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CO_2 insufflation for potentially diffi cult colonoscopies: Effi cacy when used by less experienced colonoscopists

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World Journal of Gastroenterology 2009年第41期15卷 5186-5192页

作者： Toshio Uraoka Jun Kato Motoaki Kuriyama Keisuke Hori Shin Ishikawa Keita Harada Koji Takemoto Sakiko Hiraoka Hideyuki Fujita Joichiro horii Yutaka Saito Kazuhide Yamamoto Department of Endoscopy Okayama University Hospital Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Division of Endoscopy National Cancer Center Hospital

AIM： To clarify the effectiveness of CO2 insufflation in potentially difficult colonoscopy cases, particularly in relation to the experience level of colonoscopists. METHODS： One hundred twenty potentially difficult cases were included in this study, which involved females with a low body mass index and patients with earlier abdominal and/or pelvic open surgery or previously diagnosed left-side colon diverticulosis. Patients receiving colonoscopy examinations without sedation using a pediatric variable-stiffness colonoscope were divided into two groups based on either CO2 or standard air insuffiation. Both insufflation procedures were also evaluated according to the experience level of the respective colonoscopists who were divided into an experienced colonoscopist （EC） group and a less experienced colonoscopist （LEC） group. Study measurements included a 100-mm visual analogue scale （VAS） for patient pain during and after colonoscopy examinations, in addition to insertion to the cecum and withdrawal times. RESULTS： Examination times did not differ, however, VAS scores in the CO2 group were significantly better than in the air group （P〈 0.001, two-way ANOVA） from immediately after the procedure and up to 2 h later. There were no significant differences between either insufflation method in the EC group （P = 0.29）, however, VAS scores for CO2 insufflation were significantly better than air insufflation in the LEC group （P = 0.023） immediately after colonoscopies and up to 4 h afterwards. CONCLUSION： CO2 insufflation reduced patient pain after colonoscopy in potentially difficult cases when performed by LECs.

关键词： CO2 insufflation Colonoscopy Difficult colonoscopy Experienced colonoscopist Training

Investigation of Braking Timing of Drivers for Design of Pedestrian Collision Avoidance System

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Journal of Mechanics Engineering and Automation 2016年第3期6卷 118-127页

作者： Keisuke Suzuki Takuya Kakihara Yasutoshi horii Faculty of Engineering Kagawa University Takamatsu 761-0396 Japan DENSO SALES SWEDEN AB Goteborg 417 55 Sweden

The braking behavior of drivers when a pedestrian comes out from the sidewalk to the road was analyzed using a driving simulator. Based on drivers＇ braking behavior, the braking control timing of the system for avoiding the collision with pedestrians was proposed. In this study, the subject drivers started braking at almost the same time in terms of TTC （Time to Collision）, regardless of the velocity of a subject vehicle and crossing velocity of pedestrians. This experimental result showed that brake timing of the system which can minimize the interference for braking between drivers and the system is 1.3 s of TTC. Next, the drivers＇ braking behavior was investigated when the system controlled braking to avoid collision at this timing. As a result, drivers did not show any change of braking behavior with no excessive interference between braking control by the system and braking operation by drivers for avoiding collisions with pedestrians which is equivalent to the excessive dependence on the system.

关键词： Active safety collision avoidance pedestrian brake timing TTC driving simulator.

An extremely rare case of pancreatic metastasis of esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2014年第2期20卷 593-597页

作者： Hiroshi Okamoto Yasuyuki Hara Masahiro Chin Motohisa Hagiwara Yuji Onodera Shinichiro horii Yasuhiro Shirahata Takashi Kamei Eiji Hashizume Noriaki Ohuchi Department of Surgery Nihonkai General HospitalSakata 998-8501Japan Division of Advanced Surgical Science and Technology Graduate School of MedicineTohoku UniversitySendai 980-8574Japan

We report a rare case of a 68-year-old male with metachronous pancreatic metastasis that was resected2 years after salvage esophagectomy for local recurrence of esophageal squamous cell carcinoma(ESCC).Two years and 8 mo ago,he had undergone definitive chemoradiotherapy for the lower thoracic ESCC and achieved a complete *** used the protocol of the Japan Clinical Oncology Group trial *** 8 mo later,he developed a local recurrence of the ESCC and underwent thoracoscopic salvage esophagectomy followed by reconstruction with a conduit colon graft via a subcutaneous ***,a tumor of the pancreatic body was found on routine follow-up computed tomography(CT).The tumor diameter was 15 mm on CT,and the maximum standardized uptake value of the lesion was 5.49at 18F-2-fluoro-2-deoxy-D-glucose positron-emission tomography,strongly suggesting pancreatic *** addition,all tumor markers were within the reference ***,distal pancreatectomy was performed with the resultant histological diagnosis being confirmed as pancreatic metastasis of the *** was treated with adjuvant chemotherapy,and there has been no evidence of recurrence 9 mo after the *** of pancreatic metastasis offers a good prognosis and should be considered for solitary ESCC metastasis.

关键词： Metachronous pancreatic metastasis Esophagus Squamous cell carcinoma Pancreatectomy Salvage esophagectomy Definitive chemoradiotherapy

Early effects of Lansoprazole orally disintegrating tablets on intragastric pH in CYP2C19 extensive metabolizers

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World Journal of Gastroenterology 2008年第13期14卷 2049-2054页

作者： Hatsushi Yamagishi Tomoyuki Koike Shuichi Ohara Toru horii Ryousuke Kikuchi Shigeyuki Kobayashi Yasuhiko Abe Katsunori Iijima Akira Imatani Kaori Suzuki Takanori Hishinuma Junichi Goto Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine 1-1 Seiryou-Machi Aobaku Sendai 9808574 Japan Division of Clinical Pharmacy Tohoku University Graduate School of Pharmaceutical Sciences 1-1 Seiryou-Machi Aobaku Sendai 9808574 Japan Division of Pharmacotherapy Tohoku University Graduate School of Pharmaceutical Sciences Department of Pharmaceutical Sciences Tohoku University Hospital 1-1 Seiryou-Machi Aobaku Sendai 9808574 Japan

AIM: To compare rabeprazole (RPZ; 10 mg) with Lansoprazole orally disintegrating tablets (LPZ; 30 mg OD) in terms of antisecretory activity and blood drug concentration after a single dose. METHODS: Eight H pylori-negative cytochrome P450 (CYP) 2C19 extensive metabolizers were assigned to receive a single oral dose of RPZ 10 mg or LPZ 30 mg OD. Twelve hour intragastric pH monitoring was perform- ed on the day of treatment. Blood samples were also collected after the administration of each drug. RESULTS: LPZ 30 mg OD induced a significantly earlier rise in blood drug concentration than RPZ 10 mg; consequently, LPZ 30 mg OD induced a significantly earlier rise in median pH in the third and fourth hours of the study. CONCLUSION: In H pylori-negative CYP2C19 extensive metabolizers, LPZ 30 mg OD induced a significantly faster inhibition of gastric acid secretion than RPZ 10 mg.

关键词： LPZ 30 mg orally disintegrating tablets Intragastric pH Blood drug concentration Cytochrome P450 2C19 extensive metabolizers H pylori-negative

Biomarkers and Environmental Toxicology

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中国药理学与毒理学杂志 2006年第3期 169-172页

作者： Xin-Biao Guo Byung-Mu Lee Seok Kwon Danai Tiwawech Petcharin Sriatanakul Anant Karalak Takafumi Ishida Ikuo horii

S3-1 Nutrient-gene interactions in chronic arsenic poisoning GUO Xin-Biao(Department of Occupational and Environmental Health Sciences,School of Public Health, Peking University,Beijing 100083, ChinaArsenic exposure has been associated with the development of skin lesions such as hyperpigmentation, hypopigmentation and hyperkeratosis, which may be harbingers of increased risk for cancers of the skin, bladder, lung and other organs. The primary metabolic pathway of ingested inorganic arsenic in humans is methylation. In human, however, there is considerable inter-individual variability in the proportions of different methylated arsenic metabolites such as monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) in urine. I

关键词： LMP Biomarkers and Environmental Toxicology gene

Stronger inhibition of gastric acid secretion by lafutidine, a novel H_2 receptor antagonist, than by the proton pump inhibitor lansoprazole

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World Journal of Gastroenterology 2008年第15期14卷 2406-2410页

作者： Hatsushi Yamagishi Tomoyuki Koike Shuichi Ohara Toru horii Ryousuke Kikuchi Shigeyuki Kobayashi Yasuhiko Abe Katsunori Iijima Akira Imatani Kaori Suzuki Takanori Hishinuma Junichi Goto Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai 9808574 Japan Division of Clinical Pharmacy Tohoku University Graduate School of Pharmaceutical Sciences Sendai 9808574 Japan Division of Pharmacotherapy Tohoku University Graduate School of Pharmaceutical Sciences and Department of Pharmaceutical Sciences Tohoku University Hospital Sendai 9808574 Japan

AIM: To compare the antisecretory activity and plasma drug concentrations of a single oral dose of 10 mg lafutidine, a novel H2 receptor antagonist, with those of the proton pump inhibitor lansoprazole (LPZ) 30 mg. METHODS: Ten volunteers without H pylori infection participated in this crossover study comparing lafutidine 10 mg with LPZ 30 mg. Intragastric pH was monitored for 6 h in all participants, and blood samples were collected from four randomly selected individuals after single-dose administration of each drug. RESULTS: The median intragastric pH was significantly higher in individuals who received lafutidine 10 mg than in those who received LPZ 30 mg 2, 3, 4, 5, and 6 h after administration. Maximal plasma drug concentration was reached more promptly with lafutidine 10 mg than with LPZ 30 mg. CONCLUSION: In H pylori-negative individuals, gastric acid secretion is more markedly inhibited by lafutidinethan by LPZ.

关键词： Lafutidine Lansoprazole H2 receptor antagonists Proton pump inhibitors Antisecretory activity

OPTICAL TELEPHONE CORD PASSING THROUGH LONG PIPE WITH SPIRAL FLOW

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Chinese Journal of Aeronautics 1991年第2期6卷 133-140页

作者： K.horii Y.Matsumae Cheng Xiaoming M.Takei E.Yasukawa B.Hashimoto Shirnyuri Women's College 1-25 Midorigaoka Chofu-shi Tokyo 182 JAPAN Shirnyuri Women's College 1-25 Midorigaoka Chofu-shi Tokyo 182 JAPANShirnyuri Women's College 1-25 Midorigaoka Chofu-shi Tokyo 182 JAPANShirnyuri Women's College 1-25 Midorigaoka Chofu-shi Tokyo 182 JAPANShirnyuri Women's College 1-25 Midorigaoka Chofu-shi Tokyo 182 JAPANShirnyuri Women's College 1-25 Midorigaoka Chofu-shi Tokyo 182 JAPAN

A new effective technique, useful in telecommunications industry for passing an optical telephone cord attached to a connector through pipeline,has been developed using the spiral flow. Using this technique, the cord could be passed through a straight pipeline 150 meters long and a roll of vinyl tube 50 meters long. However, under the same condition, the cord could not pass through when using the turbulent flow. To obtain a high speed stable spiral flow, a nozzle with an annular slit connected to a conical cylinder was used. A pressurized fluid with no tangential flow was supplied through this slit and the fluid, passing through the conical cylinder, was deformed into spiral flow with the steeper axial velocity distribution compared to that of turbulence pipe flow due to Coanda effect and instability. As a result, the cord was attracted to the axis area of the pipe, which effectively increased the ability for the work of cord passing. This high ability for cord passing is attributed mainly to the reduction of the friction made between the cord and the pipe wall, caused by the deformation to spiral flow.

关键词： PIPE OPTICAL TELEPHONE CORD PASSING THROUGH LONG PIPE WITH SPIRAL FLOW

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Metabolomic Screening Applied to Rice FOX Arabidopsis Lines Leads to the Identification of a Gene-Changing Nitrogen Metabolism

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Molecular Plant 2010年第1期3卷 125-142页

作者： Doris Albinsky Miyako Kusano Mieko Higuchi Naomi Hayashi Makoto Kobayashi Atsushi Fukushima Masaki Mori Takanari Ichikawa Keiko Matsui Hirofumi Kuroda Yoko horii Yuko Tsumoto Hitoshi Sakakibara Hirohiko Hirochika Minami Matsui Kazuki Saito RIKEN Plant Science Center Tsurumi-ku Yokohama 230-0045 Japan National Institute of Agrobiological Sciences Tsukuba 305-8602 Japan Graduate School of Pharmaceutical Sciences Chiba University Inage-ku Chiba 263-8522 Japan

Plant metabolomics developed as a powerful tool to examine gene functions and to gain deeper insight into the physiology of the plant cell. In this study, we screened Arabidopsis lines overexpressing rice full-length （FL） cDNAs （rice FOX Arabidopsis lines） using a gas chromatography-time-of-flight mass spectrometry （GC-TOF/MS）-based technique to identify rice genes that caused metabolic changes. This screening system allows fast and reliable identification of candi- date lines showing altered metabolite profiles. We performed metabolomic and transcriptomic analysis of a rice FOX Ara- bidopsis line that harbored the FL cDNA of the rice ortholog of the Lateral Organ Boundaries （LOB） Domain （LBD）/ Asymmetric Leaves2-1ike （ASL） gene of Arabidopsis, At-LBD37/ASL39. The investigated rice FOX Arabidopsis line showed prominent changes in the levels of metabolites related to nitrogen metabolism. The transcriptomic data as well as the results from the metabolite analysis of the Arabidopsis At-LBD37/ASL39-overexpressor plants were consistent with these findings. Furthermore, the metabolomic and transcriptomic analysis of the Os-LBD37/ASL39-overexpressing rice plants indicated that Os-LBD37/ASL39 is associated with processes related to nitrogen metabolism in rice. Thus, the combination of a metabolomics-based screening method and a gain-of-function approach is useful for rapid characterization of novel genes in both Arabidopsis and rice.

关键词： Metabolite profiling GC-TOF/MS rice FOX Arabidopsis lines transcript profiling LBD37/ASL39 nitrogenmetabolism.

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带钢轧机领域新技术的应用

世界钢铁 2011年第3期11卷 49-54页

作者： Kenji horii 三菱日立制铁机械株式会社技术开发部

为应对不断提高产量、改善产品质量的需求,研发了许多新型轧机。介绍了三菱日立制铁机械株式会社(以下简称M-H)开发的一些创新技术,包括PC轧机的发展、轧机稳定装置、在线磨辊、热轧板形仪、无头轧制、UCM轧机最新应用、M-H机架分体式2... 详细信息

为应对不断提高产量、改善产品质量的需求,研发了许多新型轧机。介绍了三菱日立制铁机械株式会社(以下简称M-H)开发的一些创新技术,包括PC轧机的发展、轧机稳定装置、在线磨辊、热轧板形仪、无头轧制、UCM轧机最新应用、M-H机架分体式20辊轧机。

关键词：轧机 PC轧机轧机稳定装置在线磨辊热轧板形仪无头轧制 UCM轧机机架分体式20辊