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ERp57 in neurodegenera.ion a.d regenera.ion

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Neura. Regenera.ion Resea.ch 2016年第2期11卷 232-233页

作者： leslie Ba.gsted Cla.dio Hetz Soleda. Ma.us Neurounion Biomedica. Founda.ion CENPAR Santiago Chile Biomedica. Neuroscience Institute Faculty of Medicine University of Chile Santiago Chile Center for Geroscience Brain Health and Metabolism Institute of Biomedica. Sciences Center for Molecular Studies of the Cell Program of Cellular and Molecular Biology University of ChileSantiago Chile Depa.tment of Immunology a.d Infectious Disea.es Harvard School of Public Health

The protein disulfide isomera.es（PDIs）fa.ily ha. a.centra. function in the folding of proteins synthetized through the secretory ***57,a.so known a. Grp58 or PDIa.,is one of the ma.n studied members of this fa.ily.

关键词： ERp57 in neurodegenera.ion a.d regenera.ion PDI

Sa.iva.y flow ra.es, per se, ma. not serve a. consistent predictors for denta. ca.ies

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Open Journa. of Stoma.ology 2013年第2期3卷 133-141页

作者： Cynthia.P. Tra.tenberg Julia.a.a. Ba.ros Sha.izeh a. Pa.el leslie Miles Cha.les F. Streckfus Depa.tment of Dia.nostic & Biomedica. Sciences University of Texas School of Dentistry at Houston Houston USA Depa.tment of Medica./Surgica. Reha.ilita.ion University of Texas School of Nursing at Houston Houston USA Depa.tment of Periodontics Case Western Reserve University School of Dental Medicine Cleveland USA Depa.tment of Restora.ive Dentistry Prosthodontics and Biomaterials University of Texas School of Dentistry at Houston Houston USA

Ba.kground: This clinica. study eva.ua.ed the effects of sa.iva.y flow ra.e, a.e, ra.e, hea.th sta.us a.d medica.ions on the incidence of ca.ies. Methods:Ca.ca.sia. a.d a.rica.-a.erica. men a.d women (n = 501), a.ed 22-93 yea.s pa.ticipa.ed in the study. Stimula.ed (S) a.d unstimula.ed (U) pa.otid (P) a.d subma.dibula. gla.ds (SM) sa.iva.y secretions were collected. Stimula.ed whole sa.iva.(SWS) wa. collected a. control. Gla.dula. stimula.ion wa. a.hieved using 2% citric a.id a. 30-second interva.s to the dorsa. surfa.e of the tongue. Sa.iva.y flow ra.es (SFR) were ca.cula.ed by tota. weight of sa.iva.divided by 5 minutes a.d expressed in ml/minute. Corona. ca.ies were scored using the NIDR DMFS index. Ca.ious lesions were cla.sified a.cording to tooth surfa.es by a.ca.ibra.ed single exa.iner. Spea.ma. correla.ion coefficients were ca.cula.ed to determine the a.socia.ion between SFR with a.e a.d percenta.e of ca.ious teeth. Multiple regression a.a.yses were ca.cula.ed a. (p a.ia.les gender, ra.e, a.e, hea.th sta.us, medica.ion usa.e a.d sa.iva.y function were not predictors for denta. disea.e. a.ditiona.ly, these risk fa.tors were not risk fa.tors for missing teeth. Conclusions: In conclusion, cross-sectiona. investiga.ions a.e limited in their a.ility to identify the releva.t va.ia.les for disea.e prediction. In a.dition, clinica. a.d ba.ic science investiga.ions will be necessa.y to a.sess risk fa.tors for denta. ca.ies.

关键词： Sa.iva.y Gla.ds Sa.iva Ca.ies a.ing Medica.ions

Hydrogeology of Pumice-Hosted Fens in the Winema.Fremont Na.iona. Forest, Oregon, USA

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Journa. of Wa.er Resource a.d Protection 2014年第19期6卷 1762-1780页

作者： Micha.l L. Cummings Jona.ha. M. Wea.herford leslie a. Mowbra. Depa.tment of Geology Portland State University Portland USA

Suba.ria. fa.lout from the Holocene eruption of Mount Ma.a.a.in the Oregon Ca.ca.e Ra.ge wa. deposited upon rela.ively low permea.ility volca.ic a.d volca.icla.tic bedrock a.d regolith. In the Wa.ker Rim study a.ea. erosion by ephemera. strea.s shortly a.ter the eruption disrupted the la.era. continuity of the 270 to 300 cm-thick pumice deposit. Co-evolution of the surfa.e- a.d ground-wa.er systems in a.low-relief, low-slope la.dsca.e a.lowed diffuse groundwa.er discha.ge from the ba.ks of the evolving strea. system. a.cumula.ion of orga.ic ma.eria. from groundwa.er dependent ecosystems a. these sites of discha.ge a.lowed pea. deposits to form on gently sloping erosion surfa.es cut into the pumice deposit. Following ea.ly strea. incision, fine-gra.ned, silt-rich deposits a.cumula.ed in va.leys a.d contributed permea.ility ba.riers to the la.era. migra.ion of wa.er in the pumice a.uifer. Fens discha.ge from the pumice a.uifer through gently sloping surfa.es pa.terned a.ter the slope of the erosion surfa.e cut into the pumice deposit a.d overla.n by a.proxima.ely 1 m of pea. on the sloping surfa.e a.d a.luvium or iron-cemented pumice overla.n by a.luvium a. the toe of the slope. The predomina.t source of groundwa.er is snowmelt which infiltra.es the pumice deposit during the freshet. However, sha.low groundwa.er flow a.so ta.es pla.e a.ong permea.le pa.hwa.s in bedrock units. Loca.ly, low volume discha.ge ta.es pla.e a.ong fa.lts. The snowmelt-dependent hydrologic system tha. supports the fens of the Wa.ker Rim study a.ea.occurs a. eleva.ions prima.ily a.ove 1585 m.

关键词： Groundwa.er Dependent Ecosystem Fen Pumice a.uifer Mount Ma.a.a Oregon

Na.ure of the Supercritica. Mesopha.e

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Na.ura. Science 2014年第10期6卷 797-807页

作者： Ha.za.J. Ma.nier Robin a. Curtis leslie V. Woodcock Depa.tment of Physics University of Algarve Faro Portugal Ma.chester Institute of Biotechnology University of Manchester Manchester UK

It ha. been reported tha. a. tempera.ures a.ove the critica. there is no “continuity of liquid a.d ga.”, a. origina.ly hypothesized by va. der Wa.ls [1]. Ra.her, both ga. a.d liquid pha.es, with cha.a.teristic properties a. such, extend to supercritica. tempera.ures [2]-[4]. Ea.h pha.e is bounded by the locus of a.percola.ion tra.sition, i.e. a.higher-order thermodyna.ic pha.e cha.ge a.socia.ed with percola.ion of ga. clusters in a.la.ge void, or liquid interstitia. va.a.cies in a.la.ge cluster. Between these two-pha.e bounds, it is reported there exists a.mesopha.e tha. resembles a. otherwise homogeneous dispersion of ga. micro-bubbles in liquid (foa.) a.d a.dispersion of liquid micro-droplets in ga. (mist). Such a.colloida.-like sta.e of a.pure one-component fluid represents a.hitherto uncha.tered equilibrium sta.e of ma.ter besides pure solid, liquid or ga.. Here we provide compelling evidence, from molecula. dyna.ics (MD) simula.ions, for the existence of this supercritica. mesopha.e a.d its colloida. na.ure. We report prelimina.y results of computer simula.ions for a.model fluid using a.simplistic representa.ion of a.oms or molecules, i.e. a.ha.d-core repulsion with a. a.tra.tion so short tha. the a.oms a.e referred to a. “a.hesive spheres”. Molecula. clusters, a.d hence percola.ion tra.sitions, a.e una.biguously defined. Gra.hics of color-coded clusters show colloida. cha.a.teristics of the supercritica. mesopha.e. We a.pend this Letter to Na.ura. Science with a.deba.e on the scientific merits of its content courtesy of correspondence with Na.ure (a.pendix).

关键词： Supercritica. Mesopha.e a.hesive-Sphere Critica.ity Liquid-Ga.

BMP decision support system for eva.ua.ing stormwa.er ma.a.ement a.terna.ives

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Frontiers of Environmenta. Science & Engineering 2009年第4期3卷 453-463页

作者： Mow-Soung CHENG Jenny X.ZHEN leslie SHOEMa.ER Depa.tment of Environmenta. Resources Prince George’s County Government9400 Peppercorn PlaceLargo MD 20774USA Tetra.Tech Inc.10306 Eaton PlaceFairfax VA 22030USA

Prince George’s County,Ma.yla.d,in the Wa.hington *** a.ea.ha. developed a.best ma.a.ement pra.tice decision support system(BMPDSS)to support a.a.ysis a.d decision ma.ing for stormwa.er ma.a.ement pla.ning a.d design a. both the site sca.e a.d the wa.ershed *** pa.er presents a.deta.led description of the BMPDSS.a.ca.e study tha. demonstra.es the a.plica.ion of the system is a.so *** ca.e study involves a.Green Highwa. project loca.ed in a.highly urba.ized a.ea.within the a.a.ostia.River wa.ershed of the *** best ma.a.ement pra.tices(BMP)such a. bioretention,filter vegeta.ive swa.e,porous pa.ing,a.d la.dsca.e infiltra.ion a.e proposed for reducing highwa. runoff a.d improving wa.er *** BMPDSS is used to identify a.d eva.ua.e va.ious a.terna.ives to determine the most costeffective types a.d combina.ions of BMPs tha. minimize the highwa. runoff pollution.

关键词： best ma.a.ement pra.tices decision support system low impa.t development geogra.hic informa.ion system optimiza.ion

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哈贝马斯

THE PRESS a.D THE JUDICIa.Y： COURT a.D JUDICIa. REPORTS IN THE PREss IN ENGLa.D a.D Wa.ES

作者： (美)莱斯利·a. 豪(leslie a. Howe)

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Frontiers of La. in China.Selected Publica.ions from Chinese Universities 2014年第2期9卷 131-158页

作者： leslie J. MORa. Depa.tment of La. University of Lancaster Lancaster UK Professor at School of Law Birkbeck College University of London London UK Prima.y resea.ch fields a.e the judicia.y law and visual culture and sexuality and law. The author wishes to thank Professor Feng of the Renmin University of China Law School in Beijing Dr Andy Chiu of Hong Kong Shue Yan University Department of Law and Business and Mr. Paul K. C. Chung for their generous supports and for providing me with the opportunity to present this research to scholars and students in China. Responsibility for the shortcoming of the analysis remains mine

Western schola.s ha.e a.gued tha. ima.e ma.ing a.d ima.e ma.a.ement a.e a.preoccupa.ion of the judicia.y. Ima.es of the judicia.y ma. ta.e a.va.iety of forms a.d be produced for kinds of a.diences. One form of judicia. ima.e ma.ing a.d ima.e ma.a.ement is live performa.ces in the courtroom a.d other court settings. a.other is the written judgment where the preoccupa.ion is the style of the written text. Press a.d other ma.s media.reports of judicia. a.tivity a.e a.other. The a.dience for judicia. ima.es is equa.ly diverse, from fellow judges, la.yers in the courts a.d the wider lega. community, the litiga.ts before the courts to the executive, legisla.ure a.d the public both in the courtroom a.d beyond. The ima.e of the judicia.y tha. is a.a.0}ble to the public ha. a.pa.ticula. significa.ce in Western rule of la. democra.ies. a. a.genera. rule courts a.d the judicia.y a.e required to opera.e in public a.d their a.tivities must be open to public scrutiny. a.recent policy ma.ifesta.ion of this goa. is deba.ed a.out confidence in the justice system a.d initia.ives designed to improve confidence. In the ma.ority of ca.es public scrutiny of judicia. a.tivity a.d public confidence in the judicia.y relies upon the media. Objective a.d a.cura.e press a.d media.reports pla. a.key role in sha.ing public understa.ding of the judicia.y a.d genera.ing or undermining confidence in tha. institution. Reports in regiona. a.d na.iona. newspa.ers ha.e long been a. importa.t source of informa.ion, sha.ing public knowledge a.d fa.ilita.ing public scrutiny of the justice system. In the UK, there is a.most no schola.ship on these representa.ions pa.t or present. The result is little known a.out the representa.ion of the courts a.d the judicia.y in press reports. Little is known a.out wha. the diligent rea.er of these reports ca. lea.n a.out judicia. a.tivity. The a.m of this a.ticle is to ta.e a.first step towa.ds cha.ging tha. sta.e of a.fa.rs. It uses a.da.a.set ma.e up of 205 contempor

关键词： JUSTICE CRIME

Synthesizing molecula.ly imprinted polymer bea.s for the purifica.ion of vita.in E

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Pa.ticuology 2021年第4期19卷 10-18页

作者： Youhong Zha.g Yinpei Zhua.leslie S.Loo Jia.guo Yin Kea. Wa.g School of Environmenta. Ecology a.d Biologica. Engineering Wuhan Institute of TechnologyWuhan 430205PR China Key La.ora.ory for Green Chemica. Process of Ministry of Educa.ion Wuhan Institute of TechnologyWuhan 430205PR China Singa.ore Institute of Technology 10 Dover Drive138683 Singapore Jia.gsu Xixin Vita.in Co. Ltd.Jiangsu 223600PR China Center for Ca.a.ysis a.d Sepa.a.ion(CeCa.) Chemical Engineering DepartmentKhalifa University of Science&TechnologyAbu DhabiUnited Arab Emirates

Molecula.ly imprinted polymer(MIP)bea.s imprinted with vita.in E(V_(E))were synthesized via.a.two-step swelling polymeriza.ion method,using metha.rylic a.id(Ma.)a.d other functiona. monomers together with polystyrene(PS)microspheres a. the *** initia. tria.s,different functiona. monomers were a.sessed,a.ong with a.va.iety of solvents a.d imprinting *** MIP_(Ma.) sa.ple exhibited the highest performa.ce a.d wa. cha.a.terized a.d a.so a.sessed with rega.d to V_(E) a.sorption under va.ious experimenta. *** ma.eria. exhibited rea.ona.ly good sphericity,porosity a.d sta.ility,a.ong with a. excellent a.sorption ca.a.ity of 46 mg/*** wa. much higher tha. the va.ue for the corresponding non-imprinted polymer ma.e with the sa.e monomer,a.d 20%higher tha. tha. for a. a.ryla.ide-ba.ed MIP synthesized using a.precipita.ion polymeriza.ion *** core-shell structured MIP_(Ma.) a.so demonstra.ed fa.t a.sorption kinetics,a.low pressure drop a.d good reusa.ility in fixed bed *** V_(E) a.sorption equilibrium,selectivity,kinetics,thermodyna.ics a.d regenera.ion ca.a.ity of this ma.eria. were a.so exa.ined a.d a.e reported herein.

关键词： Vita.in E α-Tocopherol MIP Molecula.ly imprinting a.sorption Sepa.a.ion

Identifica.ion of crysta. symmetry from noisy diffra.tion pa.terns by a.sha.e a.a.ysis a.d deep lea.ning

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npj Computa.iona. Ma.eria.s 2020年第1期6卷 35-45页

作者： leslie Ching Ow Tiong Jeongra. Kim Sa.g Soo Ha. Donghun Kim Computa.iona. Science Resea.ch Center Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

The robust a.d a.toma.ed determina.ion of crysta. symmetry is of utmost importa.ce in ma.eria. cha.a.teriza.ion a.d *** studies ha.e shown tha. deep lea.ning(DL)methods ca. effectively revea. the correla.ions between X-ra. or electron-bea. diffra.tion pa.terns a.d crysta. *** their promise,most of these studies ha.e been limited to identifying rela.ively few cla.ses into which a.ta.get ma.eria. ma. be *** the other ha.d,the DL-ba.ed identifica.ion of crysta. symmetry suffers from a.dra.tic drop in a.cura.y for problems involving cla.sifica.ion into tens or hundreds of symmetry cla.ses(e.g.,up to 230 spa.e groups),severely limiting its pra.tica. usa.e.

关键词： symmetry crysta. limiting