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r.gula.or.of G pr.tein s.gna.ing 6 media.es.exer.is.-induced r.cover. of hippoca.pa. neur.genes.s.lea.ning,a.d memor. in a.mous. model of a.zheimer.s.dis.a.e

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Neur.0} r.gener.0}ion r.s.a.ch 2025年第10期20卷 2969-2981页

作者： ma.kenzie m.s.icer.Jia.qi Ya.g Da.iel Fu a.is.n N.DeVor. ma.is.l La.ffer.Nilufer.s.a.a.oy Deniz a.a.oy r.r. a.Fis.er Depa.tment of Neur.s.ience a.d Pha.ma.ology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa.Neur.s.ience Ins.itute University of Iowa Carver College of MedicineIowa CityIAUSA Inter.is.iplina.y Gr.1}ua.e Pr.gr.1} in molecula. medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neur.0} Cir.uits.a.d Beha.ior.Cor. University of Iowa Carver College of MedicineIowa CityIAUSA

Hippoca.pa. neur.na. los. ca.s.s.cognitive dys.unction in a.zheimer.s.*** hippoca.pa. neur.genes.s.is.r.duced in pa.ients.with a.zheimer.s.*** s.imula.es.a.ult hippoca.pa. neur.genes.s.in r.dents.a.d impr.ves.memor. a.d s.ows.cognitive decline in pa.ients.with a.zheimer.s.***,the molecula. pa.hwa.s.for.exer.is.-induced a.ult hippoca.pa. neur.genes.s.a.d impr.ved cognition in a.zheimer.s.dis.a.e a.e poor.y ***,r.gula.or.of G pr.tein s.gna.ing 6(r.s.)wa. identified a. the media.or.of volunta.y r.nning-induced a.ult hippoca.pa. neur.genes.s.in ***,we gener.0}ed novel r.s.fl/fl;a.P_(s.E) mice a.d us.d r.tr.vir.0} a.pr.a.hes.to exa.ine the impa.t of r.s. deletion fr.m denta.e gyr.s.neur.na. pr.genitor.cells.on volunta.y r.nning-induced a.ult hippoca.pa. neur.genes.s.a.d cognition in a. a.yloid-ba.ed a.zheimer.s.dis.a.e mous. *** found tha. volunta.y r.nning in a.P_(s.E) mice r.s.or.d their.hippoca.pa. cognitive impa.r.ents.to tha. of contr.l *** cognitive r.s.ue wa. a.olis.ed by r.s. deletion in denta.e gyr.s.neur.na. pr.genitor.cells.which a.s. a.olis.ed r.nning-media.ed incr.a.es.in a.ult hippoca.pa. *** hippoca.pa. neur.genes.s.wa. r.duced in s.denta.y a.P_(s.E) mice ver.3}s.contr.l mice,with ba.a. a.ult hippoca.pa. neur.genes.s.r.duced by r.s. deletion in denta.e gyr.s.neur.0} pr.cur.3}r.***6 wa. expr.s.ed in neur.ns.within the denta.e gyr.s.of pa.ients.with a.zheimer.s.dis.a.e with s.gnifica.t los. of thes. r.s.-expr.s.ing ***,r.s. media.ed volunta.y r.nning-induced r.s.ue of impa.r.d cognition a.d a.ult hippoca.pa. neur.genes.s.in a.P_(s.E) mice,identifying r.s. in denta.e gyr.s.neur.0} pr.cur.3}r.cells.a. a.pos.ible ther.0}eutic ta.get in a.zheimer.s.dis.a.e.

关键词： a.ult hippoca.pa. neur.genes.s a.zheimer.s.dis.a.e denta.e gyr.s exer.is. lea.ning/memor. neur.0} pr.cur.1}r.cells r.gula.or.of G pr.tein s.gna.ing 6(r.s.)

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Impa.t of Zika.vir.s.non-s.r.ctur.0} pr.tein muta.ions.on hippoca.pa. da.a.e

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Neur.0} r.gener.0}ion r.s.a.ch 2025年第8期20卷 2307-2308页

作者： La.is.a.m.G.Ca.s.a.o r.ney s.Coimbr. Neur.genômica.Imunopa.ologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Depa.ta.ento de Bioquímica.e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika.vir.s.ZIKV),a.member.of the Fla.ivir.da. fa.ily,a.tr.0}ted wor.dwide a.tention for.its.connection to s.ver. neur.logica. effects.nota.ly micr.cepha.y in newbor.s.fir.1} r.por.ed dur.ng the 2015 epidemic in ***,its.impa.t goes.beyond feta. a.d neona.a. a.nor.a.ities.a.s. a.fecting the centr.0} ner.ous.s.s.em(CNs.in both childr.n a.d a.ults.lea.ing to endur.ng cognitive a.d beha.ior.0} impa.r.ents.

关键词： da.a.e feta. neona.a.

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r.vis.ting cer.br.1} endothelia. cells.in a.zheimer.s.dis.a.e

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Neur.0} r.gener.0}ion r.s.a.ch 2025年第10期20卷 2911-2912页

作者： a.ir.0}s.Ha.a.y Depa.tment of Neur.s.r.er. University Hospital BonnBonnGermany

a.zheimer.s.dis.a.e(a.)is.the mos. common neur.degener.0}ive dis.r.er.cha.a.ter.zed by s.ow a.d pr.gr.s.ive decline of cognitive a.d memor. *** only a.pr.xima.ely 5%of the ca.es.a. is.fa.ilia.,a. often pr.dis.os.d by genetic muta.ions.Hoogma.tens.et a..,2021),while s.or.0}ic a. a.counts.for.a.pr.xima.ely 95%of the *** a.yloid ca.ca.e hypothes.s.is.one of the funda.enta. hypothes.s.put out to expla.n a. pa.hogenes.s.a. dys.egula.ed homeos.a.is.of a.yloid-β(a.)peptides.tha. lea.s.to the a.cumula.ion of a.pla.ues.in the pa.enchyma.a. a.a.omica. ha.lma.k of a..

关键词： a.zheimer a. cer.br.0}

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Geomecha.ica. monitor.ng of r.ck's.ma.s.ve in zones.of br.a.s

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中国有色金属学会会刊：英文版 2005年第S1期15卷 275-278页

作者： m. a. Zhur.0}kov s. I. Bogda. m. a. Kova.eva Bela.us.s.a.e Univer.1}ty Minsk 220050 BelarusBelarus State University Minsk 220050 BelarusBelarus State University Minsk 220050 Belarus

For.s.0}e development of under.r.und s.a.e a.d es.ecia.ly in a.ea. of geologica. infr.ngements.it is.neces.a.y to cr.a. effective s.s.em of tr.2}king, for.ca.ting a.d ma.a.ement for.defor.ing pr.ces.es.in s.ch a.ea.-s.s.em of geomecha.ica. monitor.ng. Bes.des.it is.neces.a.y to s.udy a.d ima.ine the inter.a. mecha.is. of defor.ing pr.ces.es.in s.ch s.ecia. zones. In the pa.er.s.me ba.ic a.pects.of cr.a.ion of geomecha.ica. monitor.ng s.s.ems.for.r.a.iza.ion of s.per.is.on, s.udy a.d modelling of defor.ing pr.ces.es. for.modelling a.d s.udy of the s.r.s.-s.r.2}n s.a.e of ma.s.f in a.ea. of la.ge-s.a.e under.r.und mining wor.s.in view of a.block-hier.2}chica. s.r.ctur. of r.ck’s.ma.s.ve (pr.s.nce of geologica. infr.ngements. a.e cons.der.d. In pa.ticula. s.ch impor.a.t ta.ks. a. r.s.a.ch of defor.ing pr.ces.es.in a.ea. of geologica. infr.ngements.with the help of GPs.technologies.a.d us. of the r.ceived r.s.lts.for.the modeling; cons.r.ction of models.a.equa.ely des.r.bing a.condition of r.ck’s.ma.s.ve in a.ea.of geologica. infr.ngement. s.me r.s.lts.of r.s.a.ches.on s.udy of ca.ities.influence on occur.ence of a. a.ea.of limiting conditions.in r.gion of geologica. infr.ngement a.d pos.ible s.ift a.ong infr.ngement a.e s.bmitted.

关键词： geologica. infr.ngement s.ift dis.la.ement s.r.s.-s.r.3}n s.a.e

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a.compr.hens.ve inves.iga.ion on nonlinea. vibr.0}ion a.d bending cha.a.ter.s.ics.of bio-ins.ir.d helicoida. la.ina.ed compos.te s.r.ctur.s

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a.plied ma.hema.ics.a.d mecha.ics.Englis. Edition) 2025年第1期46卷 81-100页

作者： s.s.0}r.2}H r.KIr.2} D.s.NGH r.Va.s. V.s.CHa.Ha. s.hool of mecha.ica. a.d ma.er.a.s.Engineer.ng Indian Institute of Technology Mandi

Bio-ins.ir.d helicoida. compos.te la.ina.es. ins.ir.d by the intr.ca.e helica. s.r.ctur.s.found in na.ur., pr.s.nt a.pr.mis.ng fr.ntier.for.enha.cing the mecha.ica. pr.per.ies.of s.r.ctur.1} des.gns. Hence, this.s.udy pr.vides.a.compr.hens.ve inves.iga.ion into the nonlinea. fr.e vibr.1}ion a.d nonlinea. bending beha.ior.of bio-ins.ir.d compos.te pla.es. The inver.0} hyper.olic s.ea. defor.a.ion theor.(IHs.T) of pla.es.is.employed to cha.a.ter.ze the dis.la.ement field, with the incor.or.1}ion of Gr.en-La.r.1}ge nonlinea.ity. The pr.blem is.modeled us.ng the C0finite element method(FEm), a.d a. in-hous. code is.developed in the ma.La. envir.nment to s.lve it numer.ca.ly. Va.ious.helicoida. la.up configur.1}ions.including helicoida. r.cur.0}ve(Hr., helicoida. exponentia.(HE), helicoida. s.mi-cir.ula.(Hs., linea. helicoida.(LH), a.d Fibona.ci helicoida.(FH)with differ.nt la.up s.quences.a.d qua.i-is.tr.pic configur.1}ions.a.e s.udied. The model is.va.ida.ed, a.d pa.a.etr.c s.udies.a.e conducted. Thes. s.udies.inves.iga.e the effects.of la.up configur.1}ions. s.de-to-thicknes. r.1}io, modulus.r.1}ios. bounda.y conditions. a.d loa.ing conditions.a. differ.nt loa. a.plitudes.on the nonlinea. vibr.1}ion a.d nonlinea. bending beha.ior.0}of bio-ins.ir.d compos.te pla.es. The r.s.lts.s.ow tha. the la.ina.e s.quence exer.s.a.s.bs.a.tia. impa.t on both nonlinea. na.ur.1} fr.quencies.a.d nonlinea. bending beha.ior.0} mor.over. this.influence va.ies.a.r.s. differ.nt s.de-to-thicknes. r.1}ios.a.d bounda.y conditions.of the bio-ins.ir.d compos.te pla.e.

关键词： finite element method (FEm) nonlinea. Gr.en-La.r.0}ge inver.0} hyper.olic s.ea. defor.a.ion theor. (IHs.T) bio-ins.ir.d compos.te pla.e helicoida. O322

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New Ins.ghts.on the mecha.is. of Ther.a. Clea.a.e of Uns.0}ur.2}ed Bicyclic Dia.ir.dines. a.DFT s.udy

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Chines. Jour.a. of Chemis.r. 2011年第7期29卷 1347-1352页

作者： a.s.a.i, s. Bekhr.0}nia. a. r. a.ma.i, s. Ka.a.i, a. r. Pour.eyr.0}, s. Depa.tment of Chemis.r. Payame Noor University Tehran Iran Pha.ma.eutica. s.iences.r.s.a.ch Center Department of Medicinal Chemistry Mazandaran University of Medical Sciences Sari Iran s.a.id r.1}a.e Tea.her.Tr.1}ning Univer.0}ty Tehran Iran

a.DFT ca.cula.ions.a.e ca.r.ed out a. UB3LYP/6-311＋＋G （3df, 2p） levels.of theor. to s.udy electr.cyclic ther.a. clea.a.e of four.（r. der.va.ives.of uns.0}ur.0}ed bicyclic dia.ir.dines. Ix-r. to pr.duce cor.es.onding （Z） a.d （E） a.omethine imides.（2X-Z, 2X-E, 3X-Z a.d 3X-E）, wher. X=H, me, t-Bu a.d Ph. Clea.a.e of 1X-r.s.r.es.to for. the mos. s.a.le 3X-Z pr.duct, （pa.h 2） is.found the fa.or.d pr.cedur. beca.s. of deloca.ized nega.ive cha.ge on five a.oms.a.d lower.s.er.c effect in r.la.ed tr.0}s.tion s.a.e. a.cor.ing to Ir. ca.cula.ions.in pa.hs.1 a.d 2, C6--N1 bond is.clea.ed befor. the r.0}e deter.ina.ing s.ep （tr.0}s.tion s.a.e）. The s.a.ility of uns.0}ur.0}ed bicyclic dia.ir.dines.a.d their.cor.es.onding （Z） a.d （E） a.omethine imides.is.in the following or.er.in ga. pha.e a.d chlor.for., tetr.0}ydr.fur.0}, a.d a.etone s.lvents. 3X-Z〈3X-F〈2X-Z 〈2X-E 〈 1X-r.〈 1X-s.

关键词： uns.0}ur.1}ed bicyclic dia.ir.dines a.omethine imides electr.cyclic ther.a. clea.a.e conr.ta.or. motion molecula. modeling confor.a.iona. a.a.ys.s

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Emer.ing s.r.ctur.s.a.d dyna.ic mecha.is.s.ofγ-s.cr.ta.e for.a.zheimer.s.dis.a.e

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Neur.0} r.gener.0}ion r.s.a.ch 2025年第1期20卷 174-180页

作者： Yinglong mia. micha.l s.Wolfe Computa.iona. medicine Pr.gr.0} a.d Depa.tment of Pha.ma.ology University of North Carolina–Chapel HillChapel HillNCUSA Depa.tment of medicina. Chemis.r. University of KansasLawrenceKSUSA

γ-s.cr.ta.e,ca.led“the pr.tea.ome of the membr.1}e,”is.a.membr.1}e-embedded pr.tea.e complex tha. clea.es.150+peptide s.bs.r.1}es.with centr.1} r.les.in biology a.d medicine,including a.yloid pr.cur.0}r.pr.tein a.d the Notch fa.ily of cell-s.r.a.e *** inγ-s.cr.ta.e a.d a.yloid pr.cur.0}r.pr.tein lea. to ea.ly-ons.t fa.ilia. a.zheimer.s.dis.a.e.γ-s.cr.ta.e ha. thus.s.r.ed a. a.cr.tica. dr.g ta.get for.tr.a.ing fa.ilia. a.zheimer.s.dis.a.e a.d the mor. common la.e-ons.t a.zheimer.s.dis.a.e a. ***,cr.tica. ga.s.r.ma.n in under.0}a.ding the mecha.is.s.of pr.ces.ive pr.teolys.s.of s.bs.r.1}es.the effects.of fa.ilia. a.zheimer.s.dis.a.e muta.ions.a.d a.los.er.c modula.ion of s.bs.r.1}e clea.a.e byγ-*** this.r.view,we focus.on r.cent s.udies.of s.r.ctur.1} dyna.ic mecha.is.s.ofγ-*** mecha.is.s.including the“Fit-s.a.-Tr.m,”“s.iding-Unwinding,”a.d“Tilting-Unwinding,”ha.e been pr.pos.d for.s.bs.r.1}e pr.teolys.s.of a.yloid pr.cur.0}r.pr.tein byγ-s.cr.ta.e ba.ed on a.l-a.om molecula. dyna.ics.*** a. incor.ect r.gis.r. of the Notch1 s.bs.r.1}e wa. identified in the cr.o-electr.n micr.s.opy s.r.ctur. of Notch1-boundγ-s.cr.ta.e,molecula. dyna.ics.s.mula.ions.on a.r.s.lved model of Notch1-boundγ-s.cr.ta.e tha. wa. r.cons.r.cted us.ng the a.yloid pr.cur.0}r.pr.tein-boundγ-s.cr.ta.e a. a.templa.e s.cces.fully ca.tur.dγ-s.cr.ta.e a.tiva.ion for.pr.per.clea.a.es.of both wildtype a.d muta.t Notch,being cons.s.ent with biochemica. exper.menta. *** a.pr.a.h could be potentia.ly a.plied to decipher.the pr.ces.ing mecha.is.s.of va.ious.s.bs.r.1}es.byγ-*** a.dition,contr.ver.0} over.the effects.of fa.ilia. a.zheimer.s.dis.a.e muta.ions.pa.ticula.ly the is.ue of whether.they s.a.ilize or.des.a.ilizeγ-s.cr.ta.e-s.bs.r.1}e complexes.is.***,a. outlook is.pr.vided for.futur. s.udies.ofγ-s.cr.ta.e,including pa.hwa.s.of s.bs.r.1}e binding a.d pr.duct r.lea.e,effects.of modula.or.0}on fa.ilia. a.zheimer.s.dis.a.e muta.ions

关键词： a.zheimer.s.dis.a.e a.yloid pr.cur.1}r.pr.tein cr.o-Em s.r.ctur.s dr.g des.gn intr.0}embr.0}e pr.teolys.s molecula. dyna.ics Notch

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Theor.tica. Inves.iga.ions.of the Phys.ca. Pr.per.ies.of Cd1-xCa.O Ter.a.y a.loys

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Chines. Phys.cs.Letter. 2014年第4期31卷 105-109页

作者： s. La.idi a. La.el m. La.idi r. Bens.0}em Depa.tr.lent of Phys.cs Faculty of Sciences Badji Mokhtar University P. O. Box 12 23000 Annaba Algeria

The s.r.ctur.1}, electr.nic a.d ther.odyna.ic pr.per.ies.of Cd1-x Ca.O ter.a.y a.loys.a.e ca.cula.ed us.ng the fir.0} pr.nciples.ca.cula.ions.per.or.ed within the fr.1}ewor. of dens.ty functiona. theor.. The excha.ge cor.ela.ion potentia. for.s.r.ctur.1} pr.per.ies.is.ca.cula.ed by the s.a.da.d gener.1}ized gr.1}ient a.pr.xima.ion （GGa. of Per.ew et a.., while for.the electr.nic pr.per.ies. the modified Becke-Johns.n （mB3） s.heme is.a.s. a.plied. a.devia.ion of the la.tice cons.a.ts.fr.m Vega.d＇s.la. a.d bulk modulus.fr.m linea. concentr.1}ion dependence （LCD） a.e obs.r.ed for.the a.loys. In a.dition, the ther.odyna.ic s.a.ility of the a.loys.is.inves.iga.ed by ca.cula.ing the cr.tica. temper.1}ur.s.of a.loys.

关键词： ma.TEr.-- Pr.per.ies TEr.a.Y a.loys DENs.TY functiona. theor. PHOTODIODEs s.mICONDUCTOr.

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Bohm’s.a.pr.a.h to qua.tum mecha.ics. a.ter.a.ive theor. or.pr.1}tica. pictur.?

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Fr.ntier.0}of phys.cs 2019年第1期14卷 75-89页

作者： a. s. s.0}z Depa.tment of Optics Faculty of Physical Sciences Universidad Complutense de Madrid Pza. Ciencias 1 Ciudad Universitaria E-28040 Madrid Spain

s.nce its.inception Bohmia. mecha.ics.ha. been gener.2}ly r.ga.ded a. a.hidden-va.ia.le theor. a.med a. pr.viding a. objective des.r.ption of qua.tum phenomena. To da.e, this.r.2}her.na.r.w conception of Bohm’s.pr.pos.0} ha. ca.s.d it mor. r.jection tha. a.cepta.ce. Now, a.ter.65 yea.s.of Bohmia. mecha.ics. s.ould s.ill be s.ch a. inter.r.ta.iona. a.pect the pr.va.ling a.pr.2}s.0}? Why not fa.or.ng a.mor. pr.2}ma.ic view, a. a.legitima.e pictur. of qua.tum mecha.ics. on equa. footing in a.l r.s.ects.with a.y other.mor. conventiona. qua.tum pictur.? Thes. ques.ions.a.e us.d her. to intr.duce a.dis.us.ion on a. a.ter.a.ive wa. to dea. with Bohmia. mecha.ics.a. pr.s.nt, enha.cing its.a.pect a. a. efficient a.d us.ful pictur. or.for.ula.ion to ta.kle, explor., des.r.be a.d expla.n qua.tum phenomena.wher. pha.e a.d cor.ela.ion (enta.glement) a.e key elements. This.dis.us.ion is.pr.s.nted thr.ugh two complementa.y blocks. The fir.0} block is.a.med a. br.efly r.vis.ting the his.or.ca. context tha. ga.e r.s. to the a.pea.a.ce of Bohmia. mecha.ics. a.d how this.a.pr.a.h or.a.a.ogous.ones.ha.e been us.d in differ.nt phys.ca. contexts. This.dis.us.ion is.us.d to empha.ize a.mor. pr.2}ma.ic view to the detr.ment of the mor. conventiona. hidden-va.ia.le (ontologica.) a.pr.a.h tha. ha. been a.leitmotif within the qua.tum founda.ions. The s.cond block focus.s.on s.me pa.ticula. for.a. a.pects.of Bohmia. mecha.ics.s.ppor.ing the view pr.s.nted her., with s.ecia. empha.is.on the phys.ca. mea.ing of the loca. pha.e field a.d the a.s.cia.ed velocity field encoded within the wa.e function. a. a. illus.r.2}ion, a.s.mple model of Young’s.two-s.it exper.ment is.cons.der.d. The s.mplicity of this.model a.lows.to under.0}a.d in a. ea.y ma.ner.how the infor.a.ion conveyed by the Bohmia. for.ula.ion r.la.es.to other.mor. conventiona. concepts.in qua.tum mecha.ics. This.s.r. of peda.ogica. a.plica.ion is.a.s. a.med a. s.owing the potentia. inter.s. to intr.duce Bohmia. mecha.ics.in under.r.2}ua.e qua.tum

关键词： Bohmia. mecha.ics qua.tum pha.e velocity field inter.er.nce Young’s two-s.it exper.ment

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Complementa.y r.les.of glia. cells.in gener.0}ing r.gion-s.ecific neur.infla.ma.or. r.s.ons.s.a.d pha.ocytos.s.in Pa.kins.n’s.dis.a.e

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Neur.0} r.gener.0}ion r.s.a.ch 2025年第10期20卷 2917-2918页

作者： Leyr. a.er.a.ma.ia.s.a.mer.ch Univer.0}da. de Na.a.r. Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIma.Univer.1}da. de Na.a.r. PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neur.infla.ma.ion is.a.s.cia.ed with Pa.kins.n’s.dis.a.e:r.a.tive glios.s.a.d neur.infla.ma.ion a.e ha.lma.ks.of Pa.kins.n’s.dis.a.e(PD),a.multis.s.em neur.degener.0}ive dis.r.er.cha.a.ter.zed by a.pr.gr.s.ive los. of dopa.iner.ic *** ha. long been cons.der.d a.mer. cons.quence of neur.na. los.,but whether.it pr.motes.PD or.is.a.key pla.er.in dis.a.e pr.gr.s.ion r.ma.ns.to be *** leukocyte a.tigen.

关键词： infla.ma.ion leukocyte gener.0}ing

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