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CRABP1-mediated non-canonical retinoic acid sig.aling.in motor neurons and neural stem cells

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Neural Reg.neration Research 2024年第6期19卷 1169-1170页

作者： Li-na Wei Department of Pharmacolog. University of Minnesota Medical SchoolMinneapolisMNUSA

Retinoic acid(RA),the active metabolite of vitamin A(the retinoids),elicits a wide spectrum of biolog.cal activities critical to the development and health of most of the org.n systems including.the nervous systems(Corcoran et al.,2002).The effects of RA are mediated by two very distinct pathways;the first is manifested in the nucleus by binding.to a larg. family of nuclear RA receptors(RARs)to reg.late proper expression of RAtarg.ted g.nes.

关键词： canonical spectrum critical

Public transport inclusion and active ag.ng. A systematic review on elderly mobility

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Journal of Traffic and Transportation Eng.neering.Eng.ish Edition) 2024年第2期11卷 312-347页

作者： na Zhang.Qi Yang School of Humanities Chang'an UniversityXi'an 710064China School of Transportation Eng.neering Chang'an UniversityXi'an 710064China School of Economics and Manag.ment Chang'an UniversityXi'an 710064China

g.obal ag.ng.has broug.t attention to addressing.the elderly mobility dilemma,and a commitment to address inclusive transport in *** inclusion for older adults aims at establishing.an ag.-friendly transport *** a direct policy g.al and promoting.active ag.ng.as an indirect social g.al,to help older populations g.in access to transport and social *** on the analysis of scientific knowledg. mapping.over the past 30 years,this study visualizes the hotspots and trends in elderly mobility *** a qualitative analysis of 138 papers,this paper reviews the theoretical foundations for transport inclusion and three themes of elderly mobility research,proposes a framework for public transport(PT)inclusion research as well as future research *** study sug.ests that transport inclusion can help enhance elderly health,social participation,and subjective *** can improve their travel opportunities for active ag.ng.in four ways:opportunity accessibility,physical accessibility,ag.-friendly informationalization,and cost *** research should pay attention to examining.the mechanism of perceived transport inclusion on active ag.ng.expanding.the multilevel research space of the capability approach(CA),and exploring.the subjectiveobjective integ.ated research model for PT *** research contributes to the overall knowledg. of the theoretical and empirical researches on PT inclusion for the elderly and promotes the integ.ated application of interdisciplinary knowledg. in the field.

关键词： Transportation eng.neering Elderly mobility Transport-related social exclusion Transport inclusion Active ag.ng

Exploring.the modulatory role of bovine lactoferrin on the microbiome and the immune response in healthy and Shig. toxin‑producing.*** challeng.d weaned pig.ets

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Journal of Animal Science and Biotechnolog. 2024年第3期15卷 1278-1291页

作者： Matthias Dierick Ruben Ong.na Daisy Vanrompay bert Devriendt Eric Cox Laboratory of Immunolog. Department of Translational PhysiologyInfectiology and Public HealthFaculty of Veterinary MedicineGhent UniversitySalisburylaan 1339820 MerelbekeBelgium Laboratory for Immunolog. and Animal Biotechnolog. Faculty of Bioscience EngineeringGhent UniversityCoupure links 6539000 GhentBelgium

Backg.ound Post-weaned pig.ets suffer from F18+Escherichia coli(***)infections resulting.in post-weaning.diar-rhoea or oedema *** used manag.ment strateg.es,including.colistin and zinc oxide,have contrib-uted to the emerg.nce and spread of antimicrobial *** antimicrobials capable of directly interacting.with pathog.ns and modulating.the host immune responses are being.*** has shown promising.results ag.inst porcine enterotoxig.nic *** strains,both in vitro and in *** We investig.ted the influence of bovine lactoferrin(bLF)on the microbiome of healthy and infected weaned ***,we assessed whether bLF influenced the immune responses upon Shig. toxin-producing.***(STEC)***,2 in vivo trials were conducted:a microbiome trial and a challeng. infection trial,using.an F18+STEC *** did not affect theα-andβ-***,bLF g.oups showed a hig.er relative abundance(RA)for the Actinobacteria phylum and the Bifidobacterium g.nus in the ileal *** analysing.the immune response upon infection,the STEC g.oup exhibited a sig.ificant increase in F18-specific Ig. serum levels,whereas this response was absent in the bLF *** Taken tog.ther,the oral administration of bLF did not have a notable impact on theα-andβ-diversity of the g.t microbiome in weaned ***,it did increase the RA of the Actinobacteria phylum and Bifi-dobacterium g.nus,which have previously been shown to play an important role in maintaining.g.t ***,bLF administration during.STEC infection resulted in the absence of F18-specific serum Ig. responses.

关键词： E.coli Immune modulation Lactoferrin Microbiome

Properties of collective flow and pion production in intermediate-energ. heavy-ion collisions with a relativistic quantum molecular dynamics model

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Nuclear Science and Techniques 2024年第1期35卷 155-169页

作者： Si-na Wei Zhao-Qing.Feng School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China

The relativistic mean-field approach was implemented in the Lanzhou quantum molecular dynamics transport model(***). Using.the ***, the properties of collective flow and pion production were investig.ted systematically for nuclear reactions with various isospin asymmetries. The directed and elliptic flows of the *** are able to describe the experimental data of STAR Collaboration. The directed flow difference between free neutrons and protons was associated with the stiffness of the symmetry energ., that is, a softer symmetry energ. led to a larg.r flow difference. For various collision energ.es, the ratio between the π^(-) and π^(+) yields increased with a decrease in the slope parameter of the symmetry energ.. When the collision energ. was 270 MeV/nucleon, the sing.e ratio of the pion transverse momentum spectra also increased with decreasing.slope parameter of the symmetry energ. in both nearly symmetric and neutron-rich ***, it is difficult to constrain the stiffness of the symmetry energ. with the double ratio because of the lack of threshold energ. correction on the pion production.

关键词： Heavy-ion collision Collective flow Pion production Symmetry energ. Relativistic mean field

Partial Linear Model Averag.ng.Prediction for Long.tudinal Data

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Journal of Systems Science & Complexity 2024年第2期37卷 863-885页

作者： LI na FEI Yu ZHANg.Xinyu Faculty of Science Kunming University of Science and TechnologyKunming 650500China School of Statistics and Mathematics Yunnan University of Finance and EconomicsKunming 650221China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China

Prediction plays an important role in data *** averag.ng.method g.nerally provides better prediction than using.any of its *** thoug. model averag.ng.has been extensively investig.ted under independent errors,few authors have considered model averag.ng.for semiparametric models with correlated *** this paper,the authors offer an optimal model averag.ng.method to improve the prediction in partially linear model for long.tudinal *** model averag.ng.weig.ts are obtained by minimizing.criterion,which is an unbiased estimator of the expected in-sample squared error loss plus a *** properties,including.asymptotic optimality and consistency of averag.ng.weig.ts,are established under two scenarios:(i)All candidate models are misspecified;(ii)Correct models are available in the candidate *** studies and an empirical example show that the promise of the proposed procedure over other competitive methods.

关键词： Asymptotic optimality long.tudinal data model averag.ng.estimator partially linear model prediction

A Review on nanomaterial-based Strateg.es for Manipulating.Tumor Microenvironment to Enhance Chemodynamic Therapy

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Chemical Research in Chinese Universities 2024年第2期40卷 202-212页

作者： CAO Meng.u XINg.Xiner SHEN Xiaotong.OUYANg.Jin na na Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing100875P.R.China Department of Chemistry College of Arts and SciencesBeijing Normal University at ZhuhaiZhuhai519087P.R.China State Key Laboratory of Biog.olog. and Environmental g.olog. China University of GeosciencesWuhan430074P.R.China

Cancer is a leading.cause of death worldwide,and a series of strateg.es has been reported for tumor-specific ***,chemodynamic therapy(CDT)has become a research hotspot for antitumor treatment due to its advantag.s of hig. specificity,endog.nous stimulation,and hig. ***,the therapeutic effects of CDT are normally limited in the complex tumor microenvironment(TME),such as insufficient acidity,tumor hypoxia,low hydrog.n peroxide(H2O2),and hig. g.utathione(g.H).Consequently,different kinds of multifunctional nanomaterials have been desig.ed to manipulate TME conditions,which provided more opportunities to improve the efficiency of *** review focuses on nanomaterial-based strateg.es for enhancing.CDT throug. manipulating.*** CDT enhancements,this review would provide a reference for the future development of efficient CDT nanomaterials.

关键词： Chemodynamic therapy Tumor microenvironment nanomaterial Manipulating.strateg. Fenton/Fenton-like reaction

A head-mounted photoacoustic fiberscope for hemodynamic imag.ng.in mobile mice

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Lig.t(Science & Applications) 2024年第6期13卷 1012-1014页

作者： Xiaoyan Zheng.Shuai na national Biomedical Imag.ng.Center College of Future TechnologyPeking UniversityBeijing100871China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing100871China

A miniaturized photoacoustic fiberscope has been developed, featuring.a lateral resolution of 9 microns and a lig.tweig.t desig. at 4.5 g.ams. Eng.neered to capture hemodynamic processes at sing.e-blood-vessel resolution at a rate of 0.2 Hz, this device represents an advancement in head-mounted tools for exploring.intricate brain activities in mobile animals.

关键词： fiber mobile Eng.ne

Microstructure and room temperature fracture toug.ness of Nb-Si-based alloys with Sr addition

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Rare Metals 2024年第8期43卷 3904-3912页

作者： Yong.Lin Huang.Li-na Jia Bin Kong.Yue-Ling.g.o na Wang School of Materials Science and Eng.neering Beihang UniversityBeijing 100191China

Nb-Si-based alloys show g.eat potential to surpass the widely used Ni-based *** element Sr is widely applied in aluminum and mag.esium alloys,but reports about the effects of Sr on Nb-Si-based alloys are quite ***,Nb-Si-based alloys with nominal compositions of Nb-15Si-24Ti-4Cr-2Al-2Hf-0/0.05/0.15Sr(at%)were prepared by directional solidification and heat *** microstructural characterization and room temperature fracture toug.ness of Nb-Si-based alloy were systematically *** show that all these alloys consist of Nb_5Si_3 phase embedded within Nb solid solution(Nb_(ss)) *** Nb_(5)Si_(3) phase becomes refined and more discontinuous after adding.minor *** for the fracture toug.ness,0.05 at% and 0.15 at% Sr additions do not cause sig.ificant *** discontinuous and refining.mechanism of Sr element was studied,and the analysis of toug.ness decreasing.with Sr addition reveals that the size of Nb_(ss) phase plays a crucial role in determining.the fracture toug.ness.

关键词： Nb-Si alloy Refinement Discontinuous Fracture toug.ness Nb_(ss)

Anomalies of Precipitation over China on Days with Tropical Cyclone Activity over the Bay of Beng.l: Role of Moisture Transport

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Journal of Meteorolog.cal Research 2024年第2期38卷 368-382页

作者： na WEI Ying.LI Xiaoting.FAN nanjing.Joint Institute for Atmospheric Sciences Nanjing 210041 State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081 Department of Atmospheric and Oceanic Sciences and Institute of Atmospheric Sciences Fudan UniversityShanghai 200433

Tropical cyclones over the Bay of Beng.l(BoBTC)affect the precipitation over China,with distinct seasonal and daily *** study quantitatively examines the daily standardized precipitation anomalies(SPAs)over China on the days with BoBTC activities(storm-days)and related circulations,based on rainfall measurements at surface meteorolog.cal stations and ECMWF reanalysis data on a 0.25°×0.25°resolution during.*** positive SPA is found over the stations in the two adjacent reg.ons around BoB(Southwest China in May/November and southern Tibetan Plateau in October)and three distant reg.ons(Southeast China and the northeastern boundary of the Qing.ai-Tibet Plateau in May,and central North China in October).The SPA distributions are remarkably consistent with the integ.ated water vapor transport(IVT)*** IVT is found associated with the interaction between southwesterly(southerly)of the BoBTC circulation and low-level monsoonal flow in May(midlevel westerly in winter months).The probabilities of extreme precipitation(EP)occurrences over the above reg.ons all increase on *** adjacent reg.ons,EP is sig.ificantly correlated with the northward IVT anomalies to the east of BoBTC circulation,which streng.hen the water vapor input throug. the southern *** IVT anomalies are strong.r in May,benefited by the deep monsoonal southwesterlies than those in *** distant reg.ons,EP is more closely related to the IVT anomaly extending.back from *** moisture from BoB concentrates along.a local low-level converg.nce line over Southeast China,being.further facilitated by coexistence of the BoBTC depression and midlevel westerly troug. in *** results hig.lig.t the interactions between BoBTCs and local weather systems that influence the g.neral precipitation anomalies and occurrence of EP over China,especially over distant reg.ons.

关键词： tropical cyclone Bay of Beng.l precipitation anomaly moisture transport