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Tra.sient receptor potentia. cha.nels a.d ca.cium dysregula.ion: a.pa.hogenic duo in Pa.kinson's disea.e

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 808-810页

作者： Iqira.Sa.ed Linlin ma Griffith Institute for drug discovery Griffith UniversityNathanBrisbaneQLDAustralia School of Environment a.d Science Griffith University NathanBrisbaneQLDAustralia

Pa.kinson's disea.e(Pd) ha. a.complex a.d multifa.toria. pa.hophysiology. Va.ious studies, conducted both in pre-clinica. models a.d Pd pa.ients, ha.e reported a.link between the disruption of ca.cium(Ca.(2+)) homeosta.is a.d the subsequent development of Pd. Ca.(2+) regula.ion is crucia. for neurona. surviva., differentia.ion,exocytosis a. syna.ses,gene tra.scription,a.d prolifera.ion.

关键词： homeosta.is clinica. subsequent

Ha.nessing thera.eutic potentia. of induced pluripotent stem cell–derived endothelia. cells for remyelina.ion in the centra. nervous system

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Neura. Regenera.ion Resea.ch 2025年第6期20卷 1715-1716页

作者： da. Ma.Nona.Pop a.ton Medica. School College of Health and Life SciencesAston UniversityBirminghamUK

Myelin is the protective shea.h surrounding nerve fibers, a.d its da.a.e(demyelina.ion) occurs in ma.y centra. nervous system(CNS) disea.es, including multiple sclerosis(MS), tra.ma.ic injury, neurodegenera.ive disea.es such a. a.zheimer's disea.e, a.d menta. disorders such a. schizophrenia.Ba.a.eiro et a.., 2016). Repa.r of da.a.ed myelin shea.hs(remyelina.ion) often fa.ls in MS, lea.ing to neurona. loss a.d irreversible functiona. deficits.

关键词： myelin protective disea.es

Resea.ch sta.us a.d prospects of the fra.ta. a.a.ysis of meta. ma.eria. surfa.es a.d interfa.es

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Interna.iona. Journa. of Minera.s,Meta.lurgy a.d Ma.eria.s 2025年第1期32卷 20-38页

作者： Qinjin da. Xuefeng Liu Xin Ma.Sha.jie Tia. Qinghe Cui Beijing a.va.ced Innova.ion Center for Ma.eria.s Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing La.ora.ory of Meta.lic Ma.eria.s a.d Processing for Modern Tra.sporta.ion University of Science and Technology BeijingBeijing 100083China La.ora.ory for a.va.ced Ma.eria.s Processing of Ministry of Educa.ion University of Science and Technology BeijingBeijing 100083China School of Mecha.ica. a.d Electrica. Engineering Xinjiang Institute of EngineeringUrumqi 830023China

a. a.ma.hema.ica. a.a.ysis method,fra.ta. a.a.ysis ca. be used to qua.tita.ively describe irregula. sha.es with self-simila. or self-a.fine *** a.a.ysis ha. been used to cha.a.terize the sha.es of meta. ma.eria.s a. va.ious sca.es a.d *** methods ma.e it difficult to qua.tita.ively describe the rela.ionship between the regula. cha.a.teristics a.d properties of meta. ma.eria. surfa.es a.d ***,fra.ta. a.a.ysis ca. be used to qua.tita.ively describe the sha.e cha.a.teristics of meta. ma.eria.s a.d to esta.lish the qua.tita.ive rela.ionships between the sha.e cha.a.teristics a.d va.ious properties of meta. *** the perspective of two-dimensiona. pla.es a.d three-dimensiona. curved surfa.es,this pa.er reviews the current resea.ch sta.us of the fra.ta. a.a.ysis of meta. precipita.e interfa.es,meta. gra.n bounda.y interfa.es,meta.-deposited film surfa.es,meta. fra.ture surfa.es,meta. ma.hined surfa.es,a.d meta. wea. *** rela.ionship between the fra.ta. dimensions a.d properties of meta. ma.eria. surfa.es a.d interfa.es is *** from three perspectives of fra.ta. a.a.ysis,na.ely,resea.ch scope,ima.e a.quisition methods,a.d ca.cula.ion methods,this pa.er identifies the direction of resea.ch on fra.ta. a.a.ysis of meta. ma.eria. surfa.es a.d interfa.es tha. need to be *** is believed tha. revea.ing the deep influence mecha.ism between the fra.ta. dimensions a.d properties of meta. ma.eria. surfa.es a.d interfa.es will be the key resea.ch direction of the fra.ta. a.a.ysis of meta. ma.eria.s in the future.

关键词： meta. ma.eria. surfa.es a.d interfa.es fra.ta. a.a.ysis fra.ta. dimension homogeneity

New glucocerebrosida.e a.tibodies ca. a.va.ce resea.ch in the field of neurodegenera.ive disorders

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Neura. Regenera.ion Resea.ch 2025年第4期20卷 1085-1086页

作者： Cha.is Ma.Krystyna.Rytel Yu Chen Ellen Sidra.sky Medica. Genetics Bra.ch National Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA

In medica. resea.ch,there a.e times when the introduction of a.new tool ca. la.nch scientific discovery in new *** a.tibody development ma. be considered munda.e,in the field of glucocerebrosida.e(GCa.e)resea.ch,the dea.th of va.ida.ed a.tibodies for different a.plica.ions ha. impeded progress in studies of disea.e pa.hogenesis a.d thera.eutic *** recent introduction of new,rigorously eva.ua.ed a.tibodies ca. now propel resea.ch into the link between glucocerebrosida.e a.d Pa.kinson’s disea.e(Pd)a. well a. a.pects of the pa.hobiology of Ga.cher disea.e(Jong et a..,2024).

关键词： a.tibodies cerebro

a.cura.e ma.ipula.ion of a.thropomorphic robotic a.m ba.ed on 3d huma. eye ga.ing with posture error compensa.ion

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Science China.Technologica. Sciences 2025年

作者： Qua.lin LI Xia.zong Wa.G Jia.i Ma.Qia.jun HUa.G Qizhi JIa.G Wenbin CHEN Ca.hua.XIONG Sta.e Key La.ora.ory of Intelligent Ma.ufa.turing Equipment a.d Technology School of Mechanical Science and Engineering Huazhong University of Science and Technology Institute of Medica. Equipment Science a.d Engineering Huazhong University of Science and Technology

a. huma.s a.d robots work closer together tha. ever, a.thropomorphic robotic a.ms with intuitive huma.-robot intera.tion interfa.es ha.e dra.n ma.sive a.tention to improving the qua.ity of robot-a.sisted ma.ipula.ion. In pursuit of this,we designed a.dedica.ed 7-degrees-of-freedom (doF) a.thropomorphic robotic a.m ha.ing three compa.t differentia. joints a.d a.hea.-mounted ga.e tra.ker ena.ling hea.-pose-tra.ked 3d ga.e estima.ion. Moreover, two key cha.lenges were a.dressed to a.hieve a.cura.e robot-a.sisted ma.ipula.ion of the object indica.ed by the direction of huma. ga.e. First, a.novel predictive pupil fea.ure wa. proposed for 3d ga.e estima.ion. differing from most existing fea.ures subjected to the common pa.a.ia. a.proxima.ion a.sumption, the proposed novel predictive pupil fea.ure considered the light refra.tion a. two cornea. surfa.es with a.more rea.istic eye model, significa.tly improving the 3d ga.e estima.ion a.cura.y when the eyeba.l rota.es a. la.ge a.gles. Second, a.novel optimiza.ion-ba.ed a.proa.h wa. developed to efficiently compensa.e for the posture errors of the designed 7-doF a.thropomorphic robotic a.m for a.cura.e ma.ipula.ion. Compa.ed with the existing Ja.obia.-ba.ed or optimiza.ion-ba.ed a.proa.hes with nomina. joint va.ues a. itera.ion initia., the proposed a.proa.h computed the optima. itera.ion initia. a.d rea.ized fa.ter convergence for rea.-time posture error compensa.ion. With the posture error compensa.ion in rea. time a.d 3d ga.e estima.ed a.cura.ely, the huma. ca. comma.d a.cura.e robot-a.sisted ma.ipula.ion using his eyes intuitively. The proposed system wa. successfully tested on five hea.thy subjects.

关键词：

Integra.ion of Electrica. Properties a.d Pola.iza.ion Loss Modula.ion on a.omic Fe–N‑RGO for Boosting Electroma.netic Wa.e a.sorption

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Na.o-Micro Letters 2025年第2期17卷 517-532页

作者： Ka.li Zha.g Yuefeng Ya. Zhen Wa.g Gua.sheng Ma.decha.g Jia.Xia.xia. Hua.g Yu Zhou Sta.e Key La.ora.ory of Precision Welding&Joining of Ma.eria.s a.d Structures Harbin Institute of TechnologyHarbin 150001People’s Republic of China School of Ma.eria.s Science a.d Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China MIIT Key La.ora.ory of a.va.ced Structura.‑Functiona. Integra.ion Ma.eria.s&Green Ma.ufa.turing Technology Harbin Institute of TechnologyHarbin 150001People’s Republic of China

developing effective stra.egies to regula.e gra.hene’s conduction loss a.d pola.iza.ion ha. become a.key to expa.ding its a.plica.ion in the electroma.netic wa.e a.sorption(EMWa.*** on the unique energy ba.d structure of gra.hene,regula.ing its ba.dga. a.d electrica. properties by introducing heteroa.oms is considered a.fea.ible ***,meta.-nitrogen doping reduced gra.hene oxide(M–N-RGO)wa. prepa.ed by embedding a.series of single meta. a.oms M–N_(4) sites(M=Mn,Fe,Co,Ni,Cu,Zn,Nb,Cd,a.d Sn)in RGO using a. N-coordina.ion a.om-a.sisted *** composites ha. a.justa.le conductivity a.d pola.iza.ion to optimize dielectric loss a.d impeda.ce ma.ching for efficient EMWa.*** results showed tha. the minimum reflection loss(RL_(min))of Fe–N-RGO rea.hes−74.05 dB(2.0 mm)a.d the ma.imum effective a.sorption ba.dwidth(Ea._(ma.))is 7.05 GHz(1.89 mm)even with a.low filler loa.ing of only 1 wt%.Combined with X-ra. a.sorption spectra.Xa.S),a.omic force microscopy,a.d density functiona. theory ca.cula.ion a.a.ysis,the Fe–N_(4) ca. be used a. the pola.iza.ion center to increa.e dipole pola.iza.ion,interfa.e pola.iza.ion a.d defect-induced pola.iza.ion due to d-p orbita. hybridiza.ion a.d structura. ***,electron migra.ion within the Fe further lea.s to conduction loss,thereby synergistica.ly promoting energy *** study demonstra.es the effectiveness of meta.-nitrogen doping in regula.ing the gra.hene′s dielectric properties,which provides a. importa.t ba.is for further investiga.ion of the loss mecha.ism.

关键词： Electroma.netic wa.e a.sorption Fe-N-RGO dipole pola.iza.ion Conduction loss Impeda.ce ma.ching

Intera.tion of ma.or fa.ilita.or superfa.ily doma.n conta.ning 2a.with the blood-bra.n ba.rier

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Neura. Regenera.ion Resea.ch 2025年第8期20卷 2133-2152页

作者： Yilun Ma.Ta.wei dong Fei Lua. Jua.jua. Ya.g Feng Mia. Peifeng Wei College of Pha.ma.y a.d First Clinica. Medica. College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina Na.iona. drug Clinica. Tria. a.ency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functiona. a.d structura. integrity of the blood-bra.n ba.rier is crucia. in ma.nta.ning homeosta.is in the bra.n microenvironment;however,the molecula. mecha.isms underlying the forma.ion a.d function of the blood-bra.n ba.rier rema.n poorly *** ma.or fa.ilita.or superfa.ily doma.n conta.ning 2a.ha. been identified a. a.key regula.or of blood-bra.n ba.rier *** pla.s a.critica. role in promoting a.d ma.nta.ning the forma.ion a.d functiona. sta.ility of the blood-bra.n ba.rier,in a.dition to the tra.sport of lipids,such a. docosa.exa.noic a.id,a.ross the blood-bra.n ***,a. increa.ing number of studies ha.e suggested tha. ma.or fa.ilita.or superfa.ily doma.n conta.ning 2a.is involved in the molecula. mecha.isms of blood-bra.n ba.rier dysfunction in a.va.iety of neurologica. disea.es;however,little is known rega.ding the mecha.isms by which ma.or fa.ilita.or superfa.ily doma.n conta.ning 2a.a.fects the blood-bra.n *** pa.er provides a.comprehensive a.d systema.ic review of the close rela.ionship between ma.or fa.ilita.or superfa.ily doma.n conta.ning 2a.proteins a.d the blood-bra.n ba.rier,including their ba.ic structures a.d functions,cross-linking between ma.or fa.ilita.or superfa.ily doma.n conta.ning 2a.a.d the blood-bra.n ba.rier,a.d the in-depth studies on lipid tra.sport a.d the regula.ion of blood-bra.n ba.rier *** comprehensive systema.ic review contributes to a. in-depth understa.ding of the importa.t role of ma.or fa.ilita.or superfa.ily doma.n conta.ning 2a.proteins in ma.nta.ning the structure a.d function of the blood-bra.n ba.rier a.d the resea.ch progress to *** will not only help to elucida.e the pa.hogenesis of neurologica. disea.es,improve the a.cura.y of la.ora.ory dia.nosis,a.d optimize clinica. trea.ment stra.egies,but it ma. a.so pla. a. importa.t role in prognostic *** a.dition,the effects of ma.or fa.ilita.or superfa.ily doma.n conta.ning 2a.on blood-bra.n ba.rier lea

关键词： blood-bra.n ba.rier(BBB) ca.eolin-1 centra. nervous system docosa.exa.noic a.id endothelia. cells lysophospha.idylcholine ma.or fa.ilita.or superfa.ily doma.n conta.ning 2a.MFSd2a. tra.scytosis

FK506 contributes to periphera. nerve regenera.ion by inhibiting neuroinfla.ma.ory responses a.d promoting neuron surviva.

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Neura. Regenera.ion Resea.ch 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yusong Yua. Bo Ma.Wenyong Xie Na.Ha. depa.tment of Tra.ma.a.d Orthopedics Peking University People’s HospitalBeijingChina Na.iona. Center for Tra.ma.Medicine Peking University People’s HospitalBeijingChina Key La.ora.ory of Tra.ma.a.d Neura. Regenera.ion(Peking University) Ministry of EducationBeijingChina Tra.ma.Medicine Center Peking University People’s HospitalBeijingChina depa.tment of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Ta.rolimus)is a.systemic immunosuppressa.t a.proved by the *** a.d drug ***506 ha. been shown to promote periphera. nerve regenera.ion,however,its precise mecha.ism of a.tion a.d its pa.hwa.s rema.n *** this study,we esta.lished a.ra. model of scia.ic nerve injury a.d found tha. FK506 improved the morphology of the injured scia.ic nerve,increa.ed the numbers of motor a.d sensory neurons,reduced infla.ma.ory responses,ma.kedly improved the conduction function of the injured nerve,a.d promoted motor function *** findings suggest tha. FK506 promotes periphera. nerve structure recovery a.d functiona. regenera.ion by reducing the intensity of infla.ma.ion a.ter neurona. injury a.d increa.ing the number of surviving neurons.

关键词： FK506 infla.ma.ion motor neurons nerve regenera.ion neuron periphera. nerve injury sensory neurons

Experimenta. Study for Effect of Multi-Site Spa.k Ignition on dedica.ed Hybrid Engine Performa.ce under High dilution Condition

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Journa. of Therma. Science 2025年第1期34卷 254-267页

作者： Ya. Bowen Wa.ERS Benja.in Ha.NES a.drew MCGHEE Mike HU Tiega.g dENG Wei PU Yongxia. Ma.Tia.yu Powertra.n Engineering R&d Center Chongqing Changan Automobile Co.Ltd. Cha.ga. UK R&d Centre Limited

In this study,a.triple spa.k ignition scheme wa. first designed on a.three-cylinder 1.5-L dedica.ed hybrid engine（dHE）.On this ba.is,the effect of different ignition modes on engine combustion a.d emission cha.a.teristics wa. studied,especia.ly under high dilution *** results tested a. 2000 r/min a.d 0.8 MPa.BMEP（bra.e mea. effective pressure） show tha. with highly increa.ed in-cylinder flow intensity,using only pa.sive precha.ber（PPC） ha. a.lower lea. limit tha. tha. with single centra. spa.k plug（CSP）,thereby lea.ing to slightly higher minimum fuel consumption a.d nitrogen oxides（NOx） *** side spa.k plugs（SSP）ba.ed on PPC ca. result in improved ca.a.ility of lea. limit extension a.d engine performa.ce tha. ***,the improvement level is lower tha. tha. with triple spa.k plugs（TSP）.a. the excess a.r ra.io λincrea.es,the a.va.ta.e of PPC a.d PPC with SSP in improving the combustion pha.ing compa.ed with CSP gra.ua.ly ***,the increa.ing tendency of their ignition dela. a.d combustion dura.ion is more *** a.ded SSP ba.ed on PPC ca. effectively shorten the ignition dela. of lea.er mixture,but the combustion dura.ion ca. be only slightly *** a.result,under extremely lea. condition,the a.va.ta.e of PPC a.d PPC with SSP in terms of combustion cha.a.teristics over CSP becomes much *** contra.t,the TSP ignition ca. a.hieve much shorter ignition dela. a.d combustion dura.ion simulta.eously under this *** to the highest a.a.la.le dilution level,the TSP ignition a.hieves the lowest ra. ***,it ca. a.so reduce the ra. ca.bon monoxide（CO） a.d hydroca.bons（HC） emissions compa.ed to CSP due to a.more thorough combustion of the end ga. *** on the excellent performa.ce of TSP,the highest engine bra.e therma. efficiency（BTE） wa. further *** results show tha. with norma. RON 92 fuel,the engine fina.ly a.hieved 43.69% a.d 45.02% BTE under stochiometric mode with exha.st

关键词： dedica.ed hybrid engine high dilution condition NOx emissions pa.sive precha.ber therma. efficiency triple spa.k plug scheme