检索结果-南通市图书馆

Pan-TRK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report

引用

World Journal of Clinical Cases 2025年第2期13卷 39-49页

作者： Seungmee lee Yu-ra Jeon Changmin Shin Sun-Young Kwon Sojin Shin Department of Obstetrics and Gynecology Keimyung University School of MedicineDaegu 42601South Korea Department of Pathology and Institute for Cancer Research Keimyung University School of MedicineDaegu 42601South Korea

BACKGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic *** on neurotrophic tyrosine receptor kinase(NTRK)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent ***-TRK immunohistochemistry(IHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTRK-fusion *** SUMMARY We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TRK IHC-positive but lacked NTRK gene fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic *** examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTRK sarcoma with positive immunochemical pan-TRK ***,subsequent next generation sequencing revealed no NTRK gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage *** The clinical significance of NTRK gene fusion lies in potential treatment with TRK inhibitors for positive *** such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.

关键词： Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next generation sequencing Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hölder,Sobolev,weak-type and BMO estimates in mixed-norm with weights for parabolic equations

引用

Science China Mathematics 2021年第1期64卷 129-154页

作者： Pablo raúl Stinga José l.Torrea Department of Mathematics Iowa State UniversityAmesIA50011USA Departamento de Matemáticas Universidad Autónoma de MadridMadrid28049Spain

We prove weighted mixed-norm lqt(W2,px)and lqt(C2,αx)estimates for 10,x∈Rn.x∈Rn,The coefficients a(t)=(aij(t))are just bounded,measurable,symmetric and uniformly ***,we show strong,weak type and BMO-Sobolev estimat... 详细信息

We prove weighted mixed-norm lqt(W2,px)and lqt(C2,αx)estimates for 1l∞t(lpx)−BMOt(W2,px)and l∞t(Cαx)−BMOt(C2,xx),and *** formulas for derivatives,for the solutions u=u(t,x)to parabolic equations of the form∂tu−aij(t)∂iju+u=f,t∈,x∈n and for the Cauchy problem{∂tv−aij(t)∂ijv+v=fv(0,x)forfort>0,x∈Rn.x∈Rn,The coefficients a(t)=(aij(t))are just bounded,measurable,symmetric and uniformly ***,we show strong,weak type and BMO-Sobolev estimates with parabolic Muckenhoupt *** is quite remarkable that most of our results are new even for the classical heat equation∂tu−Δu+u=f.

关键词： Calderón-Zygmund parabolic singular integrals weak type and BMO estimates representation formulas parabolic equations mixed-norm Sobolev and Schauder estimates

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

引用

Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Histone methylation in Huntington's disease:are bivalent promoters the critical targets?

引用

Neural Regeneration Research 2018年第7期13卷 1191-1192页

作者： Nóra Zsindely lászló Bodai Department of Biochemistry and Molecular Biology University of Szeged

Huntington’s disease（HD）is a currently incurable,late onset,progressive,ultimately fatal neurological disorder（Bates et al.,2015）.We have recently published the results of comprehensive genetic interaction tests aimed at identification of histone methyltransferases and demethylases involved in HD pathogenesis in a Drosophila model of the disease（Song et al.,2018）.

关键词： Histone methylation in Huntington’s disease:are bivalent promoters the critical targets PRC HD Mll

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multiple sclerosis is at a checkpoint: advancing the program

引用

Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

引用

Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Role of seed size, phenology, oogenesis and host distribution in the specificity and genetic structure of seed weevils (Curculio spp.) in mixed forests

引用

Integrative Zoology 2018年第3期13卷 267-279页

作者： Harold ARIAS-lEClAIRE raúl BONAl Daniel GARCÍA-lÓPEZ Josep Maria ESPElTA CREAF Centre for Ecological Research and Forestry ApplicationsCerdanyola del Vallès08193Spain Exact and Natural Sciences School State Distance University of Costa RicaUNEDMercedes de Montes de OcaSan JoséCosta Rica Forest Research Group INDEHESAUniversity of ExtremaduraPlasenciaSpain DITEG Research Group University of Castilla-La ManchaToledoSpain Zoology Department Autonomous University of BarcelonaCerdanyola del VallèsSpain

Synchrony between seed growth and oogenesis is suggested to largely shape trophic breadth of seed-feeding insects and ultimately to contribute to their co-existence by means of resource partitioning or in the time when infestation *** we investigated:(i)the role of seed phenology and sexual maturation of females in the host specificity of seed-feeding weevils(Curculio spp.)predating in hazel and oak mixed forests;and(ii)the consequences that trophic breadth and host distribution have in the genetic structure of the weevil *** analyses were used to establish unequivocally host specificity and to determine the population genetic *** identified 4 species with different specificity,namely Curculio nucum females matured earlier and infested a unique host(hazelnuts,Corylus avellana)while 3 species(Curculio venosus,Curculio glandium and Curculio elephas)predated upon the acorns of the 2 oaks(Quercus ilex and Quercus pubescens).The high specificity of *** coupled with a more discontinuous distribution of hazel trees resulted in a significant genetic structure among *** addition,the presence of an excess of local rare haplotypes indicated that *** populations went through genetic expansion after recent ***,these effects were not observed in the more generalist Curculio glandium predating upon ***,co-existence of weevil species in this multi-host-parasite system is influenced by both resource and time *** what extent the restriction in gene flow among *** populations may have negative consequences for their persistence in a time of increasing disturbances(*** in Mediterranean areas)deserves further research.

关键词： Corylus avellana Curculio spp. genetic structure Quercus spp. trophic breadth

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Distribution and space use of seed-dispersing rodents in central Pyrenees:implications for genetic diversity,conservation and plant recruitment

引用

Integrative Zoology 2018年第3期13卷 307-318页

作者： Jon URGOITI Alberto MUÑOZ Josep Maria ESPElTA raúl BONAl CREAF Cerdanyola del VallésCataloniaSpain Department of Didactics of Experimental Sciences Faculty of EducationUniversity Complutense of MadridMadridSpain Forest Research Group INDEHESAUniversity of ExtremaduraPlasenciaSpain DITEG Research Group University of Castilla-La ManchaToledoSpain Research group of Genetic and Cultural Biodiversity Research centre for Cinegetic Resources(CSIC-UCLM-JCCM)Ciudad RealSpain

The function and conservation of many forest ecosystems depend on the distribution and diversity of the community of rodents that consume and disperse *** habitat preferences and interactions are especially relevant in alpine systems where such granivorous rodents reach the southernmost limit of their distribution and are especially sensitive to global *** analyzed the community of granivorous rodents in the Pyrenees,one of the southernmost mountain ranges of *** species were identified by DNA with particular attention to the Apodemus species,which are prominent seed-dispersing rodents in *** confirmed for the first time the presence of the yellow-necked mouse,Apodemus flavicollis,in central Pyrenees,a typical Eurosiberian species that reaches its southernmost distribution limit in this *** also found the wood mouse,Apodemus sylvaticus,a related species more tolerant to Mediterranean *** rodents were spatially segregated by *** was rare at high altitudes,which might cause the genetic differentiation between populations of the different valleys reported *** also found other seed consumers like dormice,Elyomis quercinus,and voles,Myodes glareolus,with marked habitat *** suggest that population isolation among valleys may increase the genetic diversity of rodents,like *** also highlight the potential threat that global warming may represent for species linked to high-altitude refuges at the southern edge of its distribution,like Apodemus ***,we discuss how this threat may have a dimension in the conservation of alpine forests dispersed by these rodent populations.

关键词： DNA analysis Pyrenees rodents seed dispersal vegetation structure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineered biomimicry for harvesting solar energy:a bird’s eye view

引用

International Journal of Smart and Nano Materials 2013年第2期4卷 83-90页

作者： raúl J.Martín-Palma Akhlesh lakhtakia Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA

All three methodologies of engineered biomimicry–bioinspiration,biomimetics,and bioreplication–are represented in current research on harvesting solar *** processes and porous surfaces inspired by plants and certain marine animals,respectively,are being investigated for solar *** dye-sensitized solar cells deploy artificial photosynthesis,bioinspired nanostructuring of materials in solar cells improves *** textured coatings for solar cells have been shown to reduce optical reflectance and increase optical absorptance over a broad spectral *** lenses fabricated by a bioreplication technique offer similar promise for reduced reflectance by increasing the angular field of view.

关键词： bioinspiration biomimetics bioreplication solar cell artificial photosynthesis antireflective coating engineering biomimicry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

引用

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling lü Chunchi Zhang Dong liang lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：