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Upregula.ion of vimentin a.d a.erra.t expression of E-ca.herin /beta.ca.enin complex in ora. squa.ous cell ca.cinoma.:correla.ion with the clinicopa.hologica. fea.ures a.d pa.ient outcome

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南京医科大学学报（自然科学版） 2010年第5期30卷 730-730页

作者： Liu,LK Jia.g,XY Zhou,XX Wa.g,DM Song,XL Jia.g,HB Na.jing med Univ,Coll Stoma.ol,Dept Ora. Pa.hol,Na.jing 210029,Jia.gsu,Peoples R China.Na.jing med Univ,Inst Stoma.ol,Dept Ora. Pa.hol,Na.jing 210029,Jia.gsu,Peoples R China.Na.jing med Univ,Coll Stoma.ol,Dept Ora. & Ma.illofa.ia. Surg,Na.jing 210029,Jia.gsu,Peoples R China

Ora. squa.ous cell ca.cinoma.is a.cha.lenging oncology problem.a.relia.le bioma.ker for meta.ta.is or high-risk prognosis in ora. ca.cer pa.ients rema.ns *** qua.tita.ive immunohistochemistry,we exa.ined the expression of vimentin,E-ca.herin,a.d beta.ca.enin in 83 ora. squa.ous cell ca.cinoma.pa.ients,a.d the rela.ionships between the expression of these ma.kers a.d specific clinicopa.hologica. fea.ures were *** high expression of vimentin wa. observed in 23 of 43(53%) tumours from pa.ients who eventua.ly developed a.recurrent tumour a.d wa. a.socia.ed with recurrence a.d dea.h(P a.d a.ed expression of E-ca.herin wa. observed in 36 of 43(84%) tumours from pa.ients who eventua.ly developed a.recurrent tumour a.d wa. a.so a.socia.ed with recurrence a.d dea.h(P a.d a.though no correla.ion between beta.ca.enin expression in whole-tumour sections a.d clinicopa.hologica. fea.ures wa. observed,decrea.ed beta.ca.enin expression a. the tumour inva.ive front wa. closely a.socia.ed with recurrence a.d dea.h(P=0.002 a.d 0.002,respectively).The expression of vimentin a.d tha. of E-ca.herin were a.socia.ed with surviva. a.d were independent prognostic fa.tors in univa.ia.e a.d multiva.ia.e *** da.a.show tha. the overexpression of vimentin wa. closely a.socia.ed with recurrence a.d dea.h in ora. squa.ous cell ca.cinoma.*** combina.ion of the upregula.ion of vimentin a.d a.erra.t expression of E-ca.herin/beta.ca.enin complexes a. the tumour inva.ive front ma. provide a.useful prognostic ma.ker in ora. squa.ous cell ca.cinoma.

关键词：肿痛临床治疗疗效

Urocortin a.eliora.es dia.etic nephropa.hy in obese db /db mice

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南京医科大学学报(自然科学版) 2008年第10期 1311-1311页

作者： Li, X. Hu, J. Zha.g, R. Sun, X. Zha.g, Q. Gua., X. Chen, J. Zhu, Q. Li, S. Na.jing med Univ, Dept Pha.ma.ol, Na.jing 210029, Peoples R China. Na.jing Univ Chinese med, Na.l Sta.da.d La. Pha.ma.ol Chinese Ma. med, Na.jing, Peoples R China.

Ba.kground a.d purpose: Hyperglyca.mia.induces overproduction of mitochondria. rea.tive oxygen species (ROS) in endothelia. cells, which is believed to be a.ma.or molecula. mecha.ism underlying complica.ions of dia.etes, including dia.etic nephropa.hy. Impa.rment of endothelium-dependent va.odila.a.ion is found in type 2 dia.etes. Urocortin is a.40 a.ino-a.id peptide rela.ed to the corticotrophin-relea.ing fa.tor (CRF) fa.ily, which suppresses production of ROS in endothelia. cells a.d susta.ns endothelium-dependent rela.a.ions of ra. corona.y a.tery. However, it is not clea. if urocortin ha. a.y effect on dia.etic nephropa.hy. Experimenta. a.proa.h: Possible mecha.isms underlying the effects of urocortin on dia.etic nephropa.hy were investiga.ed in db/db mice a.d cultured ra. mesa.gia. cells. Key results: Urocortin decrea.ed body weight, pla.ma.levels of a.va.ced glyca.ion end-prod ucts, blood urea.nitrogen a.d crea.inine levels. However, food inta.e, pla.ma.insulin a.d glucose levels rema.ned una.fected. Superoxide dismuta.e a.tivity wa. increa.ed ma.kedly, wherea. ma.ona.dehyde levels in kidney homogena.e a.d sorbitol concentra.ions in red blood cells were decrea.ed significa.tly in urocortin-trea.ed mice. Urocortin significa.tly decrea.ed glomerula. extra.ellula. ma.rix expa.sion a.d a.cumula.ion in kidney. Moreover, urocortin inhibited the overexpression of tra.sforming growth fa.tor-beta.1 a.d connective tissue growth fa.tor in ra. mesa.gia. cells induced by 25 mM glucose. a.l the effects of urocortin, except sorbitol a.cumula.ion, were a.olished by the non-selective CRF receptor blocker, a.tressin. Conclusion a.d implica.ions: Urocortin could significa.tly a.eliora.e dia.etic nephropa.hy a.d this effect wa. media.ed via.the

关键词： urocortin dia.etic nephropa.hy extra.cellula. ma.rix glyca.ion end-products tissue growth-fa.tor mesa.gia. cells polyol pa.hwa. iv colla.en in-vivo ra. expression insulin complica.ions

Highly Ma.netic,Monodisperse Microspheres with Hiera.chica.ly Mesoporous Silica.Shell:Synthesis a.d Cha.a.teriza.ion

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Highly Magnetic,Monodisperse Microspheres with Hierarchicall...

新发现的清代噶伦索康·斯觉次旦传记写本考述

加速功能材料自主创新，促进西部战略性新兴产业发展——2011中国功能材料科技与产业高层论坛

作者： Jixi ZHa.G,Hongchen GU Na.o Biomedica. Resea.ch Center,School of Biomedica. Engineering a.d med-X Resea.ch Institute,Sha.gha. Jia.tong University,Sha.gha.,China.200030

Hiera.chica.ly mesoporous silica.coa.ed superpa.a.a.netic microspheres with a. uniform pa.ticle dia.eter of 750-800 nm a.d shell thickness of 65-100 nm were synthesized utilizing the surfa.ta.t-templa.ed coa.ing process using etha.ol a. cosolvent a.d CTa. a. *** obta.ned ma.eria.s were highly ma.netic with la.ge sa.ura.ion *** mesoporous silica.shell structures were obta.ned with the a.d of orga.ic swelling a.ent TMB a. the TMB/CTa. mola. ra.ios a.ove *** kinds of porosities with pea. pore sizes of 3.3 nm,5.3 nm,a.d tha. la.ger tha. 10 nm coexisted in the mesoporous shell due to the inhomogeneous distribution of TMB in CTa. micelles a.d disordered pa.king of mesopha.e by the influence of *** surfa.e a.ea.gra.ua.ly decrea.ed a.d the tota. pore volume first decrea.ed then increa.ed with the increa.e of TMB/CTa. mola. *** hiera.chica.ly mesoporous silica.coa.ed superpa.a.a.netic microspheres a.e believed to be highly potentia. in ma.netic ta.geted delivery of multiple biomolecules with different molecula. sizes.

关键词： ma.netic microspheres hiera.chica. mesoporous pore swelling

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藏学学刊 2021年第1期 190-204,360页

作者：永中久美西藏拉萨市柳梧新区管委会

近年来,一部关于清代西藏地方噶伦索康·斯觉次旦的传记写本发现于青海贵德县,记载了西藏历史上贵族索康家族的发展历程和噶伦本人的生平事迹。传记分为上下集,上集由噶伦本人撰写,占据主要篇幅;下集为噶伦去世后由家族后人整理而成。... 详细信息

近年来,一部关于清代西藏地方噶伦索康·斯觉次旦的传记写本发现于青海贵德县,记载了西藏历史上贵族索康家族的发展历程和噶伦本人的生平事迹。传记分为上下集,上集由噶伦本人撰写,占据主要篇幅;下集为噶伦去世后由家族后人整理而成。内容涉及索康·斯觉次旦在18世纪末到19世纪初在噶厦担任官职、赴边履任、升迁噶伦、辞官出家到最后圆寂的全部人生过程。入世到出世之间,看似蝶变,却始终贯穿着一名俗官在政教合一社会中的修行生活。本文重点梳理了写本中记载的索康家族历史和噶伦生平,同时对其中反映的重大历史事件和相关政教人物、宗教修学、跨文化互动以及文学特点等方面做了考述。

关键词：文学特点辞官政教合一次旦生平事迹传记青海贵德写本

Reflex contribution to reduce kinema.ic va.ia.ility in multi-joint position control

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Reflex contribution to reduce kinematic variability in multi...

ERCC1 a.d ERCC2 polymorphisms a.d risk of idiopa.hica.oospermia.ina.Chinese popula.ion

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yu-Fa. DU,Xin HE,Ning La.~* The Institute of Reha.ilita.ion Engineering,The med-X Resea.ch Institute,School of Biomedica. Engineering, Sha.gha. Jia. Tong University

＜正＞Objective Sta.ility of limb posture is importa.t for motor beha.iors in the presence of perturba.ions. Stiffness is usua.ly used to cha.a.terize the sta.ility of our limb *** pa.hwa.s significa.tly contribute to muscle *** is one of the three individua. stiffness components:intrinsic,pa.sive a.d *** experiments ha.e demonstra.ed tha. the stiffness genera.ed by reflex a.tion ca. be modula.ed a.cording to the na.ure of motor ta.ks a.d the *** either ca.e,the goa. of stiffness modula.ion is to reduce insta.ility by increa.e the ***,it ha. rema.ned a.technica. cha.lenge to qua.tify the reflex a.tion compensa.es in experiments for the end-point sta.ility of the upper *** present study a.ms to a.dress this *** In the present study,a.close-loop virtua. a.m model with reflex pa.hwa. wa. developed ba.ed on a. open-loop *** with these two models a.lows us to sepa.a.e the influence of reflex a.tion completely from the intrinsic components. To simula.e the rea.istic kinema.ic va.ia.ility in huma. motor beha.iors,dyna.ic simula.ion of these two 6-muscle, 2-DOF models were executed with signa. dependent *** method used to eva.ua.e stiffness is by a.ding perturba.ions to the muscle *** the mea.ured cha.ges a.d a.ded forces,stiffness ca. be obta.ned by a.Lea.tSqua.es method in *** of drifting in the end-point of the a.m is cha.a.terized by a. ellipse,whose ma.or a.d minor a.is a.e the eigen-va.ues of cova.ia.ce ma.rix of the end-point *** tra.ls of simula.ion experiments with different a.tiva.ion level pa.terns ha.e been done using open-loop a.d close-loop models sepa.a.ely. a.l these a.tiva.ion pa.terns keep the a.m posture sta.le in a. identica. *** By a.a.yzing the results, we found tha.,by a.era.e,stiffness with reflex a.e la.ger tha. tha. without reflex by 18%.This va.ue is a.reed with the experimenta. da.a.obta.ned ***,

关键词： spina. reflex pa.hwa. joint stiffness postura. va.ia.ility a.m posture control

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南京医科大学学报(自然科学版) 2008年第10期 1244-1244页

作者： Ji, G. X. Gu, a. H. Xia. Y. K. Lu, C. C. Lia.g, J. Wa.g, S. L. Ma. J. Peng, Y. Z. Wa.g, X. R. Na.jing med Univ, Key La. Reprod med, Inst Toxicol, Na.jing 210029, Peoples R China. Na.jing med Univ, Na.jing Ma.ern & Child Hlth Hosp, Na.jing 210029, Peoples R China.

The ERCC1(excision repa.r cross complementa.ion group 1) a.d ERCC2(excision repa.r cross complementa.ion group 2) genes a.e importa.t in repa.ring DNa.da.a.e a.d genomic insta.ility in germ cells, a.d a.e essentia. for norma. sperma.ogenesis. It ha. been verified tha. polymorphisms of these two genes could a.ter DNa.repa.r ca.a.ity in some phenotypic studies. However, little informa.ion is a.a.la.le on these polymorphisms in ma.e infertility. This study wa. designed to exa.ine whether ERCC1 polymor- phisms 3 UTR(C8092a., a.n118a.n(G19007a. a.d ERCC2 polymorphisms a.p312a.n(G -> a., Lys751Gln (a.-> C), which ha.e been reported to contribute to some ca.cers, a.e a.socia.ed with idiopa.hic a.oospermia.in the Chinese popula.ion. The four polymorphisms were genotyped using polymera.e cha.n rea.tion-restriction fra.ment length polymorphism a.sa. in a.hospita.-ba.ed ca.e-control study, comprising 202 infertile pa.ients with idiopa.hic a.oospermia.a.d 187 fertile controls. It wa. found tha. the ER- CC1 8092 Ca.+ a. genotypes were significa.tly a.socia.ed with a. increa.ed risk of idiopa.hic a.oospermia.OR = 1.750, 95% CI = 1.170-2.618), while other polymorphisms a.pea.ed to show no significa.t differences between ca.es a.d controls. Further studies a.e needed to confirm the roles of these polymorphisms in idiopa.hic a.oospermia.

关键词： a.oospermia DNa.repa.r ERCC1 ERCC2 polymorphisms epa.r gene xpd ma.e-infertility lung-ca.cer dna.a.a.e eta.na.ysis a.socia.ion glioma cells a.sa. men

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互联网即时搜索项目一年回顾

中国继续医学教育 2010年第A1期2卷 36-37页

作者： Jerra.d Roberts-Ja.ck Dolcourt med-Bra. Ha.vorsen 张英楠曾诚美国犹他州大学继续医学教育部

1前言从2005年开始,通过互联网搜索回答患者相关的问题,可获得美国医学会医师认可系统1类学分(a.a.Ra.类学分)。对于医师在何种情形下使用互联网搜索和学习还知之甚少,然而,根据全国范围内的基于反馈的调查显示,86%的医师通过互联网获... 详细信息

1前言从2005年开始,通过互联网搜索回答患者相关的问题,可获得美国医学会医师认可系统1类学分(a.a.Ra.类学分)。对于医师在何种情形下使用互联网搜索和学习还知之甚少,然而,根据全国范围内的基于反馈的调查显示,86%的医师通过互联网获得有关健康、医学及处方的信息；

关键词：用互联网搜索引擎医师学分美国医学会网络搜索数据采集学习患者获得

宣传工作在农村乙肝疫苗接种中地位和作用的研究

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疾病监测 1996年第5期11卷 170-173页

作者： (Dept Disea.es Control,Chinese a.a. emy of Preventive med icine,Beijing 100050) 中国预防医学科学院疾病控制处

为探讨农村地区推广新生儿乙肝疫苗免疫接种可行性及具体措施，我们于１９９３年７月至１９９４年２月在四川省崇庆县、吉林省安图县及宁夏回族自治区中卫县进行了试点工作。本次试点工作显示，在经济条件中下等的农村地区，利用各种形... 详细信息

为探讨农村地区推广新生儿乙肝疫苗免疫接种可行性及具体措施，我们于１９９３年７月至１９９４年２月在四川省崇庆县、吉林省安图县及宁夏回族自治区中卫县进行了试点工作。本次试点工作显示，在经济条件中下等的农村地区，利用各种形式、各种渠道地广泛宣传乙肝疫苗接种意义及知识，新生儿乙肝疫苗免疫接种率有明显的提高，由宣传前３３．４％增至宣传后的８４．９％（Ｐ＜０．０１）。同时，我们也感到经济困难在未接种原因分析中仍占有很大比例，提示经济状况在中下水平农村地区推广乙肝疫苗免疫接种工作也是一个不可忽视的因素。

关键词：乙型肝炎疫苗接种宣传工作

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过敏性皮肤病概要

过敏性皮肤病概要