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Overproduction of nitric oxide inhibits vascular reactivity in portal hypertensive rats

World Journal of Gastroenterology 1997年第4期3卷 23-26页

作者： LI XiRu, WU JinSheng, HE ZeSheng, ma QingJiu and GAO DeMing

IM To evaluate the relationship between nitric oxide (nO) and hyperdynamic circulatory status in portal hypertension.METHODS Twenty male SpragueDawley rats (weighing 200g±20g) randomized into two groups, portal hypertension group (n=12) and the controls (n=8). Portal hypertensive models were established by means of graded constriction of the portal vein. The concentrations of nitrite (nO2) in portal vein and peripheral blood were measured to reflect nO levels with flourimetric a.a.ysis. The reactivitiy of isolated abdominal aortic rings from partial portal veinconstricted and shamoperated rats was observed by potassium chloride (KCl) (10mmol/L-80mmol/L) and phenylephrine (10-9mol/L10-4mol/L) with or without nO synthase inhibitor nωnitroLarginine (LnnA).RESULTS Serum concentrations of nO2 in portal vein (0766μmol/L±0097μmol/L) and peripheral blood (0687μmol/L±0092μmol/L) were elevated in portal hypertensive rats as compared with those in controls (0613μmol/L±0084μmol/L, 0591μmol/L±0045μmol/L, PnO2 in portal vein blood were markedly higher than those in peripheral blood (Pnsive rats. Abdominal aortic rings from portal veinconstricted rats exhibited significantly impaired contractility to phenylephrine and potassium chloride as compared with the controls. The EC50 values of KCl were markedly higher in portal hypertensive rings (265mmol/L±09mmol/L) than those of the control rings (223mmol/L±17mmol/L, Pnd so were the EC50 values of phenylephrine (372nmol/L±04nmol/L) vs (281nmol/L±02nmol/L, Pncubation of rings with LnnA, the difference in EC50 values no longer statistically significant between portal hypertensive and control rings in both KCl (2018mmol/L±08mmol/L, and 194mmol/L±12mmol/L, P>005) and phenylephrine (224nmol/L±18nmol/L, 218nmol/L±14nmol/L, P>005). However, the maximal KCl and phenylephrinei

关键词： portal hypertension nitric oxide vascular reactivity hyperdynamic circulatory status vasodila.a.ion

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Chemical Vapour Deposition Graphene Radio-Frequency Field-Effect Transistors

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Chinese Physics Letters 2012年第5期29卷 205-208页

作者： ma Peng JIn Zhi GUO Jian-nan PAn Hong-Liang LIU Xin-Yu YE Tian-Chun WAnG Hong WAnG Guan-Zhong Department of Microwave IC Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029 Hefei national Laboratory for Physical Sciences at Microscale and Department of PhysicsUniversity of Science and Technology of ChinaHefei 230026

We report the dc and rf performance of graphene rf field-effect transistors,where the graphene films are grown on copper by using the chemical vapour deposition (CVD) method and transferred to SiO2/Si *** materials,benzocyclobutene and atomic layer deposition Al2O3 are used as the gate *** observation of n- and p-type transitions verifies the ambipolar cha.a.teristics in the graphene *** the intrinsic carrier mobility of CVD graphene is extracted to be 1200cm2/V·s,the pa.a.itic series resistances are demonstrated to have a serious impact on device *** a gate length of 1 μm and an extrinsic transconductance of 72 mS/mm,a cutoff frequency of 6.6 GHz and a maximum oscillation frequency of 8.8 GHz are measured for the transistors,illustrating the potential of the CVD graphene for rf applications.

关键词： SiO2/Si vapour transferred

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Stable ni-rich layered oxide cathode for sulfide-based all-solid-state lithium battery

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eScience 2022年第5期2卷 537-545页

作者： Yue Wang Zhixuan Wang Dengxu Wu Quanhai niu Pushun Lu Tenghuan ma Yibo Su Liquan Chen Hong Li Fan Wu Tianmu Lake Institute of Advanced Energy Storage Technologies Liyang213300JiangsuChina Yangtze River Delta Physics Research Center Liyang213300JiangsuChina Key Laboratory for Renewable Energy Beijing Key Laboratory for New Energy Materials and DevicesBeijing National Laboratory for Condensed Matter PhysicsInstitute of PhysicsChinese Academy of SciencesBeijing100190China University of Chinese a.a.emy of Sciences Beijing100049China nano Science and Technology Institute University of Science and Technology of ChinaSuzhou215123China Science and Technology Research Institute China Three Gorges Corporation Beijing China

Sulfide-based all-solid-state lithium-ion batteries(ASSLIBs)are one of the most promising energy storage technologies due to their high safety and ionic *** achieve greater energy density,a ni-rich layered oxide Lini_(x)Co_(y)M_(1-x-y)O_(2)(nCM,MMn/Al,x≥0.6)is desirable due to its relatively high voltage and large ***,interfacial side reactions between the nCM and sulfide solid electrolytes lead to undesirable interfacial passivation layers and low ionic conductivity,thereby degrading the electrochemical performance of nCM sulfide all-solid-state ***,a time-/cost-effective sulfidation strategy is exploited to sulfidize a ni-rich nCM_(88) cathode in a mixed gas atmosphere of n_(2) and CS_(2).A new type of cathode(nCM88-S)with an ultrathin(∼2nm)surface layer is obtained,which significantly reduces the interfacial side reactions/resistance and improves the interfacial *** resulting nCM_(88)-S/Li_(6)PS_(5)Cl/Li_(4)Ti_(5)O_(12) ASSLIB exhibits superior performance,including a high discharge specific ca.a.ity(200.7 mah g−1)close to that of liquid batteries,excellent cycling performance(a ca.a.ity retention of 87%after 500 cycles),and satisfactory rate performance(158.3 mah g^(−1) at 1C).

关键词： Sulfide solid electrolytes ni-rich oxide cathode All-solid-state batteries Surface modification Interface engineering

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氮掺杂还原氧化石墨烯负载铂催化剂的制备及甲醇电氧化性能

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物理化学学报 2014年第7期30卷 1267-1273页

作者：王丽马俊红新疆大学化学化工学院乌鲁木齐830046 新疆大学应用化学研究所先进功能材料自治区级重点实验室乌鲁木齐830046

采用高温热解聚苯胺修饰的氧化石墨烯(PAnI-GO),得到了氮掺杂的还原氧化石墨烯碳材料(n-RGO),以其负载Pt制备了Pt/n-RGO纳米结构电催化剂.采用透射电镜(TEM)、X射线光电子能谱(XPS)、X射线衍射(XRD)谱及拉曼光谱等技术对n-RGO和Pt/n-RG... 详细信息

采用高温热解聚苯胺修饰的氧化石墨烯(PAnI-GO),得到了氮掺杂的还原氧化石墨烯碳材料(n-RGO),以其负载Pt制备了Pt/n-RGO纳米结构电催化剂.采用透射电镜(TEM)、X射线光电子能谱(XPS)、X射线衍射(XRD)谱及拉曼光谱等技术对n-RGO和Pt/n-RGO的形貌及结构进行了表征,用循环伏安、计时电流等电化学技术研究了Pt/n-RGO电极催化剂对CO溶出反应和甲醇电氧化反应的催化性能.结果表明:高温热解PAnIGO可同时实现GO的还原及其氮掺杂的过程,氮掺杂引起还原氧化石墨烯碳材料表面缺陷结构和导电性的增加;与相应的未掺杂氮样品Pt/RGO相比较,Pt/n-RGO样品上Pt颗粒的分散更均匀,显示出更强的抗CO毒化能力和更高的甲醇电氧化催化活性及稳定性.

关键词：聚苯胺还原氧化石墨烯氮掺杂铂电催化剂甲醇氧化

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Effects of moxibustion at bilateral Feishu(BL13)and Xinshu(BL15)combined with benazepril on myocardial cells apoptosis index and apoptosis-related proteins cytochrome c and apoptosis-inducing factor in rats with chronic heart failure

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Journal of Traditional Chinese Medicine 2022年第2期42卷 227-233页

作者： WAnG Wei LI Qingling ma Qiang XIA Ran GAO Bing WAnG Yi WAnG Jing College of Chinese Medicine Anhui University of Chinese MedicineHefei 230012China Graduate school Anhui University of Chinese MedicineHefei 230012China College of Acupuncture and massage Anhui University of Chinese MedicineHefei 230012China Xin’an Medical Key Laboratory Anhui University of Chinese MedicineHefei 230012China

OBJECTIVE:To observe the effects of moxibustion at bilateral Feishu(BL13)and Xinshu(BL15)combined with benazepril on myocardial cells apoptosis index,the expression levels of apoptosis-related proteins cytochrome c(Cyt-C)and apoptosis-inducing factor(AIF)in chronic heart failure(CHF)***:Sixty-five rats were randomly divided into normal group(n=10)and model-I group(n=55).After modeling,CHF rats in model-I group were divided into model group,moxibustion group,benazepril group,moxibustion plus benazepril group(abbreviated as aibei group,the same below),10 rats in each *** index was examined by *** indices were measured by rat cardiac function *** B-type brain natriuretic peptide(BnP)was detected by enzymelinked immunosorbent *** cells apoptosis index was detected by terminal-deoxynucleoitidyl transferase mediated nick end labeling *** changes of myocardial tissues were observed by hematoxylin and eosin *** expression levels of Cyt-C and AIF in myocardial tissues were detected by Western ***:Compared with normal group,ejection fraction and left ventricular diameter shortening rate in model-Ⅰgroup were significantly reduced,myocardial cells of rats in model group exhibited unclear transverse striations,cells swellings and vacuoles,cardiac functions were deteriorated,serum BnP level,myocardial cells apoptosis index,and the expression levels of Cyt-C and AIF were significantly *** with model group,myocardial cells of rats in moxibustion group,benazepril group,and aibei group were dyed more evenly,muscle fibers were arranged relatively neatly,cardiac functions were improved,serum BnP level,myocardial cells apoptosis index,and the expression levels of Cyt-C and AIF were significantly *** with aibei group,cardiac functions were worsened,myocardial cells apoptosis index,and the expression levels of Cyt-C and AIF were ***:Mox

关键词： heart failure moxibustion point BL13(Feishu) point BL15(Xinshu) cytochromes c apoptosis inducing factor

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Dietary carnosic acid and seleno-compounds change concentrations of fatty acids, cholesterol, tocopherols and malondialdehyde in fat and heart of lambs

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Animal nutrition 2021年第3期7卷 812-822页

作者： malgorza.a.Bialek marian Czauderna Kamil Zaworski Ka.a.zyna Krajewska The Kielanowski Institute of Animal Physiology and nutrition Polish Academy of Sciences05-110 JablonnaPoland

The aim of the current study was to evaluate the impact of carnosic acid(CA),selenised yeast(^(Y)Se)and selenate(^(VI)Se)supplemented to diets,including fish oil(FO)and rapeseed oil(RO),on the content of fatty acids,total cholesterol(TCh),tocopherols and malondialdehyde in the fat located between the thigh muscles and the heart in ***-four male Corriedale lambs were divided into 4 groups of 6 *** were fed a diet with FO and RO(the control diet)or experimental diets containing RO,FO and CA with/without Se(as^(Y)Se or^(VI)Se).The experimental diets without/with^(Y)Se or^(VI)Se changed concentrations of fatty acids in the fat and heart compared to the *** experimental diets increased the levels of c11c14C20:2,c5c8c11c14C20:4,c5c8c11c14c17C20:5 and the sums of long-chain polyunsaturated fatty acids(LPUFa.a.d conjugated linoleic acid isomers in the fat compared to the *** experimental diet containing^(Y)Se or^(VI)Se increased the content of Se,TCh,c11c14C20:2,c8c11c14C20:3,c5c8c11c14C20:4,c5c8c11c14c17C20:5,c7c10c13c16c19C22:5,c4c7c10c13c16c19C22:6 and the concentration sum of n-3LPUFA,n-6LPUFa.a.d tocopherols in the heart in comparison with the control diet and the diet containing only *** diets reduced the concentration of malon-dialdehyde in the fat and heart in comparison with the control *** dietary intervention has great potential for future practical and commercial implementations.

关键词： Selenium Carnosic acid Fatty acid Tocopherol Cholesterol Lamb

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Guilingji capsule(龟龄集胶囊)for Alzheimer's disease:secondary a.a.ysis of a randomized non-inferiority controlled trial

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中医杂志:英文版 2023年第5期43卷 1019-1025页

作者： ZHAO Ming LUO Yimiao WAnG Huichan CAO Yu ma Lina PEI Hui LI Hao Graduate School Beijing University of Chinese MedicineBeijing 100029China Department of Geriatrics Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Received:Online:2023-10-15 Published:2023-04-04

OBJECTIVE:To investigate the effectiveness and safety of Guilingji capsule(龟龄集胶囊,GLJC)in treatment of Alzheimer's disease(AD)patients with kidney-marrow deficiency pattern(KMDP)compared with gingko extract ***:This is a secondary a.a.ysis of a large-scale multicenter randomized non-inferiority clinical trial.A total of 120 AD patients with KMDP were enrolled in this *** participants were randomly categorized into two groups:(a)GLJC group(n=60)and(b)gingko group(n=60).The GLJC group was treated with GLJC and gingko extract mimetic tablets,whereas the gingko group received gingko extract tablets and mimetic *** da.a.on the Mini-Mental State Examination(MMSE),Alzheimer's Disease Assessment Scale-Cognitive Subscale(a.a.-Cog),Activities of Daily Living(ADL),and Chinese Medicine Symptom Scale(CM-SS)was evaluated at 0,12,and 24 weeks of *** serum levels of acetylcholine(Ach),acetylcholinesterase(AchE),B-cell lymphoma-2(Bcl-2),and Bcl-2-associated X protein(Bax)in the participants were measured before and after 24 weeks of *** safety was based on the incidence of adverse ***:Both interventions significantly increased the MMSE scores of the participants and decreased their a.a.-Cog,ADL,and CM-SS scores(Pngko group,the GLJC group had a higher effective rate of improvement in the symptoms of“amnesia.a.d“dull expression and slow thinking”at the 12th week and 24th week(Pn the GLJC group,serum Bcl-2 levels were significantly increased at the 24th week(Pnd AchE levels of the two groups were significantly decreased at the 24th week(Pno treatmentrelated adverse events were reported in the two ***:GLJC is equivalent to the gingko extract tablets in terms of improving cognitive function and the quality of life in AD patients with KMDP and has good clinical efficacy and *** it comes to improving TCM symptoms and anti-aging,GLJC is even more adv

关键词： Guilingji capsule gingko extract tablets kidney-marrow deficiency pattern Alzheimer disease randomized controlled trial

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Seismic sentinel? An a.a.ysis of captive giant panda behavior in response to the Lushan earthquake in China

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Earthquake Science 2021年第6期34卷 522-530页

作者： Yuan Jin Xiaozan ma Bo Luo Guiquan Zhang Rongping Wei Desheng Li Hemin Zhang Chris newman Christina Buesching Dingzhen Liu Key Laboratory of Biodiversity Science and Ecological Engineering of Ministry of Education College of Life SciencesBeijing Normal UniversityBeijing 100875China Key Laboratory of State Forestry and Grassland Administration(national Park Administration)on Conservation Biology of Rare Animals in the Giant Panda national Park Dujiangyan 611830China China Conservation and Research Center for the Giant Panda Dujiangyan 611830China Wildlife Conservation Research Unit Department of ZoologyUniversity of OxfordThe Recanati-Kaplan CenterTubneyOX135QLUK Department of Biology Irving K.Barber Faculty of ScienceUniversity of British ColumbiaOkanaganKelownaBritish ColumbiaV1V 1V7Canada

It is widely believed that various animal species can sense and respond to the geophysical stimuli that precede earthquakes,especially electromagnetic fields,although supporting field evidence is mostly *** we report on the reactions of four female giant pandas under observation over the three days prior to the Lushan(30.1°n,103.0°E)magnitude 7.0 earthquake that occurred in Sichuan province,China,on April 20,*** observed no significant generalized behavioral anomalies indicative of them perceiving an impending *** also observed no startle behaviors in the 5 s prior to tremors commencing,indicating that these pandas either did not detect or did not respond to precursor *** findings suggest that although giant pandas have evolved in,and continue to occupy exclusively,a seismically active range in central China,they do not appear to perceive pre-earthquake geophysical warning signs.

关键词： bio-sentinel giant panda earthquakes abnormal be-havior electromagnetic field P-wave.

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MULTIFRACTAL a.a.YSIS OF PARTICLE-FLUID SYSTEM In A CIRCULATInG FLUIDIZED BED

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Particuology 2005年第Z1期 80-83+6页

作者： Liping ma, Weixing Huang, Yanfu Shi, Huarui Yu and Jingxu Zhu Department of Chemical Engineering, Sichuan University, Chengdu 610065, P. R, China Department of Chemical & Biochemical Engineering, the University of Western Ontario, Ca.a.a n6A 5B9

In this paper, multifractal a.a.ysis together with wavelet transform modulus maxima (WTMM) method is used to a.a.yze the fluctuating signals of circulating fluidized bed (CFB). Singularity spectrum shows that the gas-particle flow in CFB has multifractal cha.a.ter. Motion behavior of the particle-fluid system of CFB can be described by singularity spectrum. Intermittency index can be used to determine the transition of flow regime from fast fluidization to pneumatic conveying.

关键词： multifractal a.a.ysis wavelet transform singularity spectrum intermittency index circulating fluidized bed

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Proteomic a.a.ysis of overweight/obesity and related abnormal glucose and lipid metabolism caused by phlegm-dampness retention

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Journal of Traditional Chinese Medical Sciences 2021年第3期8卷 224-237页

作者： Jiayi ma Shuxian Sun Cheng ni Lingru Li Jing Xia Houqin Li Huirong Song Xujun Heng Dandan Hu Yuanyuan Li Center for Studies in Constitution Research of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing100029China The GULOU Hospital of Traditional Chinese Medicine of BEIJInG Beijing100009China Putuo Hospital Shanghai University of Traditional Chinese Medicine Shanghai200333China

Objective:To investigate the proteomic cha.a.teristics of overweight/obesity and related abnormal glucose and lipid metabolism caused by phlegm-dampness retention to identify related ***:Seventy-one subjects were enrolled in the *** assessed blood glucose,blood lipids,body mass index(BMI),and phlegm-dampness pattern,which was confirmed by a traditional Chinese medicine *** the participants,we included healthy participants with normal weight(nW,n=23),overweight/obese participants with normal metabolism(OnM,n=19),overweight/obese participants with pre-diabetes(OPD,n=12),and overweight/obese participants with marginally-elevated blood lipids(OML,n=17).Among them,the OnM,OPD,and OML groups were diagnosed with phlegmdampness *** da.a.independent acquisition(DIA)method was first used to a.a.yze the plasma protein expression of each group,and the relevant differential proteins of each group were *** co-expressed proteins were evaluated by Venn *** pathway a.a.yses of the differential proteins were a.a.yzed using Ingenuity Pathway a.a.ysis(IPA)*** reaction monitoring(PRM)was used to verify the differential and common proteins in each ***:After comparing OnM,OPD,and OML groups with nW group,we identified the differentially expressed proteins(DEPs).next,we determined the DEPs among OPD,OML,and OnM *** Venn a.a.ysis of the DEPs in each group,24 co-expressed proteins were *** co-expressed proteins were verified by *** a.a.ysis showed that pathways including LXR/RXR activation,acute phase response signaling,and FXR/RXR activation were common to all three groups of phlegmdamp overweight/obesity ***,the activation or inhibition of these pathways was different among the three ***:Participants with overweight/obesity have similar proteomic cha.a.teristics,though each type shows specific proteomic *** co-expressed proteins,VTn and ORM1,ar

关键词： Phlegm-dampness retention Overweight Obesity Abnormal glucose and lipid metabolism Biomarkers

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