检索结果-南通市图书馆

Gasdermin d-mediated pyroptosis in myocardial ischemia.a.d reperfusion injury:Cumulative evidence for future cardioprotective strategies

引用

Acta Pharmaceutica Sinica B 2023年第1期13卷 29-53页

作者： Panat Yanpiset Chayodom Maneechote Sirawit Sriwichaiin Natthaphat siri-Angkul siriporn C.Chattipakorn Nipon Chattipakorn Cardiac Electrophysiology Research and Training Center Faculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand Cardiac Electrophysiology Unit Department of PhysiologyFaculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand Center of Excellence in Cardiac Electrophysiology Research Chiang Mai UniversityChiang Mai 50200Thailand department of Oral Biology and diagnostic Sciences Faculty of DentistryChiang Mai UniversityChiang Mai 50200Thailand

Cardiomyocyte death is one of the major mechanisms contributing to the development of myocardial infarction(MI)and myocardial ischemia/reperfusion(MI/R)*** to the limited regenerative ability of cardiomyocytes,understanding the mechanisms of cardiomyocyte death is ***,one of the regulated programmed cell death pathways,has recently been shown to play important roles in MI and MI/R *** is activated by damage-associated molecular patterns(dAMPs)that are released from damaged myocardial cells and activate the formation of an apoptosisassociated speck-like protein containing a CARd(ASC)interacting with NACHT,LRR,and PYd domains-containing protein 3(NLRP3),resulting in caspase-1 cleavage which promotes the activation of Gasdermin d(GSdMd).This pathway is known as the canonical *** has also been shown to be activated in a non-canonical pathway during MI and MI/R injury via caspase-4/5/*** of GSdMd has been shown to provide cardioprotection against MI and MI/R *** the effects of MI or MI/R injury on pyroptosis have previously been discussed,knowledge concerning the roles of GSdMd in these settings remains *** this review,the evidence from in vitro,in vivo,and clinical studies focusing on cardiac GSdMd activation during MI and MI/R injury is comprehensively summarized and *** from this review will help pave the way for a new therapeutic target in ischemic heart disease.

关键词： Pyroptosis Gasdermin d Heart Ischemia Ischemia-reperfusion injury Myocardial infarction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental and numerical study of the fragmentation of expanding warhead casings by using different numerical codes and solution techniques

引用

defence Technology（防务技术） 2014年第2期10卷 161-176页

作者： John F.MOXNES Anne K.PRYTZ Фyvind FRФYLANd siri KLOKKEHAUG Stian SKRIUdALEN Eva FRIIS Jan A.TELANd Cato dФRUM Gard ФdEGARdSTUEN Land Systems division.Norwegian defence Research Establishment P.O.Box 25 Nammo Raufoss AS.P.O.Box 162

There has been increasing interest in numerical simulations of fragmentation of expanding warheads in *** there is a pressure on developers of leading commercial codes,such as *** and IMPETUS *** implement the reliable fracture models and the efficient solution *** applicability of the Johnson—Cook strength and fracture model is evaluated by comparing the fracture behaviour of an expanding steel casing of a warhead with *** numerical codes and different numerical solution techniques,such as Eulerian,*** particle hydrodynamics(SPH).and the corpuscular models recently implemented in IMPETUS Afea are *** the same solution techniques and material models we find that the codes give similar *** SPH technique and the corpuscular technique are superior to the Eulerian technique and the Lagrangian technique(with erosion) when it is applied to materials that have fluid like behaviour such as the explosive and the *** Eulerian technique gives much larger calculation time and both the Lagrangian and Eulerian techniques seem to give less agreement with our *** more correctly simulate the fracture behaviours of the expanding steel casing,we applied that ductility decreases with strain *** phenomena may be explained by the realization of adiabatic shear *** implemented node splitting algorithm in IMPETUS Afea seems very promising.

关键词：技术试验数字代码数值模拟弹头光滑粒子流体动力学 LS-dYNA 外壳数值求解方法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impact of Nitrogen and Phosphorus Applications of Three Bioenergy C4 Crops on Biomass Production and Nutrient Balance

Impact of Nitrogen and Phosphorus Applications of Three Bioe...

引用

The 19th European Biomass Conference and Exhibition

作者： siri Prieto,G.

Arundo donax L.（Arundo d.） Pennisetum purpureum（Elephant G.）,and Panicum virgatum（Switchgrass） are three perennial C4 crops which have been received particular attention during the last years as bioenergy *** experiment located in Uruguay,were established in 2007 to determine biomass production and nutrient balance on these three energy crops.A combination of four treatments of N and P（0 or 100 kg ha-1） were applied *** *** significantly more biomass than Arundo *** Switchgrass in all *** was response to N（100 kg ha-1） in 2009,especially in Elephant G.（＞42% compared to without N）.On the other hand,there was not response to P applications for any C4 crops for any *** of major nutrient flows have shown that the N and P balance were positive with N and P applications;however,the P,N and K balance without N-P applications were *** removal was greater under Elephant G.（-1227 kg ha-1） largely due to greater K concentrations and biomass *** the component of biomass that will be removed and have to be replaced and changes in soil nutrients,should be very important for the long-term success of the bioenergy system.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

内蒙古通辽地区青贮玉米品种筛选试验

引用

养殖与饲料 2024年第7期23卷 26-31页

作者：刘殿鹏杨晓松王海锋褚景芬斯日古楞姜澜吴明浩包雨鑫内蒙古通辽市农牧科学研究所内蒙古通辽028015

[目的]为筛选出适合通辽地区推广种植的优质高产青贮玉米品种。[方法]选取22个青贮玉米品种在试验田内采取随机区组试验设计,对不同品种生育期、抗逆性(倒伏倒折率、瘤黑粉病、大斑病)、生物产量(鲜草产量、干草产量、籽粒产量)、农艺性... 详细信息

[目的]为筛选出适合通辽地区推广种植的优质高产青贮玉米品种。[方法]选取22个青贮玉米品种在试验田内采取随机区组试验设计,对不同品种生育期、抗逆性(倒伏倒折率、瘤黑粉病、大斑病)、生物产量(鲜草产量、干草产量、籽粒产量)、农艺性状(株高、茎粗,绿叶数、枯叶数、有效穗数)和营养品质(淀粉、粗蛋白、中性洗涤纤维、酸性洗涤纤维)等进行综合比较分析。[结果]不同品种生育期不同,为98~122 d。抗倒伏倒折最强的是蒙青贮17272,倒伏倒折率为0.14%,瘤黑粉病发生率最低的是先玉1611和京科968,病害率为0。干物质产量最高的是先玉1710,为1 487.44 kg/667m2。先玉1620、先玉1611、金岭青贮377、先玉1710干物质含量都达到了30%以上,其淀粉含量也较高,均达到了35%以上,但中性洗涤纤维和酸性洗涤纤维含量均较低。不同品种粗蛋白含量差距不大,北农青贮368含量最高,为10.03%。[结论]先玉系列(1710、1620、1611)、金岭青贮系列(377、97)、蒙青贮(17272、266)、京九青贮16和京科968符合通辽地区在青贮玉米种植上的产量、品质和适应性的需求,适合在本区域大面积推广种植。

关键词：青贮玉米品种农艺性状产量营养品质综合评价

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Hydrogenation of Glucose on a Carbon-Supported Ru Catalyst: Optimization of the Reaction Conditions

引用

Advances in Chemical Engineering and Science 2023年第3期13卷 224-240页

作者： Juan J. Musci María E. Chiosso Guillermo J. siri Mónica L. Casella departamento de Ciencias Básicas y Experimentales Universidad Nacional del Noroeste de la Provincia de Buenos Aires Junín Argentina Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires (CITNOBA) - UNNOBA-UNSAdA-CONICET Pergamino Argentina Centro de Investigación y desarrollo en Ciencias Aplicadas “dr. Jorge J. Ronco” (CINdECA) CCT CONICET-La Plata Universidad Nacional de La Plata Comisión de Investigaciones Científicas La Plata Argentina

The catalytic hydrogenation of d-glucose over a 3 wt% Ru/C catalyst was studied varying the operating conditions in mild conditions range to optimize the obtention of d-sorbitol. The stirring speed, temperature, pressure, and initial glucose concentration were varied between 250 - 700 rpm, 343 - 383 K, 0.5 - 2 MPa, and 0.033 - 0.133 M, respectively. To verify the absence of mass transport limitations, the diffusion of reagents in the gas-liquid interface, the liquid-solid interface, and the internal diffusion in the particles were evaluated. Under the operating conditions studied, the reaction rate showed an order with respect to H2 of 0.586 and with respect to glucose of 0.406. The kinetic data were adjusted using 3 general models and 19 different sub-models based on Langmuir-Hinshelwood-Hougen-Watson (LHHW) kinetics. Model 3a was the best one interpreting the aqueous phase hydrogenation of glucose (both reagents competitively adsorbed on the catalyst). The H2 adsorption is dissociative and the rate-limiting step is the surface chemical reaction.

关键词： 3 wt% Ru/C d-Glucose Hydrogenation Kinetic Modeling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

砂土基MICP土工材料剪切强度试验及可靠性分析

引用

防灾减灾工程学报 2018年第5期38卷 795-800,821页

作者：斯日古楞毕力贡李驰内蒙古工业大学理学院内蒙古呼和浩特010051 内蒙古工业大学土木工程学院内蒙古呼和浩特010051

选用巴氏芽孢杆菌,以不同粒径砂土为岩土基质,应用微生物诱导矿化技术生成MICP-土工材料试样,自然养护7d后,应用直剪仪进行了抗剪强度测试试验。结果表明,MICP-细砂土内摩擦角范围最大,MICP-粗粒砂土内摩擦角范围最小,这与微生物诱导生... 详细信息

选用巴氏芽孢杆菌,以不同粒径砂土为岩土基质,应用微生物诱导矿化技术生成MICP-土工材料试样,自然养护7d后,应用直剪仪进行了抗剪强度测试试验。结果表明,MICP-细砂土内摩擦角范围最大,MICP-粗粒砂土内摩擦角范围最小,这与微生物诱导生成的矿化物填充空隙的过程中形成胶结作用有重要的关系,粗粒砂土空隙大,MICP材料强度的增长主要依靠诱导生成的碳酸钙咬合力;中粗砂粒土表面粗糙度的提高有效增强了矿化土工材料的强度;细砂土主要是填充空隙,材料更加密实,导致抗剪强度最大。再运用多项式混沌扩展(PCE)方法建立代理模型,求得其前四阶统计矩,对内摩擦角输出响应的不确定性进行了量化。

关键词：微生物诱导碳酸钙沉淀砂土基质抗剪强度多项式混沌展开法不确定性量化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison of ethanolic extracts of phytoestrogenic dendrolobium lanceolatum and non-phytoestrogenic Raphanus sativus to mediate green syntheses of silver nanoparticles

引用

Chemical Reports 2019年第1期1卷 43-50页

作者： Kamchan Bamroongnok Arunrat Khmahaengpol Sineenat siri School of Biology Institute of Science Suranaree University of Technology Nakhon Ratchasima 30000 Thailand Curriculum and Instruction Program Faculty of Education Sakon Nakhon Rajabhat University Sakon Nakhon 47000 Thailand

Green synthesis of silver nanoparticles (AgNPs) mediated by plant extracts has drawn many research interests due to its simple, cost-effective, and eco-friendly approach. However, the extracts derived from phytoestrogenic plants that produce high phenolic-based compounds exhibiting the estrogenic activity have not yet investigated. This work reported the comparison of ethanolic extracts derived from phytoestogenic dendrolobium lanceolatum and non-phytoestrogenic Raphanus sativus to facilitate the green synthesis of AgNPs. The total phenolic content and the reducing activity of d. lanceolatum extract were significantly higher than those of R. sativus extract. In addition, the formation of AgNPs could detect in the reaction using d. lanceolatum extract, but not R. sativus extract, as determined by the characteristic surface plasmon resonance peak of AgNPs at 416 nm. The synthesized AgNPs were spherical with an average diameter of 74.6017.11 nm, which their face-centered cubic structure of silver was confirmed by X-ray diffraction analysis. Moreover, the synthesized AgNPs exhibited the antibacterial activity against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. The results of this work, thus, suggested the potential uses of phytoestrogenic plants as a good source of reducing and stabilizing agents for the production of AgNPs and other metallic nanoparticles.

关键词： antibacterial activity phenolic content plant extract reducing activity silver nanoparticles

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

头孢哌酮钠/舒巴坦钠静脉输注致凝血功能障碍1例

引用

中国药物应用与监测 2019年第6期16卷 380-382页

作者：斯日古楞郭小彬乌日汗杨宏昕内蒙古自治区人民医院

1例78岁男性患者,因肺部感染入院,临床诊断为肺部感染、冠状动脉粥样硬化性心脏病、心力衰竭,给予头孢哌酮钠/舒巴坦钠(3.0 g,q 8 h,ivgtt)抗感治疗。治疗第6天患者出现凝血功能异常,凝血酶原时间(PT)61.6 s,凝血酶原活动度(PTA)6%,国... 详细信息

1例78岁男性患者,因肺部感染入院,临床诊断为肺部感染、冠状动脉粥样硬化性心脏病、心力衰竭,给予头孢哌酮钠/舒巴坦钠(3.0 g,q 8 h,ivgtt)抗感治疗。治疗第6天患者出现凝血功能异常,凝血酶原时间(PT)61.6 s,凝血酶原活动度(PTA)6%,国际标准化比值(INR)5.44,活化部分凝血活酶时间(APTT)30.7 s。考虑凝血功能障碍为头孢哌酮钠/舒巴坦钠所致,立即停药。给予输注新鲜冰冻血浆,肌注维生素K1。治疗第12天,患者复查凝血功能,PTA 56%,PT 16.3 s,INR 1.4,APTT 27.2 s,停药7 d后不良反应未再发生,凝血功能无异常。

关键词：头孢哌酮钠/舒巴坦钠凝血功能障碍药品不良反应

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

磁性淀粉微球固定化乙酰乳酸脱羧酶及应用

引用

广州化工 2000年第4期28卷 24-27页

作者：邱广亮邱广明李咏兰格特乐期日古楞内蒙古师范大学生物系内蒙古呼和浩特010022 内蒙古工大电力学院动力系内蒙古呼和浩特010022

采用复合技术制备出粒径为１００～３００ｎｍ的磁性淀粉复合微球。以此为载体采用溴化氰共价结合法、戌二醛交联法、物理吸附法固定化ａ一乙酰乳酸脱羧酶。以戌二醛交联法制备的磁性酶为最佳，其活力为１１３８．８Ｕ／ｇ微球，蛋白... 详细信息

采用复合技术制备出粒径为１００～３００ｎｍ的磁性淀粉复合微球。以此为载体采用溴化氰共价结合法、戌二醛交联法、物理吸附法固定化ａ一乙酰乳酸脱羧酶。以戌二醛交联法制备的磁性酶为最佳，其活力为１１３８．８Ｕ／ｇ微球，蛋白载量为８９．７ｍｇ／ｇ微球，比活为１２．６Ｕ／ｍｇ蛋白，活性回收率为５９．６％。并对其理化性质进行了研究：磁性酶最适温度３０℃，最适ｐＨ为５．０，热稳定性及酸碱稳定性均有所提高，磁性酶重复使用１０次，其相对活性仍保持在７７．２％。将磁性固定化ＡＬＤＣ用于啤酒发酵，磁性酶用量为８０Ｕ／Ｌ麦芽汁，主发酵温度为１３℃，保持１０ｄ，发酵后双乙酰含量降到０．１３×１０－６以下。

关键词：磁性淀粉复合微球固定化乙酰乳酸脱羧酸啤酒

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：