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从富马酸替诺福韦二吡呋酯(TDF)转换为磷丙替诺福韦(TAF)后骨骼和肾脏安全性改善:两项对HBeAg阳性和HBeAg阴性的慢性乙型肝炎(CHB)患者的3期研究的初步结果

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从富马酸替诺福韦二吡呋酯(TDF)转换为磷丙替诺福韦(TAF)后骨骼和...

Efficacy and Safety of Tinefcon^® Tablets in Subjects with Plaque Psoriasis: An Open Label, Non-Compa.a.ive, Multicenter, Phase IV Trial

第九届全国疑难及重症肝病大会

作者： Henry L.Chan Scott Fung Wai Kay Seto Ed Gane John F.Flaherty Vithika Suri Lanjia Lin Anuj Gaggar G mani Subra.a.ian Wan Long Chuang Kosh agarwal Harry L.Janssen maria Buti The Chinese University of Hong Kong Toronto General Hospital Queen mary Hospital Hong Kong Kaohsiung Medical University Hospital Kings College Hospital Toronto Western Hospital Erasmus Medical Center

背景和目的:两项大型多中心3期研究中,在48周治疗后,相比于TDF,TAF治疗对骨骼和肾脏的影响更小,且疗效率相似。本文档评估了完成96周双盲TAF或TDF治疗且换为开放性标签TAF治疗的患者,以确定骨密度、肌酐清除率的变化以及病毒抑制的维持...

背景和目的:两项大型多中心3期研究中,在48周治疗后,相比于TDF,TAF治疗对骨骼和肾脏的影响更小,且疗效率相似。本文档评估了完成96周双盲TAF或TDF治疗且换为开放性标签TAF治疗的患者,以确定骨密度、肌酐清除率的变化以及病毒抑制的维持情况。方法:两项设计相同的3期研究中,HBeAg阴性(GS-US-320-0108;N=425)或HBeAg阳性

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Journal of Cosmetics, Dermatological Sciences and Applications 2016年第2期6卷 55-66页

作者： Somesh sharma Kailash Bhatia Meetesh agarwal Sandesh Gupta Leela.a.hi Buda.a.untla Sudha.a. Grandhi Vinod Titarmare Sushil Pande Ranjan Ra.a. Aruna Sa.a.th Rizwan Haq Vikrant Saoji D. V. S. Pra.a. L. M. Kansal D. G. Saple shatrughan Sa.a. Pa.a. Kalyani Puneet Goyal sharmila Patil A. J. Kanwar Bhavesh Swarna.a. Sujay Kulkarni Abhijeet Morde Hitesh Khanda.a.e Yogesh Dound Nitin Jadhav Sanjeev Hegde Murlidha.a.Padigaru Ashish C. Suthar Pira.a. Enterprises Limited Mumbai India Bhatia Skin Center Bima Nagar Indore India Agra.a. Path LAB Vijayna.a. Indore India Skin & Laser Center Krishna Nagar New Delhi India Diabetes and Shirdi Skin Care Centre Karnataka India Medipoint Hospitals Pvt. Ltd. Pentagon Research Pvt. Ltd. Pune India Skin Care Clinic Nagpur India NKP Salve Institute and La.a.mangeshkar Hospital Nagpur India Department of Dermatology Sheth VS General Hospital Ahmedabad India Sai Skin Care Clinic Hyderabad India Radiance Skin Care Clinic Nagpur India Dr. Vikrant Saoji’s Clinic Ramdaspeth Nagpur India Durga.a. Deshmukh Hospital & Research Center Hyderabad India Kansal Cosmetic & Skin Care Clinic Jaipur India Dr. Saple’s Clinic Dadar (East) Mumbai India Sri Skin Care & Laser Clinic Lucknow UP India Ruby Hall Clinic Pune India Renova Skin & Laser Clinic Sector-9 Mansarovar Jaipur India Dr. D. Y. Patil Medical College and Hospital Nerul Navi Mumbai India Department of Dermatology Venerology & Leprology Postgraduate Institute of Medical Education and Research Chandigarh India Swarna.a. Superspeciality Centre Indore India Clinical Research and Development Piramal Enterprises Limited Mumbai India

Importance: This post-marketing surveillance study was conducted to evaluate real-world information about the efficacy and safety of oral Tinefcon? tablets (Sphaeranthus indicus based) in plaque psoriasis patients. materials and Methods: Patients aged at least 18 years and older with clinical diagnosis of plaque psoriasis, were enrolled in this open label, non-compa.a.ive, multicenter trial. All eligible subjects received four 700 mg Tinefcon? tablets/day for 12 weeks. The primary outcome measure was percent change in Psoriasis Area Severity Index (PASI) score from baseline to week 12. The secondary outcome measures were Physician Global Assessment (PGA), Nail Psoriasis Severity Index (NAPSI), Psoriatic Arthritis Evaluation and Gene Expression Profiling and Immunohistochemistry. Results: After completion of Tinefcon? treatment at 12 weeks, more than half of subjects (52%) achieved PASI 50 response;PASI 75 response was attained in 68 (23%) subjects and PASI 90 response in 22 (7%) subjects. Five subjects with severe psoriasis achieved PASI 90 without receiving any concomitant medication. Reduction in severity as assessed by PGA was observed in more than half of patients with moderate disease. Histopathological evaluation revealed that epidermal thickness was considerably reduced in 66% of subjects. The expression of inflammatory marker S100A9 protein was(meaningfully reduced in 60% patients with non-significant reduction of Keratin 10 protein expression. Gene expression a.a.ysis showed increase down regulation of SERPINB4;PI3 and KRT16 genes after a 12-week treatment period in subjects with higher PASI scores. Conclusion: Oral Tinefcon? tablets showed good efficacy and had a favorable safety profile in plaque psoriasis patients.

关键词： Psoriasis Tinefcon® Tablet Sphaeranthus indicus

行不孕症检查的男性患者中吸烟与精子质量的关系

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世界核心医学期刊文摘（妇产科学分册） 2006年第1期2卷 35-35页

作者： Said T. M. Ranga G. agarwal A. 张剑萍(译) Dr. A. agarwal Center for Advanced Research in Human Reproduction Infertility and Sexual Function Glickman Urological Institute Department of Obstetrics and Gynecology 9500 Euclid Avenue Cleveland OH 44195 United States 不详

male fertility is affected by a variety of lifestyle habits that include tobacco use. A large population of Indian men is addicted to tobacco chewing. The Abstract of our study was to assess the relationship between tobacco chewing in these Indian men - who were part of an infertile couple and their sperm cha.a.teristics. Design: Retrospective study. Setting: Private infertility clinic. Patient(s): Six hundred thirty-eight male patients undergoing infertility evaluations were grouped according to the frequency of their tobacco chewing habit: mild (6 times/day, n = 197). Intervention(s): None. main Outcome Measure(s): Sperm cha.a.teristics (concentration, motility, morphology, and viability). Result(s): Sperm concentration, percentage motility, morphology, and percentage viability were significantly higher in the mild group vs the moderate group and in the moderate group vs the severe group. The percentage of men with azoospermia rose with the level of addiction (1% , 3% , and 14% ) as did the percentage of men with oligoasthenoteratozoospermia (2% , 8% , and 29% ), although the differences were not statistically significant. Conclusion(s): In our study, use of chewing tobacco by a group of Indian men who were undergoing infertility evaluation was strongly associated with a decrease in sperm quality and to a lesser extent with oligoasthenozoospermia or azoospermia. Infertile men should be counseled about the adverse effects of tobacco chewing on sperm quality.

关键词：不孕症患者重度吸烟男性患者精子质量检查少弱畸形精子症男性生育能力精子浓度生活方式观察指标

在临床研究中,索磷布韦/维帕他韦用于伴随使用质子泵抑制剂的患者时安全有效

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在临床研究中,索磷布韦/维帕他韦用于伴随使用质子泵抑制剂的患者...

第十届全国疑难及重症肝病大会

作者： Ra.a.l Esteban Kosh agarwal Jose Luis Calleja Jean Francois Dufour Steven L.Flamm Stuart C.Gordon Luisa Stamm Liyun Ni Dia.a.Brainard Kris V.Kowdley Curtis Cooper Juan Antonio Pineda Lluis Castells maria Buti Sabela Lens UniversityofBarcelona SwedishMedicalCenter GileadSciencesInc. HospitalUniversitariValld’Hebron GileadSciences Inc. VallD’hebronUniversityHospital NorthwesternUniversityHealthSystem HospitalUniversitarioPuertaDeHierro HospitalUniversitarioVirgenDeValme UniversityofBern LiverUnit InternalMedicineDepartmentHospitalUniversitariVallDeHebrón InstituteofLiverStudies King’sCollegeHospitalNHSTrust HenryFordHealthSystem TheOtta.a.ospital

背景在1期药物相互作用数据可用之前,在有关索磷布韦/维帕他韦(SOF/VEL)的临床试验中禁止伴随使用质子泵抑制剂(PPI)。之后的临床研究允许使用最多20mg的奥美拉唑或等效剂量的药物。本分析评估了接受12周的SOF/VEL治疗并且报告伴随使用...

背景在1期药物相互作用数据可用之前,在有关索磷布韦/维帕他韦(SOF/VEL)的临床试验中禁止伴随使用质子泵抑制剂(PPI)。之后的临床研究允许使用最多20mg的奥美拉唑或等效剂量的药物。本分析评估了接受12周的SOF/VEL治疗并且报告伴随使用PPI的伴有和不伴有代偿期肝硬化的患者的疗效和安全性。

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用磺胺剂与抗生素治疗沙眼

中华眼科杂志 1958年第3期09卷 153-153页

作者： agarwal.L. P. Gupta.B. M. L. 傅守靜

著者选擇250例浸潤期或濾泡期且結膜刮片檢查有沙眼包含体陽性的沙眼病例。試用土霉素,氮霉素,金霉素,与磺胺剂治疗。用Poleff氏染色法檢查沙眼包含体,每三週檢查一次,並观察角膜血管翳情况,共观

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索磷布韦(SOF)联合利巴韦林,聚乙二醇干扰素(PEG)12周和索磷布韦(SOF)联合利巴韦林16周或者24周在基因3型,以及2型经治肝硬化患者中的疗效(BOSON研究)

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索磷布韦(SOF)联合利巴韦林,聚乙二醇干扰素(PEG)12周和索磷布韦(...

第九届全国疑难及重症肝病大会

作者： Gra.a. R.Foster Stephen Pianko Curtis Cooper Ashley Brown Daniel Forton Ronald G.Na.a.s Jacob George Ellie Barnes Dia.a.M.Brainard Benedetta massetto Ming Lin John G.Mc Hutchison G.mani Subra.a.ian Kosh agarwal Queen mary's University of London Monash Medical Centre The Otta.a.Hospital University of Ottawa Imperial College Healthcare National HealthService Trust St George's University of London

介绍:索磷布韦(SOF)联合利巴韦林,联合/不联合聚乙二醇干扰素(PEG)在基因型2或3的HCV感染者中表现出较高的疗效。但是,并没有这些疗法的直接对比。这项3期BOSON研究评估了SOF+PEG/RBV(为期12星期)和SOF+RBV(为期16或24星期)用于经治的GT...

介绍:索磷布韦(SOF)联合利巴韦林,联合/不联合聚乙二醇干扰素(PEG)在基因型2或3的HCV感染者中表现出较高的疗效。但是,并没有这些疗法的直接对比。这项3期BOSON研究评估了SOF+PEG/RBV(为期12星期)和SOF+RBV(为期16或24星期)用于经治的GT2HCV感染者(伴肝硬化),以及初治和经治的GT3 HCV感染者(伴有和不伴有肝硬化)的安全性和有效性。

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糖尿病性缺血性顽固足部溃疡的静脉灌注治疗

世界核心医学期刊文摘（皮肤病学分册） 2005年第8期1卷 26-26页

作者： agarwal P. Agra.a. P.K. sharma D. Baghel K.D. 崔荣 292/293 Napier Town Jabalpur 482001 India

Diabetic and ischaemic non- healing pedal ulcers have a tendency for chronicity and increased chances of infection, which may threaten the viability of the foot. Systemic administration of therapeutic agents may be insufficient in these cases. We have assessed the role of retrograde venous perfusion (RVP) for the treatment of nine diabetic and 10 ischaemic non- healing pedal ulcers. Agents used were soda bicarbonate, heparin, lignocaine, gentamicin and pentoxiphylline. Five of nine diabetic non- healing ulcers showed complete healing and the remaining four improved. The complete recovery in the cases of diabetic ulcer occurred in 10- 24 days (mean 16 days), while ischaemic ulcers took 10- 14 days for complete recovery (mean 13.6 days). There was a reduction of rest pain in all 10 patients with ischaemic disease;fivepatientsshowedcompletehealingofulcers,andthe other five improved significantly. In two patients, pre- gangrene changes were reversed. RVP is a useful adjunct to conservative or surgical treatment of non- healing pedal ulcers. Its main impact was in improving ischaemia.a.d promoting healing.

关键词：足部溃疡静脉灌注缺血性溃疡静息痛溃疡愈合慢性化二乙氨基

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试水新兴行业：缘何黎明前退出

中欧商业评论 2014年第10期 26-35页

作者：拉基什瑞·阿加瓦尔(Rajshree agarwal) 巴里·贝耶斯(Barry L.Bayus) 玛丽·特瑞普赛斯(mary Tripsas) 王玉洁美国马里兰大学史密斯商学院美国北卡罗来纳大学肯南-弗拉格勒商学院美国波士顿大学卡罗尔管理学院不详

一个新兴行业崭露头角之时，总会有大量企业涌入，无论是来自旧行业的还是新创立的。成为最先吃螃蟹者既有利也有弊。许多先驱者失败了，在一个新产业完整浮现之前黯然退场。在新兴行业兴起阶段（行业形成伊始至销量猛增的阶段，Emergen... 详细信息

一个新兴行业崭露头角之时，总会有大量企业涌入，无论是来自旧行业的还是新创立的。成为最先吃螃蟹者既有利也有弊。许多先驱者失败了，在一个新产业完整浮现之前黯然退场。在新兴行业兴起阶段（行业形成伊始至销量猛增的阶段，Emergence Stage），有些“吃螃蟹者”退出了。而且，我们发现，退出比率还非常高。在行业成熟之前有一个优胜劣汰的震荡期，工艺流程的创新（而非产品创新）、规模经济、生产效率以及主导性设计标准化越来越重要，直到行业内的企业数量达到“平衡”，技术性活动相对稳定且进入率与退出率基本持平时，行业才最终进入了成熟期（图1）。

关键词：新兴行业产品创新企业数量设计标准化工艺流程规模经济生产效率 “平衡”

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精子DNA碎片检测的临床专家共识

生殖医学杂志 2023年第2期32卷 170-180页

作者：倪吴花 Ashok agarwal 孙莹璞孙海翔邓成艳刘平周灿权冯云郝桂敏卢文红全松沈浣师娟子滕晓明王晓红王秀霞伍琼芳曾勇张松英钟影黄学锋黄国宁中华医学会生殖医学分会第五届委员会温州医科大学附属第一医院生殖医学中心

精子DNA碎片(sperm DNA fragmentation,SDF)在男性不育症中发生率较高。SDF常伴发少、弱精子症,也可发生于常规精液指标正常的不育症患者。其发生机制包括精子成熟障碍、凋亡异常和氧化应激过高等。由于很多文献报道其与自然妊娠和辅助... 详细信息

精子DNA碎片(sperm DNA fragmentation,SDF)在男性不育症中发生率较高。SDF常伴发少、弱精子症,也可发生于常规精液指标正常的不育症患者。其发生机制包括精子成熟障碍、凋亡异常和氧化应激过高等。由于很多文献报道其与自然妊娠和辅助生殖技术结局存在负相关,SDF检测已在男性不育症和辅助生殖技术中得到越来越广泛的应用。本专家共识复习和评估了SDF相关文献,对SDF的危险因素、检测方法、临床意义和处理等提出2项良好实践要点和9项推荐建议。本共识大部分推荐建议的证据和级别属于低或中等,表明仍需要进一步的研究证实临床应用SDF检测的价值。

关键词：男性不育精子DNA碎片辅助生殖技术