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中华麻醉学杂志 2015年第5期35卷 616-619页

作者：黎笔熙巴宁殷桂林朱水波张晓明谭焱宋晓阳陶军南方医科大学研究生院广州市510515 广州军区武汉总医院心胸外科广州军区武汉总医院麻醉科

目的：评价乌司他丁对失血性休克∕复苏（ Hs∕R）大鼠急性肺损伤的影响。方法选择sPF级成年sD大鼠15只，体重300～400 g，2～3月龄，采用随机数字表法，将其分为3组（ n＝5）：假手术组（ s组）、Hs∕R组和乌司他丁组（ U组）。Hs∕R组... 详细信息

目的：评价乌司他丁对失血性休克∕复苏（ Hs∕R）大鼠急性肺损伤的影响。方法选择sPF级成年sD大鼠15只，体重300～400 g，2～3月龄，采用随机数字表法，将其分为3组（ n＝5）：假手术组（ s组）、Hs∕R组和乌司他丁组（ U组）。Hs∕R组和U组通过颈动脉放血建立失血性休克大鼠模型，维持60 min后回输自体血和生理盐水行容量复苏。 U组于容量复苏前静脉注射乌司他丁5万U∕kg（1．0 ml），s组和Hs∕R组以等容量生理盐水替代。于颈动脉穿刺置入套管针后（T0）、休克后5 min（ T1）、容量复苏前（ T2）、复苏至预定血压5 min（ T3）、容量复苏后30 min（ T4）、1．5 h（ T5）和2．5 h （ T6）时采集0．5 ml动脉血样，采用ELIsA法测定血浆白细胞介素-6（ IL-6）和肿瘤坏死因子-α（ TNF-α）浓度。于T0、T2和T6时采集动脉血样0．5 ml行血气分析，记录pH值、PaCO2、HCO－3和BE值，计算氧合指数（ OI＝PaO2∕FiO2）。于T6时取肺组织行病理学评分，另取肺组织，分离细胞核，采用ELIsA法测定核转录因子-κB（ NF-κB） p65水平。结果与s组比较， U组和Hs∕R组pH值、HCO－3、BE值和OI降低，PaCO2和血浆IL-6和TNF-α浓度、肺组织NF-κB p65水平、病理学损伤评分升高（ P＜0．05）。与Hs∕R组比较，U组血浆IL-6和TNF-α浓度、肺组织NF-κB p65水平、病理学损伤评分降低（ P＜0．05），血气分析指标比较差异无统计学意义（ P＞0．05）。结论乌司他丁虽然可减轻Hs∕R大鼠肺损伤，但不足以改善肺氧合功能。

关键词：胰蛋白酶抑制剂休克,出血性心肺复苏术呼吸窘迫综合征,成人

The influence of soil on vegetation structure and plant diversity in different tropical savannic and forest habitats

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journal of Plant Ecology 2018年第2期11卷 226-236页

作者： Priscyla Maria silva Rodrigues Carlos Ernesto Gonçalves Reynaud schaefer jhonathan de Oliveira silva Walnir Gomes Ferreira júnior Rubens Manoel dos santos Andreza Viana Neri Universidade Federal do Vale do são Francisco Campus Senhor do BonfimColegiado de EcologiaAv.Tomaz GuimarãesS/NBairro Santos DumontSenhor do BonfimBACEP 48.970-000Brazil Universidade Federal de Viçosa Departamento de SolosCampus UniversitárioViçosaMGCEP 36570-900Brazil Instituto Federal de Educação Ciência e Tecnologia do Sul de Minas GeraisRodovia Machado-ParaguaçuKm 3MachadoMGCEP 37750-000Brazil Universidade Federal de Lavras Departamento de Ciências FlorestaisLaboratório de Conservação e Manejo da BiodiversidadeCampus UniversitárioLavrasMGCEP 37200-000Brazil Universidade Federal de Viçosa Departamento de Biologia VegetalLaboratório de Ecologia e Evolução de PlantasCampus UniversitárioViçosaMGCEP 36570-900Brazil

Aims soil plays an important role in the formation and heterogene-ity of habitats and thus can cause changes in vegetation struc-ture and plant *** differentiation between Cerrado/savanna and forest is well known,but the relationship between soil and habitats from savannic or forest formations still needs to be better understood,particularly in tropical ecotonal *** studied the association between attributes of plant com-munities,namely structure and diversity,and physicochemical characteristics of soils in the Caatinga domain at the transition to Cerrado in *** Chemical and physical analyses of soils were performed in samples of 38 plots from savannic formations and 30 plots from forest *** was characterized floristically and structurally in all plots,five habitats being assessed in each plant *** features and vegetation parameters were highly distinct among the different *** Findingsin general,forest habitats were more nutrient rich than savannic ***,soil variables showed effects both on vegetation structure and on its species diversity,more pronouncedly in the savannic *** were structurally distinct,and diversity differed between savannic and forest communities;however,a higher differentiation occurred when the savannic formation habitats were compared among *** plant diversity did not differ among forest formation habitats,soil attributes showed a close relationship with edaphic factors and can contribute for similar *** soil-vegetation relationship in highly diverse ecotonal landscapes is important from the conservation biology point of view and aid in the execution of proactive plans for the maintenance of ***,we noticed that diversity and soil behaves distinctly between savannic and forest communities.

关键词： Cerrado dry forest edaphic variation vegetation-soil relationship ecotone

桐柏地区火神庙矽卡岩型铁矿床的成矿时代、矿床成因及其与古生代构造-岩浆活动的关系

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中国科学：地球科学 2021年第12期51卷 2163-2183页

作者：柴明春胡浩李建威杜世广侯林枫中国地质大学(武汉)资源学院武汉430074 中国地质大学地质过程与矿产资源国家重点实验室武汉430074 云南省普洱市自然资源和规划局普洱665000

秦岭造山带是中国最重要的金-钼-银铅锌多金属成矿带之一,成矿带内的多金属矿床主要形成于中生代,迄今为止很少发现与古生代区域地质作用有关的矿床.本文报道北秦岭桐柏地区火神庙矽卡岩型铁矿床热液石榴子石和相关岩浆岩的锆石U-Pb年龄... 详细信息

秦岭造山带是中国最重要的金-钼-银铅锌多金属成矿带之一,成矿带内的多金属矿床主要形成于中生代,迄今为止很少发现与古生代区域地质作用有关的矿床.本文报道北秦岭桐柏地区火神庙矽卡岩型铁矿床热液石榴子石和相关岩浆岩的锆石U-Pb年龄,揭示该矿床为早志留世商丹洋俯冲过程中岩浆活动和岩浆热液成矿作用的产物.该矿床以发育透镜状、似层状铁矿体为特征,主要由块状和浸染状磁铁矿、石榴子石、透辉石、绿帘石、角闪石、阳起石等组成.矿石中石榴子石主要由钙铁榴石和少量钙铝榴石(Ad;Gr;~Ad;Gr;)组成,具有富集轻稀土(∑LREE=57.85~103.82ppm)、亏损重稀土(∑HREE=5.50~11.34ppm)与显著的铕正异常(δEu=1.09~1.89)和铈正异常(δCe=1.39~1.69)等特征.这些特征显示矿石中的石榴子石为热液成因,明显不同于桐柏地区区域变质成因石榴子石,后者主要由铁铝榴石-锰铝榴石-钙铝榴石(Al;sp;Gr;~Al;sp;Gr;)组成,具有亏损轻稀土(∑LREE=0.14~0.69ppm)、富集重稀土(∑HREE=95.68~841.60ppm)、显著的铕负异常(δEu=0.24~0.51)等特征.此外,矿石中石榴子石发育含子晶多相流体包裹体,进一步支持其为热液成因,因而石榴子石U-Pb年龄可有效约束火神庙铁矿床的成矿时代.本文对采自铁矿石中的两件热液石榴子石样品进行了LAICPMs U-Pb定年,在Tera-Wasserburg谐和图中获得下交点年龄分别为(437±9)Ma和(437±10)Ma(2σ),与邻近火神庙铁矿床产出的辉长闪长岩(438±4)~(436±3)Ma和花岗岩(430±4)Ma的锆石U-Pb年龄在误差范围内完全一致,表明火神庙矽卡岩型铁矿床形成于早志留世,与区域古生代岩浆活动有关.与铁矿床时空关系密切的辉长闪长岩和花岗岩富集大离子亲石元素(ba、K、sr)和轻稀土元素,亏损高场强元素(Nb、Ta、P、Ti),全岩样品的(;sr/;sr);=0.7039~0.7042,ε;(t)=3.32~4.33,锆石的ε;(t)=13.0~14.9.上述地球化学特征表明与成矿有关的中基性-酸性岩浆岩是商丹洋俯冲过程中弧岩浆活动的产物.早古生代火神庙矽卡岩型铁矿床的厘定表明,以商丹缝合带为界线的北秦岭造山带具有寻找古生代多金属矿床的潜力.

关键词：火神庙矽卡岩型铁矿床桐柏地区北秦岭造山带古生代成矿作用

人工晶体植入术中用Zeiss IOLMaster进行生物测量时的参数优化

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世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 10-11页

作者： Madge s.N. Khong C.H. Lamont M. R.j. Antcliff 陈立军 Department of Ophth almology Royal UnitedHospital Combe Park Bath BA1 3NG United Kingdom Dr.

Purpose: To compare the accuracy of biometry using conventional A-scan ultras onography and partial coherence interferometry, and to improve the accuracy of b iometry by sequential audit of postoperative refractive error. Methods: The stud y was performed in three phases. In phase 1, 20 consecutive patients undergoing routine phacoemulsification underwent biometry using bothA-scan ultrasonography and the Zeiss IOLMaster (ZIOLM).Asingle experienced optometrist refracted all p atients 2 weeks after surgery. The errors between expected and achieved refracti on were calculated and compared between the two methods. In phases 2 and 3, a fu rther 22 and 20 patients, respectively, were recruited and only the ZIOLM was us ed for biometry. The manufacturer’s suggested A-constant was refined and the e rror between expected and achieved refraction was calculated. Results: In phase 1, the median unexpected error for the ZIOLM was +0.63 (interquartile range +0 .368 to +1.015) and for A-scan biometry was 0.24 (interqu artile range-1.335 to +0.802). In phase 1 65%of patients’- postoperative refractions were found to be within 1.0 D of emmetropia using th e ZIOLM (55%using A-scan biometry). Refinements to the A-constant improved th is to 95%by phase 3. Conclusion: An error was identified in IOL power estimatio n with the ZIOLM, when using the manufacturer’s recommended A-constant (recomm ended and previously optimized ultrasound A-constant 118.0; ZIOLMoptimized A-c onstant 118.6). serial modifications to the A-constant were successful in reduc ing the unexpected error towellwithin the tolerance limits of published internat ional standards.

关键词：晶体植入 Zeiss 生物测量人工晶体屈光不正术后屈光度验光师正视眼预计值四分位数

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七彩鲑雌核发育及其倍性研究

淡水渔业 2017年第6期47卷 21-25页

作者：代静焦雪张培军冷东泽巴翠玉茆安婷李月红吉林农业大学长春130000 吉林省卫生监测检验中心长春130000

利用紫外线照射对七彩鲑(salvelinus fontinalis)精子进行灭活处理,使其遗传物质失活,作为同源精子诱导源,与七彩鲑卵子进行受精,采用冷休克方法诱导雌核发育。结果表明:同源精子可以诱导七彩鲑的雌核发育,紫外照射强度为72 m j/cm2;距... 详细信息

利用紫外线照射对七彩鲑(salvelinus fontinalis)精子进行灭活处理,使其遗传物质失活,作为同源精子诱导源,与七彩鲑卵子进行受精,采用冷休克方法诱导雌核发育。结果表明:同源精子可以诱导七彩鲑的雌核发育,紫外照射强度为72 m j/cm2;距离为8 cm;冷休克温度为20℃。七彩鲑减数分裂雌核发育倍性测定以鸡(Gallus sp.)红细胞DNA含量(2.5 pg/N)为标准、七彩鲑普通育苗子一代为参照,采用流式细胞术和微卫星标记技术对30尾七彩鲑减数分裂雌核发育鱼苗进行分析,证明了雌核发育鱼苗为雌核发育二倍体。

关键词：七彩鲑(salvelinus fontinalis) 雌核发育流式细胞术 DNA含量微卫星标记

Phase 3 trial of first generation protease inhibitor therapy for hepatitis C virus/human immunodeficiency virus coinfection

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World journal of Hepatology 2017年第4期9卷 217-223页

作者： Kenneth E sherman Minhee Kang Richard sterling Triin Umbleja Kristen Marks jennifer j Kiser Beverly Alston-smith Wayne Greaves Adeel A Butt 无 Division of Digestive Diseases University of Cincinnati College of Medicine harvard T.h. Chan school of Public health Department of Gastroenterology Virginia Commonwealth University Division of Infectious Disease Weill Cornell Medical School University of Colorado school of Pharmacy NIAID-Division of AIDs Merck and Co Inc. University of Pittsburgh school of Medicine hamad healthcare Quality Institute the ACTG 5294 BIRTH study Team

AIMTo evaluate efficacy/safety of hepatitis C virus (HCV) protease inhibitor boceprevir with pegylated interferon (PEG-IFN) alfa and weight-based ribavirin (RBV) in a phase 3 trial. METHODsA prospective, multicenter, phase 3, open-label, single-arm study of PEG-IFN alfa, weight-based RBV, and boceprevir, with a PEG-IFN/RBV lead-in phase was performed. The HCV/human immunodeficiency virus coinfected study population included treatment naïve (TN) and treatment experienced (TE) patients. Treatment duration ranged from 28 to 48 wk dependent upon response-guided criteria. All patients had HCV Genotype 1 with a viral load > 10000 IU/mL. Compensated cirrhosis was allowed. sample size was determined to establish superiority to historical (PEG-IFN plus RBV) rates in sustained viral response (sVR). REsULTsA total of 257 enrolled participants were analyzed (135 TN and 122 TE). In the TN group, 81.5% were male and 54.1% were black. In the TE group, 76.2% were male and 47.5% were white. Overall sVR12 rates (HCV RNA P = 0.002). Among the TN, sVR12 was 42.1% among whites and 27.4% among blacks (P = 0.09). CONCLUsIONThe trial met its hypothesis of improved sVR compared to historical controls but overall sVR rates were low. All-oral HCV treatments will mitigate these difficulties.

关键词： Human immunodeficiency virus Hepatitis C virus Boceprevir Pegylated interferon alfa Ribavirin

高稳定性Tl2ba2CaCu2Ox薄膜DC-sQUID

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低温物理学报 1999年第4期21卷 57-60页

作者：王晶韩冰徐凤枝赵士平陈赓华杨乾声阎少林方兰何明路荣涛中科院物理所凝聚态物理中心南开大学电子科学系

与ＹＢＣＯ薄膜相比，Ｔｌ２Ｂａ２ＣａＣｕ２Ｏｘ薄膜具有更高的Ｔｃ和更好的抗湿性能，所以Ｔｌ２Ｂａ２ＣａＣｕ２Ｏｘ薄膜器件不仅在液氮温度下具有更好的稳定性，而且在室温下具有更长的存放寿命．我们用磁控溅射的方法分别在２４... 详细信息

与ＹＢＣＯ薄膜相比，Ｔｌ２Ｂａ２ＣａＣｕ２Ｏｘ薄膜具有更高的Ｔｃ和更好的抗湿性能，所以Ｔｌ２Ｂａ２ＣａＣｕ２Ｏｘ薄膜器件不仅在液氮温度下具有更好的稳定性，而且在室温下具有更长的存放寿命．我们用磁控溅射的方法分别在２４°和３６．８°的ＳＴＯ双晶衬底上外延出Ｔｌ２Ｂａ２ＣａＣｕ２Ｏｘ薄膜并制备成晶界结ＤＣＳＱＵＩＤ，比较了二者由于晶界夹角不同而产生的性能差异，并给出可工作在９５Ｋ的ＤＣＳＱＵＩＤ干涉曲线；对工作在７７Ｋ的Ｔｌ２Ｂａ２ＣａＣｕ２Ｏｘ和ＹＢＣＯ薄膜双晶ＤＣＳＱＵＩＤ，比较了二者在噪声特性及临界电流和结电阻随温度变化等特性，并对结果作了讨论

关键词： DC-sQUID Tl2ba2CaCu2Ox 双晶结

饮食中添加抗氧化剂与年龄相关性黄斑变性患病风险的关系

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世界核心医学期刊文摘（眼科学分册） 2006年第4期2卷 2-3页

作者： Van Leeuwen R. Boekhoorn s. Vingerling j.R. P.T.V.M. De jong 张磊 Dr. Netherlands Ophthalmic Research Institute KNAW Meibergdreef 47 1105 BA Amsterdam Netherlands

Context: Age-related macular degeneration (AMD) is the most prevalent cause of irreversible blindness in developed countries. Recently, high-dose supplementation with beta carotene, vitamins C and E, and zinc was shown to slow the progression of AMD. Objective: To investigate whether regular dietary intake of antioxidants is associated with a lower risk of incident AMD. Design: Dietary intake was assessed at baseline in the Rotterdam study (1990-1993) using a semiquantitative food frequency questionnaire. Incident AMD until final follow-up in 2004 was determined by grading fundus color transparencies in a masked way according to the International Classification and Grading system. setting: Population-based cohort of all inhabitants aged 55 years or older in a middle-class suburb of Rotterdam, the Netherlands. Participants: Of 5836 persons at risk of AMD at baseline, 4765 had reliable dietary data and 4170 participated in the follow-up. Main Outcome Measure: Incident AMD, defined as soft distinct drusen with pigment alterations, indistinct or reticular drusen, geographic atrophy, or choroidal neovascularization. Results: Incident AMD occurred in 560 participants after a mean follow-up of 8.0 years (range, 0.3-13.9 years). Dietary intake of both vitamin E and zinc was inversely associated with incident AMD. The hazard ratio (HR) per standard deviation increase of intake for vitamin E was 0.92 (95%confidence interval [CI], 0.84-1.00) and for zinc was 0.91 (95%CI, 0.83-0.98). An above-median intake of all 4 nutrients, beta carotene, vitamin C, vitamin E, and zinc, was associated with a 35%reduced risk (HR, 0.65; 95%CI, 0.46-0.92) of AMD. Exclusion of supplement users did not affect the results. Conclusion: In this study, a high dietary intake of beta carotene, vitamins C and E, and zinc was associated with a substantially reduced risk of AMD in elderly persons.

关键词：年龄相关性黄斑变性患病风险抗氧化剂脉络膜新生血管饮食 β-胡萝卜素玻璃膜疣受试者

华北克拉通北缘包头东正长岩的成因:来自岩石矿物学和地球化学的证据

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中国科学：地球科学 2016年第3期46卷 374-391,1-8页

作者：牛晓露杨经绥刘飞张红雨杨明春中国地质科学院地质研究所大陆构造与动力学国家重点实验室北京100037 中国地质大学科学研究院北京100083 北京大学地球与空间科学学院造山带与地壳演化教育部重点实验室北京100871

包头东正长岩位于内蒙古包头市东,阴山南麓,是华北克拉通北缘三叠纪碱性岩带最西端的岩体.本文对此岩体进行了锆石U-Pb年代学、矿物化学、岩石地球化学和sr-Nd同位素的研究,讨论了其成因及源区地幔性质.岩体由霞石辉石正长岩和碱性长石... 详细信息

包头东正长岩位于内蒙古包头市东,阴山南麓,是华北克拉通北缘三叠纪碱性岩带最西端的岩体.本文对此岩体进行了锆石U-Pb年代学、矿物化学、岩石地球化学和sr-Nd同位素的研究,讨论了其成因及源区地幔性质.岩体由霞石辉石正长岩和碱性长石正长岩组成,锆石LA-ICPMs U-Pb年龄为(214.7±1.1)Ma,为晚三叠世岩浆活动的产物.单斜辉石(从核部到边部,成分由透辉石向霓石-普通辉石演化),黑云母,正长石和霞石是岩体主要组成矿物.岩体稀土总量较高,稀土配分模式为右倾,无明显铕异常;相对富集轻稀土元素和大离子亲石元素(如Rb、ba、sr和Pb),亏损重稀土元素和高场强元素(如Nb、Ta和Ti);具有富集的sr-Nd同位素组成,初始^(87)sr/^(86)sr为0.7061~0.7067,εNd(t)值为–9.0~–11.2.矿物学和地球化学数据揭示包头东正长岩属于硅不饱和钾质-超钾质碱性岩岩浆系列,高CaO、Fe_2O_3、K_2O、Na_2O含量,低siO_2含量,富水,高温,高氧逸度;岩体起源于位于石榴石稳定区富含金云母的古老,富集岩石圈地幔.包括包头东正长岩在内的华北克拉通北缘三叠纪钾质碱性岩带的发育,揭示华北克拉通北缘下覆岩石圈地幔受到了来自古亚洲洋俯冲板片(及上覆沉积物)流体/熔体的交代改造;晚三叠世,华北克拉通北缘已经进入了被破坏大陆边缘的强烈伸展演化阶段.

关键词：锆石U-Pb年龄矿物学地球化学包头东正长岩钾质碱性岩三叠纪地幔交代华北克拉通北缘