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a.FORTIFIED,LEED HOME FOR THE US GULF COa.T:The How’s a.d Why’s of a.Building System that Ma.es Sense

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Journa. of Green Building 2010年第1期5卷 19-35页

作者： H.ker Thomson Dura.le Residentia. Builders LLC(DRB)

INTRODUCTION Houston is a.city where the residentia. home building industry is domina.ed by *** a.e good tra.itions a.d ba. ***,unfortuna.ely,the tra.itiona. Houston a.proa.h-wood fra.ing,fibergla.s insula.ion,ventila.ed a.tics,etc.-I feel,lies in the ba. tra.ition *** builders will tell you that they a.e building wha. the buying public ***,to a.point,that is correct.

关键词： insula.ion LEED Houston

The versa.ility of mesenchyma. stem cells:From regenera.ive medicine to COVID,wha. is next?

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BIOCELL 2022年第4期46卷 913-922页

作者： thaÍS Ca.a.Ra.DE Pa.M MÁRCIa.ROSÂNGELa.WINK La.ora.ório de Biologia.Celula. Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre90050-170Brazil

Mesenchyma. stem cells(MSCs)pla. key roles in regenera.ive medicine by promoting tissue *** ca. be isola.ed from different a.ult tissues a.d they a.e a.le to differentia.e into severa. *** to their a.tiinfla.ma.ory,a.giogenic a.d immune-modula.ory properties,MSCs a.e suita.le for tissue engineering a.plica.ions a.d,when a.socia.ed with bioma.eria.s,their benefits ca. be ***,recently,MSCs ha.e been studied for new clinica. a.plica.ions,such a. in the trea.ment of pa.ients with *** regenera.ive potentia. ha. been a.tributed to their secretome,which comprises extra.ellula. ma.rix,soluble proteins a.d severa. elements,including the relea.e of extra.ellula. *** though,in order to explore a.l their thera.eutic potentia.,it is still necessa.y to a.va.ce in the investiga.ion of their ba.ic cell biology cha.a.teristics.

关键词： Mesenchyma. stem cells Regenera.ive medicine Secretome Bioma.eria.s Extra.ellula. vesicles

Effect of Si a.dition on microstructure a.d wea. properties of Mg-Sn a.-ca.t a.loys

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Journa. of Ma.nesium a.d a.loys 2018年第4期6卷 384-389页

作者： Erdem Ka.a.ula. Yusuf Bura. Küçüker Koca.li University Faculty of EngineeringDepartment of Metallurgical and Materials Engineering41380 KocaeliTurkey a.Ka. Sila. Sa.a.i Orhanli Mah.34956 IstanbulTurkey BCa.T Brunel University London UxbridgeMiddlesex UB83PHUK

Effect of Si a.dition on microstructure,ha.dness a.d wea. resista.ce of a. ca.t Mg-5Sn a.d Mg-10Sn a.loys were *** this purpose a.loys with wt.-%0,0.5,1,1.5 Si were ca.t using a. induction *** of Si to both a.loys ca.sed a. increa.ement in the a.ount of intermeta.lic pha.es a. the gra.n *** refined gra.n structure wa. reported with increa.ing Si content in the ca.t *** increa.ed a.ount of intermeta.lics a.d decrea.ed gra.n size ca.sed a. increa.e in the ha.dness of the *** resista.ce of the bina.y a.loys first increa.ed with Si a.dition a.d then *** a.ounts of Si in the a.loys ca.sed cra.k forma.ion during wea. tests a.d decrea.ed wea. *** speed a.so ha. a.dra.a.ica. effect on the wea. resista.ce of the *** sliding speed resulted with higher wea. *** surfa.es of the a.loys a.so investiga.ed under sca.ning electron microscope to understa.d the wea. mecha.isms opera.ed during wea. tests.

关键词： Ma.nesium Ca.ting Microstructure Ha.dness Wea.

Leptin in hepa.ocellula. ca.cinoma

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World Journa. of Ga.troenterology 2010年第46期16卷 5801-5809页

作者： Shen-Nien Wa.g King Teh Lee Chen-Guo ker Division of Hepa.obilia.y Surgery Department of SurgeryKaohsiung Medical University Hospital Depa.tment of Surgery Faculty of MedicineCollege of MedicineKaohsiung Medical University Ca.cer Center Department of SurgeryKaohsiung Medical University Hospital Depa.tment of Surgery Kaohsiung Municipal Hsiao-Kang Hospital Gra.ua.e Institute of Medicine College of MedicineKaohsiung Medical University

The risk fa.tors for hepa.ocellula. ca.cinoma.(HCC) development ha.e been esta.lished,a.d include chronic hepa.itis B a.d C,hea.y a.cohol consumption,a.d *** fa.t,5%-30% of pa.ients with HCC still la.k a.rea.ily identifia.le risk *** ha. been reported that the ma.ority of "cryptogenic" HCC ma. be a.tributed to nona.coholic fa.ty liver disea.e,the hepa.ic presenta.ion of the meta.olic syndrome (MS).Obesity is a.socia.ed with the development of the ***,a.ipose tissue ha. been considered a. a. endocrine orga. beca.se of its ca.a.ity to secrete a.va.iety of cytokines,which a.e collectively known a. the ***,the product of the obese gene,is ma.nly produced by a.ipose *** leptin wa. first cha.a.terized in 1994,a.cumula.ed litera.ure ha. demonstra.ed the involvement of this a.ipokine in severa. a.ea. of huma. *** binding to its receptor,leptin initia.es a.ca.ca.e of signa.ing events a.d subsequent cellula. *** a.dition to being the regula.ory media.or of energy homeosta.is,severa. in vitro studies ha.e demonstra.ed the fibrogenic role of leptin in the ***,the deregula.ed expression of leptin a.d its receptor ha.e been demonstra.ed to be a.socia.ed with a.va.iety of meta.olic disorders a. well a. huma. *** importa.tly,direct evidence supporting the inhibitory a.d/or a.tiva.ing role of leptin in the process of ca.cinogenesis a.d progression of huma. HCC ha. been a.cumula.ing *** review a.ms to provide importa.t insights into the potentia. mecha.isms of leptin in the development of ***,further investiga.ions will shed light on a.new thera.eutic ta.get in HCC.

关键词： a.ipokine Hepa.ocellula. ca.cinoma Leptin Liver cirrhosis Meta.olic syndrome Obesity Stea.ohepa.itis

0N THE COMPLEXITY OF a. OPTIMa. ROUTING TREE PROBLEM

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a.ta.Ma.hema.ica. a.plica.a. Sinica 1989年第1期5卷 68-80页

作者：堵丁柱 ker-IKo Institute of a.plied Ma.hema.ics Academia Sinica Sta.e University of New York a. Stony Brook U.S.A. routing tree for a set of tasks is a decision tree which assigns the tasks to their destinationsaccording to the features of the tasks. A weighted routing tree is one with costs attached to each linkof the tree. Links of the same feature have the same cost. It is proved that the problem of finding ?routing tree of the minimum cost for a given set of tasks of two features is NP-complete.

a.routing tree for a.set of ta.ks is a.decision tree which a.signs the ta.ks to their destina.ionsa.cording to the fea.ures of the ta.ks. a.weighted routing tree is one with costs a.ta.hed to ea.h linkof the tree. Links of the sa.e fea.ure ha.e the sa.e cost. It is proved that the problem of finding ?routing tree of the minimum cost for a.given set of ta.ks of two fea.ures is NP-complete.

关键词： node Th THE COMPLEXITY OF a. OPTIMa. ROUTING TREE PROBLEM

Network meta.a.a.ysis of the prognosis of cura.ive trea.ment stra.egies for recurrent hepa.ocellula. ca.cinoma.a.ter hepa.ectomy

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World Journa. of Ga.trointestina. Surgery 2023年第2期15卷 258-272页

作者： Jen-Lung Chen Ya.-Sen Chen Chen-Guo ker Depa.tment of Genera. Surgery E-Da HospitalI-Shou UniversityKaohsiung 824Taiwan Depa.tment of Surgery School of MedicineI-Shou UniversityKaohsiung 824Taiwan

Ba.KGROUND Recurrent hepa.ocellula. ca.cinoma.rHCC)is a.common outcome a.ter cura.ive *** for rHCC is recommended,but no guidelines *** To compa.e cura.ive trea.ments such a. repea.ed hepa.ectomy(RH),ra.iofrequency a.la.ion(RFa.,tra.sa.teria. chemoemboliza.ion(Ta.E)a.d liver tra.spla.ta.ion(LT)for pa.ients with rHCC a.ter prima.y hepa.ectomy by conducting a.network meta.a.a.ysis(NMa..METHODS From 2011 to 2021,30 a.ticles involving pa.ients with rHCC a.ter prima.y liver resection were retrieved for this *** Q test wa. used to a.sess heterogeneity a.ong studies,a.d Egger’s test wa. used to a.sess publica.ion *** effica.y of rHCC trea.ment wa. a.sessed using disea.e-free surviva.(DFS)a.d overa.l surviva.(OS).RESULTS From 30 a.ticles,a.tota. of 17,11,8,a.d 12 a.ms of RH,RFa.Ta.E,a.d LT subgroups were collected for *** plot a.a.ysis revea.ed that the LT subgroup ha. a.better cumula.ive DFS a.d 1-yea. OS than the RH subgroup,with a. odds ra.io(OR)of 0.96(95%CI:0.31-2.96).However,the RH subgroup ha. a.better 3-yea. a.d 5-yea. OS compa.ed to the LT,RFa.a.d Ta.E *** step dia.ra. of different subgroups mea.ured by the Wa.d test yielded the sa.e results a. the forest plot *** ha. a.better 1-yea. OS(OR:1.04,95%CI:0.34-03.20),a.d LT wa. inferior to RH in 3-yea. OS(OR:10.61,95%CI:0.21-1.73)a.d 5-yea. OS(OR:0.95,95%CI:0.39-2.34).a.cording to the predictive P score eva.ua.ion,the LT subgroup ha. a.better DFS,a.d RH ha. the best ***,meta.regression a.a.ysis revea.ed that LT ha. a.better DFS(Pa. well a. 3-yea. OS(P=0.881)a.d 5-yea. OS(P=0.188).The differences in superiority between DFS a.d OS were due to the different testing methods *** a.cording to this NMa.RH a.d LT ha. better DFS a.d OS for rHCC than RFa.a.d ***,trea.ment stra.egies should be determined by the recurrent tumor cha.a.teristics,the pa.ient’s genera. hea.th sta.us,a.d the ca.e progra. a. ea.h institution.

关键词： Hepa.ocellula. ca.cinoma Recurrence Network meta.a.a.ysis Cura.ive trea.ment Outcome Surviva. ra.e

Hypothetica. hypoxia.driven ra.id disea.e progression in hepa.ocellula. ca.cinoma.post tra.sa.teria. chemoemboliza.ion:a.ca.e report

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World Journa. of Clinica. Ca.es 2023年第19期11卷 4664-4669页

作者： Ka.-Fua. Yeo a.y ker Pei-En Ka. Chi-Chih Wa.g Division of Ga.troenterology a.d Hepa.ology Department of Internal MedicineChung Shan Medical University HospitalTaichung 402306Taiwan China School of Medicine Chung Shan Medical UniversityTaichung 402306TaiwanChina

Ba.KGROUND Tra.sa.teria. chemoemboliza.ion(Ta.E)is widely performed for intermedia.esta.e or unresecta.le hepa.ocellula. ca.cinoma.HCC),but a.proxima.ely ha.f of pa.ients do not respond to Ta.E *** describe a.ca.e of ra.idly progressing of HCC a.ter Ta.E a.d provide a.possible hypothesis for this *** finding ma. contribute to identifying pa.ients who obta.n less benefit from Ta.E,thus a.oiding the unnecessa.y wa.te of medica. resources a.d trea.ment during the golden hour *** SUMMa.Y a.61-yea.-old woma. ha. been dia.nosed with chronic hepa.itis B infection a.d HCC a. Ba.celona.Clinic Liver Ca.cer sta.e B,which ha. been trea.ed by segmenta. hepa.ectomy 14 mo *** tumor recurred in the two months a.ter *** received a. initia. Ta.E a.d then underwent systemic thera.y with lenva.inib 8 mg da.ly due to a. increa.ed level of a.pha.fetoprotein(a.P)a.ter the first ***,the tumor continued to progress with a. increa.ed level of a.P,a.d she underwent a.second Ta.E,a.ter which the tumor volume did not obviously decrea.e on the contra.t-enha.ced computed tomogra.hy *** month la.er,she ha. a.third Ta.E to control the residua. HCC *** weeks a.ter that,the HCC ha. increa.ed dra.a.ica.ly with tea.colored urine a.d yellowish skin ***,the pa.ient refused further trea.ment a.d went into hospice *** Intense hypoxia.induced by Ta.E ca. trigger ra.id disea.e progression in infiltra.ive HCC pa.ients with a.la.ge tumor burden.

关键词： Ca.cinoma hepa.ocellula. Tra.sa.teria. chemoemboliza.ion Tumor hypoxia Disea.e progression Tumor burden Ca.e report

Dyna.ica. a.a.ysis of DC Shunt Motor Powered by PV Genera.or Using Perturba.ion a.d Observa.ion a. MPPT Technique

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Energy a.d Power Engineering 2017年第1期9卷 55-69页

作者： tha’er Oma. Sweida. Electrica. Engineering Depa.tment The Hashemite University Zarqa Jordan

This pa.er presents the perturba.ion a.d observa.ion (P & O) a.gorithm a. ma.imum power point tra.king (MPPT) method for the dyna.ica. a.a.ysis of DC shunt motor fed by photovolta.c genera.or a. different sola. irra.ia.ce levels. a. ea.h sola. intensity, the ma.imum power point of current/volta.e (I/V) cha.a.teristic of the PV genera.or is a.hieved by perturba.ion a.d observa.ion a.gorithm. The nonlinea. beha.ior of (I/V) cha.a.teristics of the PV genera.or a. va.ious sola. intensities a.d the ma.netiza.ion curve of the ferroma.netic ma.eria. of the DC shunt motor a.e described by high order polynomia. ma.hema.ica. expression. The dyna.ica. a.a.ysis of the DC shunt motor fed by PV genera.or a. different sola. intensity ha. been ca.ried out, a.so the dyna.ica. a.a.ysis of DC shunt motor is investiga.ed a. a.step cha.ge in sola. intensity levels with fixed loa. a. motor.

关键词： DC Shunt Motor MPPT P & O PV Genera.or Dyna.ica. a.a.ysis

Fa.ile a.d ra.id fa.rica.ion of a.novel 3D-printa.le,visible light-crosslinka.le a.d bioa.tive polythiourethane for la.ge-to-ma.sive rota.or cuff tendon repa.r

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Bioa.tive Ma.eria.s 2024年第7期37卷 439-458页

作者： Xu Zha.g Ke Li Chenya.g Wa.g Ying Ra. Rocky STua. Da. Michelle Wa.g Da. Fei Elmer ker Institute for Tissue Engineering a.d Regenera.ive Medicine The Chinese University of Hong KongNew TerritoriesHong Kong SARChina School of Biomedica. Sciences Faculty of MedicineThe Chinese University of Hong KongNew TerritoriesHong Kong SARChina Center for Neuromusculoskeleta. Restora.ive Medicine Hong Kong Science ParkHong Kong SARChina Ministry of Educa.ion Key La.ora.ory for Regenera.ive Medicine School of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongNew TerritoriesHong Kong SARChina Depa.tment of Orthopa.dics a.d Tra.ma.ology Faculty of MedicineThe Chinese University of Hong KongNew TerritoriesHong Kong SARChina

Fa.ile a.d ra.id 3D fa.rica.ion of strong,bioa.tive ma.eria.s ca. a.dress cha.lenges that impede repa.r of la.ge-to-ma.sive rota.or cuff tea.s including persona.ized gra.ts,limited mecha.ica. support,a.d ina.equa.e tissue ***,we developed a.fa.ile a.d ra.id methodology that genera.es visible light-crosslinka.le polythiourethane(PHT)pre-polymer resin(~30 min a. room tempera.ure),yielding 3D-printa.le sca.folds with tendon-like mecha.ica. a.tributes ca.a.le of delivering tenogenic bioa.tive *** vivo cha.a.teriza.ion confirmed successful fa.rica.ion,robust huma. supra.pina.us tendon(SST)-like tensile properties(strength:23 MPa.modulus:459 MPa.a. lea.t 10,000 physiologica. loa.ing cycles without fa.lure),excellent suture retention(8.62-fold lower than a.ellula. derma. ma.rix(a.M)-ba.ed clinica. gra.t),slow degra.a.ion,a.d controlled relea.e of fibrobla.t growth fa.tor-2(FGF-2)a.d tra.sforming growth fa.tor-β3(TGF-β3).In vitro studies showed cytocompa.ibility a.d growth fa.tor-media.ed tenogenic-like differentia.ion of mesenchyma. stem *** vivo studies demonstra.ed biocompa.ibility(3-week mouse subcuta.eous impla.ta.ion)a.d a.ility of growth fa.tor-conta.ning sca.folds to nota.ly regenera.e a. lea.t 1-cm of tendon with na.ive-like biomecha.ica. a.tributes a. uninjured shoulder(8-week,la.ge-to-ma.sive 1-cm ga. ra.bit rota.or cuff injury).This study demonstra.es use of a.3D-printa.le,strong,a.d bioa.tive ma.eria. to provide mecha.ica. support a.d pro-regenera.ive cues for cha.lenging injuries such a. la.ge-to-ma.sive rota.or cuff tea.s.

关键词： Photo-crosslinka.le bioma.eria.s Polyurethane Click rea.tions 3D-printing Growth fa.tors Rota.or cuff tendon tissue engineering