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A NEW CYCLOPEPTIDE FROM VACCARIA SEGETALIS

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Chinese Chemical Letters 1995年第8期6卷 681-682页

作者： Zhang, RP Zou, C Chai, yk Zhou, j Acad Sinica Kunming Inst Bot Lab Phytochem Kunming 650204 Peoples R China

A new cyclopeptide designated as vaccarin A were isolated from the seeds of Vaccaria segetalis, Its structure was obtained by spectral evidence.

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The challenge of defining rare genetic programs by single-cell RNA sequencing:Insights from phloem studies

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Molecular Plant 2024年第1期17卷 22-25页

作者： Xiaomin Liu Pawel Roszak ykäHelariutta State Key Laboratory of Tree Genetics and Breeding College of Biological Sciences and TechnologyBeijing Forestry UniversityBeijing 100083China The Sainsbury Laboratory University of CambridgeCB21TN CambridgeUK Wood Development Group University of Helsinki00100 HelsinkiFinland Organismal and Evolutionary Biology Research Programme Faculty of Biological and Environmental Sciences and Viikki Plant Science CentreUniversity of Helsinki00100 HelsinkiFinland

Single-cell RNA sequencing technology provides unprecedented opportunities to capture the spatiotemporal aspects of genetic programs that drive cell *** is a subtype of vascular tissue that is crucial for transporting sugars,proteins,and other organic *** critical role in the redistribution of carbon between photosynthetically active“source”organs(leaves,shoots)and“sink”tissues/organs incapable of fixing carbon(wood,storage organs,root system,etc.)has made phloem development and its transcriptional regulation a prime research focus.

关键词： organs sugar rare

Research on optimal immunization strategies for hepatitis B in different endemic areas in China

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World journal of Gastroenterology 2000年第3期6卷 392-394页

作者： Li H Wang L Wang SS Gong j Zeng Xj Li RC Nong Y Huang yk Chen XR Huang ZN CAMS & PUMC Inst Basic Med Sci Dept Epidemiol Beijing 100005 Peoples R China

INTRODUCTION At present hepatitis B vaccine immunization is an unique effective measure for controlling hepatitis *** is important o determine optimal immunization

关键词： hepatitis B vaccine immunization strategy cost-benefit analysis china

Transfusion-transmitted virus in association with hepatitis A-E viral infections in various forms of liver diseases in India

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World journal of Gastroenterology 2006年第15期12卷 2432-2436页

作者： M Irshad Y Sharma I Dhar j Singh yk joshi Clinical Biochemistry Division Department of Laboratory Medicine All India Institute of Medical SciencesAnsari NagarNew Delhi 110029India Department of Gastroenterology & Human Nutrition Unit All India Institute of Medical Sciences Ansari NagarNew Delhi-110029India

AIM： To describe the prevalence of transfusiontransmitted virus （TTV） infection in association with hepatitis A-E viral infections in different forms of liver diseases in North India. METHODS： Sera from a total number of 137 patients, including 37 patients with acute viral hepatitis （AVH）, 37 patients with chronic viral hepatitis （CVH）, 31 patients with cirrhosis of liver and 32 patients with fulminant hepatic failure （FHF）, were analyzed both for TTV-DNA and hepatitis A-E viral markers. Presence of hepatitis B virus （HBV）, hepatitis C virus （HCV） and hepatitis E virus （HEV） infections was detected in different proportions in different groups. Moreover, rrV-DNA was simultaneously tested in 100 healthy blood donors also. RESULTS： None of the patients had hepatitis A virus （HAV） and hepatitis D virus （HDV） infections. Overall prevalence of TTV-DNA was detected in 27.1% cases with AVH, 18.9% cases with CVH, 48.4% cases with cirrhosis and 9.4% cases with FHF. TTV-DNA simultaneously tested in 100 healthy blood donors showed 27% positivity. On establishing a relation between TTV infection with other hepatitis viral infections, TTV demonstrated co-infection with HBV, HCV and HEV in these disease groups. Correlation of TTV with ALT level in sera did not demonstrate high ALT level in TTV-infected patients, suggesting that TI-V does not cause severe liver damage. CONCLUSION： TTV infection is prevalent both in patients and healthy individuals in India. However, it does not have any significant correlation with other hepatitis viral infections, nor does it produce an evidence of severe liver damage in patients with liver diseases.

关键词： Transfusion-transmitted virus HCV hepatitis AVH

Cuscuta, the Merchant of Proteins

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Molecular Plant 2020年第4期13卷 533-535页

作者： Andrea Paterlini yka Helariutta Sainsbury Laboratory University of CambridgeCambridgeUK Institute of Biotechnology HiLIFEUniversity of HelsinkiHelsinkiFinland

"If thou wilt lend this money,lend it not As to thy friends,[...]But lend it rather to thine enemy,Who,if he break,thou mayst with better face Exact the penalty"The merchant Antonio speaking to the moneylender Shylock... 详细信息

关键词： money chant Shy

Single dose pharmacokinetic study of thalidomide in patients with multiple myeloma.

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Single dose pharmacokinetic study of thalidomide in patients...

滨里海盆地南部盐下大型油气田石油地质特征及形成条件

第十五届国际药理学大会

作者： Pathak A Malhotra j Raina V Arya DS Gupta yk Department of Pharmacology All India Institute of Medical SciencesNew DelhiIndia-110029 Department of Pharmacology All India Institute of Medical SciencesNew DelhiIndia-110029 Department of Medical Oncology BRAIRCHAll India Institute of Medical SciencesNew DelhiIndia-110029. Department of Pharmacology All India Institute of Medical SciencesNew DelhiIndia-110029 Department of Pharmacology All India Institute of Medical SciencesNew DelhiIndia-110029

＜正＞ Thalidomide has recently been approved for use in patients of multiple myeloma （MM） in India, however the pharmacokinetic data in such patients is lacking. Therefore, a single dose pharmacokinetic study of thalidomide in MM patients was carried out. Nine MM patients satisfying the inclusion criteria were enrolled. After 10h fasting, thalidomide 200mg was administered and blood samples （0. 5ml） were withdrawn at 0, 0.5, 1, 1.5, 3. 4, 6, 8, 12, 24 and 30h in tubes containing citrate phosphate dextrose adenine solution. Twenty-four hours urine samples were collected in a container with 5 ml HC1, and thoroughly mixed. The thalidomide concentrations in plasma and urine were determined by a reverse phase HPLC assay developed by us. Based on single compartmental model, the pharmacokinetic parameters are Cmax 879.7±124 ng/ml, Tmax 4.8±0. 4h, κel 0.13±0.04/h and t1/2of 7.4±1.07h. The Vdand CL are202.1±37 1 and25. 4 l/h respectively, while 24h urinary excretion was 2.57±1.19mg. The high values of Vd and CL in our study can be attributed to a significant tissue distribution of thalidomide in MM patients.

关键词： Thalidomide Multiple myeloma Pharmacokinetics.

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石油与天然气地质 2005年第6期26卷 840-846页

作者：李永宏 Burlin yk 莫斯科大学地质系

滨里海盆地南部盐下层系石油地质条件优越,广泛发育的泥岩及泥灰岩生烃潜力大,碳酸盐岩优质储层,尤其是生物礁广泛发育,除盆地边缘局部地区外,全区发育厚层孔古组优质盐岩盖层,使该区具有极好的生储盖配置条件。在厚层盐岩下长期稳定发... 详细信息

滨里海盆地南部盐下层系石油地质条件优越,广泛发育的泥岩及泥灰岩生烃潜力大,碳酸盐岩优质储层,尤其是生物礁广泛发育,除盆地边缘局部地区外,全区发育厚层孔古组优质盐岩盖层,使该区具有极好的生储盖配置条件。在厚层盐岩下长期稳定发育的古隆起及古斜坡上,发育的浅水台地相(如阿斯特拉汗凝析气田)及生物礁相(如田吉兹和卡沙干油田)优质碳酸盐岩储层及其圈闭的发育和分布控制着盐下油气田(藏)的分布。南恩巴坳陷西部(里海北部海域)为滨里海盆地南部盐下最有利的油气勘探区;南恩巴凹陷东部、里海北隆起带及毕格热勒隆起带为有利勘探区;阿斯特拉汗穹状隆起深层碳酸盐岩发育区、阿斯特拉汗南部构造带及南恩巴隆起为较有利勘探区。

关键词：盐下层系碳酸盐岩油气田油气地质有利区带滨里海盆地

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粉防己碱对离体狗隐静脉的收缩作用

基础医学与临床 1994年第2期14卷 41-46页

作者：王质良 Chao,yk 中国医学科学院基础医学研究所生理室

粉防己碱对狗隐静脉（ＤＳＶ）的去极化收缩有抑制作用。但在抑制后冲洗时却引起明显收缩。α２－肾上腺素能受体拮抗剂Ｒａｕｗｏｓｃｉｎｅ１０－７ｍｏｌ及ＫＣｌ４０ｍｍｏｌ／Ｌ能抑制冲洗波的出现；单独使用Ｔｅｔ也能诱发ＤＳＶ... 详细信息

粉防己碱对狗隐静脉（ＤＳＶ）的去极化收缩有抑制作用。但在抑制后冲洗时却引起明显收缩。α２－肾上腺素能受体拮抗剂Ｒａｕｗｏｓｃｉｎｅ１０－７ｍｏｌ及ＫＣｌ４０ｍｍｏｌ／Ｌ能抑制冲洗波的出现；单独使用Ｔｅｔ也能诱发ＤＳＶ缓慢的张力增加，而ＫＣｌ２０ｍｍｏｌ／Ｌ既能加速Ｔｅｔ诱发收缩的出现也能增强α２－肾上腺素能受体激动剂Ｂ－ＨＴ９２０的缩血管效应。对ＢａｙＫ８６４４诱发的ＤＳＶ收缩。Ｔｅｔ既不能抑制也无冲洗波出现。提示在低Ｋ＋条件下Ｔｅｔ能激活α２－肾上腺素能受体而引起收缩，在高Ｋ＋存在时激活Ｎａ－ＫＡＴＰ酶导致去极化收缩的舒张。

关键词：粉防己碱狗隐静脉肾上腺素能

The Plant Vascular System: Evolution, Development and Functions

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journal of Integrative Plant Biology 2013年第4期55卷 294-388页

作者： William j. Lucas Andrew Groover Raffael Lichtenberger Kaori Furuta Shri-Ram Yadav yk Helariutta Xin-Qiang He Hiroo Fukuda julie Kang Siobhan M. Brady john W. Patrick john Sperry Akiko Yoshida Ana-Flor López-Millan Michael A. Grusak Pradeep Kachroo Department of Plant Biology College of Biological Sciences University of California US Forest Service Pacific SW Res Stn Institute for Forest Genetics Institute of Biotechnology/Department of Biology and Environmental Sciences University of Helsinki State Key Laboratory of Protein and Plant Gene Research College of Life Sciences Peking University Department of Biological Sciences Graduate School of Science The University of Tokyo Biology Department University of Northern Iowa School of Environmental and Life Sciences The University of Newcastle Biology Department University of Utah Plant Nutrition Department Aula Dei Experimental Station (CSIC) USDA-ARS Children's Nutrition Research Center Department of Pediatrics Baylor College of Medicine Department of Plant Pathology College of Agriculture University of Kentucky

The emergence of the tracheophyte-based vascular system of land plants had major impacts on the evolution of terrestrial biology, in general, through its role in facilitating the development of plants with increased stature, photosynthetic output, and ability to colonize a greatly expanded range of environmental habitats. Recently, considerable progress has been made in terms of our understanding of the developmental and physiological programs involved in the formation and function of the plant vascular system. In this review, we first examine the evolutionary events that gave rise to the tracheophytes, followed by analysis of the genetic and hormonal networks that cooperate to orchestrate vascular development in the gymnosperms and angiosperms. The two essentialfunctions performed by the vascular system, namely the delivery of resources （water, essential mineral nutrients, sugars and amino acids） to the various plant organs and provision of mechanical support are next discussed. Here, we focus on critical questions relating to structural and physiological properties controlling the delivery of material through the xylem and phloem. Recent discoveries into the role of the vascular system as an effective long-distance communication system are next assessed in terms of the coordination of developmental, physiological and defense-related processes, at the whole-plant level. A concerted effort has been made to integrate all these new findings into a comprehensive picture of the state-of-the-art in the area of plant vascular biology. Finally, areas important for future research are highlighted in terms of their likely contribution both to basic knowledge and applications to primary industry.

关键词： Evolution vascular development phloem xylem nutrient delivery long-distance communication systemic signaling.