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Reuse of port industrial heritage in tourist cities:Shipyards as case studies

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Frontiers of Architectural Research 2024年第1期13卷 164-183页

作者： María J.Andrade Eduardo jiménez-Morales Rachel Rodríguez-Ramos Pablo Martínez-Ramírez Department of Art and Architecture School of ArchitectureMalaga UniversityMalaga 29013Spain

The progressive deindustrialisation of many western cities since the 1980s has led to many industrial zones linked to port activities being abandoned or falling into *** such as Barcelona,Naples,Lisbon,Amsterdam,and Hamburg have port industrial complexes of high tangible and intangible heritage value that could totally or partially disappear,resulting in an irreparable loss of their scientific,architectural,social,technological,and historical *** that in mind,Adaptive Reuse(AR)of the built heritage allows the industrial memory of the ports to be preserved by turning them into new functional centres within the existing urban *** occurs in the context of the contemporary challenges of those cities,such as touristification,the circular economy and climate change,while guaranteeing the life cycle of those *** article analyses two case studies—the Nederlandsche Scheepsbouw Maatschappij(NDSM)and the Rotterdamsche Droogdok Maatschappij(RDM)shipyards,both in the Netherlands—in order to contribute to the knowledge of AR of Port Industrial *** are two examples of good practices in port industrial heritage interventions,where the factors behind their acclaim can be easily highlighted.A multi-scale methodology is therefore used and tailored to the case of port industrial heritage,based on analysing previous studies of the heritage in different spheres and on different scales.A relationship matrix tool is thus *** enables a comparative study to be conducted,using key variables and indicators,and considering qualitative and quantitative *** provides extensive output information for each case study,which is summarised in the most favourable factors for the success of the AR of this port industrial heritage.

关键词： Industrial heritage Port-city Adaptive reuse Best practices Circular economy HUL Touristification

Sex differences in Alzheimer's disease:an urgent research venue to follow

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Neural Regeneration Research 2024年第12期19卷 2569-2570页

作者： Raquel jiménez-Herrera Ana Contreras Juan D.Navarro-López Lydia jiménez-Díaz Neurophysiology&Behavior Lab University of Castilla-La ManchaSchool of Medicine of Ciudad RealCiudad RealSpain

Due to increasing life expectancy,the amount of people with dementia worldwide is expected to experience a substantial rise,with estimates indicating a growth from 55 million in 2019 to a staggering 139 million by the... 详细信息

关键词： Alzheimer predominant estimates

Attaching CF3 groups to organic molecules using trifluoroacetates via ion-shielding photoelectrocatalysis

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Science China Chemistry 2024年第11期67卷 3495-3497页

作者： Paula Visiedo-jiménez Francisco Juliá-Hernández Departamento de Química Inorgánica Facultad de Química Universidad de MurciaCampus de Espinardo

Fluorinated molecules play a protagonist role in pharmaceuticals, agrochemicals, and materials. The incorporation of fluoroalkyl groups into organic compounds provides them with unique chemical properties that are key...

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Predicting grain size-dependent superplastic properties in friction stir processed ZK30 magnesium alloy with machine learning methods

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Journal of Magnesium and Alloys 2024年第5期12卷 1931-1943页

作者： Farid Bahari-Sambran Fernando Carreno C.M.Cepeda-jiménez Alberto Orozco-Caballero Physical Metallurgy Department CENIM-CSICAv.Gregorio del Amo 828040 MadridSpain Department of Mechanical Engineering Chemistry and Industrial DesignPolytechnic University of MadridRonda de Valencia 328012MadridSpain

The aim of this work is to predict,for the first time,the high tempera.ure flow stress dependency with the grain size and the underlaid deformation mechanism using two machine learning models,random forest(RF)and artificial neural network(ANN).With that purpose,a ZK30 magnesium alloy was friction stir processed(FSP)using three different severe conditions to obtain fine grain microstructures(with average grain sizes between 2 and 3μm)prone to extensive superplastic *** three friction stir processed samples clearly deformed by grain boundary sliding(GBS)deformation mechanism at high *** maximum elongations to failure,well over 400% at high strain rate of 10^(-2)s^(-1),were reached at 400℃ in the material with coarsest grain size of 2.8μm,and at 300℃ for the finest grain size of 2μ***,the superplastic response decreased at 350℃ and 400℃ due to thermal instabilities and grain coarsening,which makes it difficult to assess the operative deformation mechanism at such *** work highlights that the machine learning models considered,especially the ANN model with higher accuracy in predicting flow stress values,allow determining adequately the superplastic creep behavior including other possible grain size scenarios.

关键词： Machine learning Artificial intelligence Magnesium alloys superplasticity Friction stir processing Grain coarsening

Advancing towards accurate phenotyping based on metabolic and fibrosis risk in metabolic-dysfunction associated steatotic liver disease:one step closer to personalized care

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Hepatobiliary surgery and Nutrition 2024年第1期13卷 128-131页

作者： Sergio Muñoz-Martínez Alba jiménez-Masip Juan M.Pericàs Liver Unit Vall d’Hebron Hospital UniversitariVall d’Hebron Institut de Recerca(VHIR)Vall d’Hebron Barcelona Hospital CampusBarcelonaSpain Universitat de Barcelona BarcelonaSpain Universitat Autònoma de Barcelona BellaterraBarcelonaSpain Centros de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas(CIBERehd)MadridSpain

Relevance of liver fibrosis amongst diabetic patients with metabolic-dysfunction associated steatotic liver disease(MASLD)and knowledge gaps Insulin resistance is paramount in the crosstalk between intrahepatic and extrahepatic pathophysiological mechanisms leading to MASLD(1),hence gaining special relevance in patients diagnosed with type 2 diabetes(T2D).MASLD is the term that was recently endorsed by an international multidisciplinary consensus panel to replace non-alcoholic fatty liver disease[as non-alcoholic steatohepatitis(NASH)was replaced by metabolic dysfunction-associated steatohepatitis(MASH)](2).

关键词： Metabolic-dysfunction associated steatotic liver disease(MASLD) advanced fibrosis type 2 diabetes(T2D) non-invasive tests(NITs)

Wood anatomical acclimation in the endemic genus Polylepis in Peruvian Andean forests

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Journal of Mountain Science 2024年第9期21卷 2986-3000页

作者： Anthony GUERRA Fressia N.AMES-MARTÍnez Ernesto C.RODRÍGUEZ-RAMÍrez Postgraduate Programme in Agronomy/Plant Physiology Department of Biology-Institute of Natural Sciences Federal University of LavrasLavras 37203-202Minas Gerais 30000-31999Brazil Laboratory of Biotechnology and Molecular Biology Continental UniversitySan Antonio UrbanizationHuancayo 12000Peru Ecology and Biodiversity Research Programme ANDINUS AssociationMiguel Grau Street 370Huancayo 12000Peru Dendrochronology Laboratory Continental UniversitySan Carlos Avenue 1980Huancayo 12000Peru

Polylepis(Queñua)is a dominant woody plant genus in Andean Puna forests that occurs in a wide range of montane habitats and is ecologically diverse in endemism,which may be particularly threatened by climate *** anatomical traits are essential for understanding how plants adjust their ecophysiological requirements and maximize their resilience,resistance,and recovery to extreme *** the effects of extreme climatic conditions in high altitude ecosystems have been studied extensively,our knowledge is relatively limited to quantitative differences in the main xylem *** address this gap,we assessed the acclimation of wood anatomical traits in six Peruvian Andean Polylepis species with different water availability(semi-dry with high moisture and semiarid with dry winters).We selected hydraulic diameter,vessel density,vessel grouping index,solitary vessel index,vulnerability index,mesomorphy index,vessel element length,fiber length,fiber wall thickness,fiber lumen diameter,and total fiber diameter that can provide relevant eco-wood anatomical acclimation to hydric *** performed multivariate analysis to determine the leading dimensions of covariation among Polylepis species and climatic *** wood anatomical traits(vessel grouping index,vulnerability index,and fiber wall thickness)were dissimilar between xeric-and mesic-Polyelpis *** study demonstrates that wood anatomical traits in Peruvian Andean Polylepis species provides high-resolution and long-term eco-wood anatomical signals on how climate oscillations drive the acclimation processes of fiber and vessel *** findings underscore the significance of xylem hydraulic adjustment to various hydrological environments in Andean puna *** evaluating the effects of drought on wood anatomical characteristics and ecological function,we demonstrate the capacity of tree species to adapt and endure climate-related changes,thereby emphasizing their resilience and ada

关键词： Carlquist indices Climatic resilience Vessel traits Fiber Functional trait Hydric stress

Taurine: a promising nutraceutic in the prevention of retinal degeneration

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Neural Regeneration Research 2024年第3期19卷 606-610页

作者： Diego García-Ayuso Johnny Di Pierdomenico Ana Martínez-Vacas Manuel Vidal-Sanz Serge Picaud María PVillegas-Pérez Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaEspaña Sorbonne Université INSERMCNRSInstitut de la VisionParisFrance

Taurine is considered a non-essential amino acid because it is synthesized by most ***,dietary intake of taurine may be necessary to achieve the physiological levels required for the development,maintenance,and function of certain *** may be especially important for the *** concentration of taurine in the retina is higher than that in any other tissue in the body and taurine deficiency causes retinal oxidative stress,apoptosis,and degeneration of photoreceptors and retinal ganglion *** plasma taurine levels may also underlie retinal degeneration in humans and therefore,taurine administration could exert retinal neuroprotective *** has antioxidant,anti-apoptotic,immunomodulatory,and calcium homeostasis-regulatory *** review summarizes the role of taurine in retinal health and disease,where it appears that taurine may be a promising nutraceutical.

关键词： amino acid anti-inflammatory antioxidant gamma-aminobutyric acid nutraceutical photoreceptor degeneration retina retinitis pigmentosa taurine

Explainable Artificial Intelligence(XAI)Model for Cancer Image Classification

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 401-441页

作者： Amit Singhal Krishna Kant Agrawal Angeles Quezada Adrian Rodriguez Aguiñaga Samantha jiménez Satya Prakash Yadav Department of Computer Science&Engineering Raj Kumar Goel Institute of TechnologyGhaziabad201017India Department of School of Computing Science and Engineering Galgotias UniversityGreater Noida203201India Tecnológico Nacional de México Campus Tijuana Baja California22414México Universidad Autónoma de Baja California TijuanaBaja California22414México Department of Computer Science and Engineering G.LBajaj Institute of Technology and Management(GLBITM)Affiliated to Dr.A.P.J.Abdul Kalam Technical UniversityLucknow201306India School of Computer Science Engineering and Technology(SCSET) Bennett UniversityGreater Noida201310India

The use of Explainable Artificial Intelligence(XAI)models becomes increasingly important for making decisions in smart healthcare *** is to make sure that decisions are based on trustworthy algorithms and that healthcare workers understand the decisions made by these *** models can potentially enhance interpretability and explainability in decision-making processes that rely on artificial ***,the intricate na.ure of the healthcare field necessitates the utilization of sophisticated models to classify cancer *** research presents an advanced investigation of XAI models to classify cancer *** describes the different levels of explainability and interpretability associated with XAI models and the challenges faced in deploying them in healthcare *** addition,this study proposes a novel framework for cancer image classification that incorporates XAI models with deep learning and advanced medical imaging *** proposed model integrates several techniques,including end-to-end explainable evaluation,rule-based explanation,and useradaptive *** proposed XAI reaches 97.72%accuracy,90.72%precision,93.72%recall,96.72%F1-score,9.55%FDR,9.66%FOR,and 91.18%*** will discuss the potential applications of the proposed XAI models in the smart healthcare *** will help ensure trust and accountability in AI-based decisions,which is essential for achieving a safe and reliable smart healthcare environment.

关键词： Explainable artificial intelligence artificial intelligence XAI healthcare cancer image classification

Long-term effects of gestational diabetes mellitus on the pancreas of female mouse offspring

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World Journal of Diabetes 2024年第4期15卷 758-768页

作者： Enriqueta Muñoz-Islas Edgar David Santiago-SanMartin Eduardo Mendoza-Sánchez Héctor Fabián Torres-Rodríguez Laura Yanneth Ramírez-Quintanilla Christopher Michael Peters Juan Miguel jiménez-Andrade Unidad Académica Multidisciplinaria Reynosa-Aztlán Universidad Autónoma de TamaulipasReynosa 88740TamaulipasMexico Department of Anesthesiology Wake Forest University School of MedicineWinston SalemNC 27101United States

BACKGROUND Prolonged fetal exposure to hyperglycemia may increase the risk of developing abnormal glucose metabolism and type-2 diabetes during childhood,adolescence,and adulthood;however,the mechanisms by which gestational diabetes mellitus(GDM)predisposes offspring to metabolic disorders remain *** To quantify the nerve axons,macrophages,and vascula.ure in the pancreas from adult offspring born from mouse dams with *** GDM was induced by *** of streptozotocin(STZ)in ICR mouse *** 12 wk old,fasting blood glucose levels were determined in *** 15 wk old,female offspring born from dams with and without GDM were sacrificed and pancreata were processed for *** quantified the density of sensory[calcitonin gene-related peptide(CGRP)]and tyrosine hydroxylase(TH)axons,blood vessels(endomucin),and macro-phages(CD68)in the splenic pancreas using confocal *** Offspring mice born from STZ-treated dams had similar body weight and blood glucose values compared to offspring born from vehicle-treated ***,the density of CGRP+and TH+axons,endomucin+blood vessels,and CD68+macrophages in the exocrine pancreas was significantly greater in offspring from mothers with GDM vs control ***,the microvascula.ure in the islets was significantly greater,but not the number of macrophages within the islets of offspring born from dams with GDM compared to control *** GDM induces neuronal,vascular,and inflammatory changes in the pancreas of adult progeny,which may partially explain the higher propensity for offspring of mothers with GDM to develop metabolic diseases.

关键词： Gestational diabetes mellitus Immunohistochemistry Confocal microscopy Pancreas Offspring