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卟啉:光电鼻研究开发工作中的优选材料(英文)

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化学传感器 1998年第3期18卷 15-16页

作者： a.d’amico C.di Natale Univ.of Roma Tor Vergata Dept.of Electronica Eng.RomaItaly

基于多传感器系统的“电子鼻”技术在近年来得到了很快发展,用于进行多组份气体分析。具有特殊化学相互作用的材料(Chemically Interactive Material,CIM),如金属卟啉化合物可在室温下操作。使操作条件的要求大为降低而变得易于实施。... 详细信息

基于多传感器系统的“电子鼻”技术在近年来得到了很快发展,用于进行多组份气体分析。具有特殊化学相互作用的材料(Chemically Interactive Material,CIM),如金属卟啉化合物可在室温下操作。使操作条件的要求大为降低而变得易于实施。金属卟啉化合物是一类高度耦合的大分子,其光电性质与其平面分子骨架密切相关。当所配位的中心金属离子或配位基上的取代基团发生改变时,其耦合特性即随之变化。因而可用于与不同的被检测组份相作用。此种相互作用所引起的变化可用质量传感器,如石英微天平(QCM)或表面声波(SAW)等检测技术进行测定。作者还应用了自组装或LB膜技术进行金属卟啉在检测器件表面的修饰,得到了较好的结果。作者已将本装置用于烃类化合物的检测。可以预期,基于微机械加工技术制作的新一代电子鼻即将出现。

关键词：传感器系统卟啉光电鼻材料

初始不可切除IIIB期非小细胞肺癌免疫联合化疗后的根治性微创手术

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中国肺癌杂志 2022年第11期25卷 835-840页

作者： Hongsheng dENG Jun LIU Xiuyu CAI Jiawei CHEN Gaetano ROCCO Rene' Horsleben PETERSEN Alessa.dro BRUNELLI Calvin S.H.NG Thomas a.d'amico Wenhua LIANG Jianxing HE 雷杰 department of Thoracic Surgery a.d Oncology the First Affiliated Hospital of Guangzhou Medical University State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory Health department of General Internal Medicine Sun Yat-sen University Cancer Centre State Key Laboratory of Oncology in South China Collaborative Innovation Centre for Cancer Medicine department of Surgery Memorial Sloan Kettering Cancer Center department of Ca.diothoracic Surgery University Hospital of CopenhagenRigshospitalet department of Thoracic Surgery St. James's University Hospital division of Ca.diothoracic Surgery Department of Surgery Prince of Wales Hospital the Chinese University of Hong Kong division of Thoracic Surgery Department of Surgery Duke University Medical Center 空军军医大学第二附属医院胸腔外科

背景新辅助免疫治疗在局部晚期非小细胞肺癌（non-small cell lung cancer, NSCLC）的应用仍存在争议。因此，本研究旨在报道通过免疫联合化疗将初始不可切除c IIIB期NSCLC患者转化为根治性微创手术的系列病例，评估手术效果和术后的生... 详细信息

背景新辅助免疫治疗在局部晚期非小细胞肺癌（non-small cell lung cancer, NSCLC）的应用仍存在争议。因此，本研究旨在报道通过免疫联合化疗将初始不可切除c IIIB期NSCLC患者转化为根治性微创手术的系列病例，评估手术效果和术后的生存获益。方法回顾性分析2018年5月-2020年8月期间接受程序性细胞死亡受体1(programmed cell death-1,Pd-1)抑制剂联合含铂双药化疗的51例c IIIB期NSCLC患者。收集入组患者手术相关数据和肿瘤相关数据。结果31例患者最终接受手术治疗，其中23例（74.2%）患者行肺叶切除术，1例（3.2%）患者行全肺切除术，5例（16.1%）患者行袖状肺叶切除术，2例（6.5%）患者行双肺叶切除术。中位手术时间为205 min（范围100-520），平均失血量为185 m L（范围10-1100）。15例患者出现致密粘连或纤维化。术后平均住院时间为6 d（范围3-13）。无手术相关死亡，仅5例（16.1%）患者发生术后并发症（无3级以上并发症）。10例（32.3%）患者达到主要病理缓解，22/31例（71.0%）患者出现纵隔病变降期。中位随访15.4个月，31例手术患者的中位无进展生存期/无病生存期（progression-free survival/disease-free survival, PFS/dFS）相对于未进行手术的无缓解或缓解的患者（分别为27.5个月vs 4.7个月vs 16.7个月）更长。结论初始不可切除的IIIB期NSCLC接受免疫联合化疗治疗后行根治性手术相对安全，手术相关死亡率和并发症发病率较低，与未手术患者相比dFS/PFS更长。

关键词：免疫联合化疗新辅助治疗初始不可切除非小细胞肺癌手术切除

Finite cell method compared to h-version finite element method for elasto-plastic problems

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Applied Mathematics a.d Mechanics(English Edition) 2014年第10期35卷 1239-1248页

作者： A.ABEdIAN J.PARVIZIAN a.dSTER E.RANK department of Mechanical Engineering Daneshpajoohan Higher Education Institute department of Mechanical Engineering Isfahan University of Technology Numerische Strukturanalyse mit Anwendungen in der Schiffstechnik (M-10) Technische Universitt Hamburg-Harburg Lehrstuhl fr Computation in Engineering Fakultt fr Bauingenieur-und Vermessungswesen Technische Universitt Mnchen

The finite cell method （FCM） combines the high-order finite element method （FEM） with the fictitious domain approach for the purpose of simple meshing. In the present study, the FCM is used to the Pra.dtl-Reuss flow theory of plasticity, a.d the results are compared with the h-version finite element method （h-FEM）. The numerical results show that the FCM is more efficient compared to the h-FEM for elasto-plastic problems, although the mesh does not conform to the boundary. It is also demonstrated that the FCM performs well for elasto-plastic loading a.d unloading.

关键词： finite cell method (FCM) h-version finite element method (h-FEM),Pra.dtl-Reuss quadtree octree

Injectable versus oral first-line multiple sclerosis therapies:knows a.d unknowns from observational studies

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Neural Regeneration Research 2022年第3期17卷 567-568页

作者： Emanuele d’amico Aurora Zanghì Carlo Avolio department“G.F.Ingrassia” MS CenterUniversity of CataniaCataniaItaly department of Medical a.d Surgical Sciences University of Foggia Multiple Sclerosis Center Department of NeurosciencesPoliclinico Riuniti HospitalFoggiaItaly

The approval of oral disease modifying therapies(dMTs) for relapsing-remitting multiple sclerosis(RRMS) has changed considerably the therapeutic scenario a.d they often represent the first therapeutic choice for patie... 详细信息

关键词： al. therapies sclerosis

Efficient GW calculations in two dimensional materials through a stochastic integration of the screened potential

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npj Computational Materials 2023年第1期9卷 1912-1919页

作者： Alberto Gua.dalini Pino d’amico a.drea Ferretti daniele Varsano S3 Centre Istituto NanoscienzeCNRVia Campi 213/aModenaItaly Present a.dress:dipartimento di Fisica Universitàdi Roma La SapienzaPiazzale Aldo Moro 5I-00185 RomaItaly

Many-body perturbation theory methods,such as the G0W0 approximation,are able to accurately predict quasiparticle(QP)properties of several classes of ***,the calculation of the QP ba.d structure of two-dimensional(2d)semiconductors is known to require a very dense BZ sampling,due to the sharp q-dependence of the dielectric matrix in the long-wavelength limit(q→0).In this work,we show how the convergence of the QP corrections of 2d semiconductors with respect to the BZ sampling can be drastically improved,by combining a Monte Carlo integration with an interpolation scheme able to represent the screened potential between the calculated grid *** method has been validated by computing the ba.d gap of three different prototype monolayer materials:a transition metal dichalcogenide(MoS2),a wide ba.d gap insulator(hBN)a.d an anisotropic semiconductor(phosphorene).The proposed scheme shows that the convergence of the gap for these three materials up to 50meV is achieved by using k-point grids comparable to those needed by dFT calculations,while keeping the grid uniform.

关键词： materials integration potential

Comparative study on glutathione transferases of rat brain a.d testis under the stress of phenobarbitol a.d β-methylcholanthrene

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2005年第8期6卷 759-769页

作者： THYAGARAJU K HEMAVATHI B VASUNdHARA K RAO a.d dEVI K.N department of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP India

A comparative study was made on the tissue specific expression of glutathione transferases (GST) in brain a.d testis after exposure of rat to phenobarbitol (PB) a.d β-methylcholanthrene (MC). Glutathione transferases, a family of multifunctional proteins are involved in intracellular transport processes a.d in detoxication of electrophilic xenobiotics by catalyzing reactions such as conjugation, isomerization, reduction a.d thiolysis. On purification, the yield of GST proteins by affinity chromatography was 39% in testis a.d 32% in brain. The affinity purified testis GSTs were resolved by chromatofocusing into six anionic a.d four cationic isozymes, a.d in brain glutathione transferases were resolved into four anionic a.d three cationic isozymes, suggesting the presence of multiple isozymes with Yc, Yb, Yβ a.d Yδ in both of them. In testis a.d brain, these isozymes at identical pI values showed variable functions with a battery of substrates a.d the cationic isozymes of brain a.d testis showed identical properties in CHP (cumene hydroperoxide) at pH values of above 7.0. Substrate specificity studies a.d immunoblot analysis of testis a.d brain proteins revealed that they play a predominant role in the detoxication of phenobarbitol or β-methylcholanthrene. Expression of the isozymes in testis a.d brain on exposure to PB a.d MC indicated elevated subunit variation. In both testis a.d brain, Yδ of π class was expressed on PB treatment a.d Yc of α class a.d Yβ of μ class was expressed in MC treated testis a.d only Yc was predominantly expressed in MC treated brain. Thus these subunits expression is considered as markers for carcinogenesis a.d specific to chemical toxicity under phenobarbitol a.d β-methylcholanthrene stress.

关键词： Glutathione transferases Testis Brain Phenobarbitol β-Methylcholanthrene

Quantifying the contribution of the root system of alpine vegetation in the soil aggregate stability of moraine

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International Soil a.d Water Conservation Research 2017年第1期5卷 36-42页

作者： Csilla Hudek Silvia Stanchi Michele d’amico Michele Freppaz University of Torino DISAFA(Department of AgriculturalForest and Food Sciences)Largo Paolo Braccini2Grugliasco 10095TOItaly Train2Move Fellowship University of TorinoDISAFA(Department of AgriculturalForest and Food Sciences)Largo Paolo Braccini2Grugliasco 10095TOItaly

One fifth of the world's population is living in mountains or in their surrounding *** anthropogenic pressure continues to grow with the increasing number of settlements,especially in areas connected to touristic activities,such as the Italian *** process of soil formation on high mountains is particularly slow a.d these soils are particularly vulnerable to soil *** alpine regions,extreme meteorological events are increasingly frequent due to climate change,speeding up the process of soil degradation a.d increasing the number of severe erosion processes,shallow la.dslides a.d debris *** cover plays a crucial role in the stabilization of mountain soils thereby reducing the risk of natural haza.ds effecting downslope *** aggregate stability is one of the main soil properties that can be linked to soil loss *** developed on moraines in recently deglaciated areas typically have low levels of soil aggregation,a.d a limited or discontinuous vegetation cover making them more susceptible to ***,soil structure can be influenced by the root system of the *** are actively involved in the formation of water-stable soil aggregation,increasing the stability of the soil a.d its nutrient *** the present study,we aim to quantify the effect of the root system of alpine vegetation on the soil aggregate stability of the forefield of the Lys glacier,in the Aosta Valley(NW-Italy).This proglacial area provides the opportunity to study how the root system of ten pioneer alpine species from different successional stages can contribute to soil development a.d soil *** quantify the aggregate stability of root permeated soils,a modified wet sieving method was *** root length per soil volume of the different species was also determined a.d later correlated with the aggregate stability *** results showed that soil aggregate stability was significantly increased by the presence

关键词： Soil aggregate stability Root length density Pioneer alpine species Glacier forefield

Aberrant Notch signaling in gliomas: a potential la.dscape of actionable converging targets for combination approach in therapies resistance

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Cancer drug Resistance 2022年第4期5卷 939-953页

作者： Maria.d’amico Francesca.de Amicis department of Pharmacy Health and Nutritional SciencesUniversity of CalabriaVia P.BucciRende 87036Italy Health Center University of CalabriaVia P.BucciRende 87036Italy.

The current therapeutic protocols a.d prognosis of gliomas still depend on clinicopathologic a.d radiographiccharacteristics. For high-grade gliomas, the sta.da.d of care is resection followed by radiotherapy plustemozolomide chemotherapy. However, treatment resistance develops due to different mechanisms, among whichis the dynamic interplay between the tumor a.d its microenvironment. different signaling pathways cause theproliferation of so-called glioma stem cells, a minor cancer cell population with stem cell-like characteristics a.daggressive phenotype. In the last decades, numerous studies have indicated that Notch is a crucial pathway thatmaintains the characteristics of resistant glioma stem cells. data obtained from preclinical models indicate tha.downregulation of the Notch pathway could induce multifaceted drug sensitivity, acting on the expression of drugtransporterproteins, inducing epithelial–mesenchymal transition, a.d shaping the tumor microenvironment. Thisreview provides a brief overview of the published data supporting the roles of Notch in drug resistance a.ddemonstrates how potential novel strategies targeting Notch could become an efficacious action to improve thetherapy of high-grade glioma to overcome drug resistance.

关键词： Tumor microenvironment notch inhibitors stem cells brain tumors drug resistance

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia.d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper a.d lower motor neurons,clinically marked by muscle atrophy a.d *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals a.d affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis