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动物氧化和免疫应激模型的建立方法

中国畜牧杂志 2018年第9期54卷 20-25页

作者：赵亚波萨茹丽那.巴根那哈斯额尔敦曹琪娜敖长金内蒙古农业大学动物科学学院内蒙古呼和浩特010018 内蒙古自治区家畜改良工作站内蒙古呼和浩特010011

随着我国畜牧业由以往的散养模式逐渐转变为大规模集约化养殖模式,各种应激已经成为影响家畜正常生长和生产的重要因素。研究动物抗应激机理首先需要建立动物应激模型。本文重点阐述了国内外建立动物氧化和免疫应激模型的新近研究概况,... 详细信息

随着我国畜牧业由以往的散养模式逐渐转变为大规模集约化养殖模式,各种应激已经成为影响家畜正常生长和生产的重要因素。研究动物抗应激机理首先需要建立动物应激模型。本文重点阐述了国内外建立动物氧化和免疫应激模型的新近研究概况,旨在为我国动物应激模型的建立和相关研究提供依据与参考。

关键词：氧化应激免疫应激模型

基于3,6'-二芥子酰基蔗糖在记忆障碍模型大鼠体内表征的单体、远志及其经典方开心散药代动力学

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中国实验方剂学杂志 2012年第14期18卷 138-142页

作者：巴寅颖姜艳艳刘洋吕航萨础拉李晓婷折改梅石任兵北京中医药大学中药学院国家中医药管理局中药经典名方有效物质发现重点研究室北京100102 北京市教委中药质量控制技术工程中心北京100102

目的:建立RP-HPLC测定大鼠血清中3,6'-二芥子酰基蔗糖浓度的方法,研究3,6'-二芥子酰基蔗糖、远志及开心散中3,6'-二芥子酰基蔗糖在记忆障碍模型大鼠体内的药动学特点,评价远志药材中其他成分和复方中其他配伍对3,6'-二芥子酰基蔗糖药动... 详细信息

目的:建立RP-HPLC测定大鼠血清中3,6'-二芥子酰基蔗糖浓度的方法,研究3,6'-二芥子酰基蔗糖、远志及开心散中3,6'-二芥子酰基蔗糖在记忆障碍模型大鼠体内的药动学特点,评价远志药材中其他成分和复方中其他配伍对3,6'-二芥子酰基蔗糖药动学的影响。方法:大鼠腹腔注射东莨菪碱致记忆障碍模型,分别灌胃给予3,6'-二芥子酰基蔗糖对照品、远志水提物和开心散水提物,腹主动脉采血,离心,取血清适量,加0.1 mmol磷酸二氢钾-乙腈沉淀蛋白,取上清液氮气吹干,水溶解,过滤,用HPLC分析,以C18为固定相,流动相为乙腈-0.1%磷酸水溶液梯度洗脱,在330 nm检测3,6’-二芥子酰基蔗糖血药浓度,Kinetics 4.4软件处理数据。结果:3,6'-二芥子酰基蔗糖血清在0.052～2.08 mg.L-1线性关系良好,血浆中最低定量限为52μg.L-1。记忆障碍模型大鼠灌胃给予3,6'-二芥子酰基蔗糖对照品、远志水提物和开心散水提物后的药-时曲线均使用非房室模型处理,主要药动学参数AUC0～∞,Cmax在3,6'-二芥子酰基蔗糖对照品、远志提取物和开心散各组间均有差异(P<0.05)。结论:建立的RP-HPLC测定法,专属、准确、灵敏,适用于3,6'-二芥子酰基蔗糖在大鼠体内的药动学研究。口服开心散全方和远志提取物后3,6'-二芥子酰基蔗糖呈现双峰吸收,达峰时间均为15,150 min,口服开心散全方的3,6'-二芥子酰基蔗糖AUC值是单味药远志的1.60倍,T1/2是单味药远志的1.57倍,表明通过复方配伍,可在提高生物利用度、加速吸收、延长有效血药浓度时间诸方面,调节其药动学特性,从而更有利于发挥其药效作用。

关键词： 3,6'-二芥子酰基蔗糖远志开心散药动学高效液相色谱法

Epidemioclinical Profile and Immediate Outcome of Low Birth Weight at the Reference Health Center in Commune VI of the District of bamako, Mali

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Open Journal of Pediatrics 2023年第2期13卷 235-243页

作者： Mariam Maiga Oumar Coulibaly Mariam Traore Hibrahima Diallo Korotoumou W. Diallo Bourama Kane Alou samake Mamadou Diallo Moussa Konate Mamadou Keita Mohamed saydi Ag Med Elmehdi Elansari Diarra Sidy Moctar Mamadou Traore Djibril Kassogue Kadiatou ba Pierre Togo Pediatric Service of the Reference Health Center of the Commune VI Bamako Mali Pediatric Department of CHU Gabriel Touré Bamako Mali Mali Hospital Bamako Mali Pediatric Service of the Reference Health Center of the Commune V Bamako Mali Timbuktu Regional Hospital Bamako Mali Pediatric Service of the Reference Health Center of the Commune II Bamako Mali

Introduction: Low birth weight is responsible for 9.1 million child deaths each year worldwide. It is the leading cause of perinatal and infant mortality. The objective of this work was to determine the epidemio-clinical profile as well as the future of low birth weight at the Reference Health Center of commune VI in the district of bamako, Mali. Methods: Our study was descriptive and prospective over a year from April 1, 2018 to March 31, 2019. Data were taken from hospital records and newborn referral/evacuation forms. Data processing was performed using Epi Info software version 3.5.4 and Word. Results: The frequency of low birth weight was 34.94%. Multiparity accounted for 47.84%, sex ratio was 0.93, maternal arterial hypertension was present in 41.66%, genitourinary infection was in 58.37% and delivery was by low way in 86.12%. The majority of newborns had a gestational age between 28sa-33sa (56.52%) and a weight between 1501-1999 grams (47.36%). Mortality accounted for 18.66%. Conclusion: Low birth weight is common in our settings with modifiable risk factors. Practitioners must play on them to minimize its importance.

关键词： Low Birth Weight Future Risk Factors bamako Mali

基于远志酮在记忆障碍模型大鼠体内药代动力学特性的远志及开心散药物属性研究

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北京中医药大学学报 2012年第8期35卷 549-553页

作者：巴寅颖姜艳艳刘洋吴霞吕航萨础拉龚旭昊折改梅解素花石任兵北京中医药大学中药学院国家中医药管理局中药经典名方有效物质发现重点研究室北京100102 首都医科大学中医药学院北京市教委中药质量控制技术工程中心北京同仁堂科技发展股份有限公司

目的建立RP-HPLC测定大鼠血清中远志酮Ⅲ浓度的方法,考量远志及其经典方开心散中远志酮Ⅲ在记忆障碍模型大鼠体内的药动学特性,研究远志及其复方在治疗痴呆中的药物属性。方法大鼠腹腔注射东莨菪碱致记忆障碍模型,分别灌胃给予远志... 详细信息

目的建立RP-HPLC测定大鼠血清中远志酮Ⅲ浓度的方法,考量远志及其经典方开心散中远志酮Ⅲ在记忆障碍模型大鼠体内的药动学特性,研究远志及其复方在治疗痴呆中的药物属性。方法大鼠腹腔注射东莨菪碱致记忆障碍模型,分别灌胃给予远志水提物和开心散水提物,腹主动脉采血,离心,取血清适量,加0.1 mmol磷酸二氢钾-乙腈沉淀蛋白,取上清液氮气吹干,水溶解,过滤,用HPLC分析,以C18为固定相,流动相为乙腈-0.1%磷酸水溶液梯度洗脱,在254 nm检测远志酮Ⅲ血药浓度,Kinetica 4.4软件处理数据。结果远志酮Ⅲ血清在0.041 3～1.65 mg/L线性关系良好,最低定量限为41.3μg/L。记忆障碍模型大鼠灌胃给予远志水提物和开心散水提物后的远志酮Ⅲ药-时曲线均使用非房室模型处理,远志酮Ⅲ主要药动学参数曲线下面积(AUC),平均滞留时间(MRT)在远志提取物和开心散组间有差异(P<0.05)。口服开心散全方和远志提取物后远志酮Ⅲ呈现双峰吸收,达峰时间分别为15 min和150 min、15 min和180 min,口服开心散全方的远志酮ⅢAUC值是单味药远志的1.20倍,MRT是单味药远志的1.30倍。结论本试验建立的RP-HPLC测定法,专属、准确、灵敏,适用于远志酮Ⅲ在大鼠体内的药动学研究。大鼠口服远志药味提取物及其复方开心散提取物后远志酮Ⅲ的药代动力学结果表明通过复方配伍,可在提高生物利用度、加速吸收、延长有效血药浓度时间诸方面,调节其药动学特性,从而更有利于发挥其药效作用。

关键词：远志酮Ⅲ 远志开心散药代动力学高效液相色谱法大鼠

含流体致密砂岩的纵波频散及衰减:基于双重双重孔隙结构模型描述的特征分析

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地球物理学报 2018年第3期61卷 1053-1068页

作者：郭梦秋巴晶马汝鹏陈天胜张琳庞孟强谢剑勇河海大学地球科学与工程学院地球探测研究所南京211100 中国石化石油勘探开发研究院油气地球物理中心北京100083

致密砂岩普遍具有低孔、低渗及微裂缝发育的地质特征,并且呈现出很强的非均匀性.致密砂岩储层与常规砂岩储层比较,具有明显的岩石物理性质、渗流力学性质方面的差异.致密砂岩内部的非均匀性对弹性波频散、衰减有显著影响,其中包括孔隙... 详细信息

致密砂岩普遍具有低孔、低渗及微裂缝发育的地质特征,并且呈现出很强的非均匀性.致密砂岩储层与常规砂岩储层比较,具有明显的岩石物理性质、渗流力学性质方面的差异.致密砂岩内部的非均匀性对弹性波频散、衰减有显著影响,其中包括孔隙结构的非均匀性,即岩石内部孔隙参数的不均一性,以及孔隙内部不相混溶流体的非均匀分布;此外,非均匀性的尺度也决定了波出现显著频散与衰减的频段.综合考虑致密砂岩孔隙结构非均匀性及流体斑块状饱和的非均匀性,本文采用双双重孔隙介质结构模拟了致密砂岩的弹性波响应,分析了同时具备两类非均质性岩石中的波传播特征.调查分析了两组分别来自中国鄂尔多斯盆地苏里格气田及四川盆地广安气田的不同类型致密砂岩储层的岩芯超声波实验数据,给出了岩石样本的弹性波速度频散与衰减曲线.结果显示理论模型预测结果与完全饱和、部分饱和岩石的实验数据吻合良好.对两个地区致密砂岩岩芯数据进行对比分析,苏里格致密砂岩样本总体上比广安致密砂岩渗透率高,在各孔隙度范围内,特征模拟显示苏里格样本的裂隙尺寸明显大于广安样本.广安致密砂岩在低孔隙度范围内发育了更多、更小的颗粒裂隙/接触.致密砂岩的速度频散与衰减结果受流体黏度、晶体破裂及流体斑块状饱和的共同影响.此外,孔隙度越大,部分饱和岩石中斑块状饱和机制对总衰减的贡献越低,与之相对,结构非均质性所占的比重则有所增强.

关键词：致密砂岩非均质性部分饱和纵波频散和衰减双重双重孔隙介质模型

bacteremia in Subjects with Sickle Cell Disease: High Rate of Gram-Negative Isolates in the West African Context!

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Journal of Biosciences and Medicines 2023年第2期11卷 15-29页

作者： Papa Silman Diawara Sokhna Moumy Daffe Mamadou Wague Gueye Khadija Fall Moustapha Diop Aminata Diop Nakoulima Tagoutie Niang Mbene Fall Alice Ingabire Mor Ngom Maguette Ndoye Nata Dieng Bécaye Fall Macoura Gadji Meissa Ndew Seye Pape sa.ba.ba Yankhoba Diop Federation of Laboratories Dakar Principal Hospital Dakar Senegal Pediatrics Department Dakar Principal Hospital Dakar Senegal Infectious Diseases Department Dakar Principal Hospital Dakar Senegal Hematology Department Dakar Principal Hospital Dakar Senegal Department of Biological Hematology & Oncology-Hematology (HBOH) National Blood Transfusion Center (CNTS)/FMPOS-UCAD Dakar Senegal

background: Sickle cell disease is one of the most common monogenic diseases in the world, affecting approximately 70 million people, 80% in sub-saharan Africa and 1 in 10 in Senegal. Sickle cell anemia causes functional asplenia (associated with repeated thrombosis of splenic vessels), resulting in increased susceptibility to infection. However, several studies have reported differences in the spectrum of bacterial infections in malaria-endemic areas. Therefore, we proposed to conduct a study to determine the rate of positive blood cultures and the bacteriological spectrum in sickle cell patients. Materials and Method: This is a descriptive cross-sectional study of blood culture samples from patients who received a request for hemoglobin electrophoresis as part of their treatment at the Principal’s hospital in Dakar. The study took place from January 2008 to December 2021. For each patient, we collect demographic information, including age, gender, and the service from which the analysis request originated. Data were collected in the laboratory’s computer system and entered into Microsoft Excel (2007). Statistical analyzes were performed using Epi-Info 7 software. Results: Our study included 1419 patients. The most common types of hemoglobin profiles were: normal profile (n = 1025), AS profile (n = 283), SS profile (n = 104), SC profile (n = 7). This corresponds to the proportions of 72%, 20%, 0.5% and 7.5% for the profiles Normal, AS, SC and SS. The male proportion was 61.1%, 61.5%, 57.1, respectively %, 55.8% for Normal, sa, SC, and SS profiles. A total of 19,090 individual blood culture bottles were collected from 1419 impatient patients as follows: Normal profile (n = 18,042 bottles), AS profile (n = 677 culture bottles), SS profile (n = 362 bottles). The majority of blood culture orders come from pediatric services, accounting for 70% of the total number of orders. Of 19,090 vials examined in this current study, 19.6% developed a positive blood culture. Overal

关键词： Sickle Cell Disease Senegal bacteremia Blood Culture Infection

采前水杨酸结合采后1-MCP处理对李果实贮藏期品质及抗氧化能力的影响

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食品工业科技 2022年第9期43卷 327-333页

作者：罗冬兰瞿光凡曹森朱婷陈仁菊肖倩张迪巴良杰贵阳学院生物与环境工程学院贵州贵阳550005 贵阳学院食品与制药工程学院贵州贵阳550005

探究采前水杨酸(salicylic acid,sa)结合采后1-MCP(1-methylcyclopropene)处理对李子采后保鲜效果的影响。以李子为试材,研究采前sa(1.0 mmol/L)结合采后1-MCP处理(1μL/L)对李子贮藏期间腐烂率、失重率、硬度、丙二醛、可溶性固形物、... 详细信息

探究采前水杨酸(salicylic acid,sa)结合采后1-MCP(1-methylcyclopropene)处理对李子采后保鲜效果的影响。以李子为试材,研究采前sa(1.0 mmol/L)结合采后1-MCP处理(1μL/L)对李子贮藏期间腐烂率、失重率、硬度、丙二醛、可溶性固形物、可滴定酸、VC含量、H;O;含量、O;·产生速率以及活性氧代谢相关的过氧化物酶、超氧化物歧化酶和过氧化氢酶活性等指标的影响。试验结果表明:采前sa结合采后1-MCP处理能够有效抑制李子贮藏期腐烂率、失重率的发生,保持较好的果实硬度、可溶性固形物、可滴定酸和VC含量,抑制丙二醛和H;O;含量的增加,提高过氧化物酶、超氧化物歧化酶和过氧化氢酶的活性,降低O;·产生速率。在贮藏末期60 d时,CK、sa、1-MCP、sa+1-MCP四个处理组的腐烂率分别为11.6%、7.7%、9.1%和5.3%,sa+1-MCP处理较好地保持了李果实的贮藏品质。上述结果表明:采前sa结合采后1-MCP可以延缓李子的衰老过程,较好地保持李子的贮藏品质,为李子采后贮藏保鲜技术的应用研究提供理论依据。

关键词：李子 1-MCP 水杨酸贮藏品质

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复合缓蚀剂中海藻酸钠对AZ91D镁合金缓蚀作用的影响

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热加工工艺 2016年第24期45卷 133-137页

作者：范付军巴志新刘昊尹佳慧翟伟健景晨南京工程学院材料工程学院江苏南京211167 江苏省先进结构材料与应用技术重点实验室江苏南京211167 南京科润工业介质股份有限公司江苏南京211100

采用浸泡法、电化学方法研究了海藻酸钠浓度对AZ91D镁合金新型复合缓蚀剂缓蚀效果的影响。利用极化曲线、交流阻抗(EIS)和失重法评价了该缓蚀剂的缓蚀作用。通过扫描电镜和能谱分析了试样的腐蚀形貌以及缓蚀机理。研究表明,随着海藻酸... 详细信息

采用浸泡法、电化学方法研究了海藻酸钠浓度对AZ91D镁合金新型复合缓蚀剂缓蚀效果的影响。利用极化曲线、交流阻抗(EIS)和失重法评价了该缓蚀剂的缓蚀作用。通过扫描电镜和能谱分析了试样的腐蚀形貌以及缓蚀机理。研究表明,随着海藻酸钠浓度的提高,缓蚀效率先增后减,当浓度为0.03mol/L时,缓蚀效率最高。海藻酸钠在试样表面形成吸附膜,与其他两种成分产生协同作用,从而提高了镁合金的耐蚀性。

关键词：镁合金复合缓蚀剂缓蚀机理海藻酸钠

An exotic Cretaceous kimberlite linked to metasomatized lithospheric mantle beneath the southwestern margin of the S?o Francisco Craton,Brazil

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Geoscience Frontiers 2022年第1期13卷 182-203页

作者： Luísa D.V.Carvalho Tiago Jalowitzki Ricardo Scholz Guilherme O.Gonçalves Marcelo Peres Rocha Rogério Silvestre Pereira Cristiano Lana Marco Paulo de Castro Gláucia Queiroga Reinhardt A.Fuck Universidade Federal de Ouro Preto(UFOP) Escola de MinasDepartamento de GeologiaCampus Morro do Cruzeiro35400-000 Ouro PretoMGBrazil Universidade de Brasília(UnB) Instituto de GeociênciasCampus Universitário Darcy Ribeiro70910-900 BrasíliaDFBrazil Independent Geologist Consultant

We present major and trace element compositions of mineral concentrates comprising garnet xenocrysts,ilmenite,phlogopite,spinel,zircon,and uncommon minerals(titanite,calzirtite,anatase,baddeleyite and pyrochlore)of a newly discovered Late Cretaceous kimberlite(U-Pb zircon age 90.0±1.3 Ma;2σ)named Osvaldo Franca 1,located in the Alto Parana.ba.Igneous Province(APIP),southeastern *** grains are lherzolitic(Lherz-1,Lherz-2 and Lherz-3),harzburgitic(Harz-3)and wehrlitic(Wehr-2).The pyrope xenocrysts cover a wide mantle column in the subcratonic lithosphere(66–143 km;20–43 kbar)at relatively low temperatures(811–875°C).The shallowest part of this mantle is represented by Lherz-1 pyropes(20–32 kbar),which have low-Cr(Cr_(2)O_(3)=1.74–6.89 wt.%)and fractionated middle to heavy rare earth elements(MREE-HREE)*** deepest samples are represented by Lherz-2,Lherz-3,Harz-3,and Wehr-2 pyropes(36–43 kbar).They contain high-Cr contents(Cr_(2)O_(3)=7.36–11.19 wt.%)and are characterized by sinusoidal(Lherz-2 and Wehr-2)and spoon-like(Lherz-3 and Harz-3)REE *** to their REE and trace elements,pyrope xenocrysts have enriched nature(e.g.,Ce and Yb ***_(2)O_(3)),indicating that the cratonic lithosphere has been affected by a silicate melt with subalkaline/tholeiite composition due to their low Zr,Ti and Y *** minerals with typical kimberlitic signatures,such as ilmenite and zircon,the exotic compositions of phlogopite and ulvöspinel suggest an enriched component in the magma *** formation of rare mineral phases with strong enrichment of light-REE(LREE)and high field strength elements(HFSE)is attributed to the late-stage kimberlitic *** propose a tectonic model where a thermal anomaly,represented by the low-velocity seismic anomaly observed in P-wave seismic tomography images,supplied heat to activate the alkaline magmatism from a metasomatized cratonic mantle source during the late-stages of Gondwana fragmentation and conse

关键词： Osvaldo França 1 kimberlite Alto Parana.ba.Igneous Province Metasomatized cratonic lithosphere Zircon U-Pb geochronology