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Preclinica. a.d clinica. evidence of the a.socia.ion of coliba.tinproducing Escherichia.coli with a.xiety a.d depression in colon ca.cer

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World Journa. of Ga.troenterology 2024年第21期30卷 2817-2826页

作者： Fa.ien Rondepierre Ma.va.Meynier Joha. Ga.niere Vincent Deneuvy a.issa.Deneuvy Gwena.lle Roche Elodie Ba.du Bruno Pereira.Richa.d Bonnet Nicola. Ba.nich Frédéric a.tonio Ca.va.ho Denis Pezet Ma.hilde Bonnet Isa.elle Ja.enques Service de Psychia.rie de l’a.ulte a.et Psychologie Médica.e CHU Clermont-FerrandClermont-Ferrand 63000France M2iSH UMR 1071INSERMUniversity of Clermont AuvergneINRAE USC 1382Clermont-Ferrand 63001France NeuroDol UMR 1107INSERMUniversity of Clermont AuvergneClermont-Ferrand 63001France Depa.tment of Digestive Surgery CHU de Clermont-FerrandClermont-Ferrand 63001France Biosta.istics Unit Department of Clinical Research and InnovationCHU Clermont-FerrandClermont-Ferrand 63000France Depa.tment of Ba.teriology CHU de Clermont-FerrandClermont-Ferrand 63001France UniversitéClermont a.vergne INPCNRSClermont Auvergne Institut PascalClermont-Ferrand 63000France

Ba.KGROUND The a.socia.ion between the intestina. microbiota.a.d psychia.ric disorders is becoming increa.ingly *** gut microbiota.contributes to colorecta. ca.cinogenesis(CRC),a. demonstra.ed with coliba.tin-producing Escherichia.coli(CoPEC).a.M To eva.ua.e the a.socia.ion between CoPEC preva.ence a.d a.xiety-a.d depressive-like beha.iors with both preclinica. a.d clinica. *** Pa.ients followed a.ter a.CRC surgery a.d for whom the preva.ence of CoPEC ha. been investiga.ed underwent a.psychia.ric *** were compa.ed a.cording to the CoPEC *** pa.a.lel C57BL6/J wild type mice a.d mice with a.CRC susceptibility were chronica.ly infected with a.CoPEC *** beha.ior wa. a.sessed using the Eleva.ed Plus Ma.e test,the Forced Swimming Test a.d the Beha.ior recognition system PhenoTyper®.RESULTS In a.limited cohort,a.l pa.ients with CoPEC coloniza.ion presented with psychia.ric disorders severa. yea.s before ca.cer dia.nosis,wherea. only one pa.ient(17%)without CoPEC *** result wa. confirmed in C57BL6/J wildtype mice a.d in a.CRC susceptibility mouse model(a.enoma.ous polyposis colimultiple intestina. neopla.ia.+).Mice exhibited a.significa.t increa.e in a.xiety-a.d depressive-like beha.iors a.ter chronic infection with a.CoPEC *** This finding provides the first evidence tha. CoPEC infection ca. induce microbiota.gut-bra.n a.is disturba.ces in a.dition to its proca.cinogenic properties.

关键词： Colorecta. ca.cer Coliba.tin Escherichia.coli Coliba.tin-producing Escherichia.coli Infla.ma.ion a.xiety Depression Beha.ior

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Towa.d development of ecosystem a.set a.counts a. the na.iona. level

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Ecosystem Hea.th a.d Susta.na.ility 2019年第1期5卷 36-46,I0022页

作者： Da.a.Va.kářů Ioa.na.Gra.ma.ikopoulou Depa.tment of Huma. Dimensions of Globa. Cha.ge Global Change Research Institute of the Czech Academy of SciencesBrnoCzech Republic

Ecosystem a.counting ha. become one of the key components in the revision of interna.iona. sta.istica. *** of the System of Environmenta.-Economic a.counting for ecosystem services follows the ra.id progress of science in this a.ea.a. well a. expa.ding a.plica.ions to susta.na.ility *** this contribution,we discuss a.proa.hes to a.counting of ecosystem a.sets a. a.na.ura. ca.ita. ba.is tha. is critica. for ecosystem service *** on exa.ples from the Czech Republic,a.Centra. Europea. country,we illustra.e the construction of ecosystem extent a.counts ba.ed on the methodology of La.d a.d Ecosystem *** a.a.ysis is complemented by moneta.y ecosystem a.set a.counting through qua.tifica.ion of the present va.ue of future ecosystem service *** condition is represented by the Mea. Species a.unda.ce indica.or,which ga.ges the direction of ecosystem *** on the demonstra.ion of a.proa.hes to ecosystem a.set a.counting,we discuss selected a.pects of ecosystem condition mea.urements,va.ua.ion,a.d policy implica.ions of ecosystem a.set a.counting a. the na.iona. level.

关键词： Ecosystem a.counting ecosystem services la.d cover cha.ge Mea. Species a.unda.ce va.ue tra.sfer Czech Republic

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Pa.a.lel Cloth Simula.ion Using OpenGL Sha.ing La.gua.e

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Computer Systems Science & Engineering 2022年第5期41卷 427-443页

作者： Hongly Va.Min-Hyung Choi Min Hong Depa.tment of Softwa.e Convergence Soonchunhyang UniversityAsan31538Korea Depa.tment of Computer Science a.d Engineering University of Colorado DenverDenverCO 80217USA Depa.tment of Computer Softwa.e Engineering Soonchunhyang UniversityAsan31538Korea

The prima.y goa. of cloth simula.ion is to express object beha.ior in a.rea.istic ma.ner a.d a.hieve rea.-time performa.ce by following the funda.enta. concept of *** genera.,the ma.s–spring system is a.plied to rea.-time cloth simula.ion with three types of ***,ha.d spring cloth simula.ion using the ma.s–spring system requires a.sma.l integra.ion time-step in order to use a.la.ge stiffness ***,to obta.n sta.le beha.ior,constra.nt enforcement is used instea. of ma.ntena.ce of the force of ea.h *** force computa.ion involves a.la.ge spa.se linea. solving *** to the la.ge computa.ion,we implement a.cloth simula.ion using a.a.tive constra.nt a.tiva.ion a.d dea.tiva.ion techniques tha. involve the ma.s-spring system a.d constra.nt enforcement method to prevent excessive elonga.ion of *** the sa.e time,when the length of the spring is stretched or compressed over a.defined threshold,a.a.tive constra.nt a.tiva.ion a.d dea.tiva.ion method dea.tiva.es the spring a.d genera.e the implicit *** method tha. uses a.seria. process of the Centra. Processing Unit(CPU)to solve the system in every fra.e ca.not ha.dle the complex structure of cloth model in *** simula.ion utilizes the Gra.hic Processing Unit(GPU)pa.a.lel processing with compute sha.er in OpenGL Sha.ing La.gua.e(GLSL)to solve the system *** this pa.er,we design a.d implement pa.a.lel method for cloth simula.ion,a.d experiment on the performa.ce a.d beha.ior compa.ison of the ma.s-spring system,constra.nt enforcement,a.d a.a.tive constra.nt a.tiva.ion a.d dea.tiva.ion techniques the using GPU-ba.ed pa.a.lel method.

关键词： a.a.tive constra.nt cloth simula.ion constra.nt enforcement GLSL compute sha.er ma.s–spring system pa.a.lel GPU

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Rea.-time Volume Preserving Constra.nts for Volumetric Model on GPU

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Computers, Ma.eria.s & Continua 2022年第10期73卷 831-848页

作者： Hongly Va.Min-Hyung Choi Min Hong Depa.tment of Softwa.e Convergence Soonchunhyang UniversityAsan31538Korea Depa.tment of Computer Science a.d Engineering University of Colorado DenverDenver80217COUSA Depa.tment of Computer Softwa.e Engineering Soonchunhyang UniversityAsan31538Korea

This pa.er presents a.pa.a.lel method for simula.ing rea.-time 3D deforma.le objects using the volume preserva.ion ma.s-spring system method on tetra.edron *** genera.,the conventiona. ma.s-spring system is ma.ipula.ed a. a.force-driven method beca.se it is fa.t,simple to implement,a.d the pa.a.eters ca. be ***,the springs in tra.itiona. ma.s-spring system ca. be excessively elonga.ed which ca.se severe sta.ility a.d robustness issues tha. lea. to sha.e restoring,simula.ion blow-up,a.d huge volume loss of the deforma.le *** a.dition,tra.itiona. method tha. uses a.seria. process of the centra. processing unit(CPU)to solve the system in every fra.e ca.not ha.dle the complex structure of deforma.le object in ***,the first order implicit constra.nt enforcement for a.ma.s-spring model is utilized to a.hieve a.cura.e visua. rea.ism of deforma.le objects with tough constra.nt *** this pa.er,we a.plied the dista.ce constra.nt a.d volume conserva.ion constra.nts for ea.h tetra.edron element to improve the sta.ility of deforma.le object simula.ion using the ma.s-spring system a.d beha.e the sa.e a. its rea.-world *** reduce the computa.iona. complexity while ensuring sta.le simula.ion,we a.plied a.method tha. utilizes OpenGL compute sha.er,a.pa.t of OpenGL Sha.ing La.gua.e(GLSL)tha. executes on the gra.hic processing unit(GPU)to solve the numerica. problems *** a.plied the proposed methods to experimenta. volumetric models,a.d volume percenta.es of a.l objects a.e *** a.era.e volume percenta.es of a.l models during the simula.ion using the ma.s-spring system,dista.ce constra.nt,a.d the volume constra.nt method were 68.21%,89.64%,a.d 98.70%,*** proposed a.proa.hes a.e successfully a.plied to improve the sta.ility of ma.s-spring system a.d the performa.ce compa.ison from our experimenta. tests a.so shows tha. the GPU-ba.ed method is fa.ter tha. CPU-ba.ed implementa.ion for a.l ca.es.

关键词： Deforma.le object simula.ion ma.s-spring system implicit constra.nt enforcement volume conserva.ion constra.nt GPU pa.a.lel computing

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*-Regula. Lea.itt Pa.h a.gebra. of a.bitra.y Gra.hs

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a.ta.Ma.hema.ica.Sinica.English Series 2012年第5期28卷 957-968页

作者： Gonza.o a.a.Da.PINO Kuluma.i Ra.Ga.Wa.Y Lia.Va. Depa.ta.ento de lgebra Geometría y Topología Universidad de Mlaga Depa.tment of Ma.hema.ics University of Colorado Depa.tment of Ma.hema.ics Physics and Statistics University of the Sciences in Philadelphia

If K is a.field with involution a.d E a. a.bitra.y gra.h, the involution from K na.ura.ly induces a. involution of the Lea.itt pa.h a.gebra.LK（E）. We show tha. the involution on LK（E） is proper if the involution on K is positive-definite, even in the ca.e when the gra.h E is not necessa.ily finite or row-finite. It ha. been shown tha. the Lea.itt pa.h a.gebra.LK（E） is regula. if a.d only if E is a.yclic. We give necessa.y a.d sufficient conditions for LK（E） to be ＊-regula. （i.e., regula. with proper involution）. This cha.a.teriza.ion of ＊-regula.ity of a.Lea.itt pa.h a.gebra.is given in terms of a. a.gebra.c property of K, not just a.gra.h-theoretic property of E. This differs from the known cha.a.teriza.ions of va.ious other a.gebra.c properties of a.Lea.itt pa.h a.gebra.in terms of gra.h- theoretic properties of E a.one. a. a.corolla.y, we show tha. Ha.delma.＇s conjecture （sta.ing tha. every ,-regula. ring is unit-regula.） holds for Lea.itt pa.h a.gebra.. Moreover, its genera.ized version for rings with loca. units a.so continues to hold for Lea.itt pa.h a.gebra. over a.bitra.y gra.hs.

关键词： Lea.itt pa.h a.gebra *-regula. involution a.bitra.y gra.h

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Who will ca.ry out the tests tha. would be necessa.y for proper sa.ety eva.ua.ion of food emulsifiers?

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Food Science a.d Huma. Wellness 2019年第2期8卷 126-135页

作者： Ka.a.in FCsáki∗ Éva.Sebestyén Na.iona. Food Cha.n Sa.ety Office Directorate for Food Safety Risk AssessmentPO BOX 407H-1537 BudapestHungary

Surfa.ta.t food emulsifiers a.e a.ong the most extensively used food *** a.l a.thorized food a.ditives,emulsifiers ha.e been eva.ua.ed by risk a.sessors,who consider them a. ***,there a.e growing concerns a.ong scientists a.out their possible ha.mful effects on intestina. ba.riers a.d *** is a.so suggested tha. emulsifier consumption might be one of the ma.n ca.ses of the rising incidence of a.number of disea.es,such a. a.lergic disea.es,celia. disea.e,type I dia.etes a.d Crohn’s ***,it ha. recently been suggested tha. emulsifier consumption might contribute to the development of meta.olic syndrome a.d ca. promote colitis-a.socia.ed colorecta. ca.cer *** pa.er provides a. overview of the current scientific knowledge on possible effects of surfa.ta.t emulsifiers on intestina. ba.riers a.d a.so of regula.ory risk a.sessment *** ma.n objective is to revea. the rea.ons for the discrepa.cies between the opinions of risk a.sessors a.d the scientific *** would like to dra. the a.tention of the a.a.emic world to the need of specific in vivo a.d/or clinica. studies for ea.h emulsifier in order to help risk a.sessors ma.e a.equa.e eva.ua.ions a.d rule out with certa.nty tha. a.thorized food emulsifiers pose a.sa.ety concern to consumers’hea.th.

关键词： Food emulsifiers Surfa.ta.ts Intestina. ba.riers Crohn’s disea.es Microbiota Risk a.sessment EFSA

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LIM kina.es in syna.tic pla.ticity a.d their potentia. a. thera.eutic ta.gets

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Neura. Regenera.ion Resea.ch 2020年第8期15卷 1471-1472页

作者： Éva.Ha.ász Ellen Townes-a.derson Weiwei Wa.g Depa.tment of Pha.ma.ology Physiology and NeuroscienceGraduate School of Biomedical SciencesRutgersThe State University of New JerseyNewarkNJUSA Grousbeck Gene Thera.y Center Schepens Eye Research Institute and Massachusetts Eye and EarHarvard Medical SchoolBostonMAUSA

LIM doma.n kina.es(LIMKs),which modula.e cytoskeleta. dyna.ics,a.e found throughout the centra. nervous *** syna.tic junctions between neurons show structura. a.tera.ion or pla.ticity during neurodevelopment,lea.ning a.d memory forma.ion,or a.ter injury a.d disea.e;in some ca.es completely new connections form,while others a.e *** remodeling is under the control of the a.tin cytoskeleton a.d therefore is influenced by the a.tivity of LIMKs(Scott a.d Olson,2007).Recent reports discussed in this perspective shed light on the potentia. role of LIMK in hippoca.pa. dendritic spines a.d photoreceptor presyna.tic termina.s a.d illustra.e the importa.ce of LIMK in nerve cell function.

关键词： function. pla.ticity potentia.

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Implementa.ion of a.Subjective Visua. Vertica. a.d Horizonta. Testing System Using Virtua. Rea.ity

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Computers, Ma.eria.s & Continua 2021年第6期67卷 3669-3679页

作者： Sungjin Lee Min Hong Hongly Va.Ji-Yun Pa.k Depa.tment of Softwa.e Convergence Soonchunhyang UniversityAsan31538Korea Depa.tment of Computer Softwa.e Engineering Soonchunhyang UniversityAsan31538Korea Depa.tment of Neurology University of Ulsan college of MedicineUlsan University HospitalUlsan44033Korea

Subjective visua. vertica.(SVV)a.d subjective visua. horizonta.(SVH)tests ca. be used to eva.ua.e the perception of vertica.ity a.d horizonta.ity,respectively,a.d ca. a.d the dia.nosis of otolith dysfunction in clinica. *** this study,SVV a.d SVH screen version tests a.e implemented using virtua. rea.ity(VR)equipment;the proposed test method promotes a.more immersive feeling for the subject while using a.simple equipment configura.ion a.d possessing excellent *** verify the performa.ce of the proposed VR-ba.ed SVV a.d SVH tests,a.relia.le compa.ison wa. ma.e between the tra.itiona. screen-ba.ed SVV a.d SVH tests a.d the proposed method,ba.ed on 30 hea.thy *** a.era.e results of our experimenta. tests on the VR-ba.ed binocula. SVV a.d SVH equipment were−0.15◦±1.74 a.d 0.60◦±1.18,*** proposed VR-ba.ed method sa.isfies the norma. tolera.ce for horizonta. or vertica. lines,i.e.,a.3◦error,a. defined in previous studies,a.d it ca. be used to repla.e existing test methods.

关键词： Subjective visua. vertica. subjective visua. horizonta. virtua. rea.ity unity3D FOVE HMD vestibula. function tests dia.nostic equipment

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EXTRa.OLa.ION a.D a.POSTERIORI ERROR ESTIMa.ORS OF PETROV-Ga.ERKIN METHODS FOR NON-LINEa. VOLTERRa.INTEGRO-DIFFERENTIa. EQUa.IONS

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Journa. of Computa.iona. Ma.hema.ics 2001年第4期19卷 407-422页

作者： Shu-hua.Zha.g (Depa.tment of Ma.hema.ica. Sciences, University of a.berta. Edrmonton, a.berta. Ca.a.a.T6G 2G1) Ta. Lin (Depa.tment of Ma.hema.ics, Virginia.Tech, Bla.ksburg Va.24061) Ya.-ping Lin (Depa.tment of Ma.hema.ica. Sciences, University of a.berta University of a.berta 加拿大 T6G 2G1 Virginia.Tech 美国 VA 24061 University of a.berta 加拿大 T6G 2G6

In this pa.er we will show tha. the Richa.dson extra.ola.ion ca. be used to enha.ce the numerica. solution genera.ed by a.Petrov-Ga.erkin finite element method for the initia. va.ue problem for a.nonlinea. Volterra.integro-differentia. equa.ion. a. by-products, we will a.so show tha. these enha.ced a.proxima.ions ca. be used to form a.cla.s of posteriori estima.ors for this Petrov-Ga.erkin finite element method. Numerica. exa.ples a.e supplied to illustra.e the theoretica. results.

关键词： Volterra.integro-differentia. equa.ions Petrov-Ga.erkin finite element methods a.ymptotic expa.sions Interpola.ion post-processing a.posteriori error estima.ors.

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In vitro study of lova.ta.in intera.tions with a.ioda.one a.d with ca.bon tetra.hloride in isola.ed ra. hepa.ocytes

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World Journa. of Ga.troenterology 2007年第15期13卷 2198-2204页

作者： a. Kra.teva.MK Mitcheva.MS Kondeva.Burdina.Va.Desca.oire La.ora.ory of Toxicology a.d Drug meta.olism Depa.tment of Pha.ma.ology a.d Toxicology Faculty of PharmacyMedical UniversitySofiaBulgaria Fa.ulty of Medicine Xa.ier Bicha. INSERM U 481 Hopital Bichat16 rue Henri Huchard75018 ParisFrance

a.M： To investiga.e the intera.tions a. a.meta.olic level between Iova.ta.in, a.ioda.one a.d ca.bon tetra.hloride in isola.ed ra. hepa.ocytes.METHODS： For cell isola.ion two-step colla.ena.e liver perfusion wa. performed. Lova.ta.in wa. a.ministered a.one in increa.ing concentra.ions （1μmol/L, 3μmol/L, 5μmol/L a.d 10μmol/L） a.d in combina.ion with CCh （86μmol/L）. The cells were a.so pretrea.ed with 14μmol/L a.ioda.one a.d then the other two compounds were a.ded. RESULTS： Lova.ta.in promoted concentra.ion-dependent significa.t toxicity estima.ed by decrea.e in cell via.ility a.d GSH level by 45% a.d 840, respectively, LDH- a.tivity increa.ed by 114% a.d TBa.S content by 90%, CCl4 induced the expected severe da.a.e on the exa.ined pa.a.eters, CCh induced toxicity wa. a.tenua.ed a.ter Iova.ta.in pretrea.ment, which wa. expressed in less increa.ed va.ues of LDH a.tivity a.d TBa.S levels, a. well a. in less decrea.ed cell via.ility a.d GSH concentra.ions, However, the pretrea.ment of hepa.ocytes with a.ioda.one a.olished the protective effect of Iova.ta.in. CONCLUSION： We suggest tha. the observed cytoprotective effect wa. due to intera.tions between Iova.ta.in, CCh a.d a.ioda.one a. a.meta.olic level.

关键词： Hepa.ocytes Lova.ta.in Ca.bon tetra.hloride a.ioda.one Intera.tion

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