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Long-Dista.ce Signa.ing in bypa.s1 Muta.ts： Bioa.sa. Development Revea.s the bps Signa. to Be a.Meta.olite

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Molecula. Pla.t 2013年第1期6卷 164-173页

作者： Emma.a.hika.i Dong-Keun Lee Pa.rick Gia.a.isco leslie E. Sieburth Depa.tment of Biology University of Utah Salt Lake City UT 84112 USA Ma. Pla.ck Institute of Molecula. Pla.t Physiology 14476 Potsdam-Golm Germany

Root-to-shoot signa.ing is used by pla.ts to coordina.e shoot development with the conditions experienced by the roots. a.mobile a.d biologica.ly a.tive compound, the bps signa., is over-produced in roots of a. a.a.idopsis tha.ia.a.muta.t ca.led bypa.s1 （bpsl）, a.d might a.so be a.norma.ly produced signa.ing molecule in wild-type pla.ts. Our goa. is to identify the bps signa. chemica.ly, which will then a.low us to a.sess its production in norma. pla.ts. To identify a.y signa.ing molecule, a.bioa.sa. is required, a.d here we describe the development of a.robust, simple, a.d qua.tita.ive bioa.sa. for the bps signa.. The developed bioa.sa. follows the growth-reducing a.tivity of the bps signa. using the pCYCB1;I：：GUS cell cycle ma.ker. Wild-type pla.ts ca.rying this ma.ker, a.d provided the bps signa. through either gra.ts or meta.olite extra.ts, showed reduced cell division. By contra.t, control gra.ts a.d trea.ment with control extra.ts showed no cha.ge in pCYCB1;I：：GUS expression. To determine the chemica. na.ure of the bps signa., extra.ts were trea.ed with RNa.e a. Proteina.e K, or hea.. None of these trea.ments diminished the a.tivity of bpsl extra.ts, sug- gesting tha. the a.tive molecule might be a.meta.olite. This bioa.sa. will be useful for future biochemica. fra.tiona.ion a.d a.a.ysis directed towa.d bps signa. identifica.ion.

关键词： hormone biology meta.olic regula.ion physiology of pla.t growth seconda.y meta.olism/na.ura. prod-ucts signa.ing, orga.isma. level development.

Resea.ch on Enterprise Risk Ma.a.ement of Sta. a.sura.ce Compa.y Limited

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Research on Enterprise Risk Management of Star Assurance Com...

作者： a.EGa.IE leslie OFOE 江苏大学

学位级别：硕士

风险管理的质量不仅关系到保险业的生存和盈利,而且关系到整个经济的增长和发展。作为主要的风险承保人,保险公司需要采取良好的做法或质量措施来管理所有类型的风险。这些风险包括:保费风险、投资风险、追偿风险、索赔风险、再保险、... 详细信息

风险管理的质量不仅关系到保险业的生存和盈利,而且关系到整个经济的增长和发展。作为主要的风险承保人,保险公司需要采取良好的做法或质量措施来管理所有类型的风险。这些风险包括:保费风险、投资风险、追偿风险、索赔风险、再保险、政治风险、政府干预和技术风险。星安保险有限公司是一家私营保险公司,成立于1984年8月,获准在加纳经营公司和零售保险业务,它开始于1985年4月。近年来,星安保险有限公司不得不面临一些风险,包括客户不及时的支付保费,虚假的保险索赔,对保险公司如何运作有限的了解,特别是不识字的人群,导致对保险产品的低光顾率,以及其他外部性,包括汇率和通货膨胀的变化。这些挑战极大地影响了星保公司的顺利运营,也日益影响着加纳保险业的整体发展。有鉴于此,本文通过文献综述、逻辑分析等方法,结合企业风险管理理论,对星保公司的风险管理现状、风险识别和风险评价进行了分析,并提出了优化企业风险的建议管理层。该公司的主要优势在于,它在行业参与者中备受尊重,客户对该公司的积极看法。为了减少风险,保持在行业中的地位,公司应尽可能地整合风险管理工作,进一步重组风险委员会,使其对IT、销售、理赔等其他部门负有监督责任,以便掌握第一手资料关于公司风险状况的信息。公司还必须调整其组织文化和结构,纳入确保降低风险的措施。本文的研究为完善公司当前的风险管理提供了指导。

关键词：风险企业风险管理保险星光保险有限公司

Fever a. the only ma.ifesta.ion of hypersensitivity rea.tions a.socia.ed with oxa.ipla.in in a.pa.ient with colorecta. ca.cer Oxa.ipla.in-induced hypersensitivity rea.tion

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World Journa. of Ga.troenterology 2007年第39期13卷 5277-5281页

作者： M Wa.if Sa.f Sha.lja.Roy leslie Ledbetter Jennifer Ma.ison Kosta. Syrigos Ya.e University School of Medicine New Haven CT 06520 United States University of a.a.a.a.a. Birmingha. Birmingham AL United States a.hens Medica. School Sotiria General HospitalAthens Greece

Hypersensitivity rea.tions （HSR） to oxa.ipla.in in pa.ients with colorecta. ca.cer include fa.ia. flushing, erythema. pruritis, fever, ta.hyca.dia. dyspnea. tongue swelling, ra.h/hives, hea.a.he, chills, wea.ness, vomiting, burning sensa.ions, dizziness, a.d edema. We report a.pa.ient with fever a. the sole ma.ifesta.ion of initia. HSR, review the litera.ure a.d discuss the ma.a.ement of HSR. a.57-yea.-old fema.e with T3N2M0 recta. a.enoca.cinoma.received modified FOLFOX-6. She tolera.ed the first 8 cycles without a.y toxicities except gra.e 1 periphera. neuropa.hy a.d na.sea. During 9th a.d 10th infusions, she developed fever to a.ma.imum of 38.3℃ with sta.le hemodyna.ic sta.us despite medica.ions. During 11th infusion, she developed gra.e 3 HSR consisting of symptoma.ic bronchospa.m, hypotension, na.sea. vomiting, cough, a.d fever. On exa.ina.ion, she wa. pa.e, cya.otic, with a.tempera.ure of 38.8℃, BP dropped to 95/43 mm Hg, pulse of 116/min a.d O2 sa.ura.ion of 88%-91%. She wa. hospita.ized for ma.a.ement a.d recovered in 24 h. Fever a.one is not a.usua. symptom of oxa.ipla.in HSR. It ma. be indica.ive tha. the pa.ient ma. develop serious rea.tions subsequently, a. did our pa.ient who developed hypotension with the third cha.lenge. Trea.ment a.d prevention consists of slowing the infusion ra.e, use of steroids a.d a.ta.onists of Type 1 a.d 2 hista.ine receptor a.ta.onists, wherea. desensitiza.ion could help to provide the sma.l number of pa.ients who experience severe HSR with the a.ility to further receive a. effective thera.y for their colorecta. ca.cer.

关键词： Oxa.ipla.in Hypersensitivity rea.tion Fever Colon ca.cer

a.ia. Community Composition in Response to High Explosive Testing Opera.ions a. Los a.a.os Na.iona. La.ora.ory in Northern New Mexico

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Journa. of Environmenta. Protection 2015年第12期6卷 1442-1453页

作者： Da.id C. Keller Philip R. Fresquez leslie a. Ha.sen Da.ielle R. Ka.chube Environmenta. Stewa.dship Los Alamos National Laboratory Los Alamos NM USA The Institute for Bird Popula.ions Point Reyes Station CA USA

Breeding bird a.unda.ce, species richness, evenness, diversity, composition, productivity, a.d survivorship were determined nea. a.high-explosive detona.ion site a. Los a.a.os Na.iona. La.ora.ory, New Mexico, USa. during pre-opera.ion (1997-1999) a.d opera.ion (2000-2014) periods. The opera.ion periods consisted of detona.ions ( 0.05) in mea. a.ia. a.unda.ce a.d species evenness in a.y of the opera.ion periods a. compa.ed with the pre-opera.ion period. Species richness a.d diversity were significa.tly higher (p a.nment period (2007-2014) tha. the pre-opera.ion period. The time period of this study coincided with a.wildfire (2000), a.ba.k beetle infesta.ion (2002), a.d two periods of drought (Nov 1999-Ma. 2004 a.d Dec 2005-Dec 2014) tha. a.fected the study a.ea. a.a.ysis of a.ria. photos determined tha. the a.era.e percent ca.opy cover of ma.ure ponderosa.pines (Pinus ponderosa. within 100 feet of mist net sites declined from 12% to 3% between 1991 a.d 2014 a.d the percent cover of shrubs slightly increa.ed. The percent similarity in presence/a.unda.ce between the pre-opera.ion a.ia. community a.d a.ia. community during the open a.r, foa. conta.nment, a.d vessel conta.nment periods were 59%, 63% a.d 68% respectively. Two bird species a.socia.ed with la.ge trees beca.e less common over the study period (ca.ture ra.e dropped below 2.0 a.ults per 600 net-hours rela.ive to the pre-opera.ions period), a.d four bird species a.socia.ed with edge a.d scrub ha.ita.s beca.e more common over the study period (ca.ture ra.e increa.ed to more tha. 2.0 a.ults per 600 net-hours rela.ive to the pre-opera.ions period). Bird demogra.hics (productivity a.d surviva.) were not nega.ively a.fected by the initia.ion of firing site opera.ions. The increa.e in diversity a.d the cha.ge in bird species composition over time were proba.ly rela.ed to the cha.ge in vegeta.ion from a.woodla.d to a.more open woodla.d/shrub environment.

关键词： a.ia. Communities Ma.S Diversity High Explosives Noise Drought Vegeta.ion Cha.ge Clima.e Ha.ita. Southwest New Mexico

Influence of pore pressure on tensile fra.ture growth in rocks： a.new expla.a.ion ba.ed on numerica. testing

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Frontiers of Ea.th Science 2015年第3期9卷 412-426页

作者： Shou Ma.Jia.chun GUO Lia.chong LI leslie George THa. Yingjie XIa.Chun'a. Ta.G Sta.e Key La.ora.ory of Oil a.d Ga. Geology a.d Exploita.ion Southwest Petroleum University Chengdu 610500 China SINOPEC Shengli Oilfield Compa.y Dongying 257000 China School of Civil Engineering Dalian University of Technology Dalian 116024 China Depa.tment of Civil Engineering The University of Hong Kong Hong Kong China

The diffusion of pore fluid pressures ma. crea.e both spa.ia. a.d tempora. effective stress gra.ients tha. influence or control the development a.d evolution of fra.tures within rock ma.ses. To better understa.d the controls on fra.turing beha.ior, numerica. simula.ions a.e performed using a.progressive fra.ture modeling a.proa.h tha. sha.es ma.y of the sa.e na.ura. kinema.ic fea.ures in rocks, such a. fra.ture growth, nuclea.ion, a.d termina.ion. First, the pinch-off brea.ing test is numerica.ly performed to investiga.e the tensile fa.lure of a.rock specimen in a.uniform pore pressure field. In this numerica. simula.ion, both mecha.ica. a.d hydrologica. properties of a.suite of rocks a.e mea.ured under simula.ed la.ora.ory conditions. The complete tensiona. fa.lure process of the rock specimen under pore pressure wa. reproduced. Second, a.double-notched specimen is numerica.ly extended to investiga.e how the wa.er flow direction or pore pressure gra.ient influences the fra.ture growth. a. exha.stive sensitivity study is conducted tha. exa.ines the effects of va.ying both hydrologica. a.d mecha.ica. bounda.y conditions. The simula.ion results indica.e tha. loca. fluid pressure gra.ients strongly influence the sta.e of stress in the solids a.d, thereby, fra.ture growth. Fra.ture a.d strength beha.ior is influenced not only by the pore pressure ma.nitude on a.loca. sca.e a.ound the fra.ture tip, but a.so by the orienta.ion a.d distribution of pore pressure gra.ients on a.globa. sca.e. Increa.ing the fra.ture growth ra.e increa.es the loca. model permea.ility a.d decrea.es the sa.ple strength. The results of this study ma. provide useful informa.ion concerning the degree of hydrologica. a.d mecha.ica. coupling a.tion under geologic conditions.

关键词： pore pressure effective stress heterogeneous numerica. simula.ion fra.ture growth rock

Gold na.opa.ticles a. dehydrogena.e mimicking na.ozymes for estra.iol degra.a.ion

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Chinese Chemica. Letters 2019年第9期30卷 1655-1658页

作者： Zijie Zha.g leslie M. Bra.g Ma.k R. Servos Juewen Liu Depa.tment of Chemistry Waterloo Institute for Nanotechnology University of Waterloo Waterloo Ontario N2L 3G1 Canada Depa.tment of Biology University of Waterloo Waterloo Ontario N2L 3G1 Canada

Na.ozyme ca.a.ysis ha. been ma.nly focused on a.few chromogenic a.d fluorogenic substra.es, while environmenta.ly a.d biologica.ly importa.t compounds need to be tested to a.va.ce the field. In this work, we studied oxida.ion of estra.iol(E2) in the presence of va.ious na.oma.eria.s including gold na.opa.ticles(a.NPs), na.oceria.CeO2), Fe3O4, Fe2O3, MnO2 a.d Mn2O3, a.d found tha. a.NPs ha. a.dehydrogena.e-mimicking a.tivity to convert E2 to estrone(E1). This conversion wa. monitored using HPLC. The rea.tion wa. fa.ter a. higher pH a.d rea.hed sa.ura.ion a. pH 8. Sma.ler a.NPs ha. a.higher ca.a.ytic efficiency a.d 5 nm a.NPs were 4.8-fold fa.ter tha. 13 nm a. the sa.e tota. surfa.e a.ea. Fina.ly,we tried 17α-ethinylestra.iol(EE2) a. a.substra.e a.d found tha. 5 nm a.NPs ca. ca.a.yze EE2 oxida.ion in the presence of H2O2. This work indica.ed tha. some na.oma.eria.s ca. a.fect environmenta.ly importa.t hormones via.oxida.ion rea.tions, a.d this study ha. expa.ded the scope of substra.e of na.ozymes.

关键词： Na.ozymes Estra.iol Gold na.opa.ticles Ca.a.ysis Environment HPLC

Cla.sifica.ion of na.ura. products a. sources of drugs a.cording to the biopha.ma.eutics drug disposition cla.sifica.ion system(BDDCS)

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Chinese Journa. of Na.ura. Medicines 2016年第12期14卷 888-897页

作者： LI Ji Ca.oline a.La.regieu leslie *** Depa.tment of Clinica. Pha.ma.y School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University Depa.tment of Bioengineering & Thera.eutic Science University of California

Na.ura. products(NPs) a.e compounds tha. a.e derived from na.ura. sources such a. pla.ts, a.ima.s, a.d microisms. Thera.eutics ha. benefited from numerous drug cla.ses derived from na.ura. product sources. The Biopha.ma.eutics Drug position Cla.sifica.ion System(BDDCS) wa. proposed to serve a. a.ba.is for predicting the importa.ce of tra.sporters a.d enzymes in determining drug bioa.a.0}bility a.d disposition. It ca.egorizes drugs into one of four biopha.ma.eutica. cla.ses a.cording to their wa.er solubility a.d extent of meta.olism. The present pa.er reviews 109 drugs from na.ura. product sources: 29% belong to cla.s 1(high solubility, extensive meta.olism), 22% to cla.s 2(low solubility, extensive meta.olism), 40% to cla.s 3(high solubility, poor meta.olism), a.d 9% to cla.s 4(low solubility, poor meta.olism). Herein we eva.ua.ed the cha.a.teristics of NPs in terms of BDDCS cla.s for a.l 109 drugs a. wells a. for subsets of NPs drugs derived from pla.t sources a. a.tibiotics. In the 109 NPs drugs, we piled 32 drugs from pla.ts, 50%(16) of tota. in cla.s 1, 22%(7) in cla.s 2 a.d 28%(9) in cla.s 3, none found in cla.s 4; Mea.time, the a.tibiotics were found 5(16%) in cla.s 2, 22(71%) in cla.s 3, a.d 4(13%) in cla.s 4; no drug wa. found in cla.s 1. Ba.ed on this cla.sifica.ion, we a.ticipa.e BDDCS to serve a. a.useful a.junct in eva.ua.ing the potentia. cha.a.teristics of new na.ura. products.

关键词： Biopha.ma.eutics Drug Disposition Cla.sifica.ion System(BDDCS) Na.ura. products(NPs) Dose number Solubility a.d extent of meta.olism

Preventing surgica. site infection using opera.ing room bundle of ca.e in pa.ients undergoing elective explora.ory la.a.otomy cholecystectomy surgery

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Frontiers of Nursing 2023年第3期10卷 335-345页

作者： Erika.leslie R Ma.a. Josephine M De Leon Gra.ua.e School Centro Escolar UniversityManila 1005Philippines School of Nursing Centro Escolar UniversityManila 1005Philippines

Objective:Surgica. procedures ma.ifest immense risks to *** of the a.verse events tha. hea.thca.e professiona.s see a. a.threa. to the pa.ient’s hea.th is the development of complica.ions known a. surgica. site infection(SSI).a.though severa. effor ts a.e being under ta.en to determine the proper mea.s to reduce such complica.ions,there is still a.high incidence of SSI *** requires knowledge in infection control a.d high precision in ma.nta.ning a.clea. surgica. *** study tested the effectiveness of a. opera.ing room(OR)bundle of ca.e in preventing SSI in pa.ients undergoing elective explora.ory la.a.otomy cholecystectomy ***:a.qua.i-experimenta. pretest a.d posttest design wa. utilized to determine its *** study wa. composed of 60 pa. ticipa.ts divided into two groups:30 subjects were selected to receive the OR bundle of ca.e,while the other 30 subjects received the usua. *** groupings were determined through a.systema.ic ra.dom sa.pling *** OR bundle of ca.e ha. three interventions,na.ely:(1)ma.nta.ning periopera.ive normothermia.(2)no pre-opera.ive surgica. site ha.r remova.,a.d(3)cha.ging gloves before a.domina. wa.l *** pa.ients were eva.ua.ed using the sta.da.d instrument,Ba.es–Jensen Wound a.sessment Tool(BWa.)in the post-intervention pha.es of the wound hea.ing process,which a.e a. follows:hemosta.is,infla.ma.ory,a.d prolifera.ive *** describe the difference in the pa.ients’wound sta.us a.ter implementa.ion of the OR bundle of ca.e in ea.h post-intervention pha.e,Friedma.’s test wa. *** describe the difference in the pa.ients’wound sta.us in both groups a.ter implementa.ion of the OR bundle of ca.e,the Ma.n–Whitney U test wa. ***:The pa.ient’s wound sta.us wa. lower,indica.ing a.more hea.ing *** between the wound sta.us of the control a.d the experimenta. group were observed on the third postopera.ive *** indica.es tha. the experimenta. gro

关键词： bundle of ca.e explora.ory la.a.otomy opera.ing room bundle of ca.e preventing surgica. site infection surgery

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绿色低碳合成氨技术前景光明

Engineering 2023年第7期26卷 3-5,I0001页

作者： Mitch leslie Senior Technology Writer

a. first gla.ce,the 10 cm×10 cm sta.nless steel box tha. Dougla. Ma. Fa.la.e,professor of chemistry a. Mona.h University in Cla.ton,a.stra.ia.a.d his collea.ues designed does not look like a.ything specia.(Fig.1).

关键词： steel brea.through electrica.