互表现层的详细程度。进行了贴合驾驶员不同需求层级的导航HMI信息框架梳理与组件设计,对两个典型导航使用情境进行了交互界面设计与分析。结果表明,情境引擎能对各驾驶情境下的驾驶员需求进行自适应交互,可为智能座舱驾驶交互体验的优化与研发提供借鉴。

关键词：人车交互车载导航情境感知界面设计

Optimization of extraction process for total flavonoids of Sophorae Flos for the treatment of hyperlipidemia based on network pharmacology and molecular docking

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Journal of Polyphenols 2024年第3期6卷 117-129页

作者： Jiale mao Aijinxiu ma Lingling Wang Xu Zhao Faculty of Functional Food and Wine Shenyang Pharmaceutical UniversityShenyang 110016China

This study aimed to investigate the mechanism of action of Sophora Flos(SF)in the treatment of hyperlipidemia(HLP)using network pharmacology and molecular docking methods,and to optimize the extraction process of the predicted active *** STRING database was used for protein interaction analysis and PPI network construction via Cytoscape *** was employed for docking and *** extensive review of SF identifi ed 6 active ingredients,297 related objectives,84 disease objectives,and 57 total *** protein interaction and topology analysis,18 core targets were *** included 146 gene function entries(Pmainly flavonoids,can modulate the expression of various proteins such as TNF,IL-6,IL-1β,PPARG,and TGFB1 to achieve therapeutic effects on *** network pharmacology and molecular docking results suggested that the active fl avonoids component in SF may be related to the treatment of ***,the orthogonal experiment method was used to optimize the extraction process of total fl avonoid from SF using ethanol refl ux extraction,based on a single factor *** effects of refl ux time,solid-liquid ratio,ethanol concentration,and other factors on the extraction of total fl avonoid from SF were *** optimum process conditions were refl ux time of 1.25 h,solid-liquid ratio of 1:15 g/mL and ethanol concentration of 60%.Using these conditions,the purity of total fl avonoid extracted from SF was 70.33±0.22%.

关键词： Sophorae Flos total flavonoid process optimization network pharmacology hyperlipidemia

Unconventional Organic Low-Dimensional Crystals:Diversity and Potential Applications

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CCS Chemistry 2024年第7期6卷 1628-1653页

作者： Jin Feng mao Sun Ying-Xin ma Zhen-Yu Geng Chuan-Zeng Wang Shu-Ping Zhuo Shu-Hai Chen Hong-Tao Lin Xue-Dong Wang School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255000 School of Resources and Environmental Engineering Shandong University of TechnologyZibo 255000 Institute of Functional Nano&Soft materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123

Organic low-dimensional crystals have garnered escalating interests in the realms of miniaturized optoelectronics and integrated *** continual expansion of molecular systems and improvement in experimental conditions have given rise to unconventional organic low-dimensional crystals,which showcase a variety of appealing structure-dependent properties in the realm of organic semiconductors,owing to their adaptable physicochemical characteristics and exceptional optoelectronics ***,the development of unconventional low-dimensional crystals is filled with abundant possibilities due to their diverse application ***,we present a comprehensive overview of advancements in research on representative cases of unconventional low-dimensional organic crystals,using a systematic and rational structural ***,we have also discussed the existing challenges and future directions,aspiring to deepen understanding and encourage further research exploration in this field.

关键词： organic semiconductor crystal growth precise synthesis noncovalent interaction integrat-ed photonics