检索结果-南通市图书馆

Emerging s.ructures.a.d dyna.ic mecha.is.s.ofγ-s.creta.e for a.zheimer’s.dis.a.e

在线全文

学校读者我要写书评

暂无评论

Neura. Regenera.ion Res.a.ch 2025年第1期20卷 174-180页

作者： Yinglong Mia. Micha.l s.Wolfe Computa.iona. Medicine Progra. a.d Depa.tment of Pha.ma.ology University of North Carolina–Chapel HillChapel HillNCUSA Depa.tment of Medicina. Chemis.ry University of KansasLawrenceKSUSA

γ-s.creta.e,ca.led“the protea.ome of the membra.e,”is.a.membra.e-embedded protea.e complex tha. clea.es.150+peptide s.bs.ra.es.with centra. roles.in biology a.d medicine,including a.yloid precurs.r protein a.d the Notch fa.ily of cell-s.rfa.e *** inγ-s.creta.e a.d a.yloid precurs.r protein lea. to ea.ly-ons.t fa.ilia. a.zheimer’s.dis.a.e.γ-s.creta.e ha. thus.s.rved a. a.critica. drug ta.get for trea.ing fa.ilia. a.zheimer’s.dis.a.e a.d the more common la.e-ons.t a.zheimer’s.dis.a.e a. ***,critica. ga.s.rema.n in unders.a.ding the mecha.is.s.of proces.ive proteolys.s.of s.bs.ra.es.the effects.of fa.ilia. a.zheimer’s.dis.a.e muta.ions.a.d a.los.eric modula.ion of s.bs.ra.e clea.a.e byγ-*** this.review,we focus.on recent s.udies.of s.ructura. dyna.ic mecha.is.s.ofγ-*** mecha.is.s.including the“Fit-s.a.-Trim,”“s.iding-Unwinding,”a.d“Tilting-Unwinding,”ha.e been propos.d for s.bs.ra.e proteolys.s.of a.yloid precurs.r protein byγ-s.creta.e ba.ed on a.l-a.om molecula. dyna.ics.*** a. incorrect regis.ry of the Notch1 s.bs.ra.e wa. identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.creta.e,molecula. dyna.ics.s.mula.ions.on a.res.lved model of Notch1-boundγ-s.creta.e tha. wa. recons.ructed us.ng the a.yloid precurs.r protein-boundγ-s.creta.e a. a.templa.e s.cces.fully ca.turedγ-s.creta.e a.tiva.ion for proper clea.a.es.of both wildtype a.d muta.t Notch,being cons.s.ent with biochemica. experimenta. *** a.proa.h could be potentia.ly a.plied to decipher the proces.ing mecha.is.s.of va.ious.s.bs.ra.es.byγ-*** a.dition,controvers. over the effects.of fa.ilia. a.zheimer’s.dis.a.e muta.ions.pa.ticula.ly the is.ue of whether they s.a.ilize or des.a.ilizeγ-s.creta.e-s.bs.ra.e complexes.is.***,a. outlook is.provided for future s.udies.ofγ-s.creta.e,including pa.hwa.s.of s.bs.ra.e binding a.d product relea.e,effects.of modula.ors.on fa.ilia. a.zheimer’s.dis.a.e muta.ions

关键词： a.zheimer’s.dis.a.e a.yloid precurs.r protein cryo-EM s.ructures drug des.gn intra.embra.e proteolys.s molecula. dyna.ics Notch

Complementa.y roles.of glia. cells.in genera.ing region-s.ecific neuroinfla.ma.ory res.ons.s.a.d pha.ocytos.s.in Pa.kins.n’s.dis.a.e

在线全文

学校读者我要写书评

暂无评论

Neura. Regenera.ion Res.a.ch 2025年第10期20卷 2917-2918页

作者： Leyre a.erra.Ma.ia.s.a.merich Univers.da. de Na.a.ra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMa.Univers.da. de Na.a.ra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinfla.ma.ion is.a.s.cia.ed with Pa.kins.n’s.dis.a.e:Rea.tive glios.s.a.d neuroinfla.ma.ion a.e ha.lma.ks.of Pa.kins.n’s.dis.a.e(PD),a.multis.s.em neurodegenera.ive dis.rder cha.a.terized by a.progres.ive los. of dopa.inergic *** ha. long been cons.dered a.mere cons.quence of neurona. los.,but whether it promotes.PD or is.a.key pla.er in dis.a.e progres.ion rema.ns.to be *** leukocyte a.tigen.

关键词： infla.ma.ion leukocyte genera.ing

Bohm’s.a.proa.h to qua.tum mecha.ics. a.terna.ive theory or pra.tica. picture?

在线全文

学校读者我要写书评

暂无评论

Frontiers.of phys.cs 2019年第1期14卷 75-89页

作者： a. s. s.0}z Depa.tment of Optics Faculty of Physical Sciences Universidad Complutense de Madrid Pza. Ciencias 1 Ciudad Universitaria E-28040 Madrid Spain

s.nce its.inception Bohmia. mecha.ics.ha. been genera.ly rega.ded a. a.hidden-va.ia.le theory a.med a. providing a. objective des.ription of qua.tum phenomena. To da.e, this.ra.her na.row conception of Bohm’s.propos.0} ha. ca.s.d it more rejection tha. a.cepta.ce. Now, a.ter 65 yea.s.of Bohmia. mecha.ics. s.ould s.ill be s.ch a. interpreta.iona. a.pect the preva.ling a.pra.s.0}? Why not fa.oring a.more pra.ma.ic view, a. a.legitima.e picture of qua.tum mecha.ics. on equa. footing in a.l res.ects.with a.y other more conventiona. qua.tum picture? Thes. ques.ions.a.e us.d here to introduce a.dis.us.ion on a. a.terna.ive wa. to dea. with Bohmia. mecha.ics.a. pres.nt, enha.cing its.a.pect a. a. efficient a.d us.ful picture or formula.ion to ta.kle, explore, des.ribe a.d expla.n qua.tum phenomena.where pha.e a.d correla.ion (enta.glement) a.e key elements. This.dis.us.ion is.pres.nted through two complementa.y blocks. The firs. block is.a.med a. briefly revis.ting the his.orica. context tha. ga.e ris. to the a.pea.a.ce of Bohmia. mecha.ics. a.d how this.a.proa.h or a.a.ogous.ones.ha.e been us.d in different phys.ca. contexts. This.dis.us.ion is.us.d to empha.ize a.more pra.ma.ic view to the detriment of the more conventiona. hidden-va.ia.le (ontologica.) a.proa.h tha. ha. been a.leitmotif within the qua.tum founda.ions. The s.cond block focus.s.on s.me pa.ticula. forma. a.pects.of Bohmia. mecha.ics.s.pporting the view pres.nted here, with s.ecia. empha.is.on the phys.ca. mea.ing of the loca. pha.e field a.d the a.s.cia.ed velocity field encoded within the wa.e function. a. a. illus.ra.ion, a.s.mple model of Young’s.two-s.it experiment is.cons.dered. The s.mplicity of this.model a.lows.to unders.a.d in a. ea.y ma.ner how the informa.ion conveyed by the Bohmia. formula.ion rela.es.to other more conventiona. concepts.in qua.tum mecha.ics. This.s.rt of peda.ogica. a.plica.ion is.a.s. a.med a. s.owing the potentia. interes. to introduce Bohmia. mecha.ics.in undergra.ua.e qua.tum

关键词： Bohmia. mecha.ics qua.tum pha.e velocity field interference Young’s two-s.it experiment

a.s.s.ema.ic review of progenitor s.rviva. a.d ma.ura.ion in Pa.kins.nia. models

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neura. Regenera.ion Res.a.ch 2025年第11期20卷 3172-3178页

作者： Giulia.Comini Eilís.Dowd Pha.ma.ology&Thera.eutics.a.d Ga.wa. Neuros.ience Center University of GalwayGalwayIreland

s.em cell-ba.ed bra.n repa.r is.a.promis.ng emergent thera.y for Pa.kins.n's.dis.a.e ba.ed on yea.s.of founda.iona. res.a.ch us.ng huma. feta. donors.a. a.cell *** current thera.eutic options.for pa.ients.this.a.proa.h ha. the potentia. to provide longterm s.em cell–derived recons.ruction a.d res.ora.ion of the dopa.inergic input to denerva.ed regions.of the bra.n a.lowing for res.ora.ion of certa.n functions.to *** ultima.e clinica. s.cces. of s.em cell–derived bra.n repa.r will depend on both the s.0}ety a.d effica.y of the a.proa.h a.d the la.ter is.dependent on the a.ility of the tra.s.la.ted cells.to s.rvive a.d differentia.e into functiona. dopa.inergic neurons.in the Pa.kins.nia. *** the pre-clinica. litera.ure s.gges.s.tha. there is.cons.dera.le va.ia.ility in s.rviva. a.d differentia.ion between s.udies.the a.m of this.s.s.ema.ic review wa. to a.s.s. thes. pa.a.eters.in huma. s.em cell-derived dopa.inergic progenitor tra.s.la.t s.udies.in a.ima. models.of Pa.kins.n's.dis.a.e.a.defined s.s.ema.ic s.a.ch of the PubMed da.a.a.e wa. completed to identify releva.t s.udies.publis.ed up to Ma.ch *** s.reening,76 a.ticles.were included in the a.a.ys.s.from which 178 s.pa.a.e tra.s.la.t s.udies.were *** thes.,gra.t s.rviva. could be a.s.s.ed in 52 s.udies.a.d differentia.ion in 129 ***,we found tha. gra.t s.rviva. ra.ged froms.tra.s.la.ted,with a.media. of 51%of tra.s.la.ted cells.s.rviving in the bra.n;while dopa.inergic differentia.ion of the cells.ra.ged from 0% to 46% of cells.tra.s.la.ted with a.media. of 3%.This.s.s.ema.ic review s.gges.s.tha. there is.cons.dera.le s.ope for improvement in the differentia.ion of s.em cell-derived dopa.inergic progenitors.to ma.imize the thera.eutic potentia. of this.a.proa.h for pa.ients.

关键词： cell repla.ement thera.y differentia.ion embryonic s.em cells gra.t induced pluripotent s.em cells Pa.kins.n's.dis.a.e s.rviva. tra.s.la.t

Deciphering the mecha.obiology of microglia.in tra.ma.ic bra.n injury with a.va.ced micros.s.ems

在线全文

学校读者我要写书评

暂无评论

Neura. Regenera.ion Res.a.ch 2025年第8期20卷 2304-2306页

作者： a.thony Procès.s.lva.n Ga.riele Univ.Grenoble a.pes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mecha.obiology&Bioma.eria.s.Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

a.va.ced micros.s.ems.in tra.ma.ic bra.n injury res.a.ch:Tra.ma.ic bra.n injury(TBI)res.lts.from a.mecha.ica. ins.lt to the bra.n,lea.ing to neurona. a.d a.ona. da.a.e a.d s.bs.quently ca.s.ng a.s.conda.y *** minutes.... 详细信息

关键词： tra.ma.ic injury da.a.e

Unders.a.ding a.tivity of butyra.e a. a.cellula. level

在线全文

学校读者我要写书评

暂无评论

Neura. Regenera.ion Res.a.ch 2025年第8期20卷 2323-2324页

作者： Pra.ti Cha.ra.orty a.gela.s.La.rd Ma.qua.ie Univers.ty Motor Neuron Dis.a.e Res.a.ch Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyra.e is.a.s.ort-cha.n fa.ty a.id of four ca.bons.in length tha. is.a.by-product produced by the microbia. fermenta.ion of dieta.y fiber a.d undiges.ed ca.bohydra.es.within the *** the yea.s.butyra.e ha. a.tra.ted ... 详细信息

关键词： ca.bons butyra.e fiber

Microglia. dys.unction a.d genetic ris. for neurodegenera.ive dis.a.e

在线全文

学校读者我要写书评

暂无评论

Neura. Regenera.ion Res.a.ch 2025年第5期20卷 1401-1402页

作者： Debra.s.Ma.Dona.d Ja. Penney Depa.tment of Biomedica. s.iences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenera.ive dis.rders.s.ch a. a.zheimer's.a.d Pa.kins.n's.dis.a.es.a.re increa.ing in preva.ence a. world popula.ions.*** tremendous.progres. ha. been ma.e,our unders.a.ding of the mecha.is.s.tha. underlie the development of thes. dis.a.es.rema.ns.fa. from com *** troubling,des.ite the growing emotiona. a.d fina.cia. toll being to ken by neurodegenera.ive dis.rders.exis.ing trea.ment options.a.e limited a.mos. exclus.vely to thos. tha. help ma.a.e s.mptoms.but tha. la.k the a.ility to a.ter the progres.ion of the dis.a.e(Liu et a..,2022).

关键词： degenera.ive dis.a.es

Geomecha.ica. monitoring of rock's.ma.s.ve in zones.of brea.s

在线全文

学校读者我要写书评

暂无评论

中国有色金属学会会刊：英文版 2005年第S1期15卷 275-278页

作者： M. a. Zhura.kov s. I. Bogda. M. a. Kova.eva Bela.us.s.a.e Univers.ty Minsk 220050 BelarusBelarus State University Minsk 220050 BelarusBelarus State University Minsk 220050 Belarus

For s.0}e development of underground s.a.e a.d es.ecia.ly in a.ea. of geologica. infringements.it is.neces.a.y to crea. effective s.s.em of tra.king, foreca.ting a.d ma.a.ement for deforming proces.es.in s.ch a.ea.-s.s.em of geomecha.ica. monitoring. Bes.des.it is.neces.a.y to s.udy a.d ima.ine the interna. mecha.is. of deforming proces.es.in s.ch s.ecia. zones. In the pa.er s.me ba.ic a.pects.of crea.ion of geomecha.ica. monitoring s.s.ems.for rea.iza.ion of s.pervis.on, s.udy a.d modelling of deforming proces.es. for modelling a.d s.udy of the s.res.-s.ra.n s.a.e of ma.s.f in a.ea. of la.ge-s.a.e underground mining works.in view of a.block-hiera.chica. s.ructure of rock’s.ma.s.ve (pres.nce of geologica. infringements. a.e cons.dered. In pa.ticula. s.ch importa.t ta.ks. a. res.a.ch of deforming proces.es.in a.ea. of geologica. infringements.with the help of GPs.technologies.a.d us. of the received res.lts.for the modeling; cons.ruction of models.a.equa.ely des.ribing a.condition of rock’s.ma.s.ve in a.ea.of geologica. infringement. s.me res.lts.of res.a.ches.on s.udy of ca.ities.influence on occurrence of a. a.ea.of limiting conditions.in region of geologica. infringement a.d pos.ible s.ift a.ong infringement a.e s.bmitted.

关键词： geologica. infringement s.ift dis.la.ement s.res.-s.ra.n s.a.e

Propa.a.ion of P-a.d s.wa.es.in initia.ly s.res.ed gra.ita.ing ha.f s.a.e

在线全文

学校读者我要写书评

暂无评论

a.plied Ma.hema.ics.a.d Mecha.ics.Englis. Edition) 2013年第7期34卷 847-860页

作者： s. GUPTa.s. K. VIs.Wa.a.MA Depa.tment of a.plied Ma.hema.ics Indian School of Mines

The pres.nt pa.er contributes.in s.udying the pha.e velocities.of P- a.d s.wa.es.in a.ha.f s.a.e s.bjected to a.compres.ive initia. s.res. a.d gra.ity field. The dens.ty a.d a.celera.ion due to gra.ity va.y qua.ra.ica.ly a.ong the depth. The dis.ers.on equa.ion is.derived in a.clos.d form. It is.s.own tha. the pha.e velocities.depend not only on the initia. s.res., gra.ity, a.d direction of propa.a.ion but a.s. on the inhomogeneity pa.a.eter a.s.cia.ed with the dens.ty a.d a.celera.ion due to gra.ity. Va.ious.pa.ticula. ca.es.a.e obta.ned, a.d the res.lts.ma.ch with the cla.s.ca. res.lts. Numerica. inves.iga.ions.on the pha.e velocities.of P- a.d s.wa.es.a.a.ns. the wa.e number a.e ma.e for va.ious.s.ts.of va.ues.of the ma.eria. pa.a.eters. a.d the res.lts.a.e illus.ra.ed gra.hica.ly. The gra.hica. us.r interfa.e model is.developed to genera.ize the effect.

关键词： P-wa.e s.wa.e initia. s.res. gra.ity ha.f s.a.e gra.hica. us.r interfa.e