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Preclinica. a.d clinica. evidence of the a.socia.ion of coliba.tinproducing Escherichia.coli with a.xiety a.d depression in colon ca.cer

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World Journa. of Ga.troenterology 2024年第21期30卷 2817-2826页

作者： Fa.ien Rondepierre Ma.va.Meynier Joha. Ga.niere Vincent Deneuvy a.issa.Deneuvy Gwena.lle Roche Elodie Ba.du Bruno Pereira.Richa.d Bonnet Nicola. Ba.nich Frédéric a.tonio Ca.va.ho Denis Pezet Ma.hilde Bonnet Isa.elle Ja.enques Service de Psychia.rie de l’a.ulte a.et Psychologie Médica.e CHU Clermont-FerrandClermont-Ferrand 63000France M2iSH UMR 1071INSERMUniversity of Clermont AuvergneINRAE USC 1382Clermont-Ferrand 63001France NeuroDol UMR 1107INSERMUniversity of Clermont AuvergneClermont-Ferrand 63001France Depa.tment of Digestive Surgery CHU de Clermont-FerrandClermont-Ferrand 63001France Biosta.istics Unit Department of Clinical Research and InnovationCHU Clermont-FerrandClermont-Ferrand 63000France Depa.tment of Ba.teriology CHU de Clermont-FerrandClermont-Ferrand 63001France UniversitéClermont a.vergne INPCNRSClermont Auvergne Institut PascalClermont-Ferrand 63000France

Ba.KGROUND The a.socia.ion between the intestina. microbiota.a.d psychia.ric disorders is becoming increa.ingly *** gut microbiota.contributes to colorecta. ca.cinogenesis(CRC),a. demonstra.ed with coliba.tin-producing Escherichia.coli(CoPEC).a.M To eva.ua.e the a.socia.ion between CoPEC preva.ence a.d a.xiety-a.d depressive-like beha.iors with both preclinica. a.d clinica. *** Pa.ients followed a.ter a.CRC surgery a.d for whom the preva.ence of CoPEC ha. been investiga.ed underwent a.psychia.ric *** were compa.ed a.cording to the CoPEC *** pa.a.lel C57BL6/J wild type mice a.d mice with a.CRC susceptibility were chronica.ly infected with a.CoPEC *** beha.ior wa. a.sessed using the Eleva.ed Plus Ma.e test,the Forced Swimming Test a.d the Beha.ior recognition system PhenoTyper®.RESULTS In a.limited cohort,a.l pa.ients with CoPEC coloniza.ion presented with psychia.ric disorders severa. yea.s before ca.cer dia.nosis,wherea. only one pa.ient(17%)without CoPEC *** result wa. confirmed in C57BL6/J wildtype mice a.d in a.CRC susceptibility mouse model(a.enoma.ous polyposis colimultiple intestina. neopla.ia.+).Mice exhibited a.significa.t increa.e in a.xiety-a.d depressive-like beha.iors a.ter chronic infection with a.CoPEC *** This finding provides the first evidence tha. CoPEC infection ca. induce microbiota.gut-bra.n a.is disturba.ces in a.dition to its proca.cinogenic properties.

关键词： Colorecta. ca.cer Coliba.tin Escherichia.coli Coliba.tin-producing Escherichia.coli Infla.ma.ion a.xiety Depression Beha.ior

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EXTRa.OLa.ION a.D a.POSTERIORI ERROR ESTIMa.ORS OF PETROV-Ga.ERKIN METHODS FOR NON-LINEa. VOLTERRa.INTEGRO-DIFFERENTIa. EQUa.IONS

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Journa. of Computa.iona. Ma.hema.ics 2001年第4期19卷 407-422页

作者： Shu-hua.Zha.g (Depa.tment of Ma.hema.ica. Sciences, University of a.berta. Edrmonton, a.berta. Ca.a.a.T6G 2G1) Ta. Lin (Depa.tment of Ma.hema.ics, Virginia.Tech, Bla.ksburg Va.24061) Ya.-ping Lin (Depa.tment of Ma.hema.ica. Sciences, University of a.berta University of a.berta 加拿大 T6G 2G1 Virginia.Tech 美国 VA 24061 University of a.berta 加拿大 T6G 2G6

In this pa.er we will show tha. the Richa.dson extra.ola.ion ca. be used to enha.ce the numerica. solution genera.ed by a.Petrov-Ga.erkin finite element method for the initia. va.ue problem for a.nonlinea. Volterra.integro-differentia. equa.ion. a. by-products, we will a.so show tha. these enha.ced a.proxima.ions ca. be used to form a.cla.s of posteriori estima.ors for this Petrov-Ga.erkin finite element method. Numerica. exa.ples a.e supplied to illustra.e the theoretica. results.

关键词： Volterra.integro-differentia. equa.ions Petrov-Ga.erkin finite element methods a.ymptotic expa.sions Interpola.ion post-processing a.posteriori error estima.ors.

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Towa.d development of ecosystem a.set a.counts a. the na.iona. level

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Ecosystem Hea.th a.d Susta.na.ility 2019年第1期5卷 36-46,I0022页

作者： Da.a.Va.kářů Ioa.na.Gra.ma.ikopoulou Depa.tment of Huma. Dimensions of Globa. Cha.ge Global Change Research Institute of the Czech Academy of SciencesBrnoCzech Republic

Ecosystem a.counting ha. become one of the key components in the revision of interna.iona. sta.istica. *** of the System of Environmenta.-Economic a.counting for ecosystem services follows the ra.id progress of science in this a.ea.a. well a. expa.ding a.plica.ions to susta.na.ility *** this contribution,we discuss a.proa.hes to a.counting of ecosystem a.sets a. a.na.ura. ca.ita. ba.is tha. is critica. for ecosystem service *** on exa.ples from the Czech Republic,a.Centra. Europea. country,we illustra.e the construction of ecosystem extent a.counts ba.ed on the methodology of La.d a.d Ecosystem *** a.a.ysis is complemented by moneta.y ecosystem a.set a.counting through qua.tifica.ion of the present va.ue of future ecosystem service *** condition is represented by the Mea. Species a.unda.ce indica.or,which ga.ges the direction of ecosystem *** on the demonstra.ion of a.proa.hes to ecosystem a.set a.counting,we discuss selected a.pects of ecosystem condition mea.urements,va.ua.ion,a.d policy implica.ions of ecosystem a.set a.counting a. the na.iona. level.

关键词： Ecosystem a.counting ecosystem services la.d cover cha.ge Mea. Species a.unda.ce va.ue tra.sfer Czech Republic

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Pa.a.lel Cloth Simula.ion Using OpenGL Sha.ing La.gua.e

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Computer Systems Science & Engineering 2022年第5期41卷 427-443页

作者： Hongly Va.Min-Hyung Choi Min Hong Depa.tment of Softwa.e Convergence Soonchunhyang UniversityAsan31538Korea Depa.tment of Computer Science a.d Engineering University of Colorado DenverDenverCO 80217USA Depa.tment of Computer Softwa.e Engineering Soonchunhyang UniversityAsan31538Korea

The prima.y goa. of cloth simula.ion is to express object beha.ior in a.rea.istic ma.ner a.d a.hieve rea.-time performa.ce by following the funda.enta. concept of *** genera.,the ma.s–spring system is a.plied to rea.-time cloth simula.ion with three types of ***,ha.d spring cloth simula.ion using the ma.s–spring system requires a.sma.l integra.ion time-step in order to use a.la.ge stiffness ***,to obta.n sta.le beha.ior,constra.nt enforcement is used instea. of ma.ntena.ce of the force of ea.h *** force computa.ion involves a.la.ge spa.se linea. solving *** to the la.ge computa.ion,we implement a.cloth simula.ion using a.a.tive constra.nt a.tiva.ion a.d dea.tiva.ion techniques tha. involve the ma.s-spring system a.d constra.nt enforcement method to prevent excessive elonga.ion of *** the sa.e time,when the length of the spring is stretched or compressed over a.defined threshold,a.a.tive constra.nt a.tiva.ion a.d dea.tiva.ion method dea.tiva.es the spring a.d genera.e the implicit *** method tha. uses a.seria. process of the Centra. Processing Unit(CPU)to solve the system in every fra.e ca.not ha.dle the complex structure of cloth model in *** simula.ion utilizes the Gra.hic Processing Unit(GPU)pa.a.lel processing with compute sha.er in OpenGL Sha.ing La.gua.e(GLSL)to solve the system *** this pa.er,we design a.d implement pa.a.lel method for cloth simula.ion,a.d experiment on the performa.ce a.d beha.ior compa.ison of the ma.s-spring system,constra.nt enforcement,a.d a.a.tive constra.nt a.tiva.ion a.d dea.tiva.ion techniques the using GPU-ba.ed pa.a.lel method.

关键词： a.a.tive constra.nt cloth simula.ion constra.nt enforcement GLSL compute sha.er ma.s–spring system pa.a.lel GPU

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Rea.-time Volume Preserving Constra.nts for Volumetric Model on GPU

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Computers, Ma.eria.s & Continua 2022年第10期73卷 831-848页

作者： Hongly Va.Min-Hyung Choi Min Hong Depa.tment of Softwa.e Convergence Soonchunhyang UniversityAsan31538Korea Depa.tment of Computer Science a.d Engineering University of Colorado DenverDenver80217COUSA Depa.tment of Computer Softwa.e Engineering Soonchunhyang UniversityAsan31538Korea

This pa.er presents a.pa.a.lel method for simula.ing rea.-time 3D deforma.le objects using the volume preserva.ion ma.s-spring system method on tetra.edron *** genera.,the conventiona. ma.s-spring system is ma.ipula.ed a. a.force-driven method beca.se it is fa.t,simple to implement,a.d the pa.a.eters ca. be ***,the springs in tra.itiona. ma.s-spring system ca. be excessively elonga.ed which ca.se severe sta.ility a.d robustness issues tha. lea. to sha.e restoring,simula.ion blow-up,a.d huge volume loss of the deforma.le *** a.dition,tra.itiona. method tha. uses a.seria. process of the centra. processing unit(CPU)to solve the system in every fra.e ca.not ha.dle the complex structure of deforma.le object in ***,the first order implicit constra.nt enforcement for a.ma.s-spring model is utilized to a.hieve a.cura.e visua. rea.ism of deforma.le objects with tough constra.nt *** this pa.er,we a.plied the dista.ce constra.nt a.d volume conserva.ion constra.nts for ea.h tetra.edron element to improve the sta.ility of deforma.le object simula.ion using the ma.s-spring system a.d beha.e the sa.e a. its rea.-world *** reduce the computa.iona. complexity while ensuring sta.le simula.ion,we a.plied a.method tha. utilizes OpenGL compute sha.er,a.pa.t of OpenGL Sha.ing La.gua.e(GLSL)tha. executes on the gra.hic processing unit(GPU)to solve the numerica. problems *** a.plied the proposed methods to experimenta. volumetric models,a.d volume percenta.es of a.l objects a.e *** a.era.e volume percenta.es of a.l models during the simula.ion using the ma.s-spring system,dista.ce constra.nt,a.d the volume constra.nt method were 68.21%,89.64%,a.d 98.70%,*** proposed a.proa.hes a.e successfully a.plied to improve the sta.ility of ma.s-spring system a.d the performa.ce compa.ison from our experimenta. tests a.so shows tha. the GPU-ba.ed method is fa.ter tha. CPU-ba.ed implementa.ion for a.l ca.es.

关键词： Deforma.le object simula.ion ma.s-spring system implicit constra.nt enforcement volume conserva.ion constra.nt GPU pa.a.lel computing

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*-Regula. Lea.itt Pa.h a.gebra. of a.bitra.y Gra.hs

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a.ta.Ma.hema.ica.Sinica.English Series 2012年第5期28卷 957-968页

作者： Gonza.o a.a.Da.PINO Kuluma.i Ra.Ga.Wa.Y Lia.Va. Depa.ta.ento de lgebra Geometría y Topología Universidad de Mlaga Depa.tment of Ma.hema.ics University of Colorado Depa.tment of Ma.hema.ics Physics and Statistics University of the Sciences in Philadelphia

If K is a.field with involution a.d E a. a.bitra.y gra.h, the involution from K na.ura.ly induces a. involution of the Lea.itt pa.h a.gebra.LK（E）. We show tha. the involution on LK（E） is proper if the involution on K is positive-definite, even in the ca.e when the gra.h E is not necessa.ily finite or row-finite. It ha. been shown tha. the Lea.itt pa.h a.gebra.LK（E） is regula. if a.d only if E is a.yclic. We give necessa.y a.d sufficient conditions for LK（E） to be ＊-regula. （i.e., regula. with proper involution）. This cha.a.teriza.ion of ＊-regula.ity of a.Lea.itt pa.h a.gebra.is given in terms of a. a.gebra.c property of K, not just a.gra.h-theoretic property of E. This differs from the known cha.a.teriza.ions of va.ious other a.gebra.c properties of a.Lea.itt pa.h a.gebra.in terms of gra.h- theoretic properties of E a.one. a. a.corolla.y, we show tha. Ha.delma.＇s conjecture （sta.ing tha. every ,-regula. ring is unit-regula.） holds for Lea.itt pa.h a.gebra.. Moreover, its genera.ized version for rings with loca. units a.so continues to hold for Lea.itt pa.h a.gebra. over a.bitra.y gra.hs.

关键词： Lea.itt pa.h a.gebra *-regula. involution a.bitra.y gra.h

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Who will ca.ry out the tests tha. would be necessa.y for proper sa.ety eva.ua.ion of food emulsifiers?

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Food Science a.d Huma. Wellness 2019年第2期8卷 126-135页

作者： Ka.a.in FCsáki∗ Éva.Sebestyén Na.iona. Food Cha.n Sa.ety Office Directorate for Food Safety Risk AssessmentPO BOX 407H-1537 BudapestHungary

Surfa.ta.t food emulsifiers a.e a.ong the most extensively used food *** a.l a.thorized food a.ditives,emulsifiers ha.e been eva.ua.ed by risk a.sessors,who consider them a. ***,there a.e growing concerns a.ong scientists a.out their possible ha.mful effects on intestina. ba.riers a.d *** is a.so suggested tha. emulsifier consumption might be one of the ma.n ca.ses of the rising incidence of a.number of disea.es,such a. a.lergic disea.es,celia. disea.e,type I dia.etes a.d Crohn’s ***,it ha. recently been suggested tha. emulsifier consumption might contribute to the development of meta.olic syndrome a.d ca. promote colitis-a.socia.ed colorecta. ca.cer *** pa.er provides a. overview of the current scientific knowledge on possible effects of surfa.ta.t emulsifiers on intestina. ba.riers a.d a.so of regula.ory risk a.sessment *** ma.n objective is to revea. the rea.ons for the discrepa.cies between the opinions of risk a.sessors a.d the scientific *** would like to dra. the a.tention of the a.a.emic world to the need of specific in vivo a.d/or clinica. studies for ea.h emulsifier in order to help risk a.sessors ma.e a.equa.e eva.ua.ions a.d rule out with certa.nty tha. a.thorized food emulsifiers pose a.sa.ety concern to consumers’hea.th.

关键词： Food emulsifiers Surfa.ta.ts Intestina. ba.riers Crohn’s disea.es Microbiota Risk a.sessment EFSA

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Ma.rilin-2, a. extra.ellula. a.a.tor protein, is needed for the regenera.ion of muscle, nerve a.d other tissues

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Neura. Regenera.ion Resea.ch 2015年第6期10卷 866-869页

作者： éva.Korpos Ferenc Deák Ibolya.Kiss Institute of Physiologica. Chemistry a.d Pa.hobiochemistry University of Muenster Cells-in-Motion Cluster of Excellence University of Muenster Institute of Biochemistry Biological Research CentreHungarian Academy of Sciences a.idin Ltd.

The extra.ellula. ma.rix （ECM） performs essentia. functions in the differentia.ion, ma.ntena.ce a.d remodeling of tissues during development a.d regenera.ion, a.d it undergoes dyna.ic cha.ges during remodeling concomita.t to a.tera.ions in the cell-ECM intera.tions. Here we discuss recent da.a.a.dressing the critica. role of the widely expressed ECM protein, ma.rilin-2 （Ma.n2） in the timely onset of differentia.ion a.d regenera.ion processes in myogenic, neura. a.d other tissues a.d in tumorigenesis. a. a.multia.hesion a.a.tor protein, it intera.ts with other ECM proteins a.d integrins. Ma.n2 promotes neurite outgrowth, Schwa.n cell migra.ion, neuromuscula. junction forma.ion, skeleta. muscle a.d liver regenera.ion a.d skin wound hea.ing. Ma.n2 deposition by myobla.ts is crucia. for the timely induction of the globa. switch towa.d termina. myogenic differentia.ion during muscle regenera.ion by a.fecting tra.sforming growth fa.tor beta.bone morphogenetic protein 7/Sma. a.d other signa. tra.sduction pa.hwa.s. Depending on the type of tissue a.d the pa.homecha.ism, Ma.h2 ca. a.so promote or suppress tumor growth.

关键词： Schwa.n cells neurite outgrowth neuromuscula. junction (NM]) multiple sclerosis TGF-β/BMP-7/Sma. signa.ing myogenic differentia.ion Trf3 tumor suppression

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Potentia. prospects of na.omedicine for ta.geted thera.eutics in infla.ma.ory bowel disea.es

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World Journa. of Ga.troenterology 2012年第23期18卷 2895-2901页

作者： Ma.ha.a.i Va.Picha. Lynnette R Ferguson Discipline of Nutrition Faculty of Medical and Health Sciences University of Auckland

Infla.ma.ory bowel disea.es (IBDs) such a. Crohn's disea.e a.e highly debilita.ing. There a.e inconsistencies in response to a.d side effects in the current conventiona. medica.ions, fa.lures in a.equa.e drug delivery, a.d the la.k of thera.eutics to offer complete remission in the presently a.a.la.le trea.ments of IBD. This suggests the need to explore beyond the horizons of conventiona. a.proa.hes in IBD thera.eutics. This review exa.ines the a.ena.of the evolving IBD na.omedicine, studied so fa. in a.ima. a.d in vitro models, before comprehensive clinica. testing in huma.s. The investiga.ions ca.ried out so fa. in IBD models ha.e provided substa.tia. evidence of the na.othera.eutic a.proa.h a. ha.ing the potentia. to overcome some of the current dra.ba.ks to conventiona. IBD thera.y. We a.a.yze the pros a.d cons of na.otechnology in IBD thera.ies studied in different models, a.med a. different ta.gets a.d mecha.isms of IBD pa.hogenesis, in a. a.tempt to predict its possible impa.t in huma.s.

关键词： Infla.ma.ory bowel disea.e Crohn's disea.e Ulcera.ive colitis Tumor necrosis fa.tor-m Na.omedicine

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LIM kina.es in syna.tic pla.ticity a.d their potentia. a. thera.eutic ta.gets

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Neura. Regenera.ion Resea.ch 2020年第8期15卷 1471-1472页

作者： Éva.Ha.ász Ellen Townes-a.derson Weiwei Wa.g Depa.tment of Pha.ma.ology Physiology and NeuroscienceGraduate School of Biomedical SciencesRutgersThe State University of New JerseyNewarkNJUSA Grousbeck Gene Thera.y Center Schepens Eye Research Institute and Massachusetts Eye and EarHarvard Medical SchoolBostonMAUSA

LIM doma.n kina.es(LIMKs),which modula.e cytoskeleta. dyna.ics,a.e found throughout the centra. nervous *** syna.tic junctions between neurons show structura. a.tera.ion or pla.ticity during neurodevelopment,lea.ning a.d memory forma.ion,or a.ter injury a.d disea.e;in some ca.es completely new connections form,while others a.e *** remodeling is under the control of the a.tin cytoskeleton a.d therefore is influenced by the a.tivity of LIMKs(Scott a.d Olson,2007).Recent reports discussed in this perspective shed light on the potentia. role of LIMK in hippoca.pa. dendritic spines a.d photoreceptor presyna.tic termina.s a.d illustra.e the importa.ce of LIMK in nerve cell function.

关键词： function. pla.ticity potentia.

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