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生理科学进展 1982年第3期13卷 284-287页

作者： a.goldstein 美国斯丹福大学药理学教授美国成瘾药物研究所所长

美国斯丹福大学药理学教授、美国成瘾药物研究所所长***在1981年8月17日接受美国药理学和实验治疗学会授予Sollmann奖金时发表了演讲。经征得本人同意,将该演讲略加增删,以飨本刊读者。

关键词：药理学家美国美利坚合众国北美洲阿片受体立体构型三维结构

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全身纤溶状态对再灌注心肌的不利影响

现代临床医学生物工程学杂志 1996年第1期2卷 72-73页

作者：张彤 Yhshjo Ohnishi Michelle C. Butterfield Jeffrey E.Saffitz Burton E.Sobel Peter B.Corr a.goldstein

缺血心肌血流恢复的有利效应及再灌注损伤的不利影响已众所周知．虽然多数实验研究已能通过机械地解除非血栓形成性闭塞而造成心肌再灌注．但这种情况仅偶然存在于全身纤溶状态时．冠状动脉血栓性闭塞进行药物或机械的血管再通的病人结... 详细信息

缺血心肌血流恢复的有利效应及再灌注损伤的不利影响已众所周知．虽然多数实验研究已能通过机械地解除非血栓形成性闭塞而造成心肌再灌注．但这种情况仅偶然存在于全身纤溶状态时．冠状动脉血栓性闭塞进行药物或机械的血管再通的病人结果则有明显的差异．本研究旨在确定冠状动脉闭塞的形式与血管再通的方法是否影响心脏对再灌注的反应．

关键词：纤溶状态全身再灌注缺血心肌冠状动脉闭塞血管再通血流恢复解除机械

Long-term olfactory loss post-COVID-19:Pathobiology and potential therapeutic strategies

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 148-155页

作者： Sarah Kim John B.Finlay Tiffany Ko Bradley J.goldstein Department of Head and Neck Surgery&Communication Sciences Duke UniversityDurhamNorth CarolinaUSA Medical Scientist Training Program Duke UniversityDurhamNorth CarolinaUSA Department of Neurobiology Duke UniversityDurhamNorth CarolinaUSA

An acute loss of smell emerged as a striking symptom present in roughly half of the people infected with the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virus in the early phases of the COVID-19 *** most COVID-19 patients,olfaction recovers over the course of a few ***,a lasting partial or complete loss of smell,often associated with distorted olfactory perceptions termed parosmia,has emerged as a widespread problem impacting at least 5%-10%of those who experience anosmia due to *** inability to offer effective therapies to this hyposmic or anosmic population,comprising millions of patients,highlights an enormous unmet need for the medical ***,we summarize the current understanding of the pathobiology causing acute olfactory loss due to SARS-CoV-2 infection,focusing on how the virus interacts with the peripheral olfactory system,a major site of viral *** also explore the problem of long-COVID olfactory dysfunction,which may accompany other persistent systemic disorders collectively termed postacute sequelae of ***,we discuss an emerging model focused on unresolved immune cell activity driving ongoing ***,we review current and future therapeutic approaches aimed at restoring olfactory function.

关键词： hyposmia inflammation long-COVID parosmia

Novel transparent MgGa_(2)O_(4) and Ni^(2+)-doped MgGa_(2)O_(4) ceramics

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Journal of Advanced Ceramics 2022年第3期11卷 470-481页

作者： Guangran ZHANG Adrian goldstein Yiquan WU Kazuo Inamori School of Engineering New York State College of CeramicsAlfred UniversityAlfredNew York 14802USA Israel Ceramic and Silicate Institute HaifaIsrael

In this study we fabricated, for the first time, magnesium gallate (MgGa_(2)O_(4), a partially inverted spinel) transparent ceramics, both undoped and doped with 1 at% Ni. The specimens were derived from in-house prepared powder, with a crystallite size of ∼10 nm (by wet chemistry) and densified by pulsed electric current sintering (PECS;peak temperature 950 ℃ for 90 min). Densification levels of 99.84% and 99.52% of theoretical density were attained for doped and undoped materials, respectively. Doping with Ni was seen to marginally improve the densification level. Quite transparent specimens were produced: the best showing transmission of ∼89% of the theoretical level (thickness t = 0.85 mm). The absorption spectra revealed that the dopant was accumulated as Ni^(2+) in the octahedral sites of the lattice, as occurs in single-crystal specimens. After excitation at 980 nm, the doped disks exhibited a wide fluorescence band centered at 1264 nm.

关键词： magnesium gallate(MgGa_(2)O_(4)) spinel transparent ceramics pulsed electric current sintering(PECS)

Evolution of heart transplant donor characteristics in the 21st century: A United States single center’s experience

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World Journal of Transplantation 2024年第3期14卷 22-29页

作者： Alexander M Spring Christiana Gjelaj Shivank Madan Snehal R Patel Omar Saeed Sandhya Murthy Yogita Rochlani Daniel B Sims Sasha Vukelic Stephen J Forest Jamil F Borgi Daniel J goldstein Ulrich P Jorde Montefiore-Einstein Center for Heart and Vascular Care Montefiore Medical CenterAlbert Einstein College of MedicineBronxNY 10467United States Division of Cardiothoracic Surgery Tulane UniversityNew OrleansLA 70112United States

Despite a record setting number of heart transplants performed annually,the national donor shortage continues to plague transplant teams across the United *** we describe the barriers to adaptation of numerous“non-traditional”orthotopic heart transplant donor characteristics including donors with hepatitis C virus,those meeting criteria for donation after cardiac death,donors with coronavirus disease 19 infection,donors with the human immunodeficiency virus,and grafts with left ventricular systolic *** center’s objective was to increase our transplant volume by expanding our donor pool from“traditional”donors to these“non-traditional”*** detail how medical advances such as certain laboratory studies,pharmacologic interventions,and organ care systems have allowed our center to expand the donor pool thereby increasing transplantation volume without adverse effects on outcomes.

关键词： Orthotopic heart transplantation Hepatitis C virus COVID-19 Left ventricular systolic dysfunction Human immunodeficiency virus Donation after cardiac death

Magnetic Flux Controllers for Induction Heating Applications

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材料热处理学报 2004年第5期25卷 567-572页

作者： Valentin Nemkov Robert goldstein Robert Ruffini FluxtroUCentre for Induction Technology USAFluxtroUCentre for Induction Technology USAFluxtroUCentre for Induction Technology USA

Application of magnetic flux controllers/concentrators to induction heating coils can drastically improve the process efficiency and heat pattern control. Presentation includes: benefits provided by flux controllers, materials available for controllers, application techniques, computer assisted design of induction coils with concentrators, examples of applications. Depending on induction system design, magnetic flux controllers can concentrate heating in a specified area, change heat source distribution and shield a particular part zone or external area preventing unintended eddy current heating. Besides of the coil efficiency improvement and optimal power distribution, magnetic flux controllers reduce the coil current demand from a supplying circuitry thus strongly reducing losses in busswork, cables, transformers and inverter components. Improvement that can be achieved due to magnetic flux controllers is case dependable. 2D and 3D computer simulation allows the designer to predict accurately effect of controllers on the coil parameters and temperature distribution and optimize the whole electromagnetic system. Special attention in presentation is paid to new magnetodielectric materials optimized for induction heating conditions. These materials have high magnetic permeability and saturation flux density, excellent machinability, good chemical and temperature resistance. Concentrators from these materials can work in a wide range of frequencies and specific powers. Examples of magnetic flux controller application include surface hardening of shafts and gears, induction surface hardfacing and brazing.

关键词：热处理感应器磁通量计算机模拟

The potential of legume-derived proteins in the food industry

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Grain & Oil Science and Technology 2022年第4期5卷 167-178页

作者： Neta.goldstein Ram Reifen The Institute of Biochemistry and Nutrition The Robert H.Smith Faculty of AgricultureFood and EnvironmentThe Hebrew University of JerusalemRehovot 76100Israel

Legume-derived proteins present an opportunity to replace existing animal-source protein in various applications. Those proteins are abundant, relatively lowcost, sustainable, not highly allergenic, and widely acceptable by consumers. In this paper, it was found that legume-derived protein’s technofunctional properties(e.g. gelation, emulsification and foaming) are being investigated, in order to assess their ability to substitute for animal-derived proteins in food systems and applications. This paper reviewed the functional attributes of legume-derived proteins, their possible applications in food systems, and their potential in the food industry. The techno-functional properties of the proteins vary among different legumes, and while some proteins properties are sufficient for industrial uses, the other may need to be modified. It was concluded that legume-derived proteins could replace some existing animal-derived protein based food systems.

关键词： Legumes Plant protein Food industry Techno-functional properties Fat and protein composition

When is a varicocele repair indicated： the dilemma of hypogonadism and erectile dysfunction？

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Asian Journal of Andrology 2016年第2期18卷 213-216,J0004页

作者： Ali A Dabaja Marc goldstein Department of Male Reproductive Medicine Weill Cornell Medical College New York USA Department of Urology Henry Ford Health System Detroit MI USA.

In the past, the indications for varicocelectomy are primarily for infertility with abnormal semen parameters, testicular hypotrophy/atrophy in adolescents, and/or pain. The surgical treatment of varicocele for hypogonadism is controversial and debated. Recently, multiple reports in the literature have suggested that varicocele is associated with hypogonadism and varicocele repair can increase testosterone levels. Men with hypogonadal symptoms should have at least two serum testosterone levels. Microsurgical varicocelectomy may be beneficial for men with clinically palpable varicoceles with documented hypogonadism. In this review, we summarize the most recent literature linking varicocele to hypogonadism and sexual dysfunction and the impact of repair on serum testosterone levels. We performed a search of the published English literature. The key words used were ＂varicocele and hypogonadism＂ and ＂varicocele surgery and testosterone.＂ We included published studies after 1998. We, also, evaluated the effect of surgery on the changes in the serum testosterone level regardless of the indication for the varicocele repair.

关键词： erectile dysfunction hypogonadism varicocele varicocelectomy

Microsurgical varicocelectomy： a review

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Asian Journal of Andrology 2013年第1期15卷 56-60页

作者： Akanksha Mehta Marc goldstein Department of Urology and Center for Male Reproductive Medicine and Surgery Weill Cornell Medical College New York NY 10021 USA

Varicocelectomy is the most commonly performed surgical procedure for the treatment of male infertility. Although several different techniques for varicocele repair have been described in the literature, microsurgical varicocelectomy performed through a subinguinal or inguinal incision is recognized as the gold-standard approach for varicocelectomy, due to high success rates with minimal complications. Standard indications for varicocelectomy include palpable varicocele（s）, with one or more abnormal semen parameters, and, for the couple trying to conceive, in the setting of normal or correctable female infertility. However, varicocele repair is often recommended and undertaken for reasons other than infertility, including low serum testosterone, testicular pain, testicular hypotrophy and poor sperm DNA quality. This article reviews the technical aspects of microsurgical varicocelectomy, and its indications in adults and adolescents.

关键词： DNA fragmentation hypogonadism infertility microsurgical varicocelectomy orchalgia varicocele repair

The “PAWPER-on-a-page”: Increasing global access to a low-cost weight estimation system

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World Journal of Emergency Medicine 2019年第2期10卷 101-108页

作者： Mike Wells Lara Nicole goldstein Division of Emergency Medicine Faculty of Health Sciences University of the Witwatersrand

BACKGROUND: The PAWPER tape is one of the most accurate weight estimation systems available today, but international access to the tape is limited because it has no commercial distribution. For this reason, the "PAWPER-on-a-page" concept was devised: downloadable image fi les that allow users to print and assemble their own tapes. However, the feasibility of this method is dependent on users being able to produce accurate tapes. This study was devised to determine whether untrained participants could print and assemble the "PAWPER-on-a-page" easily and ***: Doctor and nurse volunteers downloaded the "PAWPER-on-a-page" and "PAWPER XL-on-a-page" image files and printed copies on a home-printer and also at a commercial printer. One copy of each tape was then assembled according to instructions from an online video. The accuracy of printing and assembly, the time taken for assembly and the cost were then ***: There were 32 participants. The median time for assembly was 8 minutes 19 seconds and 7 minutes 31 seconds for the "PAWPER-on-a-page" and "PAWPER XL-on-a-page" respectively, with a median cost of USD 0.09 and USD 1.00 respectively. For the assembled tapes, 71.9% of the "PAWPER-on-a-page" tapes and 65.6% of the "PAWPER XL-on-a-page" achieved the required accuracy of 0.2%. Printing errors, related to scaling, were common, but easily ***: The "PAWPER-on-a-page" system can be easily, quickly, affordably and accurately printed and assembled by end users. Stringent double checking of the printed and fully assembled tapes is essential to ensure accuracy.

关键词： PAWPER tape Weight estimation Paediatric emergency care