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Evaluation of Dynamic Modulus of HMA Sigmoidal Prediction Models and Optimization by Approach of u.S. Mesh Sieve by AFNOR and LC Mesh Sieve

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Open Journal of Civil Engineering 2020年第3期10卷 195-212页

作者： Mouhamed Lamine Chérif Aidara Makhaly ba Alan Carter uFR Sciences de l’Ingénieur Université de Thiès Thiès Sénégal Ecole de Technologie Supérieure (ETS) Director of Pavement BituminousMaterials Laboratory (LCMB) Montréal Canada

Pavement design tools are not universal. Indeed, in the sizing of pavements in the uSA, the prediction models used in the calculation of the dynamic modulus of HMA are not adapted to the characterization of the mineral skeleton of the HMA mix designed with the French method. This article aims to assess the predictive models of the dynamic modulus used in the mechanistic-empirical design for their use in the design of bituminous pavements, and to develop new predictive models taking into account the sieve series LC and AFNOR standards. A total of six types of mixtures were subjected to the determination of complex modulus testing by direct tensile-compression on cylindrical specimens (26-700 LC) over a temperature range (5) and frequency (5) data. Dynamic modulus prediction models |E*| are studied Witczak model 1999 and model Witczak 2006. These models do not take into account the AFNOR or LC mesh sieve, an approach was made in relation to the US mesh sieve to replace ρub>200ub> (0.075 mm), ρub>4ub> (4.76 mm), ρub>38ub> (9.5 mm) and ρub>34ub> (19 mm) respectively by the AFNOR mesh Pub>0.08ub> (0.08 mm), <

关键词： Dynamic Modulus Mechanistic-Empirical Design uS Sieve Mesh HMA AFNOR LC

Increased syndecan-1 and glypican-3 predict poor perinatal outcome and treatment resistance in intrahepatic cholestasis

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Hepatobiliary & Pancreatic Diseases International 2020年第3期19卷 271-276页

作者： basak Gümüs Güler Sibel Ozler Department of Health Sciences Istinye UniversityIstanbul 34010Turkey Department of Perinatology Selcuk University Faculty of MedicineKonya 42130Turkey

background:Intrahepatic cholestasis of pregnancy(ICP)increases the risk of adverse pregnancy *** study aimed to explore the association between serum syndecan-1 and glypican-3 levels and the adverse perinatal outcome as well as the responses to the treatment of ursodeoxycholic acid(uDCA).Methods:This prospective,case control study included 88 pregnant women(44 women with ICP and 44 healthy controls).The primary end points were the perinatal outcome and the response to uDCA therapy.A logistic regression model was used to identify the independent risk factors of adverse pregnancy outcomes and reduced response to uDCA ***:Women with ICP had significantly higher serum syndecan-1(1.27±0.36 ng/m L vs.0.98±0.50 ng/m L;P=0.003),glypican-3(1.78±0.13 ng/m L vs.1.69±0.16 ng/m L;P=0.004),AST(128.59±1.44 vs.13.29±1.32 u/L;Pu/L;Pial bile acid(Pba)(OR=3.392,95%CI:1.003–12.869;P=0.026)were correlated to *** adverse neonatal outcome was related to increased glypican-3(OR=4.275,95%CI:2.726–5.635;P=0.039),and Pba(OR=3.026,95%CI:1.069–13.569;P=0.037).Increases of syndecan-1(OR=7.464,95%CI:2.130–26.153,P=0.017)and glypican-3(OR=6.194,95%CI:2.951–13.002;P=0.025)were the risk factors of decreased response to uDCA ***:Syndecan-1 and glypican-3 might be powerful determinants in predicting adverse perinatal outcome in patients with ICP,and they can be used to predict the response to the uDCA treatment.

关键词： Intrahepatic cholestasis of pregnancy Syndecan-1 Glypican-3 Adverse perinatal outcome Response to uDCA

Rates and risk factors for suicidal ideation,suicide attempts and suicide deaths in persons with HIV:a systematic review and meta-analysis

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General Psychiatry 2021年第2期34卷 60-68页

作者： Matt Pelton Matt Ciarletta Holly Wisnousky Nicholas Lazzara Monica Manglani Djibril M ba Vernon M Chinchillli Ping Du Anna E Ssentongo Paddy Ssentongo Department of Public Health Sciences The Pennsylvania State University College of MedicineHersheyPennsylvaniaUSA Department of Surgery The Pennsylvania State University College of MedicineHersheyPennsylvaniaUSA Center for Neural Engineering Department of Engineering Science and MechanicsThe Pennsylvania State UniversityUniversity ParkPennsylvaniaUSA

background People living with HIV/AIDS(PLWHA)must contend with a significant burden of ***,current studies of this demographic have yielded wide variations in the incidence of suicidality(defined as suicidal ideation,suicide attempt and suicide deaths).Aims This systematic review and meta-analysis aimed to assess the lifetime incidence and prevalence of suicidality in *** Publications were identified from PubMed(MEDLINE),SCOPuS,OVID(MEDLINE),Joanna Briggs Institute EBP and Cochrane Library databases(from inception to before 1 February 2020).The search strategy included a combination of Medical Subject Headings associated with suicide and *** independently screened records,extracted outcome measures and assessed study *** were pooled using a random-effects *** and meta-regression analyses were conducted to explore the associated risk factors and to identify the sources of *** outcomes were lifetime incidence of suicide completion and lifetime incidence and prevalence of suicidal ideation and suicide *** A total of 185199 PLWHA were identified from 40 studies(12 cohorts,27 cross-sectional and 1 nested case-control).The overall incidence of suicide completion in PLWHA was 10.2/1000 persons(95%CI:4.5 to 23.1),translating to 100-fold higher suicide deaths than the global general population rate of 0.11/1000 *** lifetime prevalence of suicide attempts was 158.3/1000 persons(95%CI:106.9 to 228.2)and of suicidal ideation was 228.3/1000 persons(95%CI:150.8 to 330.1).Meta-regression revealed that for every 10-percentage point increase in the proportion of people living with HIV with advanced disease(AIDS),the risk of suicide completion increased by 34 per 1000 *** quality of evidence by Grading of Recommendations,Assessment,Development and Evaluations for the suicide deaths was graded as‘moderate’*** The risk of suicide death is 100-fold higher in people living wit

关键词： lifetime suicide analysis

滇中富碱斑岩风化成土过程中元素地球化学行为及其主控因素

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地质论评 2024年第2期70卷 512-528页

作者：徐磊赵萌生程琰勋潘江涛管继云张亚徐杰陈伟志王浩宇黄加忠杨明龙巴永王守营中国地质调查局昆明自然资源综合调查中心昆明650100 自然资源部自然生态系统碳汇工程技术创新中心昆明650100

富碱斑岩带分布较广,目前对其风化过程中的元素地球化学行为研究较少。笔者等以滇中姚安富碱斑岩为例,通过对其化学风化过程的研究,有助于了解富碱斑岩成土过程中元素富集贫化控制因素,丰富碱性岩浆岩风化成土理论。笔者等分析了富碱斑... 详细信息

富碱斑岩带分布较广,目前对其风化过程中的元素地球化学行为研究较少。笔者等以滇中姚安富碱斑岩为例,通过对其化学风化过程的研究,有助于了解富碱斑岩成土过程中元素富集贫化控制因素,丰富碱性岩浆岩风化成土理论。笔者等分析了富碱斑岩风化过程中的矿物风化特征、元素含量分布特征、化学风化趋势、元素迁移富集特征及主控因素,结果表明:富碱斑岩各风化层元素含量与基岩具有继承性,体现了原位风化的特征,符合北亚热带季风气候下云南境内上扬子地块岩石的风化特征;与大陆上地壳组成(uCC)相比,风化成土过程中Ca、Na、K等阳离子强烈淋失亏损,Fe、Al富集;化学风化过程主要发生脱Ca、Na、K、Mg、Si与富Al、Fe作用,风化早期主要为去Ca、去Na过程,风化中、晚期为去K、去Mg、富Al、富Fe过程,并伴随着强烈的脱硅作用;结合迁移系数,常量元素活动性强弱顺序为:Ca>Na>K>Mg>Si>Al>Fe;微量元素地球化学行为一方面主要受地球化学性质相似的常量元素行为控制,另一方面受Al、Fe氧化物/氢氧化物和黏土矿物吸附作用的影响,Sm、Nb、Sc、Th、Ti、u、Y、Cu、Cr、Ni随风化原地残余富集,ba、Rb、Sr与K、Na、Ca、Mg等常量元素行为一致,随风化而淋失迁出。

关键词：富碱斑岩化学风化常量元素成土过程地球化学行为主控因素姚安

Inhaled unfractionated heparin improves abnormalities of alveolar coagulation, fibrinolysis and inflammation in endotoxemia-induced lung injury rats

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Chinese Medical Journal 2013年第2期126卷 318-324页

作者： WANG Zong-yu Wu Sheng-nan ZHu Zhao-zhong YANG ba-xian ZHu Xi Department of Intensive Care unit Peking University ThirdHospital Beijing 100191 China Department of Cardiac Surgery Peking University First HospitalBeijing 100034 China Department of Biomedical Engineering Case Western ReserveUniversity Cleveland OH44106-2675 USA Department of Anesthesiology Peking University People'sHospital Beijing 100044 China

background Acute lung injury/acute respiratory distress syndrome presents with not only local inflammation, but also pulmonary coagulopathy which is characterized by an alveolar procoagulant response, anticoagulant inhibition, fibrinolytic supression and fibrin deposition. We thus had hypothesized that if aerosolized unfractionated heparin was inhaled into alveolar spaces, it could block the procoagulant tendency, lessen depletion of coagulation factors, and even influence the inflammatory response. We also assessed the effects of different administration regimens of heparin. Methods Male Wistar rats were given inhaled heparin starting 30 minutes before （prophylactic heparin） or 2 hours after （therapeutic heparin） intravenous lipopolysaccharide （LPS） was administered at 6-hour intervals; control groups received inhaled normal saline with or without being exposed to LPS. Thrombin-antithrombin complexes, activated protein C, tissue type and urokinase type plasminogen activators （t-PA/u-PA）, plasminogen activator inhibitor-1 （PAl-l）, tumor necrosis factor-a, interleukin-6 in bronchoalveolar lavage, and lung tissue myeloperoxidase activity, and histology score were measured at three time-points. PAI-1/（t-PA ＋ u-PA） was calculated based on the before-mentioned parameters. Statistical analysis was made using one-way analysis of variance （ANOVA） with post hoc test or Student＇s t test in the case of heterogeneity of variance. Results An alveolar procoagulant reaction, depressed fibrinolysis, and inflammatory response occurred in endotoxemia-induced lung injury. Local prophylactic application of heparin attenuated coagulation and early inflammation, promoted fibrinolysis, and reduced the histology score. Therapeutic application of heparin had similar, but weaker effects. Conclusions Intrapulmonary application of unfractionated heparin by inhalation might inhibit alveolar procoagulant reaction and the early inflammatory response, promote fibrinolysis, and alleviate pulmonary

关键词： acute lung injury, endotoxemia heparin,administration by inhalation, coagulation

海洋潮差区混凝土表面微生物16S rDNA分子鉴定

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哈尔滨工程大学学报 2010年第10期31卷 1386-1392页

作者：吕建福李杰莫照兰巴恒静哈尔滨工业大学交通科学与工程学院黑龙江哈尔滨150090 哈尔滨工业大学土木工程学院黑龙江哈尔滨150090 中国科学院海洋研究所山东青岛266071

针对目前海洋混凝土工程的腐蚀现状,进行了海洋微生物对潮差区混凝土的作用机理及完善海工混凝土的腐蚀机理探索.通过海工混凝土潮差区部位取样,对暴露于潮差区中部22 y的混凝土试样表面进行FE-SEM、EDAX分析,结果表明:潮差区混凝土表... 详细信息

针对目前海洋混凝土工程的腐蚀现状,进行了海洋微生物对潮差区混凝土的作用机理及完善海工混凝土的腐蚀机理探索.通过海工混凝土潮差区部位取样,对暴露于潮差区中部22 y的混凝土试样表面进行FE-SEM、EDAX分析,结果表明:潮差区混凝土表面腐蚀严重,结构疏松,表面覆盖有有机物质和微生物.并将暴露于潮差区中部22 y的混凝土试样和该取样位置挂置7 d的混凝土试样表面的微生物群落分别分离,克隆了其中30株和12株细菌的16S rDNA基因,测定其序列且进行比对,其分别属于15个和7个种属中.优势种属均为假交替单胞菌,但随着暴露时间的增加,总细菌株数和总菌属数分别增大到2.5和2.14倍,且种属的变化也很大.同时,建立了海洋混凝土工程表面细菌鉴定方法,以及分离、鉴定的菌种为后续细菌对混凝土作用的试验提供菌种.

关键词：海洋微生物 16S rDNA 海洋混凝土工程分子鉴定

Saccharomyces cerevisiae prevents postoperative recurrence of Crohn's disease modeled by ileocecal resection in HLA-B27 transgenic rats

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World Journal of Gastroenterology 2023年第5期29卷 851-866页

作者： Caroline Valibouze Silvia Speca Caroline Dubuquoy Florian Mourey Lena M'ba Lucil Schneider Marie Titecat Benoît Foligné Michaël Genin Christel Neut Philippe Zerbib Pierre Desreumaux Department of Digestive Surgery and Transplantation Lille University HospitalLille 59037France u1286-INFINITE-Institute for Translational Research in Inflammation Univ.LilleInsermCHU LilleLille 59000France Intestinal Biotech Development Lille 59045France Department of Research and Applications Gnosis by LesaffreLesaffre GroupMarcq-en-Baroeul 59700France uLR 2694-METRICS:Évaluation des Technologies de Santéet des Pratiques Médicales University of LilleLille University HospitalLille 59000France Department of Hepato-Gastroenterology Lille University HospitalLille 59037France

baCKGROuND Postoperative recurrence(POR)after ileocecal resection(ICR)affects most Crohn's disease patients within 3-5 years after ***-invasive Escherichia coli(AIEC)typified by the LF82 strain are pathobionts that are frequently detected in POR of Crohn's disease and have a potential role in the early stages of the disease *** cerevisiae CNCM I-3856 is a probiotic yeast reported to inhibit AIEC adhesion to intestinal epithelial cells and to favor their elimination from the *** To evaluate the efficacy of CNCM I-3856 in preventing POR induced by LF82 in an HLA-B27 transgenic(TgB27)rat *** Sixty-four rats[strain F344,38 TgB27,26 control non-Tg(nTg)]underwent an ICR at the 12th wk(W12)of life and were sacrificed at the 18th wk(W18)of ***27 rats were challenged daily with oral administration of LF82(109 colony forming units(CFus)/day(d),n=8),PBS(n=5),CNCM I-3856(109 CFus/d,n=7)or a combination of LF82 and CNCM I-3856(n=18).nTg rats receiving LF82(n=5),PBS(n=5),CNCM I-3856(n=7)or CNCM I-3856 and LF82(n=9)under the same conditions were used as *** was analyzed using macroscopic(from 0 to 4)and histologic(from 0 to 6)*** LF82 quantifications were performed weekly for each *** LF82 and inflammatory/regulatory cytokines were quantified in biopsies at W12 and *** are expressed as the median with the interquartile *** nTg animals did not develop POR.A total of 7/8(87%)of the TgB27 rats receiving LF82 alone had POR(macroscopic score≥2),which was significantly prevented by CNCM I-3856 administration[6/18(33%)TgB27 rats,P=0.01].Macroscopic lesions were located 2 cm above the anastomosis in the TgB27 rats receiving LF82 alone and consisted of ulcerations with a score of 3.5(2-4).Seven out of 18 TgB27 rats(39%)receiving CNCM I-3856 and LF82 had no macroscopic *** to untreated TgB27 animals receiving LF82 alone,coadministration of CNCM I-3856 and LF82 significantly red

关键词： Crohn's disease Recurrence Escherichia coli Probiotic Saccharomyces cerevisiae Colorectal surgery

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大型导料槽的焊接变形仿真及优化研究

大型导料槽的焊接变形仿真及优化研究

作者： MOHAMMED OMAR ABDuLLAH ba MATRAF 山东科技大学

学位级别：硕士

In the industrial processes of manufacturing and assembling,metal welding is often carried ***,the distortion in the output product is *** distortions are formed as a result of the high temperature transformations during the welding ***,our main aim is to reduce deformations in the hopper caused by welding by using experimental methods and Finite Element Analysis（FEA）including inherent strain *** are structures used in many industries to facilitate bulk material transfer from one conveyer belt to the other,or for redirecting flow from a delivery *** our research,we found that hopper must be designed and manufactured with high standards to reduce the distortion of metal during the welding *** paper focuses on how to control welding deformation by using a variety of *** occurs because the fast heating and cooling "thermal cycling" have an effect on its mechanical properties after it gets *** have analyzed ways to control the welding deformation by using Finite Element Analysis（FEA）.In addition,we have done further study to solve the issue by adding u shape and V shape including the bevel angle on edges of *** results obtained are promising and have shown that the maximum deformations are reduced to meet ISO *** thin plate deformation properties and residual stresses calculations among the effect of welding distortion of the *** ensure our study and methods have reduced the amount of distortion of hopper,we have done experimental analysis to compare our results with finite element method（FEA）of our study with previous ***,the investigation of welding parameter and boundary condition of welding process have been calculated and the result of experiments on hopper shows that the maximum welding deformation of hopper is similar to the result of analysis by finite element method（FEA）.This paper develops the structure of hopper by using new design as u

关键词：导料槽焊接变形仿真分析

Impact of mass screening for gluten-sensitive enteropathy in working population

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World Journal of Gastroenterology 2009年第11期15卷 1331-1338页

作者： Meritxell Mariné Fernando Fernández-baares Montserrat Alsina Carme Farré Montserrat Cortijo Rebeca Santaolalla Antonio Salas Margarita Tomàs Elias Abugattas Carme Loras Ingrid Ordás Josep M Viver Maria Esteve Department of Gastroenterology University Hospital of Mútua de TerrassaResearch Foundation Mútua de TerrassaUniversity of Barcelona08221 TerrassaCataloniaSpain Department of Immunology(Catlab) University Hospital of Mútua de TerrassaResearch Foundation Mútua de TerrassaUniversity of Barcelona08221 TerrassaCataloniaSpain Department of Biochemistry Sant Joan de DéuHospitalEsplugues08950 CataloniaSpain Occupational Health Department Egarsat(Prevention Society)Sant Cugat del Vallès08173 CataloniaSpain Department of Pathology University Hospital of Mútua de TerrassaResearch Foundation Mútua de TerrassaUniversity of Barcelona08221 TerrassaCataloniaSpain

AIM:To assess:(1)frequency and clinical relevanceof gluten sensitive enteropathy(GSE)detected by serology in a mass screening program;(2)sensitivity of antitransglutaminase(tTGA)and antiendomysium antibodies(EmA);and(3)adherence to gluten-free diet(GFD)and follow-up. METHODS:One thousand,eight hundred and sixtyeight subjects recruited from an occupational health department underwent analysis for tTGA and EmA and, if positive,duodenal biopsy,DQ2/DQ8 genotyping, clinical feature recording,blood tests,and densitometry were ***>98%of individuals had tTGA u/mL,this value was established as the cut-off limit of normality and was considered positive when confirmed twice in the same *** to a GFD and follow up were registered. RESuLTS:Twenty-six(1.39%)subjects had positive tTGA and/or EmA,and 21 underwent biopsy:six Marsh Ⅲ(oneⅢa,fourⅢb,oneⅢc),nine MarshⅠand six Marsh 0(frequency of GSE 1:125).The sensitivity of EmA for GSE was 46.6%(11.1%for MarshⅠ,100% for MarshⅢ),while for tTGA,it was 93.3%(88.8% for MarshⅠ,100%for MarshⅢ).All 15 patients with abnormal histology had clinical features related to ***ⅠandⅢsubjects had more abdominal pain than Marsh 0(P=0.029),and a similar trend was observed for distension and *** differences in the percentage of osteopenia were found between MarshⅠandⅢ(P=0.608).Adherence to follow-up was 69.2%.Of 15 GSE patients,66.7%followed a GFD with 80%responding to it. CONCLuSION:GSE in the general population is frequent and clinically relevant,irrespective of histological *** is the marker of *** screening programs are useful in identifying patients who can benefit from GFD and follow-up.

关键词： Antitransglutaminase and antiendomysiumantibodies Celiac disease Lymphocytic enteritis Massscreening