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实验与分析 2014年第6期 38-39页

作者： Jo-Ann M.Jablonski Andrew J.aubin Wendy Harrop

天然产物紫锥菊成分的分离提取本文将重点讨论Prepl50LC系统用于从紫锥菊提取物等天然产物中提取分离有效成分。系统自带ChromScope软件简单直观，可快速实现化合物的分离。本文原理同样适用于带紫外发色团的任意化合物的分离。

关键词：分离提取天然产物有效成分提取分离快速实现紫锥菊 C系统化合物

咪喹莫特对HIV感染者肛门人乳头状瘤病毒潜伏感染的影响(法语)

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世界核心医学期刊文摘（皮肤病学分册） 2005年第4期1卷 45-46页

作者： Pelletier F. Drobacheff-Thiebaut C. aubin F. 刘超 ServicedeDermatologie CHUSaint-Jacques2place Saint-Jacques 25030 Besanc.on Cedex France

Introduction. High risk human papillomaviruses (HPV) have emerged as risk factors for anal carcinoma particularly in HIV-infected patients who demonstrate a high rate of anal HPV infection. Considering the relationship between the presence of anal infection and the development of neoplastic lesions, we wished to assess the capacity of imiquimod to eradicate latent HPV infection in HIV-infected patients. Patients and methods. We conducted a prospective, randomized, double-blind and vehicle controlled study. Two consecutive anal swabs were taken at 2 month intervals and only patients with two consecutive tests positive for the detection of HPV-DNA (Hybrid Capture II.) were included. Patients with persistent latent HPV infection were divided into 2 groups who applied imiquimod versus vehicle during 6 weeks. HPV-DNA presence was then investigated 2 and 4 months following the onset of treatment. Results. Among the 80 HIV-infected patients, 26 (32.5 p. 100) had 2 positive consecutive assays, and 19 patients were included in the study. After randomization, 9 patients received imiquimod and 10 vehicle. There was no significant difference between treatment groups according to the following criteria: gender, route of HIV transmission, CDC stage, prior medical history of sexually transmitted diseases or anogenital warts. 33.3 p. 100 (3/9) of patients treated with imiquimod were negative at M2, whereas 100 p. 100 (10/10) vehicle treated-patients remained positive (p=0.08). Similar results were observed at the M4 visit. Discussion. Our study confirmed the increased prevalence of latent HPV-DNA infection in HIV-infected patients. In spite of the low number of treated patients, we did not observe a statistically significant decrease in HPV-DNA in anal swabs from france imquimod-treated patients as compared to placebo-treated patients.

关键词：人乳头状瘤病毒咪喹莫特 HIV感染潜伏感染对照试验性传播疾病赋形安慰剂程度等级

308nm单色光在皮肤科应用的评价:治疗不同的慢性限局性皮肤病的初步研究

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世界核心医学期刊文摘（皮肤病学分册） 2005年第8期1卷 12-13页

作者： aubin F. Vigan M. Puzenat E. 党倩丽 Photo- dermatology Unit Department of Dermatology University Hospital 2 Place Saint- Jacques 25030 Besanc.on Cedex France

Background: Recently, units have been developed that are capable of delivering large fluences of narrowband ultraviolet (UV) B selectively to cutaneous lesions within a reasonable time. Objectives: To analyse the efficacy of a novel non- laser 308- nm monochromatic excimer light (MEL) delivery system in various dermatoses usually treated by narrowband UVB phototherapy. Methods: Fifty- four patients with chronic and resistant localized dermatoses were enrolled in a prospective study: 17 with palmoplantar pustular psoriasis, seven with plaque- type psoriasis, four with nail psoriasis, eight with chronic atopic dermatitis of the hands, 10 with chronic non- atopic dermatitis of the hands and eight with alopecia areata. The 308- nm xenon chloride MEL delivery system (Excilite; DEKA, Florence, Italy) was used to produce an average incident dose rate of 50 mW cm- 2 at a tube- to- skin distance of 15 cm and with a maximum irradiating area of 512 *** initial dose was based on multiples of a predetermined minimal erythema dose (MED), and subsequent doses were based on the response to treatment. Treatments were scheduled weekly for a maximum of 10 weeks. Clinical responses were evaluated using photographic documentation and (except for alopecia areata) clinical score. Results: The MED ranged from 250 to 350 mJ cm- 2 (mean ± SD 318.2 ± .28.4). MEL at 308 nm was the most effective for palmoplantar pustular psoriasis with a mean improvement of 79% after a mean of 5.3 treatments and a mean dose of 11.8 MED per treatment. Plaque- type psoriasis was significantly less sensitive to treatment and nail psoriasis demonstrated no benefit from treatment. Chronic palmar atopic dermatitis was cleared in two patients and the mean improvement was 54% as compared with 46% in patients with chronic nonatopic dermatitis of the hands. Four complete re- growths among the eight patients with alopecia were observed after a mean of 5.1 treatments. The percentages of improvement had significantly d

关键词：限局性斑块型银屑病最小红斑量激发系统掌跖脓疱病平均改善率紧张性临床评分掌部反应评价

PHACE(S)综合征的不完全表达:与颈内动脉缺失相关的面部血管瘤

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世界核心医学期刊文摘（皮肤病学分册） 2005年第9期1卷 24-25页

作者： Monnier D. Pelletier F. aubin F. P. Humbert 崔荣 Service de Dermatologie I CHU Saint-Jacques 2 place Saint-Jacques 25030 Besanc.on Cedex France

Introduction. Hemangiomas are the most common benign tumors in childhood. In rare cases, they can be associated with dysmorphic malformations. The acronym, the PHACE (S) syndrome, was recently described by Frieden et al. In 1996 as a large facial or cervical Hemangioma, associated with one or more of the following systemic abnormalities including:Posterior fossa malformation, Arterial abnormalities, Coarctation of the aorta and/or cardiac defects, Eye abnormalities and Sternal clefts. Case report. A 2 year-old girl presented with a large left hemifacial hemangioma. The rest of the clinical examination was normal. Initially, simple clinical surveillance was scheduled. The outcome was good with almost complete regression of the hemangioma by the age of 8. However, there were remains to the left of the upper lip and plastic surgery was scheduled. Pre-operative conventional arteriography revealed the complete, asymptomatic, absence of the ipsilateral internal carotid artery. Cerebral MRI and cardiac ultrasonography were normal. In the absence of somatic manifestations, regular clinical surveillance was decided on. Discussion. Large facial or cervical hemagiomas can be associated with one or more systemic abnormalities described by the PHACE (S) acronym. Its prevalence is unknown, but is shows marked female preponderance. Among the systemic abnormalities, neurological and cardiac malformations predominate. Hence the PHACE (S) syndrome must be recognized. Moreover, in patients presenting with large facial or cervical hemangioma, the following examinations should be performed:neurological examination and cerebral MRI to rule out abnormality of the posterior fossa,completed by a sequence of angio-MRI in the search for cerebral artery malformations;cardiovascular exploration,completed by echocardiography in the case of doubt and examination of the eyes and sternum. Lastly, the enhanced risk of laryngeal sub-glottis hemangioma should be kept in mind.

关键词：面部血管瘤 PHACE 颈内动脉超声波检查大脑动脉无症状性神经学左侧面部全身系统性眼部异常

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使用沃特世超高效合相色谱分析短杆菌肽

食品安全导刊 2013年第3期 30-31页

作者： Sean M.McCarthy Andrew J.aubin Michael D.Jones 沃特世公司(美国马萨诸塞州米尔福德)

短杆菌肽是由芽孢杆菌产生的一种常见和已被良好表征的跨膜肽物质，被用作对抗革兰氏阳性和某些革兰氏阴性细菌的局部用抗生素。用反相液相色谱（RPLC）分析疏水性肽和蛋白质难度很大。因为溶液中经常需要使用洗涤剂保持疏水性物质的稳... 详细信息

短杆菌肽是由芽孢杆菌产生的一种常见和已被良好表征的跨膜肽物质，被用作对抗革兰氏阳性和某些革兰氏阴性细菌的局部用抗生素。用反相液相色谱（RPLC）分析疏水性肽和蛋白质难度很大。因为溶液中经常需要使用洗涤剂保持疏水性物质的稳定性，而这些洗涤剂容易发生聚集或沉淀，严重影响它们的回收，这些因素及其他原因使得难以用RPLC分离疏水性肽和蛋白质。

关键词：短杆菌肽色谱分析超高效疏水性物质革兰氏阴性细菌反相液相色谱芽孢杆菌 RPLC

Diagnostic and Prognostic Interests of Plasmatic Neuroglobin during Stroke in Adult at the Acute Phase

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World Journal of Neuroscience 2019年第2期9卷 52-70页

作者： J. F. Nnang Essone C. Allognon R. Nkiema S. R. aubin Igombé P. Nzoghe Nguema F. Ovono Abessolo E. Anyunzok E. Ngou Milama Department of Physiology Faculty of Medicine and Health Sciences of Libreville and Department of Emergency Resuscitation Anesthesia of Angondjé University Hospital Center Libreville Gabon Department of Cardiology University Hospital Angondjé Libreville Gabon Department of Chemistry-Biochemistry Faculty of Medicine and Health Sciences University of Health Sciences Libreville Gabon Department of Anesthesia Emergency Resuscitation of Owendo University Hospital Libreville Gabon Department of Mathematics and Biostatistics Faculty of Medicine and Health Sciences University of Health Sciences Li-breville Gabon

Introduction: Neuroglobin (Ngb) owes its name to its preferred location in the nervous system. Its plasma concentration increases during cerebral ischemia. However, the interest of its dosage in the diagnosis and the prognosis of the strokes in the adult is not defined. Objectives: To determine if plasmatic Ngb can be used as a diagnostic biomarker and prognostic for stroke in adults at the acute phase. Population and Methods: This was a prospective study in 69 people, including 39 suspected stroke (Cerebral ischemia or CI, Intracerebral hemorrhage or ICH) and 30 healthy volunteers (controls). The plasma concentration of Ngb (CmNgb in ng/ml) of the patients was determined at admission day (d1), at the third day (d3) and seventh day (d7). CmNgbtaken at d1 was compared between patients and controls. Its evolution over time, as well as its relation with the clinical parameters, including the Glasgow coma scale and the short-term mortality in stroke subjects was analyzed by the Mann and Whitney tests and the Wilcoxon test (p Results: At d1, the CmNgb of all types of stroke was 3.140 ± 2.700 ng/ml, and did not differ significantly from controls (0.303 ± 0.114 ng/ml, p = 0.070). On the other hand, it was higher in CI victims (5.800 ± 0.720 ng/ml) than in ICH (1.750 ± 0,090 ng/ml) (p = 0.030). It then decreased on d3 in CI victims (2.600 ± 0.112 ng/ml) and ICH (0.420 ± 0.211 ng/ml), returning to normal on d7 (0.420 ± 0.200 ng/ml for CI’s, p = 0.001, and 0.360 ± 0.300 ng/ml for ICH, p = 0.002). There was a relationship between CmNgb, delay of occurrence of the first symptoms of the stroke (3.140 ± 2.700 ng/ml before the 6th hour, and 0.643 ± 0.244 ng/ml after the 6th hour (p = 0.003) and the volume of the hematoma (p = 0.0027). None relationship existed between CmNgb, Glasgow coma scale (p = 0.427) and short-term mortality (CmNgb = 3.95 ng/ml in survivors versus 2.65 ng/ml in deceased p = 0.060). Conclusion: This study shows that the plasma concentration of Neuroglobin is h

关键词： Neuroglobin Stroke Diagnosis Prognosis

25 Gbps low-voltage hetero-structured silicongermanium waveguide pin photodetectors for monolithic on-chip nanophotonic architectures

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Photonics Research 2019年第4期7卷 437-444页

作者： DANIEL BENEDIKOVIC LéOPOLD VIROT GUY aubin FARAH AMAR BERTRAND SZELAG BAYRAM KARAKUS JEAN-MICHEL HARTMANN CARLOS ALONSO-RAMOS XAVIER LE ROUX PAUL CROZAT ERIC CASSAN DELPHINE MARRIS-MORINI CHARLES BAUDOT FRéDéRIC BOEUF JEAN-MARC FéDéLI CHRISTOPHE KOPP LAURENT VIVIEN Centre de Nanosciences et de Nanotechnologies CNRS University of Paris-Sud Université Paris-Saclay University Grenoble Alpes and CEA LETI Minatec Campus Technology R&D STMicroelectronics SAS

Near-infrared germanium(Ge) photodetectors monolithically integrated on top of silicon-on-insulator substrates are universally regarded as key enablers towards chip-scale nanophotonics, with applications ranging from sensing and health monitoring to object recognition and optical communications. In this work, we report on the highdata-rate performance pin waveguide photodetectors made of a lateral hetero-structured silicon-Ge-silicon(Si-Ge-Si) junction operating under low reverse bias at 1.55 μm. The pin photodetector integration scheme considerably eases device manufacturing and is fully compatible with complementary metal-oxide-semiconductor technology. In particular, the hetero-structured Si-Ge-Si photodetectors show efficiency-bandwidth products of^9 GHz at-1 V and ~30 GHz at-3 V, with a leakage dark current as low as ~150 nA, allowing superior signal detection of high-speed data traffic. A bit-error rate of 10-9 is achieved for conventional 10 Gbps, 20 Gbps, and25 Gbps data rates, yielding optical power sensitivities of-13.85 dBm,-12.70 dBm, and-11.25 dBm, respectively. This demonstration opens up new horizons towards cost-effective Ge pin waveguide photodetectors that combine fast device operation at low voltages with standard semiconductor fabrication processes, as desired for reliable on-chip architectures in next-generation nanophotonics integrated circuits.

关键词： germanium(Ge) photodetectors chip-scale nanophotonics waveguide photodetectors

Trends of HIV Viral Load in Patients under Combined Antiretroviral Treatment in Bangui, Central African Republic

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World Journal of AIDS 2018年第2期8卷 53-62页

作者： Yawo Tufa Nyasenu Alain Farra Serge Ghislain Djorie Brice Martial Yambiyo Alexandre Manirakiza Gilles Stephane Ngaya Sandrine Moussa Pulcherie Pelembi Davy Martial Golongba.aubin Bere Rodolphe Mambely-Nzako Marie-Joelle Mandeng Alain Berlioz-Arthaud Pierre-Alain Rubbo Jean-Pierre Lombart Institut Pasteur of Bangui Medical Analysis LaboratoryBanguiCentral African Republic Institut Pasteur of Bangui Epidemiology ServiceBanguiCentral African Republic Institut Pasteur of Bangui Retrovirus ServiceBanguiCentral African Republic

Background: The success of antiretroviral therapy requires better virological monitoring. We described the virological profile of patients on combined antiretroviral therapy (cART) for HIV/AIDS in Bangui, Central African Republic (CAR). Methods: In this prospective cohort study of patients who had been on combined antiretroviral therapy treatment (cART) for at least 12 months in Bangui, only one HIV plasma viral load per patient was realized at the Institut Pasteur of Bangui, between April 4th and November 28th, 2017. Sociodemographic and biological data were collected. Blood samples were taken for viral load. The biocentric generic human immunodeficiency virus (HIV) load test was used to quantify a ribonucleic acid (RNA) HIV-1. Data were analyzed with Stata software version 14. Chi-squared test was used to analyse viral load according to sex and age. The level of significance was set at P ≤ 0.05. Results: A total of 3569 patients were recruited, with a mean age of 40 years (median, 42 years;range, 1 - 84), patients aged 40 - 49 predominating (34.2%). The sex ratio was 0.4. No virus was detectable in plasma from 49.2% of patients, while 42.4% had virological failure (viral load, ≥1000 copies/mL) according to WHO criteria. The risk for virological failure decreased with age (P = 0.001) and was higher among females than males (P = 0.001). Conclusions: The rate of virological failure among patients on cART is very high in the CAR, despite the availability of and access to monitoring of HIV plasma viral load in Bangui. Therefore, adherence to treatment should be evaluated and reinforced in Bangui, CAR.

关键词： Plasma Viral Load Failure HIV-1 Bangui CAR

兆伏级锥形束CT:系统说明及IGRT临床应用介绍

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中国癌症杂志 2006年第6期16卷 513-524页

作者： Olivier Morin Amy Gillis Josephine Chen Michèle aubin M.Kara Bucci Jean Pouliot 索京涛陆嘉德 UCSF Comprehensive Cancer Center Department of Radiation Oncology

阐述临床用兆伏级锥形束CT(MV CBCT)系统,介绍图像采集和患者摆位的过程,并就摆位精度和图像质量进行讨论,并通过所选病例介绍该系统在影像引导下的放射治疗(IGRT)中的潜在应用价值。兆伏级锥形束CT系统由一台标准直线加速器外加配备以... 详细信息

阐述临床用兆伏级锥形束CT(MV CBCT)系统,介绍图像采集和患者摆位的过程,并就摆位精度和图像质量进行讨论,并通过所选病例介绍该系统在影像引导下的放射治疗(IGRT)中的潜在应用价值。兆伏级锥形束CT系统由一台标准直线加速器外加配备以非晶硅平板型EPID,能够适合兆伏级光子射线。一体化的计算机工作平台能够支持投照图像的自动采集,图像重建,CT到锥形束CT图像的注册,以及治疗床的移动计算。系统具有亚毫米级的定位精度和足够的软组织分辨率,能够显示前列腺等软组织结构。在我院,已经使用兆伏级锥形束CT系统检测脊髓的非刚性形变,监控肿瘤的生长和消退,以及肺内固定肿瘤的定位等。对于受到金属伪影干扰的结构,兆伏级锥形束CT还提高了其勾画的准确性。在过去的几年中,兆伏级锥形束CT有了较快的发展。现在的图像质量完全可以满足IGRT应用的需要。此外,我们希望兆伏级锥形束CT在临床上的应用将随着影像技术的发展而不断扩大。

关键词：外照射影像引导下的放射治疗放射治疗影像兆伏锥形束CT

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比利时法语区公务员政策咨询类型

国际行政科学评论（中文版） 2020年第3期86卷 65-83页

作者：大卫·奥宾玛琳·布兰斯杜明鸣(译) 王秋蕾(审校) 比利时卢汶天主教大学比利时库鲁汶大学公共治理学院中国人事科学研究院不详

在部长级顾问日益重要的背景下,本文就公务员参与政策工作的性质提供了实证依据。一项针对比利时法语区在职公务员的调查报告显示,即使在强有力的部长级内阁所领导的政治行政体系中,公务员也会大量参与政策工作。比利时法语区公务员属于... 详细信息

在部长级顾问日益重要的背景下,本文就公务员参与政策工作的性质提供了实证依据。一项针对比利时法语区在职公务员的调查报告显示,即使在强有力的部长级内阁所领导的政治行政体系中,公务员也会大量参与政策工作。比利时法语区公务员属于"次要顾问",与重点负责政策实施的事务专家相比,他们算不上流程通才,其作为政策咨询人员的角色类型不时在"理性的技术人员"和"客户顾问"之间切换。尽管在公务员制度中,政策咨询(policy advisory)的制度化程度较低,但是公务员在政策制定(协调)阶段为部长做了大量工作,包括信息补充、分析、参与相关政策内容的编写工作等。

关键词：政策咨询风格政策分析能力政策工作政治与行政关系