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Neuro.nfla.ma.io. revisited thro.gh the micro.lia. lens

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Neura. Regenera.io. Resea.ch 2025年第7期20卷 1989-1990页

作者： Rena.o.So.o.a.o.Jo.0}o.B.Relva. Institute o. Resea.ch a.d Inno.a.io. in Hea.th(i3S)a.d Institute fo. Mo.ecula. a.d Cell Bio.o.y(IBMC) University of PortoPortoPortugal depa.tment o. Bio.edicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuro.mmuno.o.y is emerging a. a.pivo.a. field,shedding light o. the intrica.e dia.o.ues between the centra. nervo.s system(CNS)a.d the immune *** explo.a.io. is pa.ticula.ly significa.t in understa.ding micro.lia.the CNS’s inna.e immune cells,beyo.d the co.ventio.a. co.fla.io. o.“neuro.nfla.ma.io.”a.d“micro.lia. a.tiva.io..”This co.fla.io. ha. clo.ded the true co.plexity o. these pro.esses,po.entia.ly sta.ling scientific pro.ress a.d the develo.ment o. new *** cha.lenge the lo.g-sta.ding perspectives tha. ha.e o.ersimplified these intera.tio.s,a.vo.a.ing fo. a.deeper explo.a.io. o. the dyna.ic rela.io.ship between neuro.nfla.ma.io. a.d micro.lia. *** dissecting specific mo.ecula. pa.hwa.s,we a.m to.illumina.e their ela.o.a.e ro.es in neuro.nfla.ma.o.y respo.ses,especia.ly in the co.text o. a.zheimer’s disea.e(a.).Here,neuro.nfla.ma.io. is no. merely a.pa.sive o.server o. a.direct a.ta.o.ist but a.co.plex a.ent in the disea.e’s *** a.ticle ca.ls fo. a.significa.t pa.a.igm shift to.a.ds a. integra.ive,multi-o.ics a.pro.0}h to.*** such a.co.prehensive fra.ewo.k is crucia. fo. a.va.cing o.r understa.ding o. neuro.nfla.ma.o.y co.ditio.s a.d pa.ing the wa. fo. ta.geted thera.eutic stra.egies fo. bra.n disea.es.

关键词： infla.ma.io. simplified a.tiva.io.

Co.tributio. o. mecha.ica. fo.ces to.structura. syna.tic pla.ticity:insights fro. 3D cellula. mo.ility mecha.isms

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Neura. Regenera.io. Resea.ch 2025年第7期20卷 1995-1996页

作者： Rita.o.Teo.o.o.Ma.a.da.Ribeiro.Ra.o. La.a.Ca.va.ho iNo.a.Hea.th NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,a.d o.ga.s a.e co.sta.tly subjected to.the a.tio. o. mecha.ica. fo.ces fro. the extra.ellula. enviro.ment-a.d the nervo.s system is no.***-intrinsic pro.erties such a. membra.e lipid co.po.itio.,a.unda.ce o. mecha.o.enso.s,a.d cyto.keleta. dyna.ics ma.e cells mo.e o. less likely to.sense these *** a.d extrinsic cues a.e integra.ed by cells a.d this co.bined info.ma.io. determines the ra.e a.d dyna.ics o. membra.e pro.rusio. gro.th o. retra.tio.(Ya.a.a.a.d Sixt,2019).Cell pro.rusio.s a.e extensio.s o. the pla.ma.membra.e tha. pla. crucia. ro.es in diverse co.texts such a. cell migra.io. a.d neuro.a. syna.se *** the nervo.s system,neuro.s a.e highly dyna.ic cells tha. ca. cha.ge the size a.d number o. their pre-a.d po.tsyna.tic elements(ca.led syna.tic bo.to.s a.d dendritic spines,respectively),in respo.se to.cha.ges in the levels o. syna.tic a.tivity thro.gh a.pro.ess ca.led *** pla.ticity is a.ha.lma.k o. the nervo.s system a.d is present thro.gho.t o.r lives,being required fo. functio.s like memo.y fo.ma.io. o. the lea.ning o. new mo.o. skills(Minegishi et a..,2023;Pilla. a.d Fra.ze,2024).

关键词： pla.ticity structura. mecha.isms

a.ples to.o.a.ges:enviro.menta.ly derived,dyna.ic regula.io. o. sero.o.in neuro. subpo.ula.io.s in a.ultho.d?

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Neura. Regenera.io. Resea.ch 2025年第9期20卷 2596-2597页

作者： Christo.her J.o.Co.nell Ma.thew J.Ro.so. depa.tment o. Genetics College of MedicineHarvard UniversityBostonMAUSA Ja.es L.Winkle Co.lege o. Pha.ma.y Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuro.cience Gra.ua.e Pro.ra. College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Tra.ma.ic bra.n injury(TBI)is a.public hea.th pro.lem with a. undue eco.o.ic burden tha. impa.ts nea.ly every a.e,ethnic,a.d gender gro.p a.ro.s the glo.e(Ca.izzi et a..,2020).TBIs a.e o.ten susta.ned during a.dyna.ic ra.ge o. expo.ures to.energetic enviro.menta. fo.ces a.d a. such o.tco.es a.e typica.ly hetero.eneo.s regarding severity a.d pa.ho.o.y(Ca.izzi et a..,2020).

关键词： susta.ned o.a.ge dyna.ic

Co.0}se to.Fine: The Ro.e o. Severe Pla.tic defo.ma.io. in a.va.cing Tita.ium-Ba.ed Medica. Impla.ts - a.Co.prehensive Review

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Jo.rna. o. Wuha. University o. Techno.o.y(Ma.eria.s Science) 2025年第1期40卷 295-306页

作者： Dra.a.a.R Miha.lo.ić Bo.a. I Međo.Iva.a.Lj Cvijo.ić-a.a.ić Veljko.R Djo.ić Fa.ulty o. Techno.o.y a.d Meta.lurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča.Institute o. Nuclea. Sci-ences-Na.io.a. Institute o. the Republic o. Serbia University of Belgrade11001BeogradSerbia Inno.a.io. Centre o. the Fa.ulty o. Techno.o.y a.d Meta.lurgy Karnegijeva 411120 BelgradeSerbia

This pa.er describes severe pla.tic defo.ma.io.(SPD)pro.edures,which a.e utilized to.fo.m a. ultra.ine-gra.ned structure in meta.lic *** the SPD pro.ess,a.so.id ma.eria. sa.ple is subjected to.very high lo.0}s witho.t a.significa.t cha.ge in sa.ple *** the present wo.k,the high-pressure to.sio.(HPT)pro.ess,a. o.e o. the SPD techniques,which a.hieves a.high degree o. defo.ma.io. a.d ensures refinement o. the micro.tructure,will be discussed in mo.e *** tha. gra.n size co.tro. is a.cepted a. a.metho. to.o.ta.n ma.eria.s with desired cha.a.teristics,a. o.erview o. the pro.erties o. ultra.ine-gra.ned tita.ium-ba.ed bio.a.eria.s to.be used in medicine is ***,pa.ticula. a.tentio. is dedica.ed to.the influences o. HPT pro.ess pa.a.eters,prima.ily hydro.ta.ic pressure,a.d number o. revo.utio.s during to.sio.,o. the gra.n size a.d physica. a.d mecha.ica. cha.a.teristics(mo.ulus o. ela.ticity,micro.a.dness,a.d tensile pro.erties),co.ro.io. resista.ce,a.d bio.o.pa.ibility o. the tita.ium-ba.ed bio.a.eria.s.a.review o. the litera.ure indica.es tha. tita.ium-ba.ed ma.eria.s o.ta.ned by the SPD pro.ess sho. impro.ed mecha.ica. a.d physica. pro.erties witho.t lo.ing bio.o.pa.ibility a.d co.ro.io. resista.ce,which suggests tha. these metho.s o. o.ta.ning impla.ts a.e so.ething tha. sho.ld be further develo.ed in the future.

关键词： high-pressure to.sio. pro.ess ultra.ine-gra.ned tita.ium-ba.ed ma.eria.s electro.hemica. a.o.iza.io. physica. pro.erties mecha.ica. pro.erties

Multi-Step Clustering o. Sma.t Meters Time Series:a.plica.io. to.dema.d Flexibility Cha.a.teriza.io. o. SME Custo.ers

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Co.puter Mo.eling in Engineering & Sciences 2025年第1期142卷 869-907页

作者： Sa.tia.o.Ba.a.es Ra.uel Do.mido.Na.ivida. Duro depa.tment o. Co.puter Sciences a.d a.to.a.ic Co.tro. Universidad Nacional de Educación a Distancia(UNED)Madrid28040Spain Iberdro.a.Inno.a.io. Middle Ea.t Doha210177Qatar

Custo.er segmenta.io. a.co.ding to.lo.0}-sha.e pro.iles using sma.t meter da.a.is a. increa.ingly impo.ta.t a.plica.io. to.vita. the pla.ning a.d o.era.io. o. energy systems a.d to.ena.le citizens’pa.ticipa.io. in the energy *** study pro.o.es a. inno.a.ive multi-step clustering pro.edure to.segment custo.ers ba.ed o. lo.0}-sha.e pa.terns a. the da.ly a.d intra.da.ly time *** meter da.a.is split between da.ly a.d ho.rly no.ma.ized time series to.a.sess mo.thly,weekly,da.ly,a.d ho.rly sea.o.a.ity pa.terns *** dimensio.a.ity reductio. implicit in the splitting a.lo.s a.direct a.pro.0}h to.clustering ra. da.ly energy time series *** intra.a. clustering pro.edure sequentia.ly identifies representa.ive ho.rly da.-unit pro.iles fo. ea.h custo.er a.d the entire *** the first time,a.step functio. a.pro.0}h is a.plied to.reduce time series *** a.tributes embedded in surveys a.e emplo.ed to.build externa. clustering va.ida.io. metrics using Cra.er’s V co.rela.io. fa.to.s a.d to.identify sta.istica.ly significa.t determina.ts o. lo.0}-sha.e in energy *** a.ditio.,a.time series fea.ures engineering a.pro.0}h is used to.extra.t 16 releva.t dema.d flexibility indica.o.s tha. cha.a.terize custo.ers a.d co.respo.ding clusters a.o.g fo.r different a.es:a.a.la.le Energy(E),Tempo.a. pa.terns(T),Co.sistency(C),a.d Va.ia.ility(V).The metho.o.o.y is implemented o. a.rea.-wo.ld electricity co.sumptio. da.a.et o. 325 Sma.l a.d Medium-sized Enterprise(SME)custo.ers,identifying 4 da.ly a.d 6 ho.rly ea.y-to.interpret,well-defined *** a.plica.io. o. the metho.o.o.y includes selecting key pa.a.eters via.grid sea.ch a.d a.tho.o.gh co.pa.iso. o. clustering dista.ces a.d metho.s to.ensure the ro.ustness o. the *** resea.ch ca. test the sca.a.ility o. the metho.o.o.y to.la.ger da.a.ets fro. va.io.s custo.er segments(ho.seho.ds a.d la.ge co.mercia.)a.d lo.a.io.s with different wea.her a.d so.io.co.o.ic co.ditio

关键词： Electric lo.0} clustering lo.0} pro.iling sma.t meters ma.hine lea.ning da.a.mining dema.d flexibility dema.d respo.se

Dyna.ic stress co.centra.io. in a. infinitely lo.g cylindrica. ca.ity due to.a.po.nt spherica. so.rce embedded within a.fluid-sa.ura.ed po.o.la.tic fo.ma.io. o. infinite extent

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a.plied Ma.hema.ics a.d Mecha.ics(English Editio.) 2025年第1期46卷 139-156页

作者： H.Ho.SEINI o.Ba.ILa.Ha.I depa.tment o. Mecha.ica. Engineering Faculty of EngineeringGolestan University

The effects o. a.ha.mo.ica.ly exciting mo.o.o.e so.rce o. a. infinitely lo.g cylindrica. ca.ity embedded entirely within a.fluid-sa.ura.ed po.o.la.tic fo.ma.io. o. infinite extent a.e exa.ined theo.etica.ly. It is a.sumed tha. the so.rce is lo.a.ed o.tside the ca.ity a. a.specified dista.ce fro. the bo.eho.e a.is. The ma.nitudes o. the ho.p a.d ra.ia. stresses beside the po.e pressures exerted o. the interfa.e a.d inside the po.o.s medium surro.nding the bo.eho.e a.e ca.cula.ed a.d discussed. Bio.'s po.o.la.tic mo.eling a.o.g with three types o. bo.nda.y co.ditio.s fo. the cylindrica. interfa.e including the idea. fluid, empty bo.eho.e, a.d rigid inclusio. with a.ha.d bo.nda.y is emplo.ed fo. the a.a.ysis. Utilizing a.pro.er tra.sla.io.a. a.ditio. theo.em fo. expressing the incident spherica. wa.e in terms o. cylindrica. wa.e expa.sio.s, the pro.o.ed bo.nda.y co.ditio.s a. the interfa.e a.e sa.isfied. Stresses a.e fo.mula.ed by mea.s o. wa.e po.entia. functio.s in a.three-dimensio.a.(3D) ma.ner. The effects o. the frequency a.d the ra.ia. dista.ce between the so.rce a.d bo.eho.e o. the induced stresses a.e exa.ined fo. the first cylindrica. mo.es o.er frequency spectra. Two.permea.ility co.ditio.s fo. the interfa.e a.d three types o. so.ls fo. the po.o.s fo.ma.io. a.e co.sidered thro.gho.t the a.a.ysis. To.give a. o.era.l o.tline o. the study, a.numerica. exa.ple is presented. The results clea.ly indica.e tha. the dista.ce is a.key pa.a.eter a.d ha. co.sidera.le effects o. the induced stress va.ues. In a.ditio., the interfa.e permea.ility co.ditio. a.d so.l cha.a.teristics pla. a. impo.ta.t ro.e in determining the dyna.ic respo.se o. the bo.eho.e. Fina.ly,the o.ta.ned results a.e co.pa.ed with the releva.t a.a.yses existing in the litera.ure fo. so.e limit ca.es, a.d go.d a.reement is a.hieved.

关键词： Stress co.centra.io.

Predictio. o. selected bio.iesel fuel pro.erties using a.tificia. neura. netwo.k

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Fro.tiers in Energy 2015年第4期9卷 433-445页

作者： So.o.o. o. GIWa.Sunda. o. a.EKo.a.a.Ka.o.e o. a.a.a.Mo.uf o. MUKa.LA depa.tment o. a.ricultura. a.d Mecha.ica. Engineering College of Engineering and Environmental Studies Olabisi Onabanjo University lbogun Campus Ifo Ogun State Nigeria

Bio.iesel is a. a.terna.ive fuel to.repla.e fo.sil- ba.ed diesel fuel. It ha. fuel pro.erties simila. to.diesel which a.e genera.ly determined experimenta.ly. The experimenta. determina.io. o. va.io.s pro.erties o. bio.iesel is co.tly, time co.suming a.d a.tedio.s pro.ess. To.so.ve these pro.lems, a.tificia. neura. netwo.k （a.N） ha. been co.sidered a. a.vita. to.l fo. estima.ing the fuel pro.erties o. bio.iesel, especia.ly fro. its fa.ty a.id （Fa. co.po.itio.. In this study, fo.r a.Ns ha.e been designed a.d tra.ned to.predict the ceta.e number （CN）, fla.h po.nt （FP）, kinema.ic visco.ity （KV） a.d density o. bio.iesel using a.N with lo.sig a.d purelin tra.sfer functio.s in the hidden la.er o. a.l the netwo.ks. The five mo.t preva.ent Fa. fro. 55 feedsto.ks fo.nd in the litera.ure utilized a. the input pa.a.eters fo. the mo.el a.e pa.mitic, stea.ic, o.eic, lino.eic a.d lino.enie a.ids except fo. density netwo.k with a.sixth pa.a.eter （tempera.ure）. o.her Fa. tha. a.e present in the bio.iesels ha.e been co.sidered ba.ed o. the number o. ca.bo. a.o. cha.ns a.d the level o. sa.ura.io.. Fro. this study, the predictio. a.cura.y a.d the a.era.e a.so.ute devia.io. o. the netwo.ks a.e CN （96.69%; 1.637%）, KV （95.80%; 1.638%）, FP （99.07%; 0.997%） a.d density （99.40%; 0.101%）. These va.ues a.e rea.o.a.ly better co.pa.ed to.previo.s studies o. empirica. co.rela.io.s a.d a.N predictio.s o. these fuel pro.erties fo.nd in litera.ure. Hence, the present study demo.stra.es the a.ility o. a.N mo.el to.predict fuel pro.erties o. bio.iesel with high a.cura.y.

关键词： bio.iesel fuel pro.erties a.tificia. neura.netwo.k fa.ty a.id predictio.

Ferulo.la.io. in Gra.ses： Current a.d Future Perspectives

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Mo.ecula. Pla.t 2009年第5期2卷 861-872页

作者： Ma.cia.M. de o. Bua.a.ina. depa.tment o. Bio.o.y 208 Mueller Laboratory Pennsylvania University University Park PA 16802 USA

In the cell wa.ls o. fo.a.e gra.ses, ferulic a.id is esterified to.a.a.ino.yla.s a.d pa.ticipa.es with lignin mo.o.ers in o.ida.ive co.pling pa.hwa.s to.genera.e ferula.e-po.ysa.cha.ide-lignin co.plexes tha. cro.s-link the cell wa.l. The a.cumula.io. o. ferula.es a.d the cro.s-linking o. a.a.ino.yla.s via.diferula.e esters a.e hypo.hesized to.functio. in va.io.s pro.esses in pla.ts. The specific ro.es o. a.a.ino.yla. ferulo.la.io. a. well a. the na.ure, cellula. lo.a.iza.io., a.d substra.e fo. a.a.ino.yla.s ferulo.la.io. o. cell wa.ls a.e reviewed. The va.io.s a.pro.0}hes tha. ha.e been used fo. a.sessing the specific ro.es o. ferulo.la.io. a.e described a.d a.sessed. I a.gue tha., until recently, the specific ro.e o. ferulo.la.io. in these va.io.s pro.esses ha. been esta.lished la.gely by indirect experiments a.d, a.tho.gh these studies rea.hed simila. co.clusio.s a.o.t the po.entia. impo.ta.ce o. wa.l ferulo.la.io., they suffer fro. a.co.mo. pro.lem： na.ely they depend o. co.rela.io.s between two.pro.esses a.d do.no. stem fro. a.deta.led understa.ding o. the mecha.isms o. ferulo.la.io.. I a.so.a.gue tha. the na.ure o. a.a.ino.yla. ferulo.la.io. rema.ns uncerta.n.

关键词： Cell wa.l ferulo.la.io. ferulic a.id cro.s-link dehydro.iferula.e gra.ses.

Po.yethylene glyco. ha. immuno.ro.ective effects o. scia.ic a.lo.ra.ts, but beha.io.a. reco.ery a.d gra.t to.era.ce require neuro.rha.hy a.d a.o.a. fusio.

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Neura. Regenera.io. Resea.ch 2025年第4期20卷 1192-1206页

作者： Tyler a.Smith Liwen Zho. Ca.ero. L.Ghergherehchi Michelle Mikesh Ca.hy Z.Ya.g Ha.ey o.Tucker Julia.ne a.lgo.d Ja.ed S.Bushma. Geo.ge D.Bittner depa.tment o. Mo.ecula. Bio.ciences University of Texas at AustinAustinTXUSA depa.tment o. Neuro.cience University of Texas at AustinAustinTXUSA Divisio. o. Pha.ma.eutica. Sciences University of WyomingLaramieWYUSA

Beha.io.a. reco.ery using(via.le)periphera. nerve a.lo.ra.ts to.repa.r a.la.io.-type(segmenta.-lo.s)periphera. nerve injuries is dela.ed o. po.r due to.slo. a.d ina.cura.e a.o.a. ***,such periphera. nerve a.lo.ra.ts undergo.immuno.o.ica. rejectio. by the ho.t immune *** co.tra.t,periphera. nerve injuries repa.red by po.yethylene glyco. fusio. o. periphera. nerve a.lo.ra.ts exhibit excellent beha.io.a. reco.ery within weeks,reduced immune respo.ses,a.d ma.y a.o.s do.no. undergo.Wa.leria. *** rela.ive co.tributio. o. neuro.rha.hy a.d po.yethylene glyco.-fusio. o. a.o.s versus the effects o. po.yethylene glyco. per se wa. unkno.n prio. to.this *** hypo.hesized tha. po.yethylene glyco. might ha.e so.e immune-pro.ective effects,but po.yethylene glyco.-fusio. wa. necessa.y to.prevent Wa.leria. degenera.io. a.d functio.a./beha.io.a. *** exa.ined ho. po.yethylene glyco. so.utio.s per se a.fect functio.a. a.d beha.io.a. reco.ery a.d periphera. nerve a.lo.ra.t mo.pho.o.ica. a.d immuno.o.ica. respo.ses in the a.sence o. po.yethylene glyco.-induced a.o.a. ***-type scia.ic nerve injuries in o.tbred Spra.ue–Da.ley ra.s were repa.red a.co.ding to.a.mo.ified pro.o.o. using the sa.e so.utio.s a. po.yethylene glyco.-fused periphera. nerve a.lo.ra.ts,but periphera. nerve a.lo.ra.ts were lo.se-sutured(lo.se-sutured po.yethylene glyco.)with a. intentio.a. ga. o. 1–2 mm to.prevent fusio. by po.yethylene glyco. o. periphera. nerve a.lo.ra.t a.o.s with ho.t *** to.negative co.tro. periphera. nerve a.lo.ra.ts no. trea.ed by po.yethylene glyco. a.d in co.tra.t to.po.yethylene glyco.-fused periphera. nerve a.lo.ra.ts,a.ima.s with lo.se-sutured po.yethylene glyco. periphera. nerve a.lo.ra.ts exhibited Wa.leria. degenera.io. fo. a.l a.o.s a.d myelin degenera.io. by 7 da.s po.to.era.ively a.d did no. reco.er scia.ic-media.ed beha.io.a. functio.s by 42 da.s *** mo.pho.o.ica. signs o. rejectio.,such a. co.

关键词： a.lo.ra.t rejectio. a.o.o.y ma.ro.ha.e myelin nerve repa.r po.yethylene glyco.(PEG) scia.ic nerve T cell tra.spla.ta.io. Wa.leria. degenera.io.