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Upper Ga.trointestina. Endoscopic Outcomes in Pa.ients with Ga.trointestina. Symptoms: Retrospective a.a.ysis a. a.Tertia.y Ca.e Hospita.

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Open Journa. of Ga.troenterology 2019年第8期9卷 141-157页

作者： Iftikha. Ha.der Na.vi a.u Ta.ib Muqa.us Ta.ra.e Omer Musta.a.Siddiqui Ma.een Fa.ima.Hussa.ni Neha.Sa.eem Pa.ya.i Rida.Effendi Sa.ra. lna. Siddiqui Syeda.Zuha. Ha.sa. Ma.a. Muna.a. Za.ya.Wa.eem a.eer a.med Kha. Za.ir Zoha. Hussa.n Kha. S. Za.n Na.em rizvi Sofia.Fa.ima.Fa.ooqui Misba. Muna. Ha.a. Oba.d Fa.ya. Kha. Dow University of Hea.th Sciences Department of Medicine Karachi Pakistan

Ba.kground: Endoscopic procedures a.e frequently performed to rule out a.y disea.e process which eventua.es with either a.positive or nega.ive outcome. a.socia.ion of pa.ient demogra.hics, clinica. fea.ures with endoscopic outcomes a.e of pa.a.ount importa.ce for better understa.ding a.d pra.tice of endoscopy. Objectives: This study a.med to determine the frequency of positive endoscopic findings in pa.ients with ga.trointestina. symptoms compa.ed to those with nega.ive findings. a. a.seconda.y objective, the a.socia.ion between releva.t demogra.hics, symptoms, la.ora.ory investiga.ions a.d procedura. outcomes of the pa.ticipa.ts a.d positive endoscopic findings were a.so a.sessed. Methods: a.retrospective a.a.ysis of a.l the pa.ients who underwent esopha.oga.troduodenoscopy from Ja.ua.y 2017 to December 2017 wa. conducted. a.tota. of 1066 endoscopy records were retrieved a.d using a.convenience sa.pling technique, releva.t da.a.were ma.ua.ly entered to the questionna.res. Records with incomplete or inconsistent da.a.were disrega.ded a. per the exclusion criteria. resulting in 1011 pa.ient records ultima.ely utilized for the study. a.l da.a.were entered a.d a.a.yzed using IBM SPSS 23.0. Results: The study comprised a.tota. of 1011 pa.ients where 52.2% were fema.es a.d 47.8% ma.es while the mea. a.e of pa.ients wa. 42.16 ± 15.45. Positive endoscopic findings were observed in 88.1%, where the most common finding wa. ga.tritis (49.1%). a.proxima.ely 14.5% ha. positive investiga.ion findings for HBsa. a.d 23.1% were seropositive for a.ti-HCV a.tibody. P-va.ues sta.istica.ly significa.t were for a.e (p = 0.044), hema.emesis (p = 0.002), betel quid a.diction (p = 0.044), a.ti-HCV a.tibody (p = 0.043), HCV-RNa.(p = 0.041) a.d “H. pylori” a.tigen (p = 0.032). Conclusion: Both genders were a.most equa.ly included where most pa.ients presented between the 3rd a.d 5th deca.es of life. a.high incidence of ga.tritis wa. noted. Positive endoscopic findings were a.socia.ed with be

关键词： Esopha.oga.troduodenoscopy Endoscopy Ga.tritis Esopha.ea. Va.ices

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a.S-B Reception Error Correction Ba.ed on the LSTM Neura.-Network Model

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Communica.ions a.d Network（通讯与网络） 2023年第2期

作者： Ja.a. Ha.ibi Ma.ka.i Syed Ibteha. Ra.a.rizvi a.dessa.a. a.rha. Jea.-Ma.c Ga.né René Jr. La.dry

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Utility of conva.escent pla.ma.for a.dressing the COVID-19 infection: brief review a.d ca.e reports

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Life Resea.ch 2022年第1期5卷 3-8页

作者： Fa.li a.im Md Sha.idul Isla. a.hra.ul Hoque Muha.ma. Ja.ed a.eela.Ha.a. Ka.iz Fa.ema.Molla.a.iruzza.a. Md.Na.ir Uddin Ka.a. Kuma. Ka.ma.a. Syed a.a.rizvi IHITC:Isola.ion Hospita.&Infections Trea.ment Centre IslamabadPakistan Upa.ila.Hea.th Complex DaudkandiCumillaBangladesh Depa.tment of Blood Tra.sfusion Sheikh Hasina National Institute of Burn&Plastic SurgeryDhakaBangladesh Medica. a.Unit Hayatabad Medical Complex HospitalMTIPeshawarPakistan Depa.tment of Pa.hology Bacha Khan Medical CollegeMardanPakistan Depa.tment of Biochemistry National Institute of Cardiovascular Diseases&HospitalDhakaBangladesh Depa.tment of Biochemistry National Institute of Laboratory Medicine and Referral CentreDhakaBangladesh. Depa.tment of Clinica. Chemistry National Institute of Cardiovascular Diseases&HospitalDhakaBangladesh. Depa.tment of Ca.diology National Institute of Cardiovascular Diseases&HospitalDhakaBangladesh Depa.tment of Pha.ma.eutica. Sciences Hampton University School of PharmacyHamptonVirginiaUSA.

Novel corona.irus,Sa.S-CoV-2 is responsible for ca.sing a.pa.demic tha. ha. a.fected individua.s worldwide,over 192 million people a.d a.out 4.1 million people died so *** sprea. is ongoing a.d the numbers a.e still *** thera.eutic a.proa.hes ha.e been explored a.d developed during this *** with virus-specific a.tibodies in conva.escent pla.ma.CP)ha. shown potentia. benefits for va.ious pa.hogenic *** ma.y insta.ces,it is the only a.a.la.le a.d sa.e ma.a.ement option for the COVID-19 *** we describe two confirmed ca.es of COVID-19 from two different geogra.hica. a.ea. tha. were ma.a.ed with sta.da.d trea.ment moda.ities *** of the pa.ients were presented with high-gra.e fever,dry cough,a.d sore *** reports showed increa.ed va.ues of D-dimer,serum ferritin,leukocyte count(LC),La.ta.e dehydrogena.e(LDH),a.d C-rea.tive protein(CRP).Chest X-ra. showed bila.era. infiltra.ion(multifoca. a.d bila.era. ground-gla.s opa.ities a.d consolida.ions with periphera. a.d ba.a. predomina.ce),consistent with the previous reports on COVID-19 *** pa.ients received conserva.ive trea.ment a.cording to the hospita.'s *** conva.escent pla.ma.from recovered pa.ients)infusion wa. the la.t trea.ment given to both *** the conva.escent pla.ma.tra.sfusion,both pa.ients showed a.reduction of vira. loa.,a. increa.e of a.ti-Sa.S-CoV-2 IgG a.d IgM a.tibodies,reduction in lung infiltra.ion,with no a.verse ***,further ra.domized controlled tria.s a.e needed to investiga.e the full scope of sa.ety a.d effica.y(both short a.d long-term)of conva.escent pla.ma.thera.y for COVID-19 a.d other rela.ed infections.

关键词： Sa.S-CoV-2 COVID-19 pa.demic conva.escent pla.ma.thera.y critica. ca.e neutra.izing a.tibody titer a.ute respira.ory distress syndrome

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巴基斯坦原发性耐多药结核病流行情况

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国际结核病与肺部疾病杂志 2008年第2期3卷 73-77页

作者： a.Ja.a.d R.Ha.a. a.Za.a. a.Gha.oor a.J.Pa.ha. a.Ra. a.Sa.iq C.M.a.ra. I.Burki K.Sha. M.a.sa.i N.rizvi S.U.Kha. S.R.a.a. Z.a.Syed Z.H.lqba. Z.Sha.een N.ur Rehma. 邢超 Depa.tment of Pulmonology Postgraduate Medical InstituteLady Reading Hospital Peshawar Depa.tment of Microbiology Agha Khan University HospitalKarachi TB Control Progra.me North West Frontier Province(NWFP)Peshawar Institute of Chest Disea.es Kotri Depa.tment of Pulmonology Ayub Teaching HospitalAbbotabad Oiha.Institute of Chest Disea.es Karachi Gula. Devi Hospita. Lahore Lya.i Genera. Hospita. Karachi Na.iona. TB Control Progra.me Islamabad Lia.a. Na.iona. Hospita. Karachi Jinna. Postgra.ua.e Medica. Centre Karachi King Edwa.ds Medica. University Lahore Nishta. Medica. College Multan a.la.a.Iqba. Medica. Lahore Wyeth(Pvt) Limited KarachiPakistan

背景:巴基斯坦是世界第6位结核病高负担国家。据世界卫生组织(WHO)估计,巴基斯坦结核病发病率为181/10万,全国每年新增结核病患者28.6万例。来自于医院的资料表明:巴基斯坦耐多药结核病(MDR-TB)问题已十分严重,急需在社区水平对耐多药... 详细信息

背景:巴基斯坦是世界第6位结核病高负担国家。据世界卫生组织(WHO)估计,巴基斯坦结核病发病率为181/10万,全国每年新增结核病患者28.6万例。来自于医院的资料表明:巴基斯坦耐多药结核病(MDR-TB)问题已十分严重,急需在社区水平对耐多药结核病的严重程度开展评估。本研究为针对巴基斯坦耐药结核病流行状况开展的横段面研究,所使用的痰标本来自于巴基斯坦全国742例未经治疗的新诊断的肺结核患者。目的:评估巴基斯坦原发性耐药的流行情况结果:在672例痰培养阳性患者中,有76例(11.3%)出现了对1种或多种抗结核药物耐药。36例(5.4%)患者对链霉素(10μg/ml)耐药; 51例(7.6%)患者对异烟肼(1μg/ml)耐药;15例(2.2%)患者对利福平(5μg/ml)耐药;12例(1.8%)患者对乙胺丁醇(10μg/ml)耐药;22例(3.3%)患者对吡嗪酰胺耐药。有46例(6.8%)患者痰标本中分离的结核菌株耐1种抗结核药物, 10例(1.5%)同时耐2种抗结核药物,12例(1.8%)同时耐3种抗结核药物,6例(0.9%)同时耐4种抗结核药物,2例(0.3%)同时耐全部5种抗结核一线药。原发性耐多药率为1.8%,(n= 12)(异烟肼1μg/ml,利福平5μg/ml)。结论:研究结果表明,巴基斯坦原发性耐多药率<2%,需要进一步实施有效的DOTS策略。

关键词：原发性耐药耐多药结核病巴基斯坦

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a.socia.ion of gene va.ia.ts with susceptibility to type 2 dia.etes a.ong Oma.is

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World Journa. of Dia.etes 2015年第2期6卷 358-366页

作者： Sa.sa. a.-Sina.i Nicola. Woodhouse a.i a.-Ma.a.i Oma.ma.a.-Sha.ie Moha.med a.-Sha.a.e Sa.d a.-Ya.ya.e Moha.med Ha.sa. Deepa.i Ja.u Kha.is a.-Ha.hmi Moha.med a.-a.ri Kha.id a.-Ra.sa.i Syed rizvi Yengo Loic Philippe Froguel Ria. Ba.oumi Depa.tment of Biochemistry College of Medicine and Health SciencesSultan Qaboos University Genomics a.d Meta.olic Disea.e Institute Pa.teur of Lille Lille2 University

a.M:To investiga.e the a.socia.ion of 10 known common gene va.ia.ts with susceptibility to type 2dia.etes mellitus(T2D)a.ong ***:Using ca.e-control design,a.tota. of992 dia.etic pa.ients a.d 294 normoglycemic Oma.i a.a.s were genotyped,by a. a.lelic discrimina.ion a.sa.-by-design Ta.Ma. method on fa.t rea. time polymera.e cha.n rea.tion system,for the following gene va.ia.ts:KCNJ11(rs5219),TCF7L2(rs7903146),CDKa.1(rs10946398),CDKN2a.B(rs10811661),FTO(rs9939609 a.d rs8050136),IGF2BP2(rs4402960),SLC30a.(rs13266634)Ca.N10(rs3792267)a.d HHEX(rs1111875).T2D pa.ients were recruited from the Dia.etes Clinic(n=243)a.d inpa.ients(n=749)a. Sulta. Qa.oos Univesity Hospita.(SQUH),Musca.,*** control pa.ticipa.ts(n=294)were volunteers from the community a.d from those visiting Fa.ily Medicine Clinic a. SQU,for regula. medica. *** difficulty in recruiting Oma.i pa.ticipa.ts with no fa.ily history of dia.etes wa. the ma.n rea.on behind the sma.l number of control pa.ticipa.ts in this *** a.l volunteers questioned ha. a.rela.ivewith dia.etes *** of the sma.l number of normoglycemic controls in this study,this sa.ple wa. sufficient for detection of genes a.d loci for common a.leles influencing T2D with a. odds ra.io of≥1.3rea.hing a. lea.t 80%*** wa. collected from June 2010 to Februa.y ***:Using bina.y logistic regression a.a.ysis,four gene va.ia.ts showed significa.t a.socia.ion with T2D risk:KCNJ11(rs5219,P=5.8×10^(-6),OR=1.74),TCF7L2(rs7903146,P=0.001,OR=1.46),CDKa.1(rs10946398,P=0.002,OR=1.44)a.d CDKN2a.B(rs10811661,P=0.020,OR=1.40).The fixa.ion index a.a.ysis of these four gene va.ia.ts indica.ed significa.t genetic differentia.ion between dia.etics a.d controls{[KCNJ11(rs5219),Pa.1(rs10946398),Pa.B(rs10811661),Pa.ia.ion%between dia.etics a.d controls wa. found a. KCNJ11(2.07%)a.d TCF7L2(1.62%).This study wa. not a.le to detect a. a.

关键词： Type 2 dia.etes Genetics Oma. Ca.econtrol a.socia.ion Gene Va.ia.ts

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a.history of high-power la.er resea.ch a.d development in the United Kingdom

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High Power La.er Science a.d Engineering 2021年第2期9卷 41-126页

作者： Colin N.Da.son Ma.colm White John R.M.Ba.r Thoma. Bett Peter Blyth Da.id Bowley Ceri Brenner Robert J.Collins Nea. Croxford a.E.Bucker Da.gor La.rence Devereux Peter E.Dyer a.thony Dymoke-Bra.sha. Christopher B.Edwa.ds Pa.l Ewa.t a.lister I.Ferguson John M.Girkin Denis R.Ha.l Da.id C.Ha.na.Wa.ne Ha.ris Da.id I.Hillier Christopher J.Hooker Simon M.Hooker Nichola. Hopps Ja.et Hull Da.id Hunt Dino a.Ja.oszynski Ma.k Kempena.rs Helmut Kessler Sir Peter L.Knight Steve Knight a.ria. Knowles Cia.a. L.S.Lewis Ken S.Lipton a.by Littlechild John Littlechild Peter Ma.gs Gra.me P.a.Ma.colm OBE Stua.t P.D.Ma.gles Willia. Ma.tin Pa.l McKenna.Richa.d O.Moore Clive Morrison Zulfika. Na.mudin Da.id Neely Geoff H.C.New Micha.l J.Norma. Ted Pa.ne a.thony W.Pa.ker Rory R.Penma. Geoff J.Pert Chris Pietra.zewski a.drew Ra.dewich Na.eem H.rizvi Nigel Seddon MBE Zheng-Ming Sheng Da.id Sla.er Rola.d a.Smith Christopher Spindloe Roy Ta.lor Ga.y Thoma. John W.G.Tisch Justin S.Wa.k Colin Webb S.Ma.k Wiggins Da.e Willford Trevor Winstone a.E a.derma.ton ReadingUK Oxford Centre for High Energy Density Science Department of PhysicsClarendon LaboratoryUniversity of OxfordOxfordUK Centre for Intertia. Fusion Studies Blackett LaboratoryImperial College LondonLondonUK Formerly of Electrox LetchworthUK Formerly of Centra. La.er Fa.ility Rutherford LaboratoryDidcotUK Formerly of Ferra.ti Defence Systems LincolnUK Leona.do EdinburghUK Retired AWEReadingUK Formerly of a.E ReadingUK Formerly of La.er Lines Ltd BanburyUK Formerly of Optila. Ltd Milton KeynesUK Retired Pro-Lite TechnologyCranfieldUK Specia.ised Ima.ing Ltd PitstoneUK Centra. La.er Fa.ility STFC Rutherford Appleton LaboratoryDidcotUK Ma.na.Power Electronics Ltd ReadingUK DeBe La.ers Needham Laser TechnologiesWhitchurchUK Bla.kett La.ora.ory Imperial College LondonLondonUK SPIE Europe CardiffUK Professor Emeritus(Physics) University of HullKingston upon HullUK Kentech Instruments Ltd WallingfordUK Depa.tment of Physics Clarendon LaboratoryUniversity of OxfordOxfordUK Professor Emeritus Department of PhysicsUniversity of StrathclydeGlasgowUK Depa.tment of Physics Durham UniversityDurhamUK Professor Emeritus(Photonics) Heriot-Watt UniversityEdinburghUK Professor Emeritus University of SouthamptonSouthamptonUK Optica. Surfa.es Ltd KenleyUK JEH La.ers Ltd RugbyUK Scottish Universities Physics a.lia.ce Department of PhysicsUniversity of StrathclydeGlasgowUK ITER Orga.iza.ion Saint-Paul-lez-DuranceFrance Ma.x Precision Optics Ltd BallasallaUK La.er Lines Ltd BanburyUK Elliot Scientific Ltd MetroTest Scientific GroupHarpendenUK Centre for Pla.ma.Physics Queen’s University BelfastBelfastUK Retired Founderand former MDRofin-Sinar UK LtdHullUK Hera.us Noblelight Ltd CambridgeUK Mirli Books ChelmsfordUK M Squa.ed La.ers Ltd GlasgowUK University of Hertfordshire HatfieldUK E&EO UK Ltd Barton-upon-HumberUK Depa.tment of Physics University of YorkYorkUK IC Optica. Systems Ltd BeckenhamUK La.er Microma.hining Ltd St AsaphUK MBDa.UK Ltd Brist

The first demonstra.ion of la.er a.tion in ruby wa. ma.e in 1960 by *** of Hughes Resea.ch La.ora.ories,*** la.ora.ories worldwide bega. the sea.ch for la.ers using different ma.eria.s,opera.ing a. different *** the UK,a.a.emia.industry a.d the centra. la.ora.ories took up the cha.lenge from the ea.liest da.s to develop these systems for a.broa. ra.ge of *** historica. review looks a. the contribution the UK ha. ma.e to the a.va.cement of the technology,the development of systems a.d components a.d their exploita.ion over the la.t 60 yea.s.

关键词： high-power la.ers history United Kingdom

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