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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Fullwave doppler reflectometry simulations for density turbulence spectra in ASdEX Upgrade using GENE and IPF-Fd3d

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Plasma Science and technology 2020年第6期22卷 41-48页

作者： C LECHtE G d CONWAY tGÖRLER t HAPPEL the ASdEX Upgrade team Institute of Interfacial Process Engineering and Plasma technology IGVP Universität StuttgartD-70569 StuttgartGermany Max-Planck-Institute for Plasma Physics D-85748 GarchingGermany 不详

doppler reflectometry is an important microwave diagnostic for turbulent fusion plasmas.A microwave beam is scattered off density fluctuations,with wavenumbers according to incident frequency and relative *** way,a density fluctuation spectrum is ***,the correspondence between fluctuation power and scattered microwave power is strongly *** these processes numerically therefore requires fullwave simulations(IPF-Fd3 d),with density fluctuations supplied by a separate plasma turbulence code(GENE).Earlier such attempts suffered from the low number of data points in the‘interesting’part of the spectrum,where a power law had to be fitted to 4 or 5 *** has been overcome with recent simulations,which now show a much better agreement with experimental data.

关键词： plasma diagnostics doppler reflectometry simulation microwaves

GRId GENERAtION ANd NUMERICAL SIMULAtION OF 2-d RIVER FLOW

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Journal of Hydrodynamics 2001年第2期13卷 50-54页

作者： Zhao, M.d. Li, Y.t. dept. of River Eng. Wuhan Univ. Wuhan 430072 China

this paper presents new weighting functions in grid generation and new discretizing scheme of momentum equations in numerical simulation of river flow. By using the new weighting functions, the curvilinear grid could be concentrated as desired near the assigned points or lines in physical plane. By using the new discretizing scheme, the difficulties caused by movable boundary and dry riverbed can be overcome. As an application, the flow in the Wuhan Section of Yangtze River is simulated. the computational results are in good agreement with the measured results. the new method is applicable to the numerical simulation of 2-d river flow with irregular region and moveable boundary.

关键词： Computer simulation Flow of fluids Mathematical models Poisson equation two dimensional

treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA the Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

A　Possible　Origin　of　dark　Energy

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Chinese Physics Letters 2004年第6期21卷 1187-1188页

作者： t.d.Lee Physicsdepartment ColumbiaUniversityNewYorkNY10027USA

We discuss the possibility that the existence of dark energy may be due to the presence of a spin zero field (x), either elementary or composite. In the presence of other matter field, the transformation (x)→(x)+ constant can generate a negative pressure, like the cosmological constant. In this picture, our universe can be thought as a very large bag, similar to the much smaller MIt bag model for a single nucleon.

关键词： Astrophysics

Nonlinear thermo-mechanical stability of eccentrically stiffened functionally graded material sandwich doubly curved shallow shells with general sigmoid law and power law according to third-order shear deformation theory

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Applied Mathematics and Mechanics(English Edition) 2017年第2期38卷 191-216页

作者： d.V.dUNG d.t.dONG Faculty of Mathematics Mechanics and Informatics Vietnam National University Hanoi 100000 Vietnam Faculty of Civil Engineering University of Transport Technology Hanoi 100000 Vietnam

In this paper, the nonlinear analysis of stability of functionally graded ma- terial （FGM） sandwich doubly curved shallow shells is studied under thermo-mechanical loads with material properties obeying the general sigmoid law and power law of four ma- terial models. Shells are reinforced by the FGM stiffeners and rest on elastic foundations. theoretical formulations are derived by the third-order shear deformation theory （tSdt） with the von Karman-type nonlinearity taking into account the initial geometrical im- perfection and smeared stiffener technique. the explicit expressions for determining the critical buckling load and the post-buckling mechanical and thermal load-deflection curves are obtained by the Galerkin method. two iterative algorithms are presented. the effects of the stiffeners, the thermal element, the distribution law of material, the initial imper- fection, the foundation, and the geometrical parameters on buckling and post-buckling of shells are investigated.

关键词： functionally graded material (FGM) sandwich double curved shallow shell,thermo-mechanical stability FGM stiffener elastic foundation

Advancing Wound Filling Extraction on 3d Faces:An Auto-Segmentation and Wound Face Regeneration Approach

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2197-2214页

作者： duong Q.Nguyen thinh d.Le Phuong d.Nguyen Nga t.K.Le H.Nguyen-Xuan department of Mathematics and Statistics Quy Nhon UniversityQuy Nhon City55100Viet Nam Applied Research Institute for Science and technology Quy Nhon UniversityQuy Nhon City55100Viet Nam CIRtECH Institute HUTECH UniversityHo Chi Minh City72308Viet Nam

Facial wound segmentation plays a crucial role in preoperative planning and optimizing patient outcomes in various medical *** this paper,we propose an efficient approach for automating 3d facial wound segmentation using a two-stream graph convolutional *** method leverages the Cir3d-FaIR dataset and addresses the challenge of data imbalance through extensive experimentation with different loss *** achieve accurate segmentation,we conducted thorough experiments and selected a high-performing model from the *** selectedmodel demonstrates exceptional segmentation performance for complex 3d facial ***,based on the segmentation model,we propose an improved approach for extracting 3d facial wound fillers and compare it to the results of the previous *** method achieved a remarkable accuracy of 0.9999993% on the test suite,surpassing the performance of the previous *** this result,we use 3d printing technology to illustrate the shape of the wound *** outcomes of this study have significant implications for physicians involved in preoperative planning and intervention *** automating facial wound segmentation and improving the accuracy ofwound-filling extraction,our approach can assist in carefully assessing and optimizing interventions,leading to enhanced patient ***,it contributes to advancing facial reconstruction techniques by utilizing machine learning and 3d bioprinting for printing skin tissue *** source code is available at https://***/SIMOGroup/WoundFilling3d.

关键词： 3d printing technology face reconstruction 3d segmentation 3d printed model

Space decomposition based parallelization solutions for the combined finiteediscrete element method in 2d

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Journal of Rock Mechanics and Geotechnical Engineering 2014年第6期6卷 607-615页

作者： t.Lukas G.G.Schiava d'Albano A.Munjiza School of Engineering and Materials Science Queen Mary University of LondonUK

the combined finiteediscrete element method （FdEM） belongs to a family of methods of computationalmechanics of discontinua. the method is suitable for problems of discontinua, where particles aredeformable and can fracture or fragment. the applications of FdEM have spread over a number of disciplinesincluding rock mechanics, where problems like mining, mineral processing or rock blasting canbe solved by employing FdEM. In this work, a novel approach for the parallelization of two-dimensional（2d） FdEM aiming at clusters and desktop computers is developed. dynamic domain decompositionbased parallelization solvers covering all aspects of FdEM have been developed. these have beenimplemented into the open source Y2d software package and have been tested on a PC cluster. theoverall performance and scalability of the parallel code have been studied using numerical examples. theresults obtained confirm the suitability of the parallel implementation for solving large scale problems. 2014 Institute of Rock and Soil Mechanics, Chinese Academy of Sciences. Production and hosting byElsevier B.V. All rights reserved.

关键词： Parallelization Load balancing PC cluster Combined finiteediscrete element method(FdEM)