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Emerging role of liquid biopsy in rat sarcoma virus mutated metastatic colorectal cancer:A case report

World Journal of Gastrointestinal Oncology 2024年第1期16卷 234-243页

作者： João Gramaça Isabel Gomes Fernandes Carolina Trabulo Joana Gonçalves Rita Gameiro dos Santos Adriano Baptista idília Pina Centro Hospitalar Barreiro Montijo Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal Medical Oncology Unit Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal

BACKGROUND In patients with metastatic colorectal cancer(mCRC),the treatment options are limited and have been proved to be affected by rat sarcoma virus(RAS)mutational *** RAS wild-type(wt)patients,the combination of antiepidermal growth factor receptor(EGFR)monoclonal antibodies with chemotherapy(CT)is more effective than CT *** the other hand,RAS-mutated patients are not eligible for treatment with anti-EGFR *** SUMMARY Eleven patients with initially RAS-mutated mCRC were followed from diagnosis to May *** the time of cell-free DNA determination,five patients had undergone one CT line,five patients had undergone two CT lines,and one patient had undergone three CT lines(all in combination with bevacizumab).At the second and third treatment lines[second line(2L),third line(3L)],patients with neo-RAS wt received a combination of CT and *** neo-RAS wt patients treated with anti-EGFR,our findings indicated an increase in progression-free survival for both 2L and 3L(14.5 mo,P=0.119 and 3.9 mo,P=0.882,respectively).Regarding 2L overall survival,we registered a slight increase in neo-RAS wt patients treated with anti-EGFR(33.6 mo vs 32.4 mo,P=0.385).At data cut-off,two patients were still alive:A RAS-mutated patient undergoing 3L treatment and a neo-RAS wt patient who received 2L treatment with anti-EGFR(ongoing).CONCLUSION Our case series demonstrated that monitoring RAS mutations in mCRC by liquid biopsy may provide an additional treatment line for neo-RAS wt patients.

关键词： Metastatic colorectal cancer Rat sarcoma virus mutational status Liquid biopsy Rat sarcoma virus wild-type Neo-rat sarcoma virus wild-type Anti-epidermal growth factor receptor therapy Case report

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The Use of Triancinolone for the Treatment of Keloid Scars

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第3期14卷 270-275页

作者： José Humberto Cardoso Resende Luís Otávio Torres Anderson Alves Brandão delma dos Santos Assis Mercadante Jessyka Oliveira Barbosa Batista William Felix de Oliveira Pacheco Elisangelo Aparecido Costa Da Silva Douglas Henrique Farias de Oliveira Nébia Maria Almeida de Figueiredo UNIFAN-Centro Universitrio Alfredo Nasser Aparecida de Goinia Brazil UNIRIO Rio de Janeiro Brazil

Scars, when in good evolution, result in a smooth, thin and discreet tissue. Keloid scars, however, are a type of abnormal and exacerbated repair response to tissue injury, whether in surgical interventions or in various injuries, which present in a prominent and gross way. In this context, there is an excess of collagen deposition in the tissue repair process, which can lead to the formation of keloids. The diagnosis of the condition presented is made by the medical professional or by the patient himself after the surgical intervention or skin injury. Under this analysis, protruding, rough and bad-looking scars are identified. In addition, we highlight the existence of keloids similar to large tumors, described as Jorge Lobo disease. The treatment encompasses massages, compressions, corticosteroids, chemotherapy, collagenase and cryotherapy. At first, we used corticosteroid-based massages, and then we started using compressive dressings until we started intrakeloid infiltrations with injectable triamcinolone. Triamcinolone 10 mg injectable—1/10—in 0.9% saline, with syringe and fixed needle 0.3 mm × 8 mm, intralesional infiltrate, in this context, proved to be effective for its treatment when applied sequentially and linearly. In cases where the medication was applied, there was an improvement after 21 days of application and a definitive improvement 2 months after the injury. In comparison, on the other hand, patients who were not subjected to the application of the medication may improve after 4 months of the injury or worsen compared to the initial case. We have come to the conclusion that this procedure may be one of the chosen ones for the treatment of keloid scars, being one of the most recommended for cases of keloid already installed.

关键词： Keloid Scar Hypertrophy Collagen Affection

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In vitro antioxidant and cytotoxic activities of essential oil of Feronia elephantum Correa

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Asian Pacific Journal of Tropical Biomedicine 2014年第4期4卷 290-293页

作者： Ramaraj Thirugnanasampandan delma David PG and Research Department of Biotechnology Kongunadu Arts and Science College

Objective:To analyse the chemical composition and evaluation of antioxidant,cytotoxic and DN A fragmentation activities of essential oil of Feronia elephantum ***:Chemical composition analysis of hydrodistilled essential oil was determined by gas chromatography-mass spectrometry and in vitro antioxidant activity of oil was determined by DPPH free radical,hydroxyly radical scavenging,metal chelating and prevention of deoxyribose *** and ONA fragmentation activities against breast cancer cells(MCF-7)were also ***:Gas chromatography-mass spectrometry analysis revealed the presence of 24compounds with caryophyllene oxide(62.29%)as major compound.A considerable antioxidant,cyotoxic and DN A fragmentation activities of oils was ***:The result of this study clearly indicates oil could be useful for food preservation and preparation.

关键词： Feronia elephantum Essential oil Antioxidant Cytotoxicity DNA fragmentation

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ADVANCED SYNTHESIS OF LIGHT METALS

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Acta Metallurgica Sinica(English Letters) 1996年第6期9卷 531-536页

作者： F.H. Froes(IMAP, University of idaho, Moscow, id 838443026, USA ) Univ of idaho Moscow United States

The synthesis, processing and mechanical properties of the light metals, aluminum,magnesium and titanium Produced by advanced techniques are reviewed. Synthesis techniques to be addressed will include rapid solidifica... 详细信息

关键词： synthesis/processing powder metallurgy lightweight metals,aluminum magnesium,titanium rapid solidification spray depositin mechanical alloying Plasma processing,vapor deposition

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Impact of China’s Outward Foreign Direct Investment on Enterprise Performance

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Journal of Donghua University(English Edition) 2019年第5期36卷 513-520页

作者： XU Qiqi WANG Lei id Bouichou Said Glorious Sun School of Business and Management Donghua University

The present study seeks to address two fundamental questions.(1)Does outward foreign direct investment(OFDI)enhance enterprise performance ultimately?(2)How does this effect come about?A new dataset from the years 2011 to 2016 based on the micro-data of 88 Chinese multinational-listed enterprises was used to test research hypotheses with the mediating effect modeling *** study results reveal that:(1)the investment intensity has a positive influence,while investment span has a negative influence on enterprise performance;(2)the enhanced innovation capability can considerably increase the enterprise performance,while investment intensity and span both hinder the upgrading of innovation capability;and(3)the innovation capability of an enterprise plays a partial intermediary role among investment span and enterprise ***,there is no mediating effect between investment intensity,innovation ability,and enterprise performance.

关键词： outward foreign direct investment(OFDI) enterprise performance innovation capability mediating effect

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Depth to the bottom of magnetic layer in South America and its relationship to Curie isotherm,Moho depth and seismicity behavior

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Geodesy and Geodynamics 2018年第1期9卷 93-107页

作者： Javier idárraga-García Carlos A.Vargas Research Group on Geophysics Universidad Nacional de ColombiaBogotáColombia Deportment of Geosciences.Universidad Nacional de Colombia.Bogota.Colombia

We have estimated the DBML（depth to the bottom of the magnetic layer） in South America from the inversion of magnetic anomaly data extracted from the EMAG2 grid. The results show that the DBML values, interpreted as the Curie isotherm, vary between -10 and -60 km. The deepest values（〉-45） are mainly observed forming two anomalous zones in the central part of the Andes Cordillera. To the east of the Andes, in most of the stable cratonic area of South America, intermediate values（between -25 and-45 km） are predominant. The shallowest values（〈-25 km） are present in northwestern corner of South America, southern Patagonia, and in a few sectors to the east of the Andes Cordillera. Based on these results, we estimated the heat flow variations along the study area and found a very good correlation with the DBML. Also striking is the observation that the thermal anomalies of low heat flow are closely related to segments of flat subduction, where the presence of a cold and thick subducting oceanic slab beneath the continent, with a virtual absence of hot mantle wedge, leads to a decrease in the heat transfer from the deeper parts of the *** comparing our results with the Moho depths reported by other authors, we have found that the Curie isotherm is deeper than Moho in most of the South American Platform（northward to -20°S）, which is located in the stable cratonic area at the east of the Andes. This is evidence that the lithospheric mantle here is magnetic and contributes to the long wavelength magnetic signal. Also, our results support the hypothesis that the Curie isotherm may be acting as a boundary above which most of the crustal seismicity is concentrated. Below this boundary the occurrence of seismic events decreases dramatically.

关键词： Magnetic layer depth Curie isotherm Heat flow Crustal seismicity Flat subduction South America

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Differential Susceptibility of <i>Conyza bonariensis</i>Biotypes to Glyphosate and ALS-Inhibiting Herbicides in Argentina

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Agricultural Sciences 2015年第1期6卷 22-30页

作者： Eduardo Puricelli delma Faccini Marcelo Metzler Patricia Torres Facultad de Ciencias Agrarias and Consejo de Investigaciones Universidad Nacional de Rosario Rosario Argentina INTA Paraná Paraná Argentina

The aim of this study was to compare control of three stages biotypes (rosette, bolting, and repro- ductive stage) of Conyza bonariensis glyphosate susceptible biotype (S) and tolerant biotype (T) to glyphosate with glyphosate and mixtures of acetolactate synthase (ALS)-inhibiting. For glyphosate, the dose-response curves confirmed that injury of the biotype T relative to biotype S was signifi- cantly lower for both rosette and bolting stages. Resistance index (RI) for this herbicide was approximately 4 for both weed stages. At bolting, for both biotypes doses much higher than the recommended dose were required. For acetolactate synthase (ALS)-inhibiting herbicides, at the rosette stage, control of both biotypes was excellent with doses significantly lower than the recommended rate. All herbicides within this group showed a very low I50 relative to the recommended rate. These results indicate that biotypes difficult to control with glyphosate at the rosette and bolting stage may be controlled using acetolacte synthase (ALS)-inhibiting herbicides. Control for the reproductive stage was poor. A management program based on the combination of glyphosate with pre- and post-emergence acetolactate synthase (ALS) herbicides may be effective to control the weed.