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Nuance of inward rectifying potassium(Kir)channel dysfunctions in neurodegenerative diseases

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Neural Regeneration Research 2024年第6期19卷 1195-1196页

作者： Benjamin Garland Linlin ma Griffith Institute for Drug Discovery&School of Environment and Science Griffith UniversityNathanBrisbaneQLDAustralia

Neurodegenerative disorders are highly prevalent and diverse in *** manifestation largely depends on the cell types involved,with aberrant inflammatory episodes progressively inducing a constellation of phenotypes that are classified into specific diseases based on their neuropathological *** two most prevalent neurodegenerative diseases worldwide,Alzheimer’s disease(AD)and Parkinson’s disease(PD),for example,share notable similarities,yet they differ in terms of the specific cell types lost within the central nervous system(CNS).The significant and progressive loss of cortical and certain subcortical neurons in various regions is a major defining trait of *** contrast,the specific loss of dopaminergic neurons(DA)within the substantial nigra pars compacta(SNpc)is sufficient to cause motor symptoms associated with *** devastating condition arising from neurodegeneration within the CNS,amyotrophic lateral sclerosis(ALS),results in the progressive death of upper and lower motor *** degeneration originates in oligodendrocytes,whose defective myelination abilities lead to the denervation of the anterior horn,aggravating motor neuron death.

关键词： diseases degenerative degeneration

DiffGR:Detecting Differentially Interacting Genomic Regions from Hi-C Contact maps

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 143-155页

作者： Huiling Liu Wenxiu ma Department of Statistics University of California RiversideRiversideCA 92521USA

Recent advances in high-throughput chromosome conformation capture(Hi-C)techniques have allowed us to map genome-wide chromatin interactions and uncover higher-order chromatin structures,thereby shedding light on the principles of genome architecture and ***,statistical methods for detecting changes in large-scale chromatin organization such as topologically associating domains(TADs)are still ***,we proposed a new statistical method,DiffGR,for detecting differentially interacting genomic regions at the TAD level between Hi-C contact *** utilized the stratum-adjusted correlation coefficient to measure similarity of local TAD *** then developed a nonparametric approach to identify statistically significant changes of genomic interacting *** simulation studies,we demonstrated that DiffGR can robustly and effectively discover differential genomic regions under various ***,we successfully revealed cell type-specific changes in genomic interacting regions in both human and mouse Hi-C datasets,and illustrated that DiffGR yielded consistent and advantageous results compared with state-of-the-art differential TAD detection *** DiffGR R package is published under the GNU General Public License(GPL)≥2 license and is publicly available at https://***/wmalab/DiffGR.

关键词： Hi-C Differential analysis Topologically associating domain Stratum-adjusted correlation coefficient Nonparametric method

Time-inconsistent stochastic linear-quadratic control problem with indefinite control weight costs

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Science China mathematics 2024年第1期67卷 211-236页

作者： Qi Lü Bowen ma School of mathematics Sichuan UniversityChengdu 610064China

A time-inconsistent linear-quadratic optimal control problem for stochastic differential equations is *** introduce conditions where the control cost weighting matrix is possibly *** such conditions,we obtain a family of closed-loop equilibrium strategies via multi-person differential *** result extends Yong’s work(2017) in the case of stochastic differential equations,where a unique closed-loop equilibrium strategy can be derived under standard conditions(namely,the control cost weighting matrix is uniformly positive definite,and the other weighting coefficients are positive semidefinite).

关键词： linear-quadratic optimal control problem time-inconsistent cost functional generalized Riccati equation indefinite control weight cost closed-loop equilibrium strategy

Development of a novel signal restoration algorithm to eliminate the distorted components in space charge measurement excited by femtosecond laser irradiation

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HIGH VOLTAGE 2024年第3期9卷 659-673页

作者： Qi, Tianrun Ren, Hanwen Gao, Haoyu Li, Qingmin ma, Yidan ma, Yiqun Xiao, Tao North China Elect Power Univ State Key Lab Alternate Elect Power Syst Renewable Beijing Peoples R China North China Elect Power Univ State Key Lab Alternate Elect Power Syst Renewable Beijing 102206 Peoples R China

For the space charge measurement method with optical excitation for electrical insulation, the distortion of the excitation laser on the measurement signal and the accumulation of space charge have not been discussed before. Both experiment and simulation results show that three types of distorted components introduced by optical excitation can lead to distortion of the upper interface signal. Further, the factors causing distortion of the measured signal and the formation mechanism are analysed. A virtual electrode potential compensation method and a distorted component extraction method are proposed. Meanwhile, an attenuation restoration and charge conversion correction factor is introduced, leading to a novel signal processing algorithm adapted to space charge optical measurement methods. Compared with the traditional algorithm, the novel algorithm has an error of less than 1% in the calculation of charge and electric field strength, with an increase in accuracy of 47.7% and 9.81%, respectively. By applying the novel restoration algorithm, the comparison shows that the space charge accumulation does not change significantly under laser irradiation, verifying the reliability of the optical excitation. The given algorithm can provide a theoretical and technical foundation for the realisation of the optical measurement method for space charge.

关键词： ULTRASOUND DECONVOLUTION DISTRIBUTIONS VOLTAGE WAVES

Take Every Step Firmly with Sharp Eyes

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Chinese Journal of Chemistry 2024年第10期42卷 1065-1066页

作者： Shengming ma Chinese Journal of Chemistry

Chinese Journal of Chemistry(CJC)is committed to becoming a prominent international journal for chemistry and the related *** are working very hard towards this *** offers a diverse range of manuscript types,including... 详细信息

关键词： journal becoming diverse

Impact of Polymer matrix on Polymer Mechanochromism from Excited State Intramolecular Proton Transfer

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Chinese Journal of Chemistry 2024年第6期42卷 611-616页

作者： Yu Wu Xin Cheng Huan Hu Shui Hu Zhimin ma Zhiyong ma Beijing Advanced Innovation Center for Soft matter Science and Engineering Beijing State Key Laboratory of Organic-Inorganic CompositesCollege of Chemical EngineeringBeijing University of Chemical TechnologyBeijing100029 China Center of Advanced Elastomer materials College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing100029 China College of Engineering Peking UniversityBeijing100871 China

Mechanochromic polymers based on non-covalent changes have attracted much attention ***,we report the impact of inter/intramolecular hydrogen bonds on polymer mechanochromism from the excited state intramolecular proton transfer (ESIPT) ***-NH2-OH and PhMz=2A are designed and obtained by simple and high-yield synthesis,and are connected into polyurethane and poly(methyl acrylate-co-2-ethylhexyl acrylate),*** the initial state,the PhMz-NH2-OH@PU sample shows blue fluorescence from the excited enol form (E*) excitons,owing to intermolecular hydrogen bonds that interrupt the ESIPT reactions but the PhMz=2A@Pma-2-EA sample expresses cyan fluorescence belonging to the excited keto form (K*) emission,implying that the intramolecular hydrogen bonds ***,under stretching,external force can tune the emission of the PhMz=2A@Pma-2-EA sample from K* to E* *** external force can putatively still promote a bond rotation,ESIPT reactions remain equivalently interrupted in both the relaxed and stressed states in a hydrogen-bond donating *** calculation confirms the force-induced increase in dihedral angle for the transition of ESIPT-on/***,PhMz-NH2-OH@PU and PhMz=2A@Pma-2-EA showed disparate initial ESIPT states and further different responses/sensitivity to *** study reports a novel and efficient strategy for enriching mechanochromic investigation and extending the applications of ESIPT reactions.

关键词： Polymer mechanochromism Excited state intramolecular proton transfer Hydrogen bonding Supramolecular chemistry Elastomers

A rigorous real-time acoustic positioning method for ocean bottom seismic exploration

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Satellite Navigation 2024年第1期5卷 168-190页

作者： Jinye ma Shouchuan Fang Jianhu Zhao School of Geodesy and Geomatics Wuhan University129 Luoyu RoadWuhan430079China Institute of marine Science and Technology Wuhan UniversityWuhan430079China Surveying Service Center BGP Inc.CNPCZhuozhou072751HebeiChina

The conventional technique for positioning seafloor geophones in ocean bottom seismic exploration encounters several challenges,including the significant impact of outliers on positioning results,underutilization of high-precision observations,and low efficiency in real-time data *** issues inevitably affect the quality of seismic exploration *** address these challenges and enhance the accuracy of geophone positioning,this paper proposes a rigorous real-time acoustic positioning method for geophones based on sequential adjustment and Baarda's outlier detection *** proposed method comprises three key steps:grouping the original acoustic observations,constructing the intra-group acoustic positioning model,and synthesizing the positioning results across the different *** validity and practicality of this approach are confirmed through a simulation experiment as well as the field experiment conducted in the Bohai Sea,*** results demonstrate that the proposed method effectively eliminates outliers in the original observations and maximizes the utilization of high-quality *** to traditional acoustic positioning methods,it significantly reduces positioning errors from meters to decimeters,and in some cases can achieve centimeter-level *** the sound velocity profile in the operating sea area is measured,the method can attain the posterior standard deviation at the millimeter level and positioning errors within 10 *** the sound velocity profile is unknown,the method can achieve the posterior standard deviation at centimeter-level and positioning errors of approximately 20 cm.

关键词： Ocean bottom seismic exploration Geophone positioning Acoustic positioning method Sequential adjustment Outlier detection

Elastic wave insulation and propagation control based on the programmable curved-beam periodic structure

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Applied mathematics and Mechanics(English Edition) 2024年第10期45卷 1791-1806页

作者： Jiajia maO Hong CHENG Tianxue ma Beijing Key Laboratory of Nonlinear Vibrations and Strength of Mechanical Structures Department of Mechanics School of Mathematics Statistics and MechanicsBeijing University of Technology Department of Mechanics School of Physical Science and EngineeringBeijing Jiaotong University

Curved-beams can be used to design modular multistable metamaterials(MMMs) with reprogrammable material properties, i.e., programmable curved-beam periodic structure(PCBPS), which is promising for controlling the elastic wave *** PCBPS is theoretically equivalent to a spring-oscillator system to investigate the mechanism of bandgap, analyze the wave propagation mechanisms, and further form its geometrical and physical criteria for tuning the elastic wave propagation. With the equivalent model, we calculate the analytical solutions of the dispersion relations to demonstrate its adjustability, and investigate the wave propagation characteristics through the PCBPS. To validate the equivalent system, the finite element method(FEM) is *** is revealed that the bandgaps of the PCBPS can be turned on-and-off and shifted by varying its physical and geometrical characteristics. The findings are highly promising for advancing the practical application of periodic structures in wave insulation and propagation control.

关键词： 74J05 74Q10 curved-beam based periodic structure dispersion relation equivalent stiffness O326 spring-oscillator system wave propagation

A Parameter Adaptive Method for Image Smoothing

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Tsinghua Science and Technology 2024年第4期29卷 1138-1151页

作者： Suwei Wang Xiang ma Xuemei Li School of Computer Science and Technology Shandong UniversityJinan 250101China School of Software Shandong UniversityJinan 250101China

Edge is the key information in the process of image smoothing. Some edges, especially the weak edges, are difficult to maintain, which result in the local area being over-smoothed. For the protection of weak edges, we propose an image smoothing algorithm based on global sparse structure and parameter adaptation. The algorithm decomposes the image into high frequency and low frequency part based on global sparse structure. The low frequency part contains less texture information which is relatively easy to smoothen. The high frequency part is more sensitive to edge information so it is more suitable for the selection of smoothing parameters. To reduce the computational complexity and improve the effect, we propose a bicubic polynomial fitting method to fit all the sample values into a surface. Finally, we use Alternating Direction Method of Multipliers (ADMM) to unify the whole algorithm and obtain the smoothed results by iterative optimization. Compared with traditional methods and deep learning methods, as well as the application tasks of edge extraction, image abstraction, pseudo-boundary removal, and image enhancement, it shows that our algorithm can preserve the local weak edge of the image more effectively, and the visual effect of smoothed results is better.

关键词： image smoothing parameter adaptation bicubic interpolation polynomial fitting