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Efficient a.d Sta.le Photoa.sisted Lithium-Ion Ba.tery Ena.led by Photoca.hode with Synergistica.ly Boosted Ca.riers Dyna.ics

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Na.O-MICRO LETTERS 2025年第1期17卷 1-15页

作者： Ma. Zelin Wa.g, Shiya. Ma. Zhua.gzhua.g Li, Jua. Zha., Luomeng Li, Zhihua. Wa.g, Shiyua. Shua.g, Ya.hou Wa.g, Jiulong Wa.g, Fa.g Xia. Weiwei Jia., Jie He, Yibo Wa.g, Junjie Guo, Pengfei Wa.g, Hongqia.g Northwestern Polytech Univ Ctr Nano Energy Mat State Key Lab Solidificat Proc Sch Mat Sci & Engn Xian 710072 Peoples R China NPU Shaanxi Joint Lab Graphene Xian 710072 Peoples R China Northwestern Polytech Univ Sch Mat Sci State Key Lab Solidificat Proc Xian 710072 Peoples R China Northwestern Polytech Univ Engn Dept Xian 710072 Peoples R China Northwestern Polytech Univ Ctr Adv Lubricat & Seal Mat Sch Mat Sci & Engn State Key Lab Solidificat Proc Xian 710072 Peoples R China Northwestern Polytech Univ Shenzhen Res & Dev Inst Shenzhen 518063 Peoples R China Sha.nxi Norma. Univ Key Lab Appl Surface & Colloid Chem Shaanxi Engn Lab Adv Energy Technol Shaanxi Key Lab Adv Energy DevicesSch Mat Sci & E Xian 710119 Peoples R China

Efficient a.d sta.le photoca.hodes with versa.ility a.e of significa.ce in photoa.sisted lithium-ion ba.teries (PLIBs), while there is a.wa.s a.request on fa.t ca.rier tra.sport in electrochemica. a.tive photoca.hodes. Present work proposes a.genera. a.proa.h of crea.ing bulk heterojunction to boost the ca.rier mobility of photoca.hodes by simply la.er a.sisted embedding of pla.monic na.ocrysta.s. When employed in PLIBs, it wa. found effective for synchronously enha.ced photocha.ge sepa.a.ion a.d tra.sport in light cha.ging process. a.ditiona.ly, experimenta. photon spectroscopy, finite difference time doma.n method simula.ion a.d theoretica. a.a.yses demonstra.e tha. the improved ca.rier dyna.ics a.e driven by the pla.monic-induced hot electron injection from meta. to TiO2, a. well a. the enha.ced conductivity in TiO2 ma.rix due to the forma.ion of oxygen va.a.cies a.ter Schottky conta.t. Benefiting from these merits, severa. benchma.k va.ues in performa.ce of TiO2-ba.ed photoca.hode a.plied in PLIBs a.e set, including the ca.a.ity of 276 ma. g(-1 ) a. 0.2 a.g(-1 )under illumina.ion, photoconversion efficiency of 1.276% a. 3 a.g(-1 ), less ca.a.ity a.d Columbic efficiency loss even through 200 cycles. These results exemplify the potentia. of the bulk heterojunction stra.egy in developing highly efficient a.d sta.le photoa.sisted energy stora.e systems.

关键词： Photoa.sisted lithium-ion ba.teries Bulk heterojunction Ca.rier dyna.ics TiO2 na.ofiber Pla.monic meta. na.ocrysta.s

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Constructing Donor–a.ceptor‑Linked COFs Electrolytes to Regula.e Electron Density a.d a.celera.e the Li^(+)Migra.ion in Qua.i‑Solid‑Sta.e Ba.tery

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Na.o-Micro Letters 2025年第1期17卷 456-471页

作者： Genfu Zha. Ha.g Ma.Conghui Zha.g Yongxin Ya.g Shuyua. Yu Ha.ye Zhu Yongjia.g Sun Hong Guo School of Ma.eria.s a.d Energy International Joint Research Center for Advanced Energy Materials of Yunnan ProvinceYunnan UniversityKunming 650091People’s Republic of China Yunna. Yuntia.hua.Co. LtdR&D CenterKunming 650228People’s Republic of China Southwest United Gra.ua.e School Kunming 650091People’s Republic of China

Regula.ion the electronic density of solid-sta.e electrolyte by donor–a.ceptor(D–a.system ca. a.hieve highly-selective Li^(+)tra.sporta.ion a.d conduction in solid-sta.e Li meta. *** study reports a.high-performa.ce solid-sta.e electrolyte thorough D–a.linked cova.ent orga.ic fra.eworks(COFs)ba.ed on intra.olecula. cha.ge tra.sfer *** other reported COFba.ed solid-sta.e electrolyte,the developed concept with D–a.linked COFs not only a.hieves electronic modula.ion to promote highly-selective Li^(+)migra.ion a.d inhibit Li dendrite,but a.so offers a.crucia. opportunity to understa.d the role of electronic density in solid-sta.e Li meta. *** introduced strong electronega.ivity F-ba.ed liga.d in COF electrolyte results in highlyselective Li^(+)(tra.sference number 0.83),high ionic conductivity(6.7×10^(-4)S cm^(−1)),excellent cyclic a.ility(1000 h)in Li meta. symmetric cell a.d high-ca.a.ity retention in Li/LiFePO_(4)cell(90.8%for 300 cycles a. 5C)tha. substituted C-a.d N-ba.ed *** is a.cribed to outsta.ding D–a.intera.tion between donor porphyrin a.d a.ceptor F a.oms,which effectively expedites electron tra.sferring from porphyrin to F-ba.ed liga.d a.d enha.ces Li^(+)***,we a.ticipa.e tha. this work crea.es insight into the stra.egy for a.celera.ing Li^(+)conduction in high-performa.ce solid-sta.e Li meta. ba.teries through D–a.system.

关键词： Electronic modula.ion engineering Donor-a.ceptor-linked cova.ent orga.ic fra.eworks Qua.i-solid-sta.e Li meta. ba.tery

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The Citron homology doma.n of Ma.4Ks improves outcomes of tra.ma.ic bra.n injury

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Neura. Regenera.ion Resea.ch 2025年第11期20卷 3233-3244页

作者： Xia.ling Zhong Wenjia. Ta. Meng-Lu Liu Shua.peng Ma.Tia.jin Shen Yuhua.Zou Chun-Li Zha.g Depa.tment of Molecula. Biology University of Texas Southwestern Medical CenterDallasTXUSA Ha.on Center for Regenera.ive Science a.d Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Bra.n Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-a.tiva.ed protein kina.e kina.e kina.e kina.es(Ma.4Ks)signa.ing pa.hwa. pla.s a.pivota. role in a.ona. regrowth a.d neurona. degenera.ion following *** ta.geting this pa.hwa. is beneficia. to bra.n injury rema.ns *** this study,we showed tha. a.eno-a.socia.ed virus-delivery of the Citron homology doma.n of Ma.4Ks effectively reduces tra.ma.ic bra.n injury-induced rea.tive gliosis,ta.opa.hy,lesion size,a.d beha.iora. *** inhibition of Ma.4Ks replica.ed the a.eliora.ive effects observed with expression of the Citron homology ***,the Citron homology doma.n a.ted a. a.domina.t-nega.ive muta.t,impeding Ma.4K-media.ed phosphoryla.ion of the dishevelled proteins a.d thereby controlling the Wnt/β-ca.enin *** findings implica.e a.thera.eutic potentia. of ta.geting Ma.4Ks to a.levia.e the detrimenta. effects of tra.ma.ic bra.n injury.

关键词： a.eno-a.socia.ed virus Citron homology Citron homology doma.n gene thera.y mitogen-a.tiva.ed protein kina.e kina.e kina.e kina.es tra.ma.ic bra.n injury

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Hypidone hydrochloride(YL-0919)a.eliora.es functiona. deficits a.ter tra.ma.ic bra.n injury in mice by a.tiva.ing the sigma.1 receptor for a.tioxida.ion

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Neura. Regenera.ion Resea.ch 2025年第8期20卷 2325-2336页

作者： Ya.a. Ba. Hui Ma.Yue Zha.g Jinfeng Li Xia.jua. Hou Yixin Ya.g Guya. Wa.g Yunfeng Li Depa.tment of a.esthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Ba.ic Medica. Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pha.ma.ology a.d Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Tra.ma.ic bra.n injury involves complex pa.hophysiologica. mecha.isms,a.ong which oxida.ive stress significa.tly contributes to the occurrence of seconda.y *** this study,we eva.ua.ed hypidone hydrochloride(YL-0919),a.self-developed a.tidepressa.t with selective sigma.1 receptor a.onist properties,a.d its a.socia.ed mecha.isms a.d ta.gets in tra.ma.ic bra.n *** experiments to a.sess functiona. deficits were followed by a.sessment of neurona. da.a.e through histologica. a.a.yses a.d exa.ina.ion of blood-bra.n ba.rier permea.ility a.d bra.n ***,we investiga.ed the a.tioxida.ive effects of YL-0919 by a.sessing the levels of tra.itiona. ma.kers of oxida.ive stress in vivo in mice a.d in vitro in HT22 ***,the ta.geted a.tion of YL-0919 wa. verified by employing a.sigma.1 receptor a.ta.onist(BD-1047).Our findings demonstra.ed tha. YL-0919 ma.kedly improved deficits in motor function a.d spa.ia. cognition on da. 3 post tra.ma.ic bra.n injury,while a.so decrea.ing neurona. morta.ity a.d reversing blood-bra.n ba.rier disruption a.d bra.n ***,YL-0919 effectively comba.ed oxida.ive stress both in vivo a.d in *** protective effects of YL-0919 were pa.tia.ly inhibited by *** results indica.ed tha. YL-0919 relieved impa.rments in motor a.d spa.ia. cognition by restra.ning oxida.ive stress,a.neuroprotective effect tha. wa. pa.tia.ly reversed by the sigma.1 receptor a.ta.onist ***-0919 ma. ha.e potentia. a. a.new trea.ment for tra.ma.ic bra.n injury.

关键词： a.tidepressa.t drug blood-bra.n ba.rier cognitive function hypidone hydrochloride(YL-0919) neurologica. function nuclea. fa.tor-erythroid 2 rela.ed fa.tor 2 oxida.ive stress sigma.1 receptor superoxide dismuta.e tra.ma.ic bra.n injury

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a.surfa.e engineering stra.egy for the sta.iliza.ion of zinc meta. a.odes with montmorillonite la.ers towa.d long-life recha.gea.le a.ueous zinc ion ba.teries

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Journa. of Energy Chemistry 2025年第1期100卷 94-105页

作者： Wenbo Wa.g Ruifeng Xu Xu Zha.g Peiyu Wa.g Ba. Ya.g Bingjun Ya.g Jua. Ya.g Ka.lima. Su Pengjun Ma.Ya.a. Deng Xia.feng Fa. Wa.jun Chen Key La.ora.ory for Electronic Ma.eria.s College of Electrical Engineering Northwest Minzu University Resource Chemistry a.d Energy Ma.eria.s Resea.ch Center State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for Ma.eria.s a.d Processes School of Engineering University of Edinburgh

Recha.gea.le a.ueous zinc-ion ba.teries （a.IBs） exhibit a.precia.le potentia. in the doma.n of electrochemica. energy ***,there a.e serious cha.lenges for a.IBs,for insta.ce zinc dendrite growth,hydrogen evolution rea.tion （HER）,a.d corrosion side ***,we propose a.surfa.e engineering modifica.ion stra.egy for coa.ing the montmorillonite （MMT） la.er onto the surfa.e of the Zn a.ode to ta.kle these issues,thereby a.hieving high cycling sta.ility for recha.gea.le *** results revea. tha. the MMT la.er on the surfa.e of the Zn a.ode is a.le to provide ordered zincophilic cha.nels for zinc ions migra.ion,fa.ilita.ing the rea.tion kinetics of zinc *** functiona. theory（DFT） ca.cula.ions a.d wa.er conta.t a.gle （Ca. tests prove tha. MMT@Zn a.ode exhibits superior a.sorption ca.a.ity for Zn2+a.d better hydrophobicity tha. the ba.e Zn a.ode,thereby a.hieving excellent cycling ***,the MMT@Zn||MMT@Zn symmetric cell holds the sta.le cycling over 5600 h a. 0.5 ma.cm-2a.d 0.125 m a.h cm-2,even exceeding 1800 h long cycling under ha.sh conditions of 5 m a.cm-2a.d 1.25 m a.h *** MMT@Zn||V2O5full cell rea.hes over 3000 cycles a. 2 a.g-1with excellent ra.e ***,this surfa.e engineering modifica.ion stra.egy for enha.cing the electrochemica. performa.ce of a.IBs represents a.promising a.plica.ion.

关键词： Surfa.e engineering stra.egy Montmorillonite la.er Protection mecha.ism of Zn a.ode Cycling sta.ility a.ueous zinc ion ba.teries

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Ma.ncha.n conforma.ion ordering self-a.sembly ta.lored room tempera.ure phosphorescence emission

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Science China.Chemistry 2025年第01期 329-336页

作者： Yuzhu Li Yumeng Ga. Feng Tia. Yu Wa.g Yua. Ya. Sha.lia.g Lin Xia.g Ma.Binbin Xu Sha.gha. Key La.ora.ory of a.va.ced Polymeric Ma.eria.s Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Sha.gha. Synchrotron Ra.ia.ion Fa.ility Shanghai Advanced Research Institute Chinese Academy of Sciences Key La.ora.ory for a.va.ce Ma.eria.s a.d Feringa.Noble Prize Scientist Joint Resea.ch Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing orga.ic room-tempera.ure phosphorescence （RTP） ma.eria.s with a.wide ra.ge of tuna.le-emission is significa.t in expa.ding the a.plica.ions of RTP ***,we ra.iona.ly designed a.phiphilic a.terna.ing copolymers poly(1,2-bis（4-a.koxyphenyl）etha.e-1,2-dione-a.t-（ethylene glycol）x)(P（Bz-a.t-EGx）) tha. combined the a.va.ta.e of a.terna.ing benzil a.d EGxskeleton,a.d tuna.le ma.ncha.n *** a.ma.ncha.n conforma.ion ordering a.sembly （COa. process,P（Bz-a.t-EGx） self-a.sembled into well-defined pla.elets,a.d such a.semblies emitted blue RTP a. ca.425 nm due to the ordered folded-cha.n conforma.ion a.d confined *** contra.t,tra.itiona. self-a.sembly （Ta. of P（Bz-a.t-EGx） obta.ned less ordered a.grega.es,such a. a.ymmetric worms,vesicles,a.d rod-like *** resulta.t less ordered a.grega.es exhibited yellow-green RTP a. ca.550 *** wide-tuning RTP emission in solution （between blue a.d yellow-green,over125 nm） is rea.ized using the P（Bz-a.t-EGx） a.terna.ing copolymers under the trea.ment of different self-a.sembly *** study uncovers a.new stra.egy to ta.lor the RTP emission through different self-a.sembly pa.hwa.s a.d holds grea. promise for the fa.rica.ion of a.va.ced optica. ma.eria.s.

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Loca.ly Enha.ced Flow a.d Electric Fields Through a.Tip Effect for Efficient Flow‑Electrode Ca.a.itive Deioniza.ion

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Na.o-Micro Letters 2025年第2期17卷 1-17页

作者： Ziqua. Wa.g Xia.gfeng Chen Yua. Zha.g Jie Ma.Zhiqun Lin a.or a.delka.er Ma.ia.Ma.da.ena.Titirici Libo Deng College of Chemistry a.d Environmenta. Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Resea.ch Center for Environmenta. Functiona. Ma.eria.s College of Environmental Science and EngineeringTongji University1239 Siping RoadShanghai 200092People’s Republic of China Depa.tment of Chemica. a.d Biomolecula. Engineering National University of SingaporeSingapore 117585Singapore Depa.tment of Engineering Faculty of Science and TechnologyBournemouth UniversityTalbot CampusFern BarrowPooleEngland BH125BBUK Institut de Chimie de Nice UniversitéCôte d’AzurUMR CNRS 727228 Av.Valrose06108 NiceFrance Depa.tment of Chemica. Engineering Imperial College LondonSouth Kensington CampusExhibition RdLondon SW72AZUK

Low-electrode ca.a.itive deioniza.ion(FCDI)is a. emerging desa.ina.ion technology with grea. potentia. for remova. a.d/or recycling ions from a.ra.ge of ***,it still suffers from inefficient cha.ge tra.sfer a.d ion tra.sport kinetics due to wea. turbulence a.d low electric intensity in flow electrodes,both restricted by the current ***,a.new tip-a.ra. current collector(designa.ed a. T-CC)wa. developed to repla.e the conventiona. pla.a. current collectors,which intensifies both the cha.ge tra.sfer a.d ion tra.sport *** effects of tip a.ra.s on flow a.d electric fields were studied by both computa.iona. simula.ions a.d electrochemica. impeda.ce spectroscopy,which revea.ed the reduction of ion tra.sport ba.rier,cha.ge tra.sport ba.rier a.d interna. *** the volta.e increa.ed from 1.0 to 1.5 a.d 2.0 V,the T-CC-ba.ed FCDI system(T-FCDI)exhibited a.era.e sa.t remova. ra.es(a.RR)of 0.18,0.50,a.d 0.89μmol cm^(-2) min^(-1),respectively,which a.e 1.82,2.65,a.d 2.48 folds higher tha. tha. of the conventiona. serpentine current collectors,a.d 1.48,1.67,a.d 1.49 folds higher tha. tha. of the pla.a. current ***,with the solid content in flow electrodes increa.ed from 1 to 5 wt%,the a.RR for T-FCDI increa.ed from 0.29 to 0.50μmol cm^(-2) min^(-1),which a.e 1.70 a.d 1.67 folds higher tha. tha. of the pla.a. current ***,a.sa.t remova. efficiency of 99.89%wa. a.hieved with T-FCDI a.d the cha.ge efficiency rema.ned a.ove 95%a.ter 24 h of opera.ion,thus showing its superior long-term sta.ility.

关键词： Flow-electrode Ca.a.itive deioniza.ion Current collector Tip effect Desa.ina.ion

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数字普惠金融的农户增收效应与作用机制——基于陕西省9市18县的调查数据

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西北农林科技大学学报（社会科学版） 2025年第1期25卷 101-110页

作者：马红刚西安交通大学经济与金融学院西安710049

拓展农民增收致富渠道是完善城乡融合发展体制机制的关键环节,也是中国实现共同富裕的核心目标。基于陕西省9市18县(区)3658份农户微观调研数据,运用逻辑回归模型与中介效应模型,分析了数字普惠金融对农户家庭收入的影响及其作用机制。... 详细信息

拓展农民增收致富渠道是完善城乡融合发展体制机制的关键环节,也是中国实现共同富裕的核心目标。基于陕西省9市18县(区)3658份农户微观调研数据,运用逻辑回归模型与中介效应模型,分析了数字普惠金融对农户家庭收入的影响及其作用机制。研究表明,数字普惠金融对农户家庭收入具有显著的正向影响,数字普惠金融发展水平越高的县域,农户的家庭收入水平越高,特别是在数字普惠金融的使用深度、覆盖广度与数字化程度方面,影响尤为显著。进一步探讨作用机制后发现,缓解家庭金融约束、促进信息对称与扩大农业经营规模是数字普惠金融促进农户增收的主要途径。此外,数字普惠金融的增收效应存在异质性,农村居民的金融素养与金融市场参与度越高,数字普惠金融对农户家庭收入的正向影响越显著。

关键词：数字普惠金融农户增收信息获取农业经营规模信贷约束

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Regula.ion a.d function of endopla.mic reticulum a.topha.y in neurodegenera.ive disea.es

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Neura. Regenera.ion Resea.ch 2025年第1期20卷 6-20页

作者： Xiu-Yun Zha. De-En Xu Ming-Lei Wu Ji-Chua. Liu Zi-Ling Shi Qua.-Hong ma Depa.tment of Neurology a.d Clinica. Resea.ch Center of Neurologica. Disea.e the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jia.gsu Key La.ora.ory of Tra.sla.iona. Resea.ch a.d Thera.y for Neuro-Psycho-Disea.es Soochow UniversitySuzhouJiangsu ProvinceChina Depa.tment of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endopla.mic reticulum,a.key cellula. orga.elle,regula.es a.wide va.iety of cellula. *** reticulum a.topha.y,one of the qua.ity control systems of the endopla.mic reticulum,pla.s a.pivota. role in ma.nta.ning endopla.mic reticulum homeosta.is by controlling endopla.mic reticulum turnover,remodeling,a.d *** this review,we briefly describe the endopla.mic reticulum qua.ity control system,a.d subsequently focus on the role of endopla.mic reticulum a.topha.y,empha.izing the spa.ia. a.d tempora. mecha.isms underlying the regula.ion of endopla.mic reticulum a.topha.y a.cording to cellula. *** a.so summa.ize the evidence rela.ing to how defective or a.norma. endopla.mic reticulum a.topha.y contributes to the pa.hogenesis of neurodegenera.ive *** summa.y,this review highlights the mecha.isms a.socia.ed with the regula.ion of endopla.mic reticulum a.topha.y a.d how they influence the pa.hophysiology of degenera.ive nerve *** review would help resea.chers to understa.d the roles a.d regula.ory mecha.isms of endopla.mic reticulum-pha.y in neurodegenera.ive disorders.

关键词： a.topha.y endopla.mic reticulum endopla.mic reticulum a.topha.y endopla.mic reticulum qua.ity control system endopla.mic reticulum receptors endopla.mic reticulum-a.socia.ed degra.a.ion neurodegenera.ion neurodegenera.ive disea.e selective a.topha.y unfolded protein response

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Recombina.t chitina.e-3-like protein 1 a.levia.es lea.ning a.d memory impa.rments via.M2 microglia.pola.iza.ion in postopera.ive cognitive dysfunction mice

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Neura. Regenera.ion Resea.ch 2025年第9期20卷 2727-2736页

作者： Yujia.Liu Xue Ha. Ya. Su Yiming Zhou Minhui Xu Jiya. Xu Zhenglia.g Ma.Xia.ping Gu Tia.jia. Xia Depa.tment of a.esthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medica. School Nanjing UniversityNanjingJiangsu ProvinceChina Jia.gsu Key La.ora.ory of Molecula. Medicine Nanjing UniversityNanjingJiangsu ProvinceChina Sta.e Key La.ora.ory of Pha.ma.eutica. Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Depa.tment of a.esthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postopera.ive cognitive dysfunction is a.seve re complica.ion of the centra. nervous system tha. occurs a.ter a.esthesia.a.d surgery,a.d ha. received a.tention for its high incidence a.d effect on the qua.ity of life of *** da.e,there a.e no via.le trea.ment options for postopera.ive cognitive *** identifica.ion of postopera.ive cognitive dysfunction hub genes could provide new resea.ch directions a.d thera.eutic ta.gets for future *** identify the signa.ing mecha.isms contributing to postopera.ive cognitive dysfunction,we first conducted Gene Ontology a.d Kyoto Encyclopedia.of Genes a.d Genomes pa.hwa. enrichment a.a.yses of the Gene Expression Omnibus GSE95426 da.a.et,which consists of mRNa. a.d long non-coding RNa. differentia.ly expressed in mouse hippoca.pus3 da.s a.ter tibia. *** da.a.et wa. enriched in genes a.socia.ed with the biologica. process"regula.ion of immune cells,"of which Chill wa. identified a. a.hub ***,we investiga.ed the contribution of chitina.e-3-like protein 1 protein expression cha.ges to postopera.ive cognitive dysfunction in the mouse model of tibia. fra.tu re *** were intra.eritonea.ly injected with vehicle or recombina.t chitina.e-3-like protein 124 hours post-surgery,a.d the injection groups were compa.ed with untrea.ed control mice for lea.ning a.d memory ca.a.ities using the Y-ma.e a.d fea. conditioning *** a.dition,protein expression levels of proinfla.ma.ory fa.tors(interleukin-1βa.d inducible nitric oxide syntha.e),M2-type ma.ropha.e ma.kers(CD206 a.d a.gina.e-1),a.d cognition-rela.ed proteins(bra.n-derived neurotropic fa.tor a.d phosphoryla.ed NMDa.receptor subunit NR2B)were mea.ured in hippoca.pus by western *** with recombina.t chitina.e-3-like protein 1 prevented surgery-induced cognitive impa.rment,downregula.ed interleukin-1βa.d nducible nitric oxide syntha.e expression,a.d upregula.ed CD206,a.gina.e-1,pNR2B,a.d bra.n-derived neurotropic fa.tor expr

关键词： Chil1 hippoca.pus lea.ning a.d memory M2 microglia neuroinfla.ma.ion postopera.ive cognitive dysfunction(POCD) recombina.t CHI3L1

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