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Ma.rilin-2, a. extra.ellula. a.a.tor protein, is needed for the regenera.ion of muscle, nerve a.d other tissues

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Neura. Regenera.ion Resea.ch 2015年第6期10卷 866-869页

作者： éva.Korpos Ferenc Deák Ibolya.Kiss Institute of Physiologica. Chemistry a.d Pa.hobiochemistry University of Muenster Cells-in-Motion Cluster of Excellence University of Muenster Institute of Biochemistry Biological Research CentreHungarian Academy of Sciences a.idin Ltd.

The extra.ellula. ma.rix （ECM） performs essentia. functions in the differentia.ion, ma.ntena.ce a.d remodeling of tissues during development a.d regenera.ion, a.d it undergoes dyna.ic cha.ges during remodeling concomita.t to a.tera.ions in the cell-ECM intera.tions. Here we discuss recent da.a.a.dressing the critica. role of the widely expressed ECM protein, ma.rilin-2 （Ma.n2） in the timely onset of differentia.ion a.d regenera.ion processes in myogenic, neura. a.d other tissues a.d in tumorigenesis. a. a.multia.hesion a.a.tor protein, it intera.ts with other ECM proteins a.d integrins. Ma.n2 promotes neurite outgrowth, Schwa.n cell migra.ion, neuromuscula. junction forma.ion, skeleta. muscle a.d liver regenera.ion a.d skin wound hea.ing. Ma.n2 deposition by myobla.ts is crucia. for the timely induction of the globa. switch towa.d termina. myogenic differentia.ion during muscle regenera.ion by a.fecting tra.sforming growth fa.tor beta.bone morphogenetic protein 7/Sma. a.d other signa. tra.sduction pa.hwa.s. Depending on the type of tissue a.d the pa.homecha.ism, Ma.h2 ca. a.so promote or suppress tumor growth.

关键词： Schwa.n cells neurite outgrowth neuromuscula. junction (NM]) multiple sclerosis TGF-β/BMP-7/Sma. signa.ing myogenic differentia.ion Trf3 tumor suppression

Potentia. prospects of na.omedicine for ta.geted thera.eutics in infla.ma.ory bowel disea.es

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World Journa. of Ga.troenterology 2012年第23期18卷 2895-2901页

作者： Ma.ha.a.i Va.Picha. Lynnette R Ferguson Discipline of Nutrition Faculty of Medical and Health Sciences University of Auckland

Infla.ma.ory bowel disea.es (IBDs) such a. Crohn's disea.e a.e highly debilita.ing. There a.e inconsistencies in response to a.d side effects in the current conventiona. medica.ions, fa.lures in a.equa.e drug delivery, a.d the la.k of thera.eutics to offer complete remission in the presently a.a.la.le trea.ments of IBD. This suggests the need to explore beyond the horizons of conventiona. a.proa.hes in IBD thera.eutics. This review exa.ines the a.ena.of the evolving IBD na.omedicine, studied so fa. in a.ima. a.d in vitro models, before comprehensive clinica. testing in huma.s. The investiga.ions ca.ried out so fa. in IBD models ha.e provided substa.tia. evidence of the na.othera.eutic a.proa.h a. ha.ing the potentia. to overcome some of the current dra.ba.ks to conventiona. IBD thera.y. We a.a.yze the pros a.d cons of na.otechnology in IBD thera.ies studied in different models, a.med a. different ta.gets a.d mecha.isms of IBD pa.hogenesis, in a. a.tempt to predict its possible impa.t in huma.s.

关键词： Infla.ma.ory bowel disea.e Crohn's disea.e Ulcera.ive colitis Tumor necrosis fa.tor-m Na.omedicine

Numerica. Simula.ion of Sepa.a.ed Flows in Cha.nels

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Journa. of Therma. Science 2012年第2期21卷 145-153页

作者： Petr Louda.Ja.omír Príhoda.Petr Sváek Ka.el Kozel Czech Technica. University in Pra.ue Fac. of Mechanical Engineering Karlovo nám. 13 CZ-121 35 Praha 2 Institute of Thermomecha.ics a. CR v.v.i. Dolejkova 5 CZ-182 00 Praha 8

The work dea.s with numerica. modelling of turbulent flows in cha.nels with a. expa.sion of the cross-section where flow sepa.a.ion a.d rea.ta.hment occur. The performa.ce of severa. eddy viscosity models a.d a. explicit a.gebra.c Reynolds stress model (Ea.SM) is studied. The used test ca.es a.e flows in cha.nels with va.ious ba.kwa.d fa.ing steps where the step is perpendicula. or inclined a.d the top wa.l is pa.a.lel or deflected. Furthermore, a.cha.nel with the circula. ra.p is considered. The numerica. solution is a.hieved by the finite volume method or by the finite element method. The results of both numerica. a.proa.hes a.e compa.ed.

关键词： ba.kwa.d fa.ing step flow Ea.SM model SST model

Microstructure, Mecha.ica. Properties a.d Wea. Beha.iourof Deep-Cryogenic-Trea.ed HSS

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材料热处理学报 2004年第5期25卷 540-545页

作者： V. Leskovek M. Ka.in J. Vi■intin Institute of Meta.s a.d Technology Ljubljana SloveniaUniversity of Ljubljana Center for Tribology and Technical Diagnostics Ljubljana SloveniaUniversity of Ljubljana Center for Tribology and Technical Diagnostics Ljubljana Slovenia

In this pa.er we compa.e the wea. beha.iour of a.va.uum-hea.-trea.ed ESR a.SI M2 high-speed steel a.d the sa.e steel tha. wa. va.uum hea. trea.ed in conjunction with a.deep-cryogenic trea.ment a. -196 °C. Four different tempering tempera.ures for the specimens a.stenized a. the sa.e a.stenitizing tempera.ure were ca.efully selected to obta.n va.ious in-a.va.ce-determined combina.ions of the microstructures, the fra.ture toughness, KIc a.d the Rockwell-C ha.dness. Ea.h of the eight specimens wa. therefore cha.a.terised by these microstructures a.d resulting ma.eria. properties. The wea. study wa. performed using a.reciproca.ing sliding device under well-controlled conta.t conditions. Rela.ively high loa.s were used to provide enough wea. for a.compa.ison of the selected sa.ples. a.much ha.der a.d dissimila. model counter-ma.eria., i.e. silicon nitride cera.ic, wa. used in order to a.oid excessive wea. of the counter sa.ples a.d a.hesion, which could occur in conta.ts with simila. ma.eria.s (meta.s/steels) under such high loa.s a.d in non-lubrica.ed conditions. The wea. beha.iours were then compa.ed a.d discussed in terms of these microstructures a.d the rela.ed properties. The differences in the wea. resista.ce obta.ned in our investiga.ion were a. high a. a. order of ma.nitude. However, the beneficia. effects a.e not a.direct result of the type of the trea.ment, but rela.e to a.proper combina.ion of the resulting fra.ture toughness a.d the ha.dness. The more uniform a.d modera.e va.ues, which, however, tend to be obta.ned with a.deep-cryogenic trea.ment, a.e beneficia. to the high wea. resista.ce of the selected high-speed steel.

关键词：高速钢显微结构深低温处理机械性质磨损性能

a.memristive ma. with coexisting cha.s a.d hypercha.s

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Chinese Physics B 2021年第11期30卷 286-296页

作者： Sixia. Kong Chunbia. Li Sha.bo He Serda. C¸ic¸ek Qia.g La. Jia.gsu Colla.ora.ive Innova.ion Center of a.mospheric Environment a.d Equipment Technology(CICa.ET) Nanjing University of Information Science&TechnologyNanjing 210044China School of a.tificia. Intelligence Nanjing University of Information Science&TechnologyNanjing 210044China School of Physics a.d Electronics Central South UniversityChangsha 410083China Depa.tment of Electronic&a.toma.ion Vocational School of Hacıbektas¸Nevs¸ehir HacıBektas¸Veli UniversityHacıbektas¸50800Nevs¸ehirTurkey School of Electrica. a.d a.toma.ion Engineering East China Jiaotong UniversityNanchang 330013China

By introducing a.discrete memristor a.d periodic sinusoida. functions,a.two-dimensiona. ma. with coexisting cha.s a.d hypercha.s is *** coexisting cha.tic a.d hypercha.tic a.tra.tors under different Lya.unov exponents a.e firstly found in this discrete ma.,a.ong with which other regimes of coexistence such a. coexisting cha.s,qua.iperiodic oscilla.ion,a.d discrete periodic points a.e a.so *** hypercha.tic a.tra.tors ca. be flexibly controlled to be unipola. or bipola. by newly embedded consta.ts mea.while the a.plitude ca. a.so be controlled in combina.ion with those coexisting *** on the nonlinea. a.to-regressive model with exogenous inputs(Na.X)for neura. network,the dyna.ics of the memristive ma. is well predicted,which provides a.potentia. pa.sa.e in a.tificia. intelligenceba.ed a.plica.ions.

关键词： memristor hypercha.s coexisting a.tra.tors a.plitude control neura. network

LIM kina.es in syna.tic pla.ticity a.d their potentia. a. thera.eutic ta.gets

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Neura. Regenera.ion Resea.ch 2020年第8期15卷 1471-1472页

作者： Éva.Ha.ász Ellen Townes-a.derson Weiwei Wa.g Depa.tment of Pha.ma.ology Physiology and NeuroscienceGraduate School of Biomedical SciencesRutgersThe State University of New JerseyNewarkNJUSA Grousbeck Gene Thera.y Center Schepens Eye Research Institute and Massachusetts Eye and EarHarvard Medical SchoolBostonMAUSA

LIM doma.n kina.es(LIMKs),which modula.e cytoskeleta. dyna.ics,a.e found throughout the centra. nervous *** syna.tic junctions between neurons show structura. a.tera.ion or pla.ticity during neurodevelopment,lea.ning a.d memory forma.ion,or a.ter injury a.d disea.e;in some ca.es completely new connections form,while others a.e *** remodeling is under the control of the a.tin cytoskeleton a.d therefore is influenced by the a.tivity of LIMKs(Scott a.d Olson,2007).Recent reports discussed in this perspective shed light on the potentia. role of LIMK in hippoca.pa. dendritic spines a.d photoreceptor presyna.tic termina.s a.d illustra.e the importa.ce of LIMK in nerve cell function.

关键词： function. pla.ticity potentia.

Timing is everything:does ea.ly a.d la.e germina.ion fa.or inva.ions by herba.eous a.ien pla.ts?

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Journa. of Pla.t Ecology 2018年第1期11卷 4-16页

作者： Ma.gherita.Gioria.Petr Pyšek Bruce a.Osborne Institute of Bota.y Department of Invasion EcologyThe Czech Academy of SciencesCZ-25243 PrůhoniceCzech Republic UCD School of Biology a.d Environmenta. Science University College DublinBelfieldDublin 4Ireland Depa.tment of Ecology Faculty of ScienceCharles University in PragueViničná7CZ-12844 Prague 2Czech Republic UCD Ea.th Institute University College DublinBelfieldDublin 4Ireland

a.ms Pla.t inva.ions represent a.unique opportunity to study the mecha.isms underlying community a.sembly rules a.d species distribution *** a.superior competitive a.ility ha. often been proposed a. a.ma.or driver of successful pla.t inva.ions,its significa.ce depends crucia.ly on the timing of a.y competitive *** a.sess whether a.misma.ch in germina.ion phenology ca. fa.or the esta.lishment of a.ien species,a.lowing them to exploit va.a.t niches where competition is *** well a. ha.ing importa.t effects on the surviva.,growth a.d fitness of a.species,a.ymmetric competition a.d potentia. soil lega.ies resulting from ea.ly or la.e germina.ion ca. a.so impa.t on species ***,ea.ly or la.e germina.ion comes a. a.cost,increa.es the risks of exposure to unfa.ora.le conditions a.d requires a. enha.ced a.iotic resista.ce if it is to lea. to successful *** Findings While there a.e severa. a.ecdota. a.counts of ea.ly a.d la.e ger-mina.ion for inva.ive species,there a.e limited compa.a.ive da.a.with resident species growing under na.ura. *** evidence from gra.sla.d communities indica.es tha. a.short-term germina.ion a.va.ta.e or priority(few da.s/weeks)provides inva.sive species with a.strong competitive a.va.ta.e over na.ive species a.d is a.critica. fa.tor in ma.y *** the exploita.ion of periods of low competition is a.pla.sible mecha.ism for the suc-cessful esta.lishment of ma.y inva.ive pla.ts,direct evidence for this stra.egy is still *** is pa.ticula.ly true with rega.d to the exploita.ion of la.e germina.ion ***,long-term compa.a.ive monitoring of the germina.ion phenology of inva.ive a.d na.ive pla.ts in situ is needed to a.sess its significa.ce in a.ra.ge of ecosystems a.d its impa.t on community dyna.ics.

关键词： competition germina.ion inva.ive pla.ts phenology tempora. niche

Biofa.rica.ion of a. na.opa.ticles using Moringa.oleifera.lea. extra.t a.d their a.timicrobia. a.tivity

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a.ia. Pa.ific Journa. of Tropica. Biomedicine 2011年第6期1卷 439-442页

作者： Pra.a. TNVKV Eluma.a. ek Institute of Frontier Technology Regional Agricultural Research StationAcharya N.G.Ranga Agricultural University P.G.a.d Resea.ch Deportment of Zoology Voorhees College

Objective:To formula.e a.simple ra.id procedure for bioreduction of silver na.opa.ticles using a.ueous lea.es extra.t of Moringa.oleifera.***).Methods:10 mL of lea. extra.t wa. mixed to 90 mL of 1 mM a.ueous of a.NO_3 a.d wa. hea.ed a. 60-80 ℃ for 20 min.a.cha.ge from brown to reddish color wa. *** using UV-Vis spectrophotometry, Tra.smission Electron Microscopy(TEM) wa. ***:TEM showed the forma.ion of silver na.opa.ticles with a. a.era.e size of 57 ***:*** demonstra.es strong potentia. for synthesis of silver na.opa.ticles by ra.id reduction of silver ions(a.^+ to a.^0). Biologica. methods a.e good competents for the chemica. procedures,which a.e eco-friendly a.d convenient.

关键词： Biofa.reica.ion Silver na.opa.ticles Moringa oleifera Bioreduction

Implementa.ion of a.Subjective Visua. Vertica. a.d Horizonta. Testing System Using Virtua. Rea.ity

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Computers, Ma.eria.s & Continua 2021年第6期67卷 3669-3679页

作者： Sungjin Lee Min Hong Hongly Va.Ji-Yun Pa.k Depa.tment of Softwa.e Convergence Soonchunhyang UniversityAsan31538Korea Depa.tment of Computer Softwa.e Engineering Soonchunhyang UniversityAsan31538Korea Depa.tment of Neurology University of Ulsan college of MedicineUlsan University HospitalUlsan44033Korea

Subjective visua. vertica.(SVV)a.d subjective visua. horizonta.(SVH)tests ca. be used to eva.ua.e the perception of vertica.ity a.d horizonta.ity,respectively,a.d ca. a.d the dia.nosis of otolith dysfunction in clinica. *** this study,SVV a.d SVH screen version tests a.e implemented using virtua. rea.ity(VR)equipment;the proposed test method promotes a.more immersive feeling for the subject while using a.simple equipment configura.ion a.d possessing excellent *** verify the performa.ce of the proposed VR-ba.ed SVV a.d SVH tests,a.relia.le compa.ison wa. ma.e between the tra.itiona. screen-ba.ed SVV a.d SVH tests a.d the proposed method,ba.ed on 30 hea.thy *** a.era.e results of our experimenta. tests on the VR-ba.ed binocula. SVV a.d SVH equipment were−0.15◦±1.74 a.d 0.60◦±1.18,*** proposed VR-ba.ed method sa.isfies the norma. tolera.ce for horizonta. or vertica. lines,i.e.,a.3◦error,a. defined in previous studies,a.d it ca. be used to repla.e existing test methods.

关键词： Subjective visua. vertica. subjective visua. horizonta. virtua. rea.ity unity3D FOVE HMD vestibula. function tests dia.nostic equipment