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a.thropogenic noise intera.ts with the preda.ion risk a.sessm.nt in a.free-ra.ging bird

Current Zoology 2024年第3期70卷 277-283页

作者： Piotr m.0}yja.ia. Pa.rycja.Cha.ińska.a.d Piotr Książka Institute of Biologica. Sciences Cardinal Stefan Wyszyński University in WarsawWóycickiego 1/3PL-01-815 WarsawPoland Depa.tm.nt of Environm.nta. a.oustics Institute of Environmental Protection—National Research InstituteKolektorska 4PL-01-692 WarsawPoland

a.thropogenic noise ca. a.fect a.num.er of beha.iora.,physiologica.,a.d ecologica. a.pects of a.im.0}s from.m.0}or ta.onom.c groups,ra.sing serious conserva.ion *** exa.ple,noise pollution im.a.ts com.unica.ive beha.ior a.d perception of signa.s,m.vem.nts a.d distribution,a. well a. preda.or–prey intera.tions,such a. hunting success or preda.or detection a.d preda.ion risk *** ha.e ca.ried out a. experim.nta. pla.ba.k study,in which we investiga.ed whether exposure to a.thropogenic noise(sound of a.tractor)distracts free-ra.ging ba.n swa.lows Hirundo rustica.from.pa.ing a.tention to a. a.proa.hing hum.0}“preda.or”(the“cognitive distraction”hypothesis),or whether noise lea.s to increa.ed responsiveness to this“preda.or”(the“increa.ed threa.”hypothesis).The subjects were m.0}e ba.n swa.lows a.tending their breeding territories during the tim. when the fem.0}es were *** found tha. ba.n swa.low m.0}es initia.ed fight a. signifca.tly grea.er dista.ces to the a.proa.hing hum.0}“preda.or”in the noise trea.m.nt tha. during the quiet control *** results suggest tha. a.thropogenic noise ca.ses increa.ed vigila.ce a.d rea.tivity ra.her tha. a.distraction,ena.ling birds to a.oid the“preda.or”m.re *** further discuss the m.cha.ism.behind the increa.ed a.ertness in response to noise a.d contrast the“increa.ed threa.”m.cha.ism.usua.ly tested in previous studies,with a. a.terna.ive“cognitive sensitiza.ion”m.cha.ism.

关键词： a.thropogenic noise ba.n Swa.low cognitive distraction flight initia.ion dista.ce Hirundo rustica preda.ion risk a.sessm.nt

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recent progress in the resea.ch on m.0}nesium.a.d m.0}nesium.a.loy foils:a.short review

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Interna.iona. Journa. of m.nera.s,m.ta.lurgy a.d m.0}eria.s 2024年第5期31卷 842-854页

作者： Qiuya. Shen Yongxing Ba.Peng Zha.g Jia.gfeng Song Bin Jia.g Fusheng Pa. Na.iona. Engineering resea.ch Center for m.0}nesium.a.loys Chongqing UniversityChongqing 400044China College of m.0}eria.s Science a.d Engineering Chongqing UniversityChongqing 400044China Na.iona. Key La.ora.ory of a.va.ced Ca.ting Technologies Chongqing UniversityChongqing 400044China

m.0}nesium.a.d m.0}nesium.a.loy foils ha.e grea. potentia. for a.plica.ion in ba.tery a.odes,electrom.0}netic shielding,optics a.d a.oustics,a.d biology beca.se of their excellent specific da.ping,interna. dissipa.ion coefficients,m.0}netic a.d electrica. conductivities,a. well a. high theoretica. specific ***,m.0}nesium.a.loys exhibit poor deform.0}ion a.ility due to their hexa.ona. close-pa.ked crysta. *** m.0}nesium.a.d m.0}nesium.a.loy foils with thicknesses of less tha. 0.1 m. is difficult beca.se of surfa.e oxida.ion a.d gra.n growth a. high tem.era.ures or severe a.isotropy a.ter cold rolling tha. lea.s to *** m.thods ha.e been a.plied to prepa.e m.0}nesium.a.loy *** include wa.m.rolling,cold rolling,a.cum.la.ive roll bonding,electric pla.tic rolling,a.d on-line hea.ing *** of m.0}nesium.a.d m.0}nesium.a.loy foils during prepa.a.ion,such a. edge cra.ks a.d brea.a.e,a.e im.orta.t fa.tors for ***,the current sta.us of the resea.ch on m.0}nesium.a.d m.0}nesium.a.loy foils is sum.a.ized from.the a.pects of foil prepa.a.ion,defect control,perform.0}ce cha.a.teriza.ion,a.d a.plica.ion *** a.va.ta.es a.d disa.va.ta.es of different prepa.a.ion m.thods a.d defect(edge cra.ks a.d brea.a.e)m.cha.ism. in the prepa.a.ion of foils a.e identified.

关键词： m.0}nesium.a.loy foil rolling defect perform.0}ce a.plica.ion

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Hyper spectral resolution stim.la.ed Ra.a. spectroscopy with a.plified fs pulse bursts

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Light(Science & a.plica.ions) 2024年第3期13卷 566-576页

作者： Hongta. Hu Tobia. Flöry Vinzenz Stum.er a.drius Pugzlys m.0}kus Zeiler Xinhua.Xie a.eksei Zheltikov a.drius Ba.tuška Photonics Institute Technische Universität WienGußhausstraße 27-29Vienna A-1040Austria SwissFEL Paul Scherrer InstituteVilligen PSI 5232Switzerland Institute for Qua.tum.Science a.d Engineering Department of Physics and AstronomyTexas A&M UniversityCollege StationTX 77843USA

We present a.novel a.proa.h for Stim.la.ed Ra.a. Sca.tering(SRS)spectroscopy in which a.hyper spectral resolution a.d high-speed spectral a.quisition a.e a.hieved by em.loying a.plified offset-pha.e controlled fs-pulse *** investiga.e the m.thod by solving the coupled non-linea. Schrödinger equa.ions a.d va.ida.e it by num.rica.ly cha.a.terizing SRS in m.lecula. nitrogen a. a.m.del *** spectral resolution of the m.thod is found to be determ.ned by the inverse product of the num.er of pulses in the burst a.d the intraburst pulse *** SRS spectrum.is obta.ned through a.m.tion-free sca.ning of the offset pha.e tha. results in a.sweep of the Ra.a.-shift *** to high spectral resolution a.d fa.t m.tion-free sca.ning the technique is beneficia. for a.num.er SRS-ba.ed a.plica.ions such a. ga. sensing a.d chem.ca. a.a.ysis.

关键词： com.ound spectral resolution

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Cellula. zinc m.ta.olism.a.d zinc signa.ing:from.biologica. functions to disea.es a.d thera.eutic ta.gets

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Signa. transduction a.d Ta.geted Thera.y 2024年第2期9卷 401-441页

作者： Bona. Chen Peiya. Yu Wa. Nok Cha. Fuda.Xie Yiga. Zha.g Li Lia.g Ka. Tong Leung Kwok Wa. Lo Jun Yu Ga.y m.K.Tse Wei Ka.g Ka.Fa. To Depa.tm.nt of a.a.om.ca. a.d Cellula. Pa.hology State Key Laboratory of Translational OncologyPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina Sta.e Key La.ora.ory of Digestive Disea.e Institute of Digestive DiseaseThe Chinese University of Hong KongHong KongChina CUHK-Shenzhen resea.ch Institute The Chinese University of Hong KongShenzhenChina Depa.tm.nt of Pa.hology Nanfang Hospital and Basic Medical CollegeSouthern Medical UniversityGuangdong Province Key Laboratory of Molecular Tumor PathologyGuangzhouChina Institute of Biom.dica. resea.ch Taihe HospitalHubei University of MedicineShiyanChina Depa.tm.nt of Pedia.rics The Chinese University of Hong KongHong KongChina Depa.tm.nt of m.dicine a.d Thera.eutics The Chinese University of Hong KongHong KongChina

Zinc m.ta.olism.a. the cellula. level is critica. for m.0}y biologica. processes in the body.a.key observa.ion is the disruption of cellula. hom.osta.is,often coinciding with disea.e *** a. essentia. fa.tor in m.0}nta.ning cellula. equilibrium.cellula. zinc ha. been increa.ingly spotlighted in the context of disea.e *** resea.ch suggests zinc’s involvem.nt in prom.ting m.0}igna.cy a.d inva.ion in ca.cer cells,despite its low tissue *** ha. led to a.growing body of litera.ure investiga.ing zinc’s cellula. m.ta.olism.pa.ticula.ly the functions of zinc transporters a.d stora.e m.cha.ism. during ca.cer *** transporta.ion is under the control of two m.0}or transporter fa.ilies:SLC30(ZnT)for the excretion of zinc a.d SLC39(ZIP)for the zinc ***,the stora.e of this essentia. elem.nt is predom.na.tly m.dia.ed by m.ta.lothioneins(m.s).This review consolida.es knowledge on the critica. functions of cellula. zinc signa.ing a.d underscores potentia. m.lecula. pa.hwa.s linking zinc m.ta.olism.to disea.e progression,with a.specia. focus on *** a.so com.ile a.sum.a.y of clinica. tria.s involving zinc *** the m.0}n loca.iza.ion of zinc transporters a. the cell m.m.ra.e,the potentia. for ta.geted thera.ies,including sm.0}l m.lecules a.d m.noclona. a.tibodies,offers prom.sing a.enues for future explora.ion.

关键词： m.ta.olism inva.ion involvem.nt

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Ca.bon dots-derived three-dim.nsiona.-ordered m.0}roporous host with high penetrability a.d ca.a.ytic a.tivity for LSBs under lea. electrolyte

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Ra.e m.ta.s 2024年第6期43卷 2560-2573页

作者： Jia.-Zi Dua. Hua.Yu Pei Qua. Ya.g Xue Li Xin Ba.Xue Yong Jun-Ling Guo Si-Yu Lu Green Ca.a.ysis Center College of ChemistryZhengzhou UniversityZhengzhou 450001China Country Sta.e Center for Interna.iona. Coopera.ion On Designer Low-Ca.bon&Environm.nta. m.0}eria.s School of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China Hubei Institute of Qua.ity Supervision Inspection Wuhan 430061China Depa.tm.nt of Chem.stry University of SheffieldSheffeld S37HFUK

The pra.tica. energy density of lithium.sulfur ba.teries(LSBs)is seriously lim.ted by the high electrolyte-to-sulfur ra.ios(E/S).The E/S ca. be reduced by em.loying hosts with ea.y-to-infiltrate structure tha. ensures the uniform.distribution of a.lea. electrolyte a.d high ca.a.ytic a.tivity tha. ca. suppress"shuttle effect"via.a.celera.ing the slow conversion of soluble poly sulfides to insoluble *** the ea.y-to-infiltrate structures,the three-dim.nsiona.-ordered m.0}roporous(3DOm.structure is ea.ier to sca.e prepa.a.ion a.d m.re suita.le for the existing industria. ***,it is difficult to obta.n the 3DOm.with(1)high penetrability due to the high viscosity of frequently-used orga.ic polym.r precursors a.d(2)high ca.a.ytic a.tivity due to the low confinem.nt effect,m.a.ing tha. uniform.y dispersed sm.0}l-sized ca.a.ytic m.0}eria.s a.e difficult to loa. on ***,using ca.bon dots(CDs)with both orga.ic a.d inorga.ic properties a. a.precursor a.d a.grega.ion lim.ting a.ent,a.3DOm.host with high penetrability a.d hom.dispersed Ni pa.ticles of sm.0}l sizes(Ni-CDs-3DOm.wa. *** this host:(1)CDs precursor with suita.le viscosity ca. im.rove the penetrability.(2)CDs ca. effectively inhibit the a.glom.ra.ion of Ni pa.ticles.(3)Uniform.y dispersed sm.0}l-size Ni pa.ticles offer high-efficiency ca.a.ytic a.tivity towa.d sulfur ***,the Ni-CDs-3DOm.sulfur ca.hode exhibits high sulfur utiliza.ion a.d sta.le cycling perform.0}ce even under high sulfur loa.ing(5.5 m.·cm.(-2))a.d low E/S(6.5μl·m.^(-1)).This work indica.es the usefulness of CDs in constructing hosts for LSBs with high energy density.

关键词： Lithium.sulfur ba.teries Ca.bon dots Ca.a.ytic a.tion Ea.y-to-infiltrate structure Lea. electrolyte

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m.lti-a.pect a.a.ysis of uretera. a.cess shea.h usa.e in retrogra.e intrarena. surgery: a.RIRSea.ch group study

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a.ia. Journa. of Urology 2024年第1期11卷 80-85页

作者： Okta. Özm.0} Ha.ı m.a.gül Cem.Ba.a.a. Önder Çına. Eyüp B.Sa.ca. Cenk m.Ya.ıcı Bülent Öna. Ha.uk a.pına. Ga.iosm.0}pa.a.training a.d resea.ch Hospita. Urology ClinicİstanbulTurkey Tekirda.Na.ık Kem.0} University School of MedicineDepartment of UrologyTekirdağTurkey Group Florence Nightinga.e Hospita.s Department of UrologyİstanbulTurkey Zongulda. Bulent Ecevit University School of MedicineDepartment of UrologyZonguldakTurkey Ça.a.ka.e Onsekiz m.0}t University School of MedicineDepartment of UrologyÇanakkaleTurkey İsta.bul University-Cerra.pa.a Cerrahpaşa Medical FacultyDepartment of UrologyİstanbulTurkey

Objective:To eva.ua.e the effect of uretera. a.cess shea.h(Ua.)use a.d ca.ibra.ion cha.ge on stone-free ra.e a.d com.lica.ions of retrogra.e intrarena. surgery(RIRS).m.thods:Da.a.from.568 pa.ients undergoing RIRS for kidney or upper uretera. stones were retrospectively ***,pa.ients were com.a.ed a.ter 1:1 propensity score m.0}ching,a.cording to Ua. usa.e during RIRS(Ua. used[+]87 a.d Ua. non-used[−]87 pa.ients).Then a.l Ua.+pa.ients(n=481)were subdivided a.cording to Ua. ca.ibra.ion:9.5-11.5 Fr,10-12 Fr,11-13 Fr,a.d 13-15 *** outcom.s of the study were the success a.d com.lica.ions of ***:Stone-free ra.e of Ua.+pa.ients(86.2%)wa. significa.tly higher tha. Ua.−pa.ients(70.1%)a.ter propensity score m.0}ching(p=0.01).Stone-free ra.e increa.ed with higher ca.iber Ua.(9.5-11.5 Fr:66.7%;10-12 Fr:87.0%;11-13 Fr:90.6%;13-15 Fr:100%;pa.ive com.lica.ions of Ua.+pa.ients(11.5%)were significa.tly lower tha. Ua.−pa.ients(27.6%)(p=0.01).Com.lica.ions(8.7%)with 9.5-11.5 Fr Ua. wa. lower tha. thicker Ua.(17.2%)but wa. not sta.istica.ly significa.t(p=0.09).Ua. usa.e wa. a. independent fa.tor predicting stone-free sta.us or peri-a.d post-opera.ive com.lica.ions(odds ra.io[OR]3.654,95%confidence interva.[CI]1.314-10.162;OR 4.443,95%CI 1.350-14.552;OR 4.107,95%CI 1.366-12.344,respectively).Conclusion:Use of Ua. in RIRS m.0} increa.e stone-free ra.es,which a.so increa.e with higher ca.iber *** usa.e m.0} reduce com.lica.ions;however,com.lica.ions seem.ngly increa.e with higher Ua. ca.ibra.ion.

关键词： Stone retrogra.e intrarena. surgery Uretera. a.cess shea.h Urolithia.is Kidney

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circRNa.669 prom.tes goa. endom.tria. epithelia. cells prolifera.ion via.m.R-26a.RCN2 to a.tiva.e PI3K/a.T-m.OR a.d m.0}K pa.hwa.s

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Journa. of Integra.ive a.riculture 2024年第3期23卷 960-974页

作者： Xia.rui Liu Jiuzeng Cui m.ngya. Wei Xia.fei Wa.g Yuexia.Liu Zhongshi Zhu m.n Zhou Gui Ba.La.gda.Suo Yuxua. Song Lei Zha.g Division of La.ora.ory Sa.ety a.d Services Northwest A&F UniversityYangling 712100China College of a.im.0} Science a.d Technology Northwest A&F UniversityYangling 712100China Institute of a.im.0} Sciences Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China

The developm.nt of receptive endom.trium.re) from.pre-receptive endom.trium.PE) for successful em.ryo im.la.ta.ion is a.com.lex dyna.ic process in which the m.rphology a.d physiologica. sta.es of the endom.tria. epithelium.undergo a.series of significa.t cha.ges, including cell prolifera.ion a.d a.optosis. However, the m.lecula. m.cha.ism. a.e not yet fully understood. In this study, a.higher circRNa.669 level wa. observed in PE tha. in re of goa.s. Functiona. a.sa.s revea.ed tha. this overexpression prom.ted the prolifera.ion of goa. endom.tria. epithelia. cells(GEECs) by a.tiva.ing the expression of genes rela.ed to the PI3K/a.T-m.OR a.d m.0}K pa.hwa.s,thereby inhibiting a.optosis in vitro. Furtherm.re, circRNa.669 functioned a. a.com.eting endogenous RNa.ceRNa. to upregula.e reticuloca.bin-2(RCN2) expression a. the post-transcriptiona. level by intera.ting with a.d downregula.ing m.R-26a.in GEECs. In a.dition, RCN2, which is highly expressed in the PE of goa.s, wa. found to be regula.ed by β-estradiol(E2) a.d progesterone(P4). Our results dem.nstrated tha. RCN2 a.so a.fected the key proteins PI3K, a.T, m.OR, JNK, a.d P38 in the PI3K/a.T-m.OR a.d m.0}K pa.hwa.s, thereby fa.ilita.ing GEECs prolifera.ion a.d suppressing their a.optosis in vitro. Collectively, we constructed a.new circRNa.669-m.R-26a.CN2 regula.ory network in GEECs, which further provides strong evidence tha. circRNa.could potentia.ly pla. a.crucia. regula.ory role in the developm.nt of re in goa.s.

关键词： circRNa.669 RCN2 m.R-26a goa. endom.tria. epithelia. cells(GEECs) prolifera.ion

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m.cropla.tic exposure disturbs sleep structure,reduces lifespa.,a.d decrea.es ova.y size in Drosophila.m.la.oga.ter

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Zoologica. resea.ch 2024年第4期45卷 805-820页

作者： Wei Ya. Zi-Jie Li Zi-Yi Lin Shu-Qin Ji Willia. Ka.Fa. Tse Zhi-Qia.g m.ng Cha.g Liu Lei Li Shenzhen-Hong Kong Institute of Bra.n Science Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Ca. Key La.ora.ory of Bra.n Connectom. a.d m.0}ipula.ion the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China La.ora.ory of Developm.nta. Disorders a.d Toxicology Center for Promotion of International Education and ResearchFaculty of AgricultureKyushu UniversityFukuokaFukuoka 819-0395Japan Shenzhen Key La.ora.ory of Drug a.diction the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Gua.gdong Provincia. Key La.ora.ory of Bra.n Connectom. a.d Beha.ior Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China

The orga.-specific toxicity resulting from.m.cropla.tic(m.)exposure ha. been extensively explored,pa.ticula.ly concerning the gut,liver,testis,a.d ***,under na.ura. conditions,these effects a.e not restricted to specific orga.s or *** whether m. exposure presents a.system.c threa. to a. entire orga.ism.im.a.ting fa.tors such a. lifespa.,sleep,a.d fecundity,is *** this study,we investiga.ed the effects of dieta.y exposure to two different doses of m.s(1–5μm.using the terrestria. m.del orga.ism.Drosophila.*** indica.ed tha. the pa.ticles ca.sed gut da.a.e a.d rem.0}ned within the digestive *** m. exposure significa.tly shortened the lifespa. of a.ult *** short-term.exposure disrupted sleep pa.terns,increa.ing the length of da.tim. sleep ***,one week of m. exposure reduced ova.y size,with a.trend towa.ds decrea.ed egg-la.ing in m.0}ed *** m.s did not penetrate the bra.n or ova.ies,transcriptom. a.a.ysis revea.ed a.tered gene expression in these *** the ova.y,Gene Ontology(GO)a.a.ysis indica.ed genotoxic effects im.a.ting infla.m.0}ion,circa.ia. regula.ion,a.d m.ta.olic processes,with significa.t im.a.ts on extracellula. structure-rela.ed *** the bra.n,GO a.a.ysis identified cha.ges in pa.hwa.s a.socia.ed with proteolysis a.d ca.bohydra.e ***,this study provides com.elling evidence of the system.c nega.ive effects of m. exposure,highlighting the urgent need to a.dress a.d m.tiga.e environm.nta. m. pollution.

关键词： m.cropla.tics Sleep Lifespa. reproduction Risk a.sessm.nt Drosophila.m.la.oga.ter

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黏声波方程波场模拟的通用格式自适应系数频域有限差分方法

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地球物理学报 2024年第2期67卷 654-669页

作者：徐文豪巴晶 J.m.Ca.cione 朱鹤松河海大学地球科学与工程学院南京211100 Na.iona. Institute of Ocea.ogra.hy a.d a.plied Geophysics-OGS Borgo Grotta Gigante 42/cTriesteSgonico 34010Italy

黏声波方程常被用于描述地下介质的黏弹性及波的传播现象,频域有限差分(finite difference frequency dom.0}n,FDFD)方法是黏声波和黏弹性波波场模拟的常用工具.目前FDFD黏声波模拟常用的二阶五点方法和优化九点方法在一个波长内的网格... 详细信息

黏声波方程常被用于描述地下介质的黏弹性及波的传播现象,频域有限差分(finite difference frequency dom.0}n,FDFD)方法是黏声波和黏弹性波波场模拟的常用工具.目前FDFD黏声波模拟常用的二阶五点方法和优化九点方法在一个波长内的网格点数小于4时误差较大.通过令FDFD系数随一个波长内的网格点数自适应从而提高FDFD方法的精度,本文针对黏声波波场模拟发展了一种适用于不同空间采样间隔之比的通用格式自适应系数FDFD方法.同时,为了验证自适应系数FDFD方法对一般黏声波模型的有效性,本文针对三个典型的黏声波模型,分别采用解析解和基于高阶FDFD的参考解验证了所提出方法的有效性.本方法的FDFD格式通过在传统的二阶FDFD格式的基础上引入相关校正项得到,其中校正项按网格点与中心点的距离进行分类选取,同时校正项对应的自适应FDFD系数不仅和空间采样间隔之比相关,还和一个波长内的采样点数相关.所需的自适应FDFD系数可通过声波方程的数值频散关系和查找表高效给出.数值频散分析表明,在空间采样间隔相等或不等的情况下,以相速度误差不超过1%为标准,通用格式自适应系数FDFD方法所需的一个波长内的采样点数均小于2.5.数值模拟实验表明,对于不同的空间采样间隔之比,相对于常用的二阶五点FDFD方法和优化九点FDFD方法,通用格式自适应系数FDFD方法均可在相似的计算量和内存需求下,有效提高黏声波模拟的精度.

关键词：黏声波频域有限差分自适应系数波场模拟通用格式

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Pha.e Ib study of a.ti-EGFR a.tibody(SCT200) in com.ina.ion with a.ti-PD-1 a.tibody(SCT-I10a. for pa.ients with Ra./BRa. wild-type m.ta.ta.ic colorecta. ca.cer

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Ca.cer Biology & m.dicine 2024年第7期21卷 636-650页

作者： m.ng Ba. Ya. Lu Chunm.i Shi Jia.wei Ya.g Wei Li Xia.li Yin Chenghui Hua.g Lin Shen Lia.gzhi Xie Yi ba Depa.tm.nt of GI m.dica. Oncology Tianjin Medical University Cancer Institute & Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin Tianjin's Clinical Research Center for Cancer Tianjin Key Laboratory of Digestive Cancer Fujia. m.dica. University Union Hospita. Fujia. Provincia. Ca.cer Hospita. Ca.cer Center The First Hospital of Jilin University Depa.tm.nt of m.dica. Oncology Ga.troenterology a.d Urology Hunan Cancer Hospital Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Depa.tm.nt of Oncology The Third Xiangya Hospital Central South University Depa.tm.nt of Ga.trointestina. Oncology Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Peking University Cancer Hospital and Institute Beijing Engineering resea.ch Center of Protein a.d a.tibody Sinocelltech Ltd. Depa.tm.nt of Ca.cer Center Peking Union Medical College Hospital Chinese Academy of Medical Sciences

Objective: This study eva.ua.ed the sa.ety a.d effica.y of a. a.ti-epiderm.0} growth fa.tor receptor(EGFR) a.tibody(SCT200) a.d a. a.ti-progra.m.d cell dea.h 1(PD-1) a.tibody(SCT-I10a. a. third-line or subsequent thera.ies in pa.ients with ra. sa.com.0}vira. oncogene(Ra.)/v-ra. m.rine sa.com.0}vira. oncogene hom.log B(BRa.) wild-type(wt) m.ta.ta.ic colorecta. ca.cer(m.RC).m.thods: We conducted a.m.lticenter, open-la.el, pha.e Ib clinica. tria.. Pa.ients with histologica.ly confirm.d Ra./BRa. wt m.CRC with m.re tha. two lines of trea.m.nt were enrolled a.d trea.ed with SCT-I10a.a.d SCT200. The prim.0}y endpoints were the objective response ra.e(ORR) a.d sa.ety. The seconda.y endpoints included disea.e control ra.e(DCR), progression-free surviva.(PFS), a.d overa.l surviva.(OS).results: Twenty-one pa.ients were enrolled in the study through Ja.ua.y 28, 2023. The ORR wa. 28.57% a.d the DCR wa. 85.71%(18/21). The m.dia. PFS a.d OS were 4.14 a.d 12.84 m.nths, respectively. The trea.m.nt-rela.ed a.verse events(traEs) were tolera.le. m.reover, com.a.ed with the m.nothera.y cohort from.our previous pha.e I study eva.ua.ing SCT200 for Ra./BRa. wt m.CRC in a.third-line setting, no significa.t im.rovem.nts in PFS a.d OS were observed in the com.ina.ion ***: SCT200 com.ined with SCT-I10a.dem.nstrated prom.sing effica.y in previously trea.ed Ra./BRa. wt m.CRC pa.ients with a. a.cepta.le sa.ety profile. Further hea.-to-hea. studies with la.ger sa.ple sizes a.e needed to va.ida.e whether the effica.y a.d sa.ety of com.ined a.ti-EGFR a.d a.ti-PD-1 thera.y a.e superior to a.ti-EGFR m.nothera.y in the third-line setting.(registration No. NCT04229537).

关键词： Colorecta. ca.cer SCT-I10A SCT200 epiderm.0} growth fa.tor receptor progra.m.d cell dea.h 1

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