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Epidemiology of insertional and midportion Achilles tendinopathy in runners:A prospective cohort study

Journal of Sport and Health Science 2024年第2期13卷 256-263页

作者： Wenbo Chen Kyra L.A.Cloosterman Sita m.A.Bierma-Zeinstra marienke van middelkoop Robert-Jan de vos department of Orthopaedic Surgery and Sports medicine Erasmus MC University Medical CenterRotterdam 3015GDthe Netherlands department of General Practice Erasmus MC University Medical CenterRotterdam 3015GDthe Netherlands department of Sports medicine Huashan HospitalFudan UniversityShanghai 200040China

Background:Achilles tendinopathy(AT)is a common problem among *** is only limited evidence for risk factors for AT,and most studies have not defined the AT *** study has compared the incidence and risk factors between insertional AT and midportion AT,though they are considered *** study aimed to assess incidence and risk factors of AT based on data from a large prospective *** secondary aim was to explore differences in risk factors between insertional and midportion ***:Participants were recruited from among registered runners at registration for running *** were completed at baseline,1 month before the event,1 week before the event,and 1 month after the *** concerning demographics,training load,registered events,and running-related injuries were collected at *** follow-up questionnaires collected information about new injuries.A pain map was used to diagnose midportion and insertional *** primary outcome was the incidence of *** logistic regression analysis was applied to identify risk factors for the ***:We included 3379 participants with a mean follow-up of 20.4 *** incidence of AT was 4.2%.The proportion of insertional AT was 27.7%and of midportion AT was 63.8%;the remaining proportion was a combined type of insertional and midportion *** had a significantly higher incidence(5%,95%confidence interval(95%CI):4.1%-6.0%)than women(2.8%,95%CI:2.0%-3.8%).AT in the past12 months was the most predominant risk factor for new-onset AT(odds ratio(OR)=6.47,95%CI:4.27-9.81).This was similar for both subcategories of AT(insertional:OR=5.45,95%CI:2.51-11.81;midportion:OR=6.96,95%CI:4.24-11.40).Participants registering for an event with a distance of 10/10.55 km were less likely to develop a new-onset AT(OR=0.59,95%CI:0.36-0.97)or midportion AT(OR=0.47,95%CI:0.23-0.93).Higher age had a significant negative association with insertional AT(OR=0.97,95%CI:0.9

关键词： Achilles tendon injury Incidence Risk factor Running-related injury

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心脏CT双期对比剂注射:相同碘流量和碘剂量的中和高浓度对比剂的对比

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国际医学放射学杂志 2010年第5期 505-505页

作者： A.Rutten m.F.L.meijs a.m.de vos P.R.Seidensticker m.Prokop 卞读军 department of Radiology University Medical Center UtrechtUtrechtThe Netherlands

关键词： CT 冠状动脉CT血管成像对比剂浓度对比剂注射方式

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利用择形分子筛异构化亚甲基二苯胺

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Chinese Journal of Catalysis 2024年第7期62卷 124-130页

作者： Sam Van minnebruggen Ka Yan Cheung Trees de Baerdemaeker Niels Van Velthoven matthias degelin Galahad O’Rourke Hiroto Toyoda Andree Iemhoff Imke muller Andrei-Nicolae Parvulescu Torsten mattke Jens Ferbitz 吴勤明肖丰收 Toshiyuki Yokoi Nils Bottke Dirk de vos 巴斯夫股份有限公司膜分离、吸附、催化和光谱学可持续解决方案中心(cmACS) 比利时巴斯夫股份有限公司研究组德国东京工业大学纳米空间催化研究所横滨日本浙江大学化学系浙江杭州310028

亚甲基二苯胺(mDA)被广泛用作生产聚氨酯和聚异氰脲酸酯的中间体.然而,当前mDA的生产工艺在控制(4,4’/(2,4’+2,2’))异构体比例方面还存在局限.其中,4,4’-mDA被认为是最有价值的异构体.尽管2,4'-mDA在市场上也有一定的需求,但如果能... 详细信息

亚甲基二苯胺(mDA)被广泛用作生产聚氨酯和聚异氰脲酸酯的中间体.然而,当前mDA的生产工艺在控制(4,4’/(2,4’+2,2’))异构体比例方面还存在局限.其中,4,4’-mDA被认为是最有价值的异构体.尽管2,4'-mDA在市场上也有一定的需求,但如果能将其有效地转化为4,4'-mDA,将能显著提升其附加值.本文在使用苯胺的条件下,利用β分子筛等催化剂,通过双分子机制,可以选择性地将2,4'-mDA异构化为4,4'-mDA.尽管实验显示,多种酸性沸石具有较高的异构化活性,但mCm-68(具有mSE拓扑结构)的催化性能尤为出色,它不仅展现出高异构化活性,而且具有很好的选择性.mCm-68主要催化2,4'-mDA异构化为4,4'-mDA,而2,2'-mDA和低聚物的形成则可以忽略不计.本文还深入探讨了该择形作用的原因,并详细研究了酸位置在mSE分子筛孔道限制中的关键作用.

关键词：铝分布多相催化异构化亚甲基二苯胺聚氨酯择形

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A giant crocodile in the Dubois Collection from the Pleistocene of Kali Gedeh(Java)

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Integrative Zoology 2014年第2期9卷 141-147页

作者： massimo deLFINO John de vos Earth Sciences department University of TorinoTorinoItaly Catalan Institute of Palaeontology miquel Crusafont Autonomous University of BarcelonaCerdanyola del VallèsSpain Naturalis Biodiversity Center LeidenNetherlands

The fauna of the Pleistocene Homo-bearing sites of Java has been well known for more than a century.A recent revision of the crocodylian remains confirmed both the validity of Gavialis bengawanicus and the synonymiza-tion of Crocodylus ossifragus with *** we report on a still unpublished crocodylian specimen collected by Eugene Dubois in the latest Early Pleistocene of Kali Gedeh that can be tentatively referred to the genus *** size of the specimen,the approximately 1 m long lower jaw in particular,indicat-ed that this crocodile attained a total length of approximately 6 or 7 *** with specimens from the Plio-Pleistocene of Africa,this material provides evidence for gigantism in *** is not clear whether or not the‘temperature-size rule’applies to fossil crocodylians,but due to the growing interest in predicting future temperature-related size changes of the extant organisms,it would be interesting to study in detail the past reac-tion to temperature changes of crocodylians and other terrestrial ectothermic animals.

关键词： Crocodylus fossil Homo erectus fauna Pleistocene gigantism temperature-size rule

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National trends and outcomes of genetically inherited non-alcoholic chronic liver disease in the USA:estimates from the National Inpatient Sample(NIS)database

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Gastroenterology Report 2021年第1期9卷 38-48,I0002页

作者： Eric m.Sieloff Brian Rutledge Cuyler Huffman Duncan vos Thomas melgar department of Internal medicine Western Michigan University Homer Stryker MD School of MedicineKalamazooMIUSA department of Internal medicine Division of GastroenterologyWayne State University School of MedicineDetroitMIUSA department of Biostatistics Western Michigan University Homer Stryker MD School of MedicineKalamazooMIUSA department of Pediatrics Adolescent and Internal MedicineWestern Michigan University Homer Stryker MD School of MedicineKalamazooMIUSA

Background:medical literature on the prevalence of genetic liver disease is *** this study,we investigated the inhospital healthcare and economic burden from genetic causes of non-alcoholic chronic liver disease(NACLD)and nonalcoholic liver cirrhosis(NALC)in the ***:Data were abstracted from the National Inpatient Sample database between 2002 and 2014 using ICD9 codes for patients discharged with NACLD and NALC secondary to genetic diseases including alpha-1 antitrypsin deficiency(A1ATd),cystic fibrosis(CF),Wilson disease(WD),hereditary hemochromatosis(HHC),glycogen storage disease,and disorders of aromatic amino-acid metabolism(DAAAm).Results:Throughout the study period,there were 19,332 discharges for NACLD associated with the six genetic diseases including 14,368 for *** were$1.09 billion in hospital charges,790 in-hospital deaths,and 955 liver transplants ***,A1ATd was associated with 8,983(62.52%)hospitalizations for NALC followed by WD,CF,and *** highest in-hospital mortality was seen with *** greatest frequency of liver transplants was seen with ***:The number of hospitalizations for genetic liver diseases continues to *** increased funding and directed research efforts,we can aim to improvemedical treatments and the quality of life for patients at risk for liver deterioration.

关键词： liver cirrhosis inherited metabolic disease epidemiology

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Trends in treatment and overall survival among patients with proximal esophageal cancer

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World Journal of Gastroenterology 2019年第47期25卷 6835-6846页

作者： Judith de vos-Geelen Sandra mE Geurts Liselot BJ Valkenburg-van Iersel Evelien Jm de Jong Vivianne CG Tjan-Heijnen margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj mohammad Frank JP Hoebers Chantal V Hoge Paul m Jeene Hanneke Wm van Laarhoven Tom Rozema marije Slingerland Grard AP Nieuwenhuijzen department of Internal medicine Division of Medical OncologyGROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands department of Research Netherlands Comprehensive Cancer Organization(IKNL)Eindhoven 5612 HZNetherlands department of Pathology GROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands Pathology and Data Analytics Leeds Institute of Medical Research at St James”sUniversity of LeedsLeeds LS97TFUnited Kingdom department of medical Oncology University Medical Center UtrechtUtrecht 3584 CXNetherlands department of Radiation Oncology(mAASTRO clinic) GROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6229 ETNetherlands department of Internal medicine Division of GastroenterologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands department of Radiotherapy RadiotherapiegroepDeventer 7416 SENetherlands department of medical Oncology Amsterdam University Medical CentersUniversity of AmsterdamAmsterdam 1105 AZNetherlands department of Radiotherapy Insituut VerbeetenTilburg 5042 SBNetherlands department of medical Oncology Leiden University Medical CenterLeiden 2333 ZANetherlands department of Surgery Catharina Hospital EindhovenEindhoven 5623 EJNetherlands department of Public Health Erasmus Medical Center RotterdamRotterdam 3015 GDNetherlands

BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital ***-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been *** trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease *** optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life *** To establish trends in treatment and OS in patients with proximal esophageal *** In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer *** proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the *** in radiotherapy,chemotherapy,and surgery,and OS were *** were stratified by presence of distant *** Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment *** In total,2783 patients were *** the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,*** metastatic disease,the use of chemotherapy and radiotherapy increased over *** OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank Pmetastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank Pmultivariable regression analysis demonstrated a significant treatment effect over time on ***

关键词： Esophagus Esophageal cancer Proximal Cervical Upper thoracic Trends Treatment Survival Outcome

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Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review

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World Journal of Gastroenterology 2015年第17期21卷 5359-5371页

作者： Noortje G Rossen John K mac Donald Elisabeth m de Vries Geert R D'Haens Willem m de vos Erwin G Zoetendal Cyriel Y Ponsioen department of Gastroenterology and Hepatology Academic Medical Center Amsterdam1105 AZ AmsterdamThe Netherlands Division of Gastroenterology Robarts Clinical trialsRobarts Research Institutethe University of Western OntarioLondonCanada and Amsterdamthe NetherlandsOntario N6A 5K8Canada departments of Bacteriology and Immunology and Veterinary Biosciences University of HelsinkiFI-00014 HelsinkiFinland Laboratory of microbiology Wageningen University6703 HA Wageningenthe Netherlands

AIm:To study the clinical efficacy and safety of Fecal microbiota transplantation(FmT).We systematically reviewed FmT used as clinical ***:We searched mEDLINE,EmBASE,the Cochrane Library and Conference proceedings from inception to July,*** effect of FmT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat ***:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FmT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was *** IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved *** RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were ***:FmT is highly effective in CDI,and holds promise in *** for CD,chronic constipation,pouchitis and IBS data are too limited to draw *** increases insulin sensitivity in metabolic syndrome.

关键词： Fecal microbiota transplantation microbiota Clostridium difficile infection Inflammatory boweldisease metabolic syndrome

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Specific inulin-type fructan dietary fibers protect against murine autoimmune diabetes by modulating gut immunity, integrity and microbiota homeostasis

Specific inulin-type fructan dietary fibers protect against ...

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第十一届全国免疫学学术大会

作者： Chen Kang Chen Hao Li Jiahong Faas marijke m de Haan Bart J de vos Paul Sun Jia State Key Laboratory of Food Science and Technology School of Food Science and TechnologyJiangnan University School of medicine Jiangnan University

Both beneficial and diabetogenic effects have been attributed to consumption of dietary *** fibers may be fermented by gut microbiota to produce health-promoting short chain fatty acids(SCFA)and modulate gut immune **... 详细信息

关键词： Type 1 diabetes nutritional intervention inulin type fructan immunomodulation

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Action-oriented obesity counseling attains weight stabilization and improves liver enzymes among overweight and obese children and adolescents

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Open Journal of Pediatrics 2012年第3期2卷 236-243页

作者： Allison C. Sylvetsky Jean A. Welsh Stephanie m. Walsh miriam B. vos Children’s Healthcare of Atlanta at Egleston Atlanta USA department of Pediatrics School of Medicine Emory University Atlanta USA Nutrition and Health Sciences Program Division of Biological and Biomedical Sciences Laney Graduate School Emory University Atlanta USA

Introduction: Pediatricians are encouraged to promote behavior modification to reduce childhood obesity and its co-morbidities, yet the effectiveness of office counseling is unclear. We aimed to evaluate if a low-intensity intervention (action-oriented counseling) in a clinic setting results in weight stabilization, and if the effect is modified by a diagnosis of non-alcoholic fatty liver disease (NAFLD). We hypothesized that patients with NAFLD would be more motivated to adhere to the lifestyle goals set in clinic, due to the diagnosis of an obesity-related condition;and, would therefore achieve greater weight reduction compared to similarly overweight and obese patients without a diagnosis of NAFLD. methods: A retrospective chart review was conducted on 73 (35 male, 38 female) overweight and obese patients (BmI ≥ 85th percentile) attending a pediatric GI clinic between January 2006 and October 2011. Analysis was conducted to determine if lifestyle goals discussed with the patient at each clinic visit were associated with improved BmI, BmI z-score, and liver enzymes. Treatment outcomes among NAFLD patients and similarly obese patients without NAFLD were compared using t-tests and chi-square tests. Results: Of the children evaluated, 74.0% achieved a reduction or stabilization in BmI z-score after 3 months of follow-up. Among NAFLD patients, liver enzymes improved in 72% of those who were able to stabilize or reduce their BmI and among 43% of those who gained weight. Treatment outcome did not significantly differ based on having a diagnosis of NAFLD, although there was a trend towards greater improvements. Conclusion: Our study suggests that action oriented counseling including goal-setting in a low intensity, clinic based approach is effective in improving patient BmI, in the presence or absence of an obesity-related co-morbidity, such as NAFLD. Further, we demonstrated that lifestyle modification led to improvement of liver enzymes in NAFLD patients and may result

关键词： Obesity Non-Alcoholic Fatty Liver Disease Lifestyle Behavior Change

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Tailoring the properties of quantum dot-micropillars by ultrafast optical injection of free charge carriers

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Light(Science & Applications) 2021年第11期10卷 2083-2097页

作者： Emanuel Peinke Tobias Sattler Guilherme m.Torelly Patricia L.Souza Sylvain Perret Joel Bleuse Julien Claudon Willem L.vos Jean-michel Gerard UniversitéGrenoble Alpes CEAIRIG-PHELIQS“Nanophysique et Semiconducteurs”groupF-38000GrenobleFrance LabSem-CETUC Pontificia Universidade Catolica do Rio de JaneiroRio de Janeiro22451-900Brazil Complex Photonic Systems(COPS) MESA+Institute for NanotechnologyUniversity of TwenteP.O.Box 2177500 AEEnschedethe Netherlands

We review recent studies of cavity switching induced by the optical injection of free carriers in micropillar cavities containing quantum *** the quantum dots as a broadband internal light source and a streak camera as detector,we track the resonance frequencies for a large set of modes with picosecond time *** report a record-fast switch-on time constant(1.5 ps)and observe major transient modifications of the modal structure of the micropillar on the 10 ps time scale:mode crossings are induced by a focused symmetric injection of free carriers,while a lifting of several mode degeneracies is observed when off-axis injection breaks the rotational symmetry of the *** show theoretically and experimentally that cavity switching can be used to tailor the dynamic properties of the coupled QD-cavity *** report the generation of ultrashort spontaneous emission pulses(as short as 6 ps duration)by a collection of frequency-selected QDs in a switched pillar *** pulses display a very small coherence length,attractive for ultrafast speckle-free ***,the control of QD-mode coupling on the 10 ps time scale establishes cavity switching as an appealing resource for quantum photonics.

关键词： lifting injection cavity

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