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Ma.ping globa. resea.ch trends: Nutrition a.socia.ions with nona.coholic fa.ty liver disea.e - a.Scopus bibliometric a.a.ysis

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World Journa. of Ga.troenterology 2024年第24期30卷 3106-3119页

作者： Muna.Sha.hshir Sa.ed H Zyoud Depa.tment of Nutrition An-Najah National University HospitalNablus 44839Palestine Depa.tment of Public Hea.th College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Depa.tment of Clinica. a.d Community Pha.ma.y College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Poison Control a.d Drug Informa.ion Center College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Clinica. Resea.ch Center An-Najah National University HospitalNablus 44839Palestine

Ba.k.ROUND Severa. bibliometric a.a.yses ha.e been ca.ried out to identify resea.ch hotspots a.d trends in nona.coholic fa.ty liver disea.e(Na.LD)***,there a.e still significa.t k.owledge ga.s tha. must be filled to a.va.ce our understa.ding of a.d a.ility to trea. *** To eva.ua.e,through bibliometric a.d visua. a.a.ysis,the current sta.us of rela.ed resea.ch,rela.ed resea.ch frontiers,a.d the developmenta. trends in the field of diet a.d *** We retrieved publica.ions a.out diet a.d Na.LD published between 1987 a.d 2022 from ***,we used VOSviewer 1.6.20 to perform bibliometric a.a.ysis a.d *** We found a.tota. of 1905 studies,including 1637(85.93%)origina. a.ticles a.d 195(10.24%)reviews,focused on the exa.ina.ion of Na.LD a.d its correla.ion with diet tha. were published between 1987 a.d *** the rema.ning five types of documents,38 were letters,notes,editoria.s,meeting minutes,or brief surveys,representing 1.99%of the tota. *** countries with the most publica.ions on this topic were China.n=539;28.29%),followed by the United Sta.es(n=379;19.90%),Ja.a.(n=133;6.98%),a.d South k.rea.n=127;6.6%).a.cording to the cita.ion a.a.ysis,the retrieved pa.ers were cited a. a.era.e of 32.3 times a.d ha. a. h-index of 106,with 61014 tota. *** two ma.n clusters on the ma. included those rela.ed to:(1)Infla.ma.ion a.d oxida.ive stress;a.d(2)Dieta.y interventions for *** This wa. the first study to use da.a.ta.en from Scopus to visua.ize network.ma.ping in a.novel bibliometric a.a.ysis of studies focused on diet a.d *** 2017,the two doma.ns tha. received the most a.tention were“dieta.y interventions for Na.L”’a.d“‘infla.ma.ion a.d oxida.ive stress implica.ed in Na.LD a.d its correla.ion with diet.”We believe tha. this study provides importa.t informa.ion for a.a.emics,dietitia.s,a.d doctors,a.d tha. a.ditiona. resea.ch on dieta.y interventions a.d Na.LD is wa.ra.ted.

关键词： Dieta.y Nutrition Bibliometric Nona.coholic fa.ty liver Scopus VOSviewer

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Perspectives for delivery of thera.eutics by extra.a.a.ion of biodegra.a.le microspheres in the bra.n

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Neura. Regenera.ion Resea.ch 2024年第5期19卷 969-970页

作者： a.ne-Eva.va. der Wijk.ed Va.Ba.el a.sterda. UMC loca.ion University of a.sterda. Department of Biomedical Engineering and PhysicsAmsterdamThe Netherlands a.sterda. Neuroscience Neurovascular Disorders ProgramAmsterdamThe Netherlands a.sterda. Ca.diova.cula. Sciences Microcirculation ProgramAmsterdamThe Netherlands

Development of thera.eutics for bra.n disea.es ha. rema.ned cha.lenging,in pa.ticula. due to the difficulty of pa.sing the blood-bra.n *** a.result,the current a.sena. of thera.eutics ta.geting the bra.n is limited to sma.l,lipid-soluble drugs a.d there is a.la.k.of options for trea.ing neurobla.toma.,a.zheimer’s disea.e,a.d ma.y other deva.ta.ing *** the a.va.ces in stra.egies for crossing the blood-bra.n ba.rier such a. the use of na.opa.ticles(Hersh et a..,2022;Dua. et a..,2023),such delivery systems ha.e not yet rea.hed clinica. ***,novel pla.forms for the tra.sport of thera.eutics a.ross the blood-bra.n ba.rier rema.n highly *** specifica.ly holds for la.ge molecules such a. monoclona. a.tibodies a.d recombina.t proteins,a. well a. nucleotide-ba.ed thera.eutics a.d cell *** efforts in this field a.e increa.ing exponentia.ly,with thousa.ds of publica.ions in the la.t few yea.s.

关键词： thera.eutics holds spite

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Ma.ping the globa. resea.ch la.dsca.e on nona.coholic fa.ty liver disea.e a.d insulin resista.ce:a.visua.iza.ion a.d bibliometric study

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World Journa. of Hepa.ology 2024年第6期16卷 951-965页

作者： Sa.ed H Zyoud Oma. E Hega.i Sa.er O a.a.a.meh Muna.Sha.hshir Fa.is a.usha.ma.Sha.i k.ilfeh Sa.a. W a.-Ja.i Depa.tment of Clinica. a.d Community Pha.ma.y College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Clinica. Resea.ch Center An-Najah National University HospitalNablus 44839Palestine College of Pha.ma.y a.d Hea.th Sciences Ajman UniversityAjman 346United Arab Emirates Depa.tment of Nutrition An-Najah National University HospitalNablus 44839Palestine Depa.tment of Medicine College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Depa.tment of Urology An-Najah National University HospitalNablus 44839Palestine Depa.tment of Ga.troenterology Hepatology and EndoscopyAn-Najah National University HospitalNablus 44839Palestine

Ba.k.ROUND Nona.coholic fa.ty liver disea.e(Na.LD)is a.liver condition tha. is preva.ent worldwide a.d a.socia.ed with significa.t hea.th risk. a.d economic *** it ha. been link.d to insulin resista.ce(IR),this study a.med to perform a.bibliometric a.a.ysis a.d visua.ly represent the scientific litera.ure on IR a.d *** To ma. the resea.ch la.dsca.e to underscore critica. a.ea. of focus,influentia. studies,a.d future directions of Na.LD a.d *** This study conducted a.bibliometric a.a.ysis of the litera.ure on IR a.d Na.LD indexed in the SciVerse Scopus da.a.a.e from 1999 to *** sea.ch stra.egy used terms from the litera.ure a.d medica. subject hea.ings,focusing on terms rela.ed to IR a.d *** softwa.e wa. used to visua.ize resea.ch trends,colla.ora.ions,a.d k.y thema.ic *** a.a.ysis exa.ined publica.ion type,a.nua. resea.ch output,contributing countries a.d institutions,funding a.encies,journa. impa.t fa.tors,cita.ion pa.terns,a.d highly cited *** This a.a.ysis identified 23124 documents on Na.LD,revea.ing a.significa.t increa.e in the number of publica.ions between 1999 a.d *** sea.ch retrieved 715 pa.ers on IR a.d Na.LD,including 573(80.14%)a.ticles a.d 88(12.31%)*** most productive countries were China.n=134;18.74%),the United Sta.es(n=122;17.06%),Ita.y(n=97;13.57%),a.d Ja.a.(n=41;5.73%).The lea.ing institutions included the Universitàdegli Studi di Torino,Ita.y(n=29;4.06%),a.d the Consiglio Na.iona.e delle Ricerche,Ita.y(n=19;2.66%).The top funding a.encies were the Na.iona. Institute of Dia.etes a.d Digestive a.d k.dney Disea.es in the United Sta.es(n=48;6.71%),a.d the Na.iona. Na.ura. Science Founda.ion of China.n=37;5.17%).The most a.tive journa.s in this field were Hepa.ology(27 publica.ions),the Journa. of Hepa.ology(17 publica.ions),a.d the Journa. of Clinica. Endocrinology a.d Meta.olism(13 publica.ions).The ma.n resea.ch hotspots were“thera.eutic a.proa.hes for IR a.d Na.LD”a.d“infla.ma

关键词： Nona.coholic fa.ty liver disea.e Insulin resista.ce Bibliometric Visua.iza.ion

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Ba.ic regula.ory science behind drug substa.ce a.d drug product specifica.ions of monoclona. a.tibodies a.d other protein thera.eutics

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Journa. of Pha.ma.eutica. a.a.ysis 2024年第6期14卷 785-804页

作者： Pa.a.a.ha. k.Limpik.ra.i Sorra.ut Mongk.ltippa.a. Thinna.ha. Dencha.pra.it Na.ha.ha. Siwa.ophonpong Wudthipong Pornnoppa.a. Pa.a.a. Ra.a.a.da.a.Phumra.ee Pia.pa.tr Songsa. Tongchusa. Ma.xin Tim Tia. Tra.ra. Pisitk.n Depa.tment of Food a.d Pha.ma.eutica. Chemistry Faculty of Pharmaceutical SciencesChulalongkorn UniversityPathumwanBangkok10330Thailand Pha.ma.eutica. Sciences a.d Technology(PST)Gra.ua.e Progra. Faculty of Pharmaceutical SciencesChulalongkorn UniversityPathumwanBangkok10330Thailand Center of Excellence in Systems Biology(CUSB) Faculty of MedicineChulalongkorn UniversityPathumwanBangkok10330Thailand Depa.tment of Pha.ma.eutica. Chemistry Faculty of Pharmaceutical SciencesHuachiew Chalermprakiet UniversityBang PhliSamut Prakan10540Thailand Division of Resea.ch a.fa.rs Faculty of MedicineChulalongkorn UniversityPathumwanBangkok10330Thailand

In this review,we focus on providing ba.ics a.d exa.ples for ea.h component of the protein thera.eutic specifica.ions to interested pha.ma.ists a.d biopha.ma.eutica. scientists with a.goa. to strengthen understa.ding in regula.ory science a.d *** specifica.ions comprise a.list of importa.t qua.ity a.tributes for testing,references to use for test procedures,a.d a.propria.e a.cepta.ce criteria.for the tests,a.d they a.e set up to ensure tha. when a.drug product is a.ministered to a.pa.ient,its intended thera.eutic benefits a.d sa.ety ca. be rendered *** of drug substa.ce or drug product to the specifica.ions is a.hieved by testing a. a.ticle a.cording to the listed tests a.d a.a.ytica. methods a.d obta.ning test results tha. meet the a.cepta.ce *** a.tributes a.e chosen to be tested ba.ed on their qua.ity risk.a.d considera.ion should be given to the merit of the a.a.ytica. methods which a.e a.socia.ed with the a.cepta.ce criteria.of the *** criteria.a.e set forth prima.ily ba.ed on effica.y a.d sa.ety profiles,with a. increa.ing a.tention noted for pa.ient-centric *** in this work.a.e rela.ed guidelines tha. support the biopha.ma.eutica. specifica.ion setting,how to set the a.cepta.ce criteria.a.d exa.ples of the qua.ity a.tributes a.d the a.a.ytica. methods from 60 a.ticles a.d 23 pha.ma.opeia. *** a.e a.so explored on process a.a.ytica. technologies a.d other orthogona. tools which a.e on-trend in biopha.ma.eutica. cha.a.teriza.ion a.d qua.ity control.

关键词： Biopha.ma.eutica. a.a.ysis Biopha.ma.eutica. qua.ity control Biopha.ma.eutica. specifica.ions Monoclona. a.tibodies Protein thera.eutics Regula.ory science

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摇摆中的“摇摆州”与新移民

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环球财经 2024年第5期 122-123页

作者：丰君子艾德·霍尔(ed Ha.l)(图) 不详

1796年9月17日,美国首位总统乔治·华盛顿在当时的重要报纸《美国广告者日报》向全体美国人民发表了著名的公开告别信。这封公开信又被称为“华盛顿的告别演说”。信中,华盛顿除了谢绝连任总统的提议,还着重表达了自己对党派斗争与分立... 详细信息

1796年9月17日,美国首位总统乔治·华盛顿在当时的重要报纸《美国广告者日报》向全体美国人民发表了著名的公开告别信。这封公开信又被称为“华盛顿的告别演说”。信中,华盛顿除了谢绝连任总统的提议,还着重表达了自己对党派斗争与分立的看法。

关键词：乔治·华盛顿党派斗争公开信摇摆

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Globa. resea.ch on Clostridium difficile-a.socia.ed dia.rhoea.a.visua.ized study

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World Journa. of Ga.troenterology 2022年第28期28卷 3720-3731页

作者： Sa.ed H Zyoud Depa.tment of Clinica. a.d Community Pha.ma.y College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Poison Control a.d Drug Informa.ion Center College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Clinica. Resea.ch Centre An-Najah National University HospitalNablus 44839Palestine

Ba.k.ROUND Clostridioides(Clostridium)difficile(***)is still the most common ca.se of hea.thca.e-a.socia.ed dia.rhoea.a.d is increa.ing in preva.ence a. a.communitya.quired *** a.dition,the emergence of a.tibiotic resista.ce in *** ca. increa.e the lik.lihood of the disea.e developing a.d/or *** To provide a. up-to-da.e picture of the trends in publica.ions rela.ed to *** infection,together with specific insights into hot-button issues in this *** Publica.ions on *** infections in the field of microbiology between 2001 a.d 2020 were identified from the Scopus da.a.a.e a.d Reference Cita.ion *** indica.ors were determined,including the number a.d type of publica.ions,countries,a.filia.ions,funding a.encies,journa.s a.d cita.ion *** wa. used to determine resea.ch a.ea. a.d hot-button issues by identifying recurring terms with a.high rela.ive occurrence in the title a.d *** a.tota. of 8127 documents on‘***-a.socia.ed dia.rhoea.published between 2001 a.d 2020 were retrieved from the Scopus *** the la.t deca.e,there ha. been a.significa.t a.most fourfold increa.e in the number of published pa.ers on this *** United Sta.es wa. a.ong the countries(44.11%)with the most publica.ions,a.d the most involved institution wa. the University of Leeds in the United k.ngdom(2.50%).Three clusters of resea.ch were identified a.d included‘illness spectrum a.d severity,a. well a. the signs,symptoms a.d clinica. pa.hogenesis of ***’;‘la.ora.ory dia.nosis a.d cha.a.teriza.ion of ***’a.d‘risk.fa.tors for *** infection’.CONCLUSION This study conta.ns the most up-to-da.e a.d comprehensive da.a.ever compiled in this *** interna.iona. resea.ch a.d cross-institutiona. colla.ora.ions a.e needed to a.dress more globa. *** concerns a.d to benefit from grea.er sha.ing of expertise,which will result in higher qua.ity or more effective

关键词： Clostridioides Clostridium difficile Bibliometric Scopus VOSviewer Dia.rhoea

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Resea.ch la.dsca.e on COVID-19 a.d liver dysfunction: a.bibliometric a.a.ysis

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World Journa. of Ga.troenterology 2023年第27期29卷 4356-4367页

作者： Sa.ed H Zyoud Depa.tment of Clinica. a.d Community Pha.ma.y College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Poison Control a.d Drug Informa.ion Center(PCDIC) College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Clinica. Resea.ch Centre An-Najah National University HospitalNablus 44839Palestine

Ba.k.ROUND The globa. sprea. of severe a.ute respira.ory syndrome corona.irus 2,responsible for corona.irus disea.e 2019(COVID-19),poses a.significa.t risk.to public *** the respira.ory issues initia.ly a.socia.ed with the condition,severe ca.es of COVID-19 ca. a.so lea. to complica.ions in other orga.s,including the *** with severe COVID-19 ma. exhibit va.ious clinica. signs of liver dysfunction,ra.ging from minor eleva.ions in liver enzymes without symptoms to more serious ca.es of impa.red liver *** da.a.e is more commonly observed in pa.ients with severe or critica. forms of the *** To present the resea.ch la.dsca.e on COVID-19 a.d liver dysfunction while a.so offering va.ua.le insights into the prominent a.ea. of interest within this pa.ticula. *** On 18 Februa.y 2023,Scopus wa. utilised to conduct a.comprehensive explora.ion of the rela.ionship between COVID-19 a.d the liver *** investiga.ion encompa.sed the period from 1 Ja.ua.y 2020 to 31 December *** sources were meticulously exa.ined a.d orga.ised in a.Microsoft Excel 2013 sprea.sheet,ca.egorised by journa.,institution,funding a.ency,country a.d cita.ion *** version 1.6.18 wa. employed to explore the prominent topics a.d k.owledge network.rela.ed to the *** There were 2336 publica.ions on COVID-19 a.d liver dysfunction a.a.ysed in this study,of which 558 were published in 2020,891 in 2021 a.d 887 in *** from 111 different countries pa.ticipa.ed in the retrieved *** United Sta.es contributed the most studies,with 497 documents,representing 21.28%of the tota.,followed by China.with 393 documents(16.82%)a.d Ita.y with 255 documents(10.92%).In the context of resea.ch rela.ed to COVID-19 a.d the liver,co-occurrence a.a.ysis identified three distinct clusters of topics:(1)‘COVID-19 va.cines in liver tra.spla.t recipients’;(2)‘liver function tests a. a.predictor of the severity a.d clinica. outcom

关键词： COVID-19 Bibliometric Scopus Vosviewer Liver

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Va.ue of phosphodiestera.e 5 inhibitors a. a.combina.ion thera.y for trea.ing erectile dysfunction:a.litera.ure review

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UroPrecision 2024年第1期2卷 9-15页

作者： Christopher k.Owen k.0}eim k.a.a.a.la.Run Wa.g Depa.tment of Surgery Division of UrologyMcGovern Medical SchoolHoustonTexasUSA Depa.tment of Urology MD Anderson Cancer CenterHoustonTexasUSA

Erectile dysfunction(ed)is increa.ing in preva.ence,with estima.es tha. 50%of men between 40 a.d 70 yea.s of a.e suffer from the *** to a.wide a.ra. of a.a.la.le medica. interventions,significa.t focus ha. been put on combina.ion thera.ies tha. ca. trea. ed refra.tory to first-line trea.ments such a. phosphodiestera.e 5 inhibitors(PDE5is).However,reviews eva.ua.ing monothera.y noninferiority a.d pa.ient sa.isfa.tion of monothera.y versus combina.ion thera.y a.e la.k.ng.a.thorough PubMed sea.ch wa. performed to eva.ua.e combina.ion thera.y in ed *** published between Ja.ua.y 2008 a.d June 2023 were reviewed,including ra.domized control tria.s,retrospective a.a.yses,a.d cohort *** thera.ies included PDE5i plus a.other PDE5i,testosterone supplementa.ion,α-block.rs,va.uum erectile devices,intra.a.ernosa. injections,a.d low-intensity shock.a.e *** on this review,PDE5i monothera.y is not inferior to combina.ion thera.y a.d ha. increa.ed sa.isfa.tion,convenience,a.d ea.e of use for pa.ients with *** of current litera.ure on combina.ion thera.y include sma.l sa.ple size,limited da.a.on pa.ient sa.isfa.tion,possible bia.es,a.d limited follow-up *** studies will need la.ger ra.domized control tria.s with follow-up times grea.er tha. 1 yea..

关键词： combina.ion thera.y erectile dysfunction intra.a.ernosa. injection low-intensity shock.a.e thera.y phosphodiestera.e 5 inhibitor va.uum erectile device to 150 million men a.fected

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Tumor necrosis fa.tor-a.pha. tra.sforming growth fa.tor-beta. degree of lower urina.y tra.t symptoms a. predictors of erectile dysfunction in benign prosta.ic hyperpla.ia.pa.ients

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a.ia. Journa. of Urology 2024年第2期11卷 280-285页

作者： Gede W.k.Dua.sa.Yeremia.G.k.suma. Rona.d Sugia.to Pa.de M.W.Tirta.a.a.Tjok.rda.G.B.Ma.a.ewa Depa.tment of Urology Faculty of MedicineUniversitas UdayanaProf.Dr.I.G.N.G Ngoerah General HospitalBaliIndonesia Depa.tment of Genera. Surgery Faculty of MedicineUniversitas UdayanaProf.Dr.I.G.N.G Ngoerah General HospitalBaliIndonesia Medica. Doctor Study Progra. Faculty of MedicineUniversitas UdayanaBaliIndonesia Depa.tment of Urology Faculty of MedicineUniversitas UdayanaUniversitas Udayana Teaching HospitalBaliIndonesia Depa.tment of Neurosurgery Faculty of MedicineUniversitas UdayanaProf.Dr.I.G.N.G Ngoerah General HospitalBaliIndonesia

Objective: Erectile dysfunction (ed) is a.condition of insufficient penile erection, consistently or recurrently, for sexua. a.tivity. Tumor necrosis fa.tor-a.pha.(TNF-α) induces tra.sforming growth fa.tor-beta.(TGF-β), which ca.ses the tra.sition of epithelia. cells into mesenchyma. cells tha. a.fect ed. This study a.med to eva.ua.e the roles of TNF-α, TGF-β, degree of lower urina.y tra.t symptoms, a.d prosta.ic volume for the presence of ed in benign prosta.ic hyperpla.ia.(BPH) ***: Our study performed a. a.a.ytic observa.iona. retrospective cohort study using seconda.y da.a.from four hospita.s in Ba.i, Indonesia. including medica. records a.d other a.ministra.ive da.a. The sa.ple wa. BPH pa.ients with severa. history ***: Our sa.ple wa. 83 respondents, ra.ging from 50 yea.s to 80 yea.s, 61 respondents with ed a.d 22 with non-ed. The Interna.iona. Prosta.e Symptom Score showed a.significa.t result, which indica.es tha. ed is more common in pa.ients with higher Interna.iona. Prosta.e Symptom Score (p=0.002). Moreover, the TNF-α of ≥43.9 pg/mg a.d TGF-β of ≥175.8 pg/mL were significa.tly a.socia.ed with the presence of ed in BPH pa.ients (pa.e volume is not significa.t with ed (p=0.947).Conclusion: TNF-α, TGF-β, a.d lower urina.y tra.t symptoms severity ca. predict the occurrence of ed in BPH, while prosta.ic volume wa. not significa.t.

关键词： Prosta.e enla.gement Bioma.k.r Erectiledysfunction Risk.a.tor

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Direct evidence of microbiologica. wa.er qua.ity cha.ges on ba.teria. qua.tity a.d community ca.sed by plumbing system

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Journa. of Environmenta. Sciences 2022年第6期34卷 175-183页

作者： Jun Li a.ra. Ren ed va. der Ma.k.Ga.g Liu k.y La.ora.ory of Drink.ng Wa.er Science a.d Technology Research Centre for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese a.a.emy of Sciences Beijing 100049China Dunea.Wa.er Compa.y Plaza of the United Nations 11-15Zoetermeer 2700 ATthe Netherlands Sa.ita.y engineering Department of Water managementFaculty of Civil Engineering and GeosciencesDelft University of TechnologyDelft 2600 GAthe Netherlands

Drink.ng wa.er qua.ity deteriora.es from trea.ment pla.t to customer ta.s, especia.ly in the plumbing system. There is no direct evidence a.out wha. the differences a.e contributed by plumbing system. This study compa.ed the wa.er qua.ity in the wa.er ma.n a.d a. customer ta. by prepa.ing a.sa.pling ta. on the wa.er ma.n. The bioma.s wa. qua.tified by a.enosine triphospha.e(a.P) a.d the microbia. community wa. profiled by 454 *** results showed tha. in distribution pipes, biofilm contributed >94% of the tota. bioma.s,while loose deposits showed little contribution(a.se of the low a.ount of loose deposits. The distribution of biologica. sta.le wa.er ha. minor effects on the microbiocida. wa.er qua.ity rega.ding both qua.tity(a.P 1 ng/L vs. 1.7 ng/L) a.d community of the ba.teria. Wherea. the plumbing system ha. significa.t contribution to the increa.e of a.tive bioma.s(1.7 ng/L vs. 2.9 ng/L) a.d the cha.ges of ba.teria. community. The rela.ive a.unda.ce of Sphingomona. spp. a. ta.(22%) wa. higher tha. tha. a. wa.er ma.n(2%), while the rela.ive a.unda.ce of Pseudomona. spp. in ta. wa.er(15%) wa. lower tha. tha. in the wa.er from street wa.er ma.n(29%). Though only one loca.ion wa. prepa.ed a.d studied, the present study showed tha. the protocol of ma.ing sa.pling ta. on wa.er ma.n offered directly evidences a.out the impa.ts of plumbing system on ta. wa.er qua.ity, which ma.es it possible to distinguish a.d study the processes in distribution system a.d plumbing system sepa.a.ely.

关键词： Drink.ng wa.er distribution system Plumbing system Microbiologica. wa.er qua.ity Sa.pling progra. 454 pyrosequencing

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