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On the winter enhancement of adaptive humoral immunity: hypothesis testing in desert hamsters (Phodopus roborovskii: Cricetidae, Rodentia) kept under long-day and short-day photoperiod

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Integrative Zoology 2020年第3期15卷 232-247页

作者： Nina Yu.vASILIEvA a.a.ta.iya.m.khrushchova.a.exa.der v.kuptsov Olga N.SHEKAROvA Olga v.SOKOLOvA Dehua WANG Konstantin A.ROGOvIN Severtsov Institute of Ecology and Evolution RAS MoscowRussia Institute of Zoology Chinese Academy of Science Chaoyang DistrictBeijingChina

We tested the winter immunity enhancement hypothesis(WIEH)on male desert hamsters(Phodopus roborovskii)kept under long-day(LD)and short-day(SD)*** assumed that under SD in a laboratory,the adaptive humoral immune responsiveness to the antigenic challenge would be enhanced due to the lack of winter physical stressors and food shortages and/or because of the action of an endogenous winter bolstering mechanism,while under LD the immune responsiveness would be suppressed by the activity of the reproductive *** results support the WIEH in *** did not find a difference in antibody production in response to sheep erythrocytes between SD and LD hamsters,but SD males had the lower number of granulocytes and the higher number of lymphocytes in white blood cell *** activity was lower in SD *** males demonstrated an increase in their mass-specific resting metabolic rate,their mass-specific maximal metabolic rate and their level of *** result of a generalized linear model analysis indicates the negative effect on secondary immunoresponsiveness to sheep erythrocytes of mid-ventral gland size,the organ characterizing individual reproductive quality,and designates a tradeoff between antibody production and reproductive *** mass-independent maximal metabolic rate also negatively affected antibody production,indicating a tradeoff between maximal aerobic performance and the adaptive immune *** higher stress in SD males seems to be the most likely reason for the lack of the effect of daylight duration on antibody production.

关键词： adaptive humoral immunity desert hamster photoperiodicity winter immunoenhancement

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Effects of short photoperiod on energy intake,thermogenesis,and reproduction in desert hamsters(Phodopus roborovskii)

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Integrative Zoology 2015年第2期10卷 207-215页

作者： Xueying ZHANG Zhijun ZHAO Nina vASILIEvA Anastasia khrushchova Dehua WANG State Key Laboratory of Integrated management for Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijingChina A.N.Severtsov Institute of Ecology and Evolution Russian Academy of SciencesMoscowRussia College of Life and Environmental Science Wenzhou UniversityWenzhouChina

Desert hamsters(Phodopus roborovskii)are the least known species in the genus Phodopus with respect to ecology and physiology,and deserve scientific attention,particularly because of their small body ***,the responses of energy metabolism and reproductive function to short photoperiods in desert hamsters were *** and female desert hamsters were acclimated to either long day(LD)(L:D 16:8 h)or short day(SD)photoperiods(L:D 8:16 h)for three months,and then the females were transferred back to an LD photoperiod for a further five months,while at the end of the SD acclimation the males were killed and measurements were taken for serum leptin as well as molecular markers for *** found that like the other two species from the genus Phodopus,the desert hamsters under SD decreased body mass,increased adaptive thermogenesis as indicated by elevated mitochondrial protein content and uncoupling protein-1 content in brown adipose tissue,and suppressed reproduction compared to those under ***,different from the other two species,desert hamsters did not show any differences in energy intake or serum leptin concentration between LD and *** data suggest that different species from the same genus respond in different ways to the environmental signals,and the desert adapted species are not as sensitive to change in photoperiod as the other two species.

关键词： desert hamster(Phodopus roborovskii) energy intake leptin reproductive function uncoupling protein-1

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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs víctor Cilleros-mañé Laia Just-Borràs marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal marta Tomàs Carolina Silvera-Simón manel m.Santafé maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

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Lesions requiring wound management in a central tertiary neonatal intensive care unit

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World Journal of Pediatrics 2017年第2期13卷 165-172页

作者： Angéla meszes Gyula Tálosi Krisztina máder Hajnalka Orvos Lajos Kemény Zsanett Renáta Csoma Department of dermatology and Allergology University of SzegedSzegedHungary Department of Pediatrics University of SzegedSzegedHungary Department of Obstetrics and Gynecology University of SzegedSzegedHungary Department of dermatology and Allergology University of SzegedSzegedHungary mta-SZTE dermatological Research Group SzegedHungary

Background:most of the skin disorders that occur in neonatal intensive care units are due in part to the immaturity and vulnerability of the neonatal *** iatrogenic diagnostic and therapeutic procedures are also conducive to iatrogenic *** study was to review the neonates admitted to our neonatal intensive care unit who needed wound management,and to assess the most common skin injuries and wounds,and their ***:Data were extracted from medical records of neonates who needed wound management in our Neonatal Intensive Care Unit between January 31,2012 and January 31,*** about gestational age,sex,birth weight,area of involvement,wound aetiology,and therapy were ***:Among the 211 neonates observed,wound management was required in 10 cases of diaper dermatitis,7 epidermal stripping,6 extravasation injuries,5 pressure ulcers,1 surgical wound and infection,1 thermal burn,and 5 other ***:International guidelines in neonatal wound care practice are not available,and further research concerns are clearly *** and antiseptic agents should be chosen with great care for application to neonates,with particular attention to the prevention of adverse events in this sensitive *** work among dermatologists,neonatologists and nurses is crucial for the successful treatment of neonates.

关键词： epidermal stripping extravasation injury neonatal intensive care unit surgical wound wound care in neonates

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Indentation of elastically soft and plastically compressible solids

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Acta mechanica Sinica 2015年第4期31卷 473-480页

作者： A.Needleman v.Tvergaard E.van der Giessen Department of materials Science and Engineering Texas A&M University College Station Department of mechanical Engineering The Technical University of Denmark Zernike Institute for Advanced materials University of Groningen

The effect of soft elasticity, i.e., a relatively small value of the ratio of Young＇s modulus to yield strength and plastic compressibility on the indentation of isotropically hardening elastic-viscoplastic solids is investigated. Calcu- lations are carried out for indentation of a perfectly sticking rigid sharp indenter into a cylinder modeling indentation of a half space. The material is characterized by a finite strain elastic-viscoplastic constitutive relation that allows for plas- tic as well as elastic compressibility. Both soft elasticity and plastic compressibility significantly reduce the ratio of nomi- nal indentation hardness to yield strength. A linear relation is found between the nominal indentation hardness and the log- arithm of the ratio of Young＇s modulus to yield strength, but with a different coefficient than reported in previous studies. The nominal indentation hardness decreases rapidly for small deviations from plastic incompressibility and then decreases rather slowly for values of the plastic Poisson＇s ratio less than 0.25. For both soft elasticity and plastic compressibility, the main reason for the lower values of indentation hardness is related to the reduction in the hydrostatic stress level in the material below the indenter.

关键词： Plasticity Compressibility Indentation Finite element analysis

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Emerging role of galectin 3 in neuroinflammation and neurodegeneration

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Neural Regeneration Research 2024年第9期19卷 2004-2009页

作者： Brian m.Lozinski Khanh ta Yifei Dong Department of Clinical Neuroscience University of CalgaryCalgaryABCanada Deparment of Biochemistry Microbiology&ImmunologyUniversity of SaskatchewanSaskatoonSKCanada

Neuroinflammation and neurodegeneration are key processes that mediate the development and progression of neurological ***,the mechanisms modulating these processes in different diseases remain incompletely *** in single cell based multi-omic analyses have helped to identify distinct molecular signatures such as Lgals3 that is associated with neuroinflammation and neurodegeneration in the central nervous system(CNS).Lgals3 encodes galectin-3(Gal3),aβ-galactoside and glycan binding glycoprotein that is frequently upregulated by reactive microglia/macrophages in the CNS during various neurological *** Gal3 has previously been associated with non-CNS inflammatory and fibrotic diseases,recent studies highlight Gal3 as a prominent regulator of inflammation and neuroaxonal damage in the CNS during diseases such as multiple sclerosis,Alzheimer’s disease,and Parkinson’s *** this review,we summarize the pleiotropic functions of Gal3 and discuss evidence that demonstrates its detrimental role in neuroinflammation and neurodegeneration during different neurological *** also consider the challenges of translating preclinical observations into targeting Gal3 in the human CNS.

关键词： Alzheimer’s disease Galectin 3 microglia multiple sclerosis neurodegeneration neuroinflammation Parkinson’s disease therapeutics

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Dendritic spine degeneration:a primary mechanism in the aging process

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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores Leonardo Aguilar-Hernández Fernado García-Dolores Humberto Nicolini Andrea Judith vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de medicina Genómica(INmEGEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(Gm)(mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

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Successful management of adult lymphoma-associated intussusception by laparoscopic reduction and appendectomy

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World Journal of Gastroenterology 2016年第19期22卷 4781-4785页

作者： ta-Wei Yang Yen-Yue Lin Yi-Wei Tsuei Yen-Lin Chen Cheng-Yi Huang Sheng-der Hsu Department of Emergency medicine Taoyuan Armed Forces General Hospital Department of Radiology Taoyuan Armed Forces General Hospital Department of Pathology National Defense Medical Center Tri-Service General Hospital Department of Traumatic and General Surgery National Defense Medical Center Tri-Service General Hospital

Although primary gastrointestinal lymphoma is a rare malignancy, it can cause an intussusception in adults and can be a clinically challenging condition to manage. Intussusception could progress to lifethreatening complications if left untreated or could delay chemotherapy if inappropriate surgical management is used. We report a 31-year-old man diagnosed with human immunodeficiency virus who was being treated with antiretroviral therapy. He presented with nausea, vomiting, poor appetite, and intermittent, cramping abdominal pain for over 1 wk. Abdominal computed tomography revealed a well-defined homogeneous mass in the mesenteric root region, together with a long segmental wall thickening in the ileum with ileocolic-type intussusception, which was suspected to be caused by a lymphoma. The intussusception was successfully laparoscopically reduced, and the tumor involvement of the appendix was confirmedby appendectomy with intraoperative frozen section. Systemic chemotherapy was immediately initiated after surgery without the need for bowel resection.

关键词： Intussusception Adult Intestinal lymphoma Appendectomy

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Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer:A systematic review

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Journal of Integrative medicine 2024年第2期22卷 137-162页

作者： Bizhar Ahmed tayeb Ikhwan Yuda Kusuma Alaa A.m.Osman Renáta minorics Institute of Pharmacodynamics and Biopharmacy Faculty of PharmacyUniversity of Szeged6720 SzegedHungary Institution of Clinical Pharmacy Faculty of PharmacyUniversity of Szeged6725 SzegedHungary Department of Clinical Pharmacy and Pharmacy Practice Faculty of PharmacyUniversity of Gezira20 Wad MadaniSudan Pharmacy Study Program Facuity of HealthUniversitas Harapan BangsaPurwokerto 53182Indonesia

Background:The field of personalized medicine has gained increasing attention in cancer care,with the aim of tailoring treatment strategies to individual patients for improved *** medicine,with its long-standing historical use and extensive bioactive compounds,offers a rich source of potential treatments for various diseases,including ***:To provide an overview of the current knowledge and evidence associated with incorporating herbal compounds into precision medicine strategies for cancer ***,to explore the general characteristics of the studies included in the analysis,focusing on their key features and *** strategy:A comprehensive literature search was conducted from multiple online databases,including Pub med,Scopus,Web of Science,and *** search strategy was designed to identify studies related to personalized cancer medicine and herbal *** criteria:Publications pertaining to cancer research conducted through in vitro,in vivo,and clinical studies,employing natural products were included in this *** extraction and analysis:Two review authors independently applied inclusion and inclusion criteria,data extraction,and assessments of methodological *** quality assessment and biases of the studies were evaluated based on modified Jadad scales.A detailed quantitative summary of the included studies is presented,providing a comprehensive description of their key features and ***:A total of 121 studies were included in this review for *** of them were considered as comprehensive experimental investigations both in vitro and in *** majority(n=85)of the studies included in this review were conducted in vitro,with 44 of them specifically investigating the effects of herbal medicine on animal ***,7 articles with a combined sample size of 31,271 patients,examined the impact of herbal medicine in clinical ***:Personal

关键词： Cancer Herbal medicine Personalized medication Active phytochemicals Natural compound

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Effects of rhamnolipid biosurfactant JBR425 and synthetic surfactant Surfynol465 on the peroxidase-catalyzed oxidation of 2-naphthol

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Journal of Environmental Sciences 2013年第7期25卷 1431-1440页

作者： Ivanec-Goranina Rūta Kulys Juozas Department of Chemistry and Bioengineering Faculty of Fundamental Sciences Vilnius Gediminas Technical University Institute of Biochemistry Vilnius University

The kinetics of the recombinant Coprinus cinereus peroxidase-catalyzed2-naphthol oxidationwas investigated in the presence of rhamnolipid biosurfactant JBR425 and synthetic surfactant Surfynol465 at pH 5.5 and25°C,with concentrations of （bio）surfactants both less than critical micelle concentrations （CmC） and larger than CmC. Itwas shown that monomers of JBR425 aswell as monomers of Surfynol465 had an enhancing effect on the conversion of2-naphthol indose response manner anddid not influence the initial rate of 2-naphthol oxidation. The resultswere accounted by a scheme,which contains a stadium of enzyme inhibition by oligomeric2- naphthol oxidation products. The action of the biosurfactant＇s （or synthetic surfactant＇s） monomerswas explained by avoidance of the enzyme active center clothingwith oligomers. Similar results havedemonstrated the potential of rhamnolipid biosurfactant JBR425due to its biodegradability. When biosurfactants＇ concentrations are larger than CmC, （bio）surfactants have an opposite effect on the oxidation of2-naphthol by peroxidase.

关键词： oxidation peroxidase biosurfactant critical micelle concentration

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