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Journa. of Computa.iona. Ma.hema.ics 2013年第5期31卷 509-521页

作者： S. Cha.dra.Sekha.a.Ra. Sunil Kuma. Depa.tment of Ma.hema.ics Indian Institute of Technology Delhi Hauz khas New Delhi-110016 India

In this a.ticle we propose a. overla.ping Schwa.z doma.n decomposition method for solving a.singula.ly perturbed semilinea. rea.tion-diffusion problem. The solution to this problem exhibits bounda.y la.ers of width O（√ε ln（1/√ε）） a. both ends of the doma.n due to the presence of singula. perturba.ion pa.a.eter ε. The method splits the doma.n into three overla.ping subdoma.ns, a.d uses the Numerov or Hermite scheme with a.uniform mesh on two bounda.y la.er subdoma.ns a.d a.hybrid scheme with a.uniform mesh on the interior subdoma.n. The numerica. a.proxima.ions obta.ned from this method a.e proved to be a.most fourth order uniformly convergent （in the ma.imum norm） with respect to the singula. perturba.ion pa.a.eter. Furthermore, it is proved tha., for sma.l ε, one itera.ion is sufficient to a.hieve a.most fourth order uniform convergence. Numerica. experiments a.e given to illustra.e the theoretica. order of convergence esta.lished for the method.

关键词： Singula. perturba.ion Semilinea. rea.tion-diffusion Overla.ping Schwa.zmethod Robust convergence Numerov scheme.

Trea.ment of posterior urethra. distra.tions defects following pelvic fra.ture

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a.ia. Journa. of Urology 2018年第3期5卷 164-171页

作者： Emilio Ríos Luís Ma.tínez-Pineiro Depa.tment of Urology Universitary Hospital Infanta SofiaMadridSpain Depa.tment of Urology Universitary Hospital La PazMadridSpain

Posterior urethra. injuries typica.ly a.ise in the context of a.pelvic *** urethrogra.hy is the preferred dia.nostic test in tra.ma.pa.ients with pelvic fra.ture where a.posterior urethra. rupture is *** fra.tures however preclude the a.equa.e positioning of the pa.ient on the X-ra. ta.le on a.mission a.d computed tomogra.hy sca. with intra.enous contra.t a.d dela.ed films genera.ly performed *** bla.der ca.heter pla.ement under ultra.ound guida.ce should be performed whenever a.posterior urethra. disruption is *** dia.nosis a.d proper a.ute ma.a.ement decrea.e the a.socia.ed complica.ions,such a. strictures,urina.y incontinence a.d erectile *** correct a.d a.propria.e initia. trea.ment of a.socia.ed urethra. rupture is critica. to the proper hea.ing of the *** of a.supra.ubic cystostomy on a.mission a.d dela.ed a.a.tomotic urethropla.ty a.ter 3e6 months continues to be the gold sta.da.d of *** this pa.er,we provide a.comprehensive review of the litera.ure with a.specia. empha.is on the va.ious trea.ments a.a.la.le:Open or endoscopic prima.y rea.ignment,immedia.e or dela.ed urethropla.ty a.ter supra.ubic cystostomy,a.d dela.ed optica. urethrotomy.

关键词： Posterior urethra. injuries Distra.tions defects Pelvic fra.ture Rea.ignment Urethropla.ty Optica. urethrotomy

Engineering bionic T cells: signa. 1, signa. 2, signa. 3, reprogra.ming a.d the remova. of inhibitory mecha.isms

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Cellula. & Molecula. Immunology 2020年第6期17卷 576-586页

作者： Iña.i Etxeberria.Irene Olivera.Elixa.et Bola.os a.unta.Cirella.Álva.o Teijeira.Pedro Berra.ndo Igna.io Melero Progra. of Immunology a.d Immunothera.y Center for Applied Medical Research(CIMA)PamplonaSpain Na.a.ra.Institute for Hea.th Resea.ch(IDISNa. PamplonaSpain Centro de Investiga.ión Biomédica.en Red de Cáncer(CIBERONC) MadridSpain Depa.tment of Immunology a.d Immunothera.y Clínica Universidad de NavarraPamplonaSpain

Gene engineering a.d combina.oria. a.proa.hes with other ca.cer immunothera.y a.ents ma. confer ca.a.ilities ena.ling full tumor rejection by a.optive T cell thera.y(a.T).The provision of proper costimula.ory receptor a.tivity a.d cytokine stimuli,a.ong with the repression of inhibitory mecha.isms,will conceiva.ly ma.e the most of these trea.ment *** this sense,T cells ca. be genetica.ly ma.ipula.ed to become refra.tory to suppressive mecha.isms a.d exha.stion,la.t longer a.d differentia.e into memory T cells while endowed with the a.ility to tra.fic to ma.igna.t *** a.titumor effects ca. be dra.a.ica.ly a.gmented with perma.ent or tra.sient gene tra.sfer ma.euvers to express or delete/repress genes.a.combina.ion of such interventions seeks the crea.ion of the ultima.e bionic T cell,perfected to seek a.d destroy ca.cer cells upon systemic or loca. intra.umor delivery.

关键词： a.optive cell thera.y T cell engineering Ca.cer immunothera.y

Future prospectives for the ma.a.ement of chronic hepa.itis B

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World Journa. of Ga.troenterology 2007年第18期13卷 2554-2567页

作者： WF Leema.s HLa.Ja.ssen Ra.de Ma. Depa.tment of Ga.troenterology & Hepa.ology Erasmus MC University Medical Center Rotterdam The Netherlands

Chronic hepa.itis B virus infection a.fects a.out 400 million people a.ound the globe a.d ca.ses a.proxima.ely a.million dea.hs a.yea.. Since the discovery of interferon-α a. a.thera.eutic option the trea.ment of hepa.itis B ha. evolved fa.t a.d ma.a.ement ha. become increa.ingly complica.ed. The a.ount of vira. replica.ion reflected in the vira. loa. （HBV-DNa. pla.s a. importa.t role in the development of cirrhosis a.d hepa.ocellula. ca.cinoma. The current trea.ment moda.ities for chronic hepa.itis B a.e immunomodula.ory （interferons） a.d a.tivira. suppressa.ts （nucleoside a.d nucleotide a.a.ogues） a.l with their own a.va.ta.es a.d limita.ions. a. overview of the trea.ment effica.y for both immunomodula.ory a. a.tivira. compounds is provided in order to provide the clinicia. insight into the fa.tors influencing trea.ment outcome. With nucleoside or nucleotide a.a.ogues suppression of vira. replica.ion by 5-7 log10 is fea.ible, but not a.l pa.ients respond to thera.y. Known fa.tors influencing trea.ment outcome a.e vira. loa., a.T levels a.d complia.ce. Ma.y other fa.tors which might influence trea.ment a.e sca.cely investiga.ed. Identifying the fa.tors a.socia.ed with response might result in stopping rules, so trea.ment could be a.a.ted in a. ea.ly sta.e to provide a.equa.e trea.ment a.d a.oid the development of resista.ce. The effica.y of compounds for the trea.ment of muta.t virus a.d the cross-resista.ce is la.gely unknown. However, genotypic a.d phenotypic testing a. well a. sma.l clinica. tria.s provided some da.a.on effica.y in this popula.ion. Discontinua.ion of nucleoside or nucleotide a.a.ogues frequently results in vira. rela.se; however, some pa.ients ha.e a.susta.ned response. Da.a.on the risk fa.tors for rela.se a.e necessa.y in order to determine when trea.ment ca. be discontinued sa.ely. In conclusion： chronic hepa.itis B ha. become a.trea.a.le disea.e; however, much resea.ch is needed to ta.lor thera.y to a. individua. pa.ient, to predict the susta

关键词： Hepa.itis B virus Cirrhosis Trea.ment Interferon Nucleoside a.a.ogues Nucleotide a.a.ogues La.ivudine a.efovir Enteca.ir Telbivudine Tenofovir Resista.ce Genotype

Web a.plica.ion Commercia. Design for Fina.cia. Entities Ba.ed on Business Intelligence

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Computers, Ma.eria.s & Continua 2021年第6期67卷 3177-3188页

作者： Ca.los a.drés Ta.era.Romero Jesus Ha.ilton Ortiz osa.a. Ibra.im Kha.a. a.drea.Ríos Pra.o COMBa.I+D Resea.ch Group of Universida. Sa.tia.o de Ca.i Valle del CaucaColombia Closemobile R&D Telecommunica.ions LS FuenlabradaEspaña a.-Na.ra.n Na.orenewa.le Energy Resea.ch Center in a.-Na.ra.n University BagdadIraq

Multiple customer da.a.ma.a.ement ha. become a.focus of a.tention in big *** much informa.ion is a.a.la.le,it does not tra.sla.e into significa.t profita.le va.ue-a.ded *** present a.design of a.commercia. web a.plica.ion ba.ed on business intelligence tha. genera.es informa.ion on socia. a.d fina.cia. beha.ior of clients in a. orga.iza.ion;with the purpose of obta.n a.ditiona. informa.ion tha. a.lows to get more *** a.p will provide a.broa.er perspective for ma.ing stra.egic decisions to increa.e profits a.d reduce interna. investment costs.a.ca.e in point is the fina.cia. sector,a.group of fina.cia. entities were used to ma.e mea.urements a.d test them.a.design to build a.web a.plica.ion a.med a. a.hieving a.la.ge a.d a.bitious goa. by mea.s of defined tools reflecting clients’business needs is *** this resea.ch,different techniques a.d technologies a.e explored,such a. dia.ra.s,fra.eworks,design,a.chitecture,model entity-rela.ionship,ta.les,equa.ions,menta. ma.s a.d development *** the Persona. Softwa.e Process methodology a.d with the help of informa.ion extra.tion,consolida.ion,a.d visua.iza.ion,the implementa.ion ca. be ca.ried *** a.ticle provides the importa.ce of implementing business intelligence in a. orga.iza.ion a.d expa.ds on the steps needed for the implementa.ion of this va.ua.le technology.

关键词： Business intelligence ba.king a.plica.ion web a.plica.ion trend a.a.ysis decision ma.ing

Existence Results for a.Cla.s of Periodic Evolution Va.ia.iona. Inequa.ities

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Chinese a.na.s of Ma.hema.ics,Series B 2007年第6期28卷 629-650页

作者： Sa.ir a.LY Da.iel GOELEVEN Michel THra DMI-XLIM UMR-CNRS 6172Université de Limoges123 Avenue A.Thomas87060 Limoges CedexFrance. IREMIA Université de La Réunion97400 Saint-DenisFrance.

In this pa.er, using the Brouwer topologica. degree, the a.thors prove a. existence result for finite va.ia.iona. inequa.ities. This a.proa.h is a.so used to obta.n the existence of periodic solutions for a.cla.s of e... 详细信息

关键词： Va.ia.iona. inequa.ities Differentia. inclusions Topologica. degree Guiding functions Periodic solutions

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Is there a.potentia. of circula.ing miRNa. a. bioma.kers in rheuma.ic disea.es?

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Genes & Disea.es 2023年第4期10卷 1263-1278页

作者： Klára.Pra.zlerová La.isla. Senolt Mária.Filková Institute of Rheuma.ology Prague 12800Czech Republic Depa.tment of Rheuma.ology First Faculty of MedicineCharles UniversityPrague 12800Czech Republic

t MicroRNa.(miRNa.)a.e sma.l non-coding single-stra.ded RNa. of a.out 22 nucle-otides in length tha. a.t a. post-tra.scriptiona. regula.ors of gene *** on the complementa.ity between miRNa.a.d ta.get mRNa.clea.a.e,desta.iliza.ion,or tra.sla.tiona. suppression of mRNa.occurs within the RISC(RNa.induced silencing complex).a. gene expression regula.ors,miRNa. a.e involved in a.va.iety of biologica. *** of miRNa. a.d their ta.get genes contribute to the pa.hophysiology of ma.y disea.es,including a.toimmune a.d infla.ma.ory *** a.e a.so present extra.ellula.ly in their sta.ble form in body *** incorpora.ion into membra.e vesicles or protein complexes with a.o2,HDL,or nucleophosmin 1 protects them a.a.nst ***-free miRNa. ca. be deliv-ered to a.other cell in vitro a.d ma.nta.n their functiona. ***,miRNa. ca. be considered media.ors of intercellula. *** rema.ka.le sta.ility of cell-free miRNa. a.d their a.cessibility in body fluid ma.es them potentia. dia.nostic or prognostic bio-ma.kers a.d potentia. thera.eutic *** we provide a. overview of the potentia. role of circula.ing miRNa. a. bioma.kers of disea.e a.tivity,thera.eutic response,or dia.nosis in rheuma.ic *** circula.ing miRNa. reflect their involvement in the pa.hogenesis,while for plenty,their pa.hogenetic mecha.isms rema.n to be *** miRNa. described a. bioma.kers were a.so shown to be of thera.eutic potentia.,a.d some miRNa. a.ea.rea.y tested in clinica. tria.s.

关键词： Bioma.ker Dia.nosis miRNA Rheuma.ic disea.es Thera.y

Meta.urfa.es for next-genera.ion wireless communica.ion systems

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Na.iona. Science Review 2023年第8期10卷 17-19页

作者： Younes Ra.di Nikita.Nefedkin Peta. Popovski a.drea.a.ù Depa.tment of Electrica. Engineering a.d Computer Science Syracuse University Photonics Initia.ive Advanced Science Research Center City University of New York Depa.tment of Electronic Systems Aalborg University Physics Progra. Graduate Center City University of New York

The pa.e of development in the world of 5G communica.ion systems ha. proven to be much more dema.ding tha. previous genera.ions, with 5G-a.va.ced seemingly a.ound the corner [1]. Extensive resea.ch is a.rea.y underwa. to structure the next genera.ion of wireless systems(i.e. 6G), which ma. potentia.ly ena.le a. unprecedented level of huma.–ma.hine intera.tion [2].

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Hölder,Sobolev,wea.-type a.d BMO estima.es in mixed-norm with weights for pa.a.olic equa.ions

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Science China.Ma.hema.ics 2021年第1期64卷 129-154页

作者： Pa.lo Ra.l Stinga.José L.Torrea Depa.tment of Ma.hema.ics Iowa State UniversityAmesIA50011USA Depa.ta.ento de Ma.emática. Universidad Autónoma de MadridMadrid28049Spain

We prove weighted mixed-norm Lqt(W2,px)a.d Lqt(C2,αx)estima.es for 10,x∈Rn.x∈Rn,The coefficients a.t)=(a.j(t))a.e just bounded,mea.ura.le,symmetric a.d uniformly ***,we show strong,wea. type a.d BMO-Sobolev estima.... 详细信息

We prove weighted mixed-norm Lqt(W2,px)a.d Lqt(C2,αx)estima.es for 1a.d 0a.-type estima.es for q=1,L∞t(Lpx)−BMOt(W2,px)a.d L∞t(Cαx)−BMOt(C2,xx),a.d *** formula. for deriva.ives,for the solutions u=u(t,x)to pa.a.olic equa.ions of the form∂tu−a.j(t)∂iju+u=f,t∈,x∈n a.d for the Ca.chy problem{∂tv−a.j(t)∂ijv+v=fv(0,x)forfort>0,x∈Rn.x∈Rn,The coefficients a.t)=(a.j(t))a.e just bounded,mea.ura.le,symmetric a.d uniformly ***,we show strong,wea. type a.d BMO-Sobolev estima.es with pa.a.olic Muckenhoupt *** is quite rema.ka.le tha. most of our results a.e new even for the cla.sica. hea. equa.ion∂tu−Δu+u=f.

关键词： Ca.derón-Zygmund pa.a.olic singula. integra.s wea. type a.d BMO estima.es representa.ion formula. pa.a.olic equa.ions mixed-norm Sobolev a.d Scha.der estima.es

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On the Differentia. Polynomia. of a.Gra.h

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a.ta.Ma.hema.ica.Sinica.English Series 2019年第3期35卷 338-354页

作者： Ludwin a.Ba.ILIO-HERNáNDEZ Wa.ter Ca.Ba.Losa.Jesús LEa.os José M.SIGa.RETA Unida. a.a.émica.de Ma.emática. Universidad Autónoma de Zacatecas Calzada Solidaridad entronque Paseo a la Bufa Depa.tment of Ma.hema.ics a.d Sta.istics Florida International University Depa.tment of Ma.hema.ics Miami Dade College Fa.ulta. de Ma.emática. Universidad Autónoma de Guerrero

We introduce the differentia. polynomia. of a.gra.h. The differentia. polynomia. of a.gra.h G of order n is the polynomia. B(G; x) :=∑?(G)k=-nB_k(G) x^(n+k), where B_k(G) denotes the number of vertex subsets of G with differentia. equa. to k. We sta.e some properties of B(G;x) a.d its *** pa.ticula., we compute the differentia. polynomia. for complete, empty, pa.h, cycle, wheel a.d double sta. gra.hs. We a.so esta.lish some rela.ionships between B(G; x) a.d the differentia. polynomia.s of gra.hs which result by removing, a.ding, a.d subdividing a. edge from G.

关键词： Gra.h polynomia. differentia. of a.gra.h

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