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Heat Shock Protein 40 (Hsp40) and Hsp70 Protein Expression in Oral Squamous Cell Carcinoma (OSCC)

Journal of Cancer Therapy 2013年第3期4卷 734-741页

作者： Adi Prayitno Elyana Asnar Okid Parama Astirin Dinar Rosmala Suhartono Taat putra Departement of Pathobiology Faculty of Medicine University of Airlangga Surabaya Indonesia Department of Biology Faculty of Science and Mathematica University of Sebelas Maret Surakarta Indonesia Department of Dental and Oral Disease Faculty of Medicine University of Sebelas Maret Surakarta Indonesia Department of Ear-Nose-Throat Faculty of Medicine University of Sebelas Maret Surakarta Indonesia

Introduction: As a chaperone, heat shock protein acts as central integrators of protein homeostasis in cell. The form of these functions is to help setting up a complex protein molecular fold (folded protein) in many important settings, such as growth, differentiation, and the ability to live. It has become clear that the control system plays an important role if the folding process fails or an error occurs, causing folding abnormalities and targeted functionality to accumulate. The accumulation of faulty protein folding would harm cells and can result in death. Apparently, there is a correlation between protein folding error with various diseases, such as diabetes mellitus and cancer. Method: We examined protein levels in all samples using Dotblott with monoclonal antibody anti-Hsp40 and anti-Hsp70. Levels of the protein content was read using a densitometer. Modification of Dot Blot was as follows: treatment was conducted with 3 × SSC, added with 20 mL blocking solution, add with total protein samples of 10 mg/ml on nitrocellulose paper, prehybridized, incubated at 70° for 30 seconds, incubated at 70° for 30 seconds with primary antibody anti-Hsp40 or Hsp70 protein and then added with second antibody HRP anti-Hsp40 or Hsp70 protein, treated with 3 × SSC and visualized with TSA HRP, and then administered with streptavidin, biothynil tyramide, and, finally, added with chromogen (DAB) in a confined space. Result: From the analysis of the data using Manova test with Wilk’s Lambda, there were significant differences in the levels of Hsp40 between Benign Oral Lesion (mean 688.31 area) and OSCC (mean 1354.59 area) patients (p 0.070), there was also a highly significant difference in Hsp70 levels between patients who experienced Benign Oral Lesion (mean 529.82 area) and OSCC (mean 1346.32 area) patients (p 0.006). Conclusion: OSCC patients have increased Hsp70 levels, so it is possible that something is going wrong in protein folding. Errors in protein folding result in a

关键词： Chaperone Hsp40 Hsp70 Misfolding OSCC

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Squamous cell carcinoma of the oral cavity in young patients

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中国口腔颌面外科杂志 2008年第B5期6卷 105-106页

作者： Hafeza A Roslan AR Mohd Nazimi AJ Primuharsa putra SHA Ramli R Department of Otorhinolaryngology Head and Neck Surgery Faculty of Medicine Department of Oral & Maxillofacial Surgery Faculty of Dentistry & Hospital UKM Ear Nose & Throat-Head & Neck Consultant Clinic Seremban Specialist Hospital Seremban Negeri Sembilan Malaysia

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Challenges in the Technology Development for Additive Manufacturing in Space

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Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers) 2022年第1期1卷 83-95页

作者： Andrea Zocca Janka Wilbig Anja Waske Jens günster Martinus putra Widjaja Christian Neumann Mélanie Clozel Andreas Meyer Jifeng Ding Zuoxin Zhou Xiaoyong Tian BAM Bundesanstalt für Materialforschung und-prüfung Berlin12203Germany Institut für Materialphysik im Weltraum Deutsches Zentrum für Luft-und Raumfahrt(DLR)51170 KölnGermany Beijing Space Vehicle general Design Department CASTBeijing100094China State Key Laboratory for Manufacturing System Engineering Xi’an Jiaotong UniversityXi’an710049China

Instead of foreseeing and preparing for all possible scenarios of machine failures,accidents,and other challenges arising in space missions,it appears logical to take advantage of the flexibility of additive manufacturing for“in-space manufacturing”(ISM).Manned missions into space rely on complicated equipment,and their safe operation is a great *** in mind the absolute distance for manned missions to the Moon and Mars,the supply of spare parts for the repair and replacement of lost equipment via shipment from Earth would require too much *** the high flexibility in design and the ability to manufacture ready-to-use components directly from a computer-aided model,additive manufacturing technologies appear to be extremely attractive in this ***,appropriate technologies are required for the manufacture of building habitats for extended stays of astronauts on the Moon and Mars,as well as material/*** capacities for sending equipment and material into space are not only very limited and costly,but also raise concerns regarding environmental issues on ***,not all materials can be sent from Earth,and strategies for the use of in-situ resources,i.e.,in-situ resource utilization(ISRU),are being *** the manufacturing of both complex parts and equipment,as well as for large infrastructure,appropriate technologies for material processing in space need to be developed.

关键词： Zero-g Microgravity Additive manufacturing Regolith Steel Fiber PEEK

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Cembranoids of Soft Corals:Recent Updates and Their Biological Activities

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Natural Products and Bioprospecting 2021年第3期11卷 243-306页

作者： Marsya Yonna Nurrachma Deamon Sakaraga Ahmad Yogi Nugraha Siti Irma Rahmawati Asep Bayu Linda Sukmarini Akhirta Atikana Anggia Prasetyoputri Fauzia Izzati Mega Ferdina Warsito Masteria Yunovilsa putra Research Center for Biotechnology Indonesian Institute of Sciences(LIPI)Jalan Raya Jakarta-Bogor KM.46CibinongBogorWest JavaIndonesia

Soft corals are well-known as excellent sources of marine-derived natural *** them,members of the genera Sar-cophyton,Sinularia,and Lobophytum are especially attractive targets for marine natural product *** this review,we reported the marine-derived natural products called cembranoids isolated from soft corals,including the genera Sarcophyton,Sinularia,and ***,we reviewed 72 reports published between 2016 and 2020,comprising 360 compounds,of which 260 are new compounds and 100 are previously known compounds with newly recognized *** novelty of the organic molecules and their relevant biological activities,delivered by the year of publication,are *** the genera presented in this report,Sarcophyton *** the most cembranoid diterpenes;thus,they are considered as the most important soft corals for marine natural product *** display diverse biological activities,includ-ing anti-cancer,anti-bacterial,and *** cembranoids have been credited with a broad range of biological activities,they present a huge potential for the development of various drugs with potential health and ecological benefits.

关键词： Cembranoids Diterpene Soft corals Sarcophyton Sinularia Lobophytum Anti-bacterial Anti-cancer Anti-inflammatory

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The Indigenous’ Participation in Preserving Cultural Heritage of Bena Traditional Village as a Tourist Attraction in Bajawa, Ngada Regency, East Nusa Tenggara

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Management Studies 2019年第6期7卷 577-581页

作者： Francisca Titing Koerniawaty I Wayan Ardika Made Budiarsa I Nyoman Darma putra International Bali Institute of Tourism BaliIndonesia Udayana University BaliIndonesia

The commodification of cultural heritage has positive implications to encourage the creativity of cultural artists and aboriginal in creating variants of cultural products as an improvement of prosperity;however,it can also has negative implications,such as a shift or loss of the essence of cultural and religious sounds that is able to lead to conflict,natural destruction,sexual services,and *** negative implications can be overcome by the participatory of all stakeholders in preserving the sustainability of cultural heritage as *** study focused on three ***,the patterns of aboriginals’participatory in preserving cultural heritage as a ***,the level of aboriginals’response to ***,the aboriginals’complaint in preserving cultural heritage as a *** accordance with these problems,the operational definition of study is the concept of cultural heritage tourism,tourist attraction,aboriginal,and traditional village of *** theoretical review used to analyze the problem is community participatory theory in tourism development by Tosun and Irridex theory of attitude change of aboriginal by *** qualitative descriptive study is located in traditional village of Bena,Bajawa,Ngada Regency,East Nusa Tenggara with the selection of informants who understand the *** results of the study indicate that the aboriginals’participatory is *** level of aboriginals’response is apathy *** several complaints in preserving cultural heritage involving a great expense of traditional house maintenance,the processing time of traditional woven and the emergence of modern ja’i dance and music.

关键词： cultural heritage tourism tourist attraction aborignal traditional village of Bena

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Establishing the Positioning of Agritourism Product Towards the Collaborative Marketing of CBA Subak Jatiluwih Bali

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Journal of Tourism and Hospitality Management 2021年第4期9卷 221-237页

作者： I Made Sarjana I gde Pitana I Nyoman Darma putra Agung Suryawan Wiranatha Udayana University BaliIndonesia

Positioning is a tool for tourism marketing activities;thus,it directs agritourism management to have a more precise marketing plan and leads the tourism marketing to perform effectively and ***,it supports the management to compose a positive marketing plan by using marketing mix,channel,and predicting results *** article analyses the positioning of agritourism products in Community Based Agritourism(CBA)Subak Jatiluwih from visitors’*** examined six variables to create a precise positioning of CBA Subak Jatiluwih namely features,benefits,competitors,users,usages,and products’*** data gathered through a survey and interview to 125 tourists as respondents who met in the Subak Jatiluwih area during their visit while consuming agritourism *** result showed that visiting CBA Subak Jatiluwih with motivation for getting recharging and relaxing got in the average scores of 4.48 and *** scores are almost 5.0 or close to *** means the two parameters on benefits of agritourism products have strong power on CBA Subak Jatiluwih’s ***,the positioning formulation must be“by visiting CBA Subak Jatiluwih,tourists could encourage the inner motivation with relaxing and recharging their selves in the widest rice field teras in Bali”.

关键词： tourists’perspective positioning relaxing and recharging CBA Subak Jatiluwih

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Factors associated with visit-to-visit variability of blood pressure in hypertensive patients at a Primary Health Care Service,Tabanan,Bali,Indonesia

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Family Medicine and Community Health 2018年第4期6卷 191-199页

作者： gusti Ayu Riska Pertiwi Anak Agung Ngurah Aryawangsa I Putu Yuda Prabawa Ida Bagus Amertha putra Manuaba Agha Bhargah Ni Wayan Sri Ratni I Putu gede Budiana Faculty of Medicine Udayana UniversityP.B.Sudirman StreetDangin Puri KlodWest DenpasarDenpasar CityBali 80232Indonesia Biomedicine Magister Program Post Graduate ProgramFaculty of MedicineUdayana UniversityP.B.Sudirman StreetDangin Puri KlodWest DenpasarDenpasar CityBali 80232Indonesia Medical and Health Education Faculty of MedicineUdayana UniversityP.B.Sudirman StreetDangin Puri KlodWest DenpasarDenpasar CityBali 80232Indonesia International Program in Medicine College of MedicineTaipei Medical UniversityNo.250Wuxing StreetXinyi DistrictTaipei City 110TaiwanChina Tabanan III Primary Health Care Service BaliIndonesia Department of Cardiovascular Medicine Mangusada General HospitalBadungBaliIndonesia

Background:An increasing number of valid and well-designed trials have demonstrated a positive correlation between visit-to-visit variability(VVV)in systolic blood pressure(SBP)and increased risk of stroke and coronary heart disease among hypertensive ***:A cross-sectional study was conducted that involved 74 patients who visited the outpatient clinic at the Tabanan III Primary Health Care Service during April to May *** pressure was retrospectively obtained from medical *** was classified as low or high on the basis of the standard deviation of *** medication adherence was expressed as the percentage of days covered,and sodium intake was measured with 24-hour food ***-variate analysis was performed,followed by multivariate analysis for significant ***:Among the participants,67.6%were female,with a mean(standard deviation[SD])age of 62.70(10.00)*** pressure was measured 4.82±0.78 times during the period,and the mean(SD)SBP was 139.65(10.57)mm *** and sodium intake were signifi-cantly higher in the high-VVV group than in the low-VVV group(nonadherence 13.5%vs.37.8%,P=0.033;sodium intake 1278.44±43.02 mg vs.1495.85±45.26 mg,P=0.038).After adjustment for other covariates,the differences remained significant only for nonadherence(model I exp β=3.89[95.0%confidence interval 1.23-12.34,Pgnificantly associated with higher VVV of *** study is needed to assess whether improving adherence could reduce VVV and improve cardiovascular outcomes.

关键词： Blood pressure visit-to-visit-variability nonadherence sodium intake hyperten-sion

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甘美兰在广西艺术学院的教学及推广研究

甘美兰在广西艺术学院的教学及推广研究

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作者：仁迪（Randy geovani putra）广西师范大学

学位级别：硕士

甘美兰是印度尼西亚文化传统瑰宝。作为传统印尼乐器之一,在印度尼西亚拥有大量的学习者和演奏者。笔者在广西艺术学院艺术研究所实际教学时运用行动研究法,不仅观察与反思了自己的教学,同时研究了学生短时内学习甘美兰的教学方式。提... 详细信息

甘美兰是印度尼西亚文化传统瑰宝。作为传统印尼乐器之一,在印度尼西亚拥有大量的学习者和演奏者。笔者在广西艺术学院艺术研究所实际教学时运用行动研究法,不仅观察与反思了自己的教学,同时研究了学生短时内学习甘美兰的教学方式。提出了将甘美兰口头传授方法形成简易的教学方式的方法理论。文章中介绍了如Sunda甘美兰,爪哇甘美兰,巴厘甘美兰和米南甘美兰,并简介了它们的音律和演奏技法,在印尼这都是具有代表性的甘美兰。本文试图通过在中国的学习与甘美兰的教学,对甘美兰在中国的传播与推广进行探讨研究。使更多的爱好者了解和学习甘美兰。

关键词：印尼传统乐器 Sunda甘美兰甘美兰教学推广研究

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黑孜然的肝脏保护和心血管保护作用:一项荟萃分析

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Digital Chinese Medicine 2023年第2期6卷 112-120页

作者： Fathiyah Safithri Diah Hermayanti Isbandiyah Probo Yudha Pratama putra Faiq Shabri Maulana Aji Muthi’ah Nur Azizah Department of Pharmacology Medical Faculty University of Muhammadiyah MalangMalangEast Java 65145Indonesia Department of Clinical Pathology Medical Faculty University of Muhammadiyah MalangMalangEast Java 65145Indonesia Department of Internal Medicine Medical Faculty University of Muhammadiyah MalangMalangEast Java 65145Indonesia Department of Medicine Medical Faculty University of Muhammadiyah MalangMalangEast Java 65145Indonesia

目的有大量证据揭示,非酒精性脂肪性肝病患者是心血管疾病的高危人群,而心血管疾病是此类患者死亡的首要原因。本研究旨在评价黑孜然对肝脏和心血管保护作用。方法采用PRISMA指南进行荟萃分析,于2022年6月在PubMed、ScienceDirect、Coch... 详细信息

目的有大量证据揭示,非酒精性脂肪性肝病患者是心血管疾病的高危人群,而心血管疾病是此类患者死亡的首要原因。本研究旨在评价黑孜然对肝脏和心血管保护作用。方法采用PRISMA指南进行荟萃分析,于2022年6月在PubMed、ScienceDirect、Cochrane Library网站分别检索2010年1月至2021年12月发表的相关文献。应用Review Manager软件(5.3版)对天冬氨酸转氨酶和丙氨酸转氨酶水平、血脂、血糖、体重和体重指数等指标进行统计学分析。结果黑孜然能显著降低研究对象的天冬氨酸转氨酶(P=0.009)和丙氨酸转氨酶(P0.05)。结论尽管黑孜然组和安慰剂组的体重和体重指数差异不显著,但黑孜然对非酒精性脂肪性肝病或慢性肝病患者确实具有一定的肝脏保护和心血管保护作用。

关键词：保肝药保心药黑孜然血脂肝酶脂肪肝

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卢里克梭织物在现代软装中创新应用研究

卢里克梭织物在现代软装中创新应用研究

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作者：文思涌（Alam Wisesha Prima putra）南京艺术学院

学位级别：硕士

印度尼西亚是一个群岛国家。根据印度尼西亚共和国海事和投资部的数据,印度尼西亚拥有17,504个岛屿,据2017年数据记录,其中16,056个岛屿已经有名字。在印度尼西亚的许多岛屿中,较大的岛屿是印度尼西亚的文明中心,例如爪哇岛,苏门答腊岛... 详细信息

印度尼西亚是一个群岛国家。根据印度尼西亚共和国海事和投资部的数据,印度尼西亚拥有17,504个岛屿,据2017年数据记录,其中16,056个岛屿已经有名字。在印度尼西亚的许多岛屿中,较大的岛屿是印度尼西亚的文明中心,例如爪哇岛,苏门答腊岛,加里曼丹岛,苏拉威西岛和巴布亚岛。因此,印度尼西亚拥有多种文化,语言,生态环境。印度尼西亚被认为拥有742种地区语言,7241种文化作品的国家。但是,作为印度尼西亚公民,他们必须掌握统一的语言,即印度尼西亚语。印度尼西亚拥有如此众多的文化,这对印度尼西亚公民来说是一个骄傲,也因此吸引外国游客前来参观旅行。印度尼西亚的文化自豪感之一是梭织文化,这种文化在印度尼西亚的各个地区均广泛传播。这种梭织物的文化具有艺术,宗教,社会和经济价值,因此人们严重依赖于这种文化。梭织物的特性因地区而异,这种织物具有不同的历史,含义,题材和技艺。这种特征往往靠一个地域的服饰来区分。最初,这种织物具有神圣的意义,因为它是对当地部落或宗教仪式的补充。但是,随着时间的流逝,这种织物已成为可以发展社区经济的重要事物之一。该地区的梭织物手工艺人现在可以接受雅加达商家的订单。由于在社区的高度兴趣,这种织物为社区带来了繁荣。当前,许多设计师和商人使用这种织物来成为用于软装织物设计的时装设计材料。这种织物具有适合作为城市文化软装织物设计元素的特征。基本上,这种面料将传统价值带入当今的现代设计中。这些字符也成为印尼梭织字符的重要身份。关于软装织物设计,许多设计师将这种织物用于沙发罩,床罩,桌布,枕头罩,窗帘和地毯。爱好者越来越来,遍布年轻人到老年人群体。将来,这种梭织物可以帮助印尼软装织物设计在国际舞台上竞争。日惹传统的机梭织物是传统的,这种机织物也可以称为卢里克(lurik)。最初仅使用传统织机生产,逐渐随着在纺织品领域发展技术的发展,快速织机开始出现,。当然,快速织机的出现一方面,这种复杂的机器简化了生产过程,生产变得更快.,但是,生产成本更便宜,当然市场上的售价也更便宜,。但从另一个方面说,是我们中有些人可能会忘记,传统织机生产的织物质量更高,并且使用寿命足够更长。,并且蕴含更多的民族文化的元素和人民的生产智慧。卢里克(lurik)这种织物最初仅由爪哇人用于衣服,然后当这种织物与蜡染技术结合使用时出现了一些变化,然后结合了由于多种技术出现了一些变化的介入,然后引发了一些时装设计师对这种织物的独特性的关注,使其成为高价值的时尚作品。实际上,日惹独特的梭织布除了技术上的变化外,还发生了历史性的变化,材料的变化,设计的变化,用途的变化以及社区的消费方式的变化等。当然,在本课题的研究中,笔者除了讨论这些变化及其支持支撑这些变化的各种因素外。还将尝试更深入地研究日惹传统机梭织物的现代应用变化设计。

关键词：卢里克梭织物现代软装创新应用

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