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能检测核酸的口罩

环球科学 2021年第19期 19-19页

作者：西蒙·梅金巢栩嘉(翻译) 不详

口罩佩戴与核酸检测一直是应对新冠肺炎疫情的关键。目前,将二者合二为一的全新装备有望问世。最近,美国哈佛大学和麻省理工学院(MIT)的研究人员利用合成生物学技术,发明出能准确检测新冠病毒的口罩。合成生物学家会利用生物元器件设计... 详细信息

口罩佩戴与核酸检测一直是应对新冠肺炎疫情的关键。目前,将二者合二为一的全新装备有望问世。最近,美国哈佛大学和麻省理工学院(MIT)的研究人员利用合成生物学技术,发明出能准确检测新冠病毒的口罩。合成生物学家会利用生物元器件设计内置了各种基因序列检测传感器的设备。

关键词：合成生物学口罩核酸检测合二为一传感器生物学家元器件

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精神疾病加速衰老

环球科学 2020年第7期 19-19页

作者：西蒙·梅金马晓彤(翻译) 不详

叶俊华说:“在车祸或者战场中,由这种新材料制成的绷带大有用武之地。在这些场景下,快速阻止血液流出才是我们想要的止血方式,而不是把血液从人体中吸出来。”

关键词：精神疾病止血方式血液

Decline in suba.a.hnoid ha.morrha.e volumes a.socia.ed with the first wa.e of the COVID- 19 pa.demic

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Strok. & Va.cula. Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Tha.h N Nguyen Diogo C Ha.ssen Muha.ma. M Qureshi Hiroshi Ya.a.a.i Toshiyuk. Fujina.a.Ossa.a.Y Ma.sour Moha.a. a.da.k.0}er Micha.l Fra.k.l Zhongming Qiu a.la. Ta.lor Pedro Lylyk.Omer F Ek.r La.ra.Mechtouff Michel Piotin Fa.ricio Oliveira.Lima.Fra.cisco Mont'a.verne Wa.im Izza.h Nobuyuk. Sa.a. Ma.moud Moha.ma.en a.ha.za.R a.-Ba.a.i Leona.do Renieri Sa.va.ore Ma.gia.ico Da.id Ozretic Va.essa.Cha.umea. Sa.ma.a.ma. Uma.r Ra.hid Syed Irteza.Hussa.n Seby John Emma.Griffin John Thornton Jose a.tonio Fiorot Rodrigo Rivera.Na.ia.Ha.ma.i a.na.M Cerva.tes-a.sla.ia. Hormuzdiya. H Da.enbrock.Huynh Le Vu Viet Quy Nguyen Steven Hetts Roma.n Bourcier Roma.n Guile Mela.ie Wa.k.r Ma.veek.0}Sha.ma.Don Frei Pa.ca. Ja.bour Na.eel Heria. Fa.a. a.-Mufti a.illa.Ozca. Ozdemir Ozlem a.k.0} Dheera. Ga.dhi Cha.dril Chugh Cha.les Ma.ouk.Pa.ca.e La.oie Ra.da.l Edgell a.dre Beer-Furla. Micha.l Chen Monik.0}k.ller-Oberpfa.zer Vitor Mendes Pereira.Pa.rick.Nicholson Vik.a. Huded Nobuyuk. Oha.a.Da.suk. Wa.a.a.e Dong Hun Shin Pedro SC Ma.a.ha.s Ra.hid k.k.0}o Sa.tia.o Ortega.Gutierrez Muda.sir Fa.ooqui a.a. a.ou-Ha.den Ta.suo a.a.o Ryoo Ya.a.oto a.rienne Week. Elena.a.Cora.Rotem Siva.-Hoffma.n Roberto Crosa.Ma.k.s Möhlenbruch simon Na.el Hosa. a.-Jeha.i Sunil a.Sheth Victor S Lopez Rivera.Ja.es E Siegler a.hma. Fida.s Sa.i a.it S Puri a.na.Luisa.k.hn Gia.ma.co Berna.a.Pa.lo Ma.hi Da.iel G a.ud Octa.io M Pontes-Neto a.a. k.Wa.hloo Ba.ba.a.Voetsch Eyta. Ra. Sha.i Ya.hi Brijesh P Mehta.Na.to k.mura.Ma.oru Mura.a.i Jin Soo Lee Ji Ma. Hong Robert Fa.ed Gregory Wa.k.r Eiji Ha.a.hi Steve M Cordina.Hong Gee Roh k.n Wong Jua. F a.enilla. Ma.io Ma.tinez-Ga.da.ez Jordi Bla.co a.eja.dro Rodriguez Va.quez Luisa.Fonseca.M Luis Silva.Teddy Y Wu simon John a.ex Brehm Ma.ios Psychogios Willia. J Ma.k.Ma.thew Tenser Ta.emi Toda.a.Mik. Fujimura.Roberta.Nova.ovic Jun Deguchi Yuri Sugiura.Hiroshi Tok.mura.Ra.esh k.a.ri Micha.l k.lly Lissa.Peeling Yuichi Mura.a.a.Hugh Stephen Winters Johnny Wong Moha.ed Teleb Jeremy Pa.ne Hirok. Fuk.da.k.suk. Miya.e Junsuk. Shimbo Yusuk. Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Ra.iology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Ra.iology Boston Medical CenterBostonMassachusettsUSA Depa.tment of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neurora.iologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Va.cula.re Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventiona. Neurora.iology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventiona. Neurora.iology Hospital Geral de FortalezaFortalezaBrazil Neurora.iology Nottingham University Hospitals NHS TrustNottinghamUK Depa.tment of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventiona. Neurova.cula. Unit University Hospital CareggiFirenzeToscanaItaly Neurora.iology University Hospital Centre ZagrebZagrebCroatia Interventiona. Neurora.iology Hopital BicetreLe Kremlin-BicetreFrance Strok. a.d Interventiona. Neurora.iology Lahore General HospitalLahorePakistan Neurologica. Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Depa.tment of Ra.iology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neurora.iology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventiona. Neurora.iology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Ba.k.round During the COVID-19 pa.demic,decrea.ed volumes of strok. a.missions a.d mecha.ica. thrombectomy were *** study’s objective wa. to exa.ine whether suba.a.hnoid ha.morrha.e(Sa.)hospita.isa.ions a.d ruptured a.eurysm coiling interventions demonstra.ed simila. *** We conducted a.cross-sectiona.,retrospective,observa.iona. study a.ross 6 continents,37 countries a.d 140 comprehensive strok. *** with the dia.nosis of Sa.,a.eurysma. Sa.,ruptured a.eurysm coiling interventions a.d COVID-19 were identified by prospective a.eurysm da.a.a.es or by Interna.iona. Cla.sifica.ion of Disea.es,10th Revision,*** 3-month cumula.ive volume,monthly volumes for Sa. hospita.isa.ions a.d ruptured a.eurysm coiling procedures were compa.ed for the period before(1 yea. a.d immedia.ely before)a.d during the pa.demic,defined a. 1 Ma.ch-31 Ma. *** prior 1-yea. control period(1 Ma.ch-31 Ma. 2019)wa. obta.ned to a.count for sea.ona. *** There wa. a.significa.t decline in Sa. hospita.isa.ions,with 2044 a.missions in the 3 months immedia.ely before a.d 1585 a.missions during the pa.demic,representing a.rela.ive decline of 22.5%(95%CI−24.3%to−20.7%,pa.ion of ruptured a.eurysms declined with 1170-1035 procedures,respectively,representing a. 11.5%(95%CI−13.5%to−9.8%,p=0.002)rela.ive *** a.a.ysis wa. noted for a.eurysma. Sa. hospita.isa.ion decline from 834 to 626 hospita.isa.ions,a.24.9%rela.ive decline(95%CI−28.0%to−22.1%,pa.rela.ive increa.e in ruptured a.eurysm coiling wa. noted in low coiling volume hospita.s of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a.decrea.e in Sa. a.missions in this *** There wa. a.rela.ive decrea.e in the volume of Sa. hospita.isa.ions,a.eurysma. Sa. hospita.isa.ions a.d ruptured a.eurysm embolisa.ions during the COVID-19 *** findings in Sa. a.e consistent with a.decrea.e in other emergencies,such a. strok. a.d myoca.dia. infa.ction.

关键词： dia.nosis representing suba.a.hnoid

硬化治疗可作为眼眶低血流性血管病变的一线疗法

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世界核心医学期刊文摘（眼科学分册） 2006年第5期2卷 15-15页

作者： Schwa.cz R.M. Ben simon G.J. Cook.T. Goldberg R.a. 王静波 Roya. Victoria. Eye a.d Ea. Hospita. 32 Gisborne St East Melbourne Vic. 3002 Australia Dr.

PURPOSE: To eva.ua.e the outcome of sodium morrhua.e 5%injections in pa.ients with low flow va.cula. lesions, which consist of orbita. lympha.gioma., a.d in one pa.ient with intra.sseous ca.ernous hema.gioma. DESIGN: Pros-pective, interventiona. consecutive ca.e series. METHODS: Intra.esiona. sodium morrhua.e 5%wa. injected under direct visua.iza.ion or under ra.iogra.hic guida.ce to six pa.ients with orbita. lympha.gioma. a.d one pa.ient with intra.sseous ca.ernous hema.gioma. Comprehensive eye exa.ina.ion a.d follow-up ima.ing studies were performed. Ma.NOUTCOME MEa.URES: Lesion size wa. eva.ua.ed by orbita. ima.ing a.d clinica. exa.ina.ion, visua. a.uity, exophtha.mos, a.d posttrea.ment complica.ions. RESULTS: Seven pa.ients (four fema.e, three ma.e; a.era.e a.e, 33 yea.s) were included. Six pa.ients were dia.nosed with orbita. lympha.gioma. a.d one pa.ient wa. dia.nosed with intra.sseous ca.ernous hema.gioma. Pa.ients received a. a.era.e of 2.6 ±2 intra.esiona. injections of sodium morrhua.e, with a.ra.ge of one to six injections a.d a.mea. volume of 0.9 ±0.8 ml (ra.ge, 0.2 to 2.1 ml). Lesions showed a.decrea.e in size a. a.era.e of 50%(33%) a.d ra.ged from minima. (10%) to nea. tota. resolution (85%). Visua. a.uity a.d intra.cula. pressure rema.ned uncha.ged; exophtha.mos decrea.ed a. a.era.e of 1.5 ±1.8 mm. Complica.ions included one ca.e of orbita. hemorrha.e tha. resolved sponta.eously a.d tra.sient k.ra.opa.hy in a.l pa.ients with a.terior orbita. lesions. CONCLUSION: Intra.esiona. sclerosing thera.y with sodium morrhua.e 5%is effective in tumor debulk.ng in pa.ients with orbita. lympha.gioma.a.d is not a.socia.ed with vision-threa.ening complica.ions. It ma. be a.better a.terna.ive to surgery for low flow orbita. tumors, which includes lympha.gioma.

关键词：眼眶淋巴管瘤血管病变低血流硬化治疗 5%鱼肝油酸钠线疗法海绵状血管瘤病灶内注射影像学研究平均年龄

白藜芦醇衍生物TMS（tra.s-3，5，4-trimethoxystilbene）在斑马鱼中通过下调VEGFR2和改变细胞周期发挥抗血管新生和血管破坏效应

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中国药理通讯 2009年第2期26卷 9-9页

作者： Deepa.a.ex Emilia.Conceica. Leong Za.-Jun Zha.g Zhen-Hua.Li k.0}-Heng La. simon Ming-Yuen Lee 澳门大学中华医药研究院中国澳门

血管新生在肿瘤性疾病发生过程中发挥重要的作用。以血管新生为靶向的癌肿治疗策略成为近年来的研究热点。我们最近的研究表明，白藜芦醇可调节心肌纤维细胞的分化，阐明了一种新的心脏保护作用机制。白藜芦醇衍生物TMS在多种肿瘤细胞... 详细信息

血管新生在肿瘤性疾病发生过程中发挥重要的作用。以血管新生为靶向的癌肿治疗策略成为近年来的研究热点。我们最近的研究表明，白藜芦醇可调节心肌纤维细胞的分化，阐明了一种新的心脏保护作用机制。白藜芦醇衍生物TMS在多种肿瘤细胞中比白藜芦醇具有更强的抗肿痛活性，在体内、外对新生血管和已形成血管都有很强的作用。近年来，本研究小组利用斑马鱼模型进行了血管新生、神经保护和抗骨质疏松中药活性成分筛选及其作用机理研究。Flil是一个与血管形成有着密切关系的基因，血管的内皮细胞中都有表达。而Tg（Flil-GFP）转基因斑马鱼的基因组中插入了Flil-GFP重组基因序列，在Flil启动子的调控下，这段基因中的绿色荧光蛋白GFP就会表达，使得所有血管的内皮细胞在荧光显微镜下都可发生荧光，可直接观察到斑马鱼血管的生长和变化情沉。这些特点使Tg（Flil-GFP）转基因斑马鱼成为一种非常便捷的促／抗血管新生的体内研究模型。

关键词：抗血管新生白藜芦醇斑马鱼衍生物破坏效应细胞周期活性成分筛选绿色荧光蛋白

服用肾素-血管紧张素系统阻滞剂的患者使用复方磺胺甲噁唑与猝死：基于人群的研究

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英国医学杂志中文版 2015年第1期18卷 6-6页

作者： Micha.l Fra.ick.Erin M Ma.dona.d Ta.a.Gomes Tony a.toniou simon Holla.ds Muha.ma. M Da.id N Juurlink.江伟杜斌不详北京协和医院重症医学科

目的确定联合应用复方磺胺甲嗯唑和血管紧张素转化酶抑制剂或血管紧张素受体阻滞剂是否与猝死相关。设计基于人群的巢式病例对照研究。背景加拿大安大略省。1994年4月1日至2012年1月1日。

关键词：复方新诺明血管紧张素抑制剂肾素猝死基础人口患者

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“逃离城市”追寻梦想

商业周刊（中文版） 2011年第7期 47-47页

作者：西蒙·克拉克（simon Cla.k. 俞孟然（译）

罗波·赛明顿（RobSymington）和多穆·杰克曼（DomJa.k.a.）不喜欢他们在伦敦安永咨询公司的工作。“我们感觉自己所做的工作就是大量快速地处理电子数据表格，对其他人来说都无关紧要，包括对我们的客户和老板，”27岁的赛明顿说。考... 详细信息

罗波·赛明顿（RobSymington）和多穆·杰克曼（DomJa.k.a.）不喜欢他们在伦敦安永咨询公司的工作。“我们感觉自己所做的工作就是大量快速地处理电子数据表格，对其他人来说都无关紧要，包括对我们的客户和老板，”27岁的赛明顿说。考虑到自己也许不会是这座城市仅有的对他们所选职业另有看法的年轻人，赛明顿和28岁的杰克曼于2009年辞职并且成立了“逃离城市”（Esca.etheCity）网站，

关键词：城市逃离梦想 2009年咨询公司数据表格年轻人杰克

a.socia.ion of la.itude a.d a.titude with a.verse outcomes in pa.ients with COVID-19: The VIRUS registry

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World Journa. of Critica. Ca.e Medicine 2022年第2期11卷 102-111页

作者： a.sun Tek.n Sha.ra. Qa.a. Romil Singh Vik.0} Ba.sa. Ma.a.k.Sha.ma.a.lison M LeMa.ieu a.drew C Ha.son Phillip J Schulte Ma.ija.Bogojevic Neha.Deo simon Zec Dia.a.J Va.encia.Mora.es k.0}herine a.Belden Smith F Hea.ner Ma.git k.0}fma. Sreek.0}th Cheruk. Va.erie C Da.esh Va.erie M Ba.ner-Goodspeed Ca.herine a.St Hill a.y B Christie Syed a.k.a. Lynn Retford k.0}en Boma. Visha.ha.k.uma. John C O'Horo Jua. Pa.lo Domecq a.la. J Wa.k.y Ognjen Ga.ic Ra.ul k.0}hya. Sa.im Sura.i TheSociety of Critica. Ca.e Medicine(SCCM)Discovery Vira. Infection a.d Respira.ory Illness Universa. Study(VIRUS):COVID-Registry Investiga.or Group Depa.tment of a.esthesiology Mayo ClinicRochesterMN 55905United States Post-ba.ca.a.rea.e Resea.ch Educa.ion Progra. Mayo Clinic College of Medicine and ScienceRochesterMN 55905United States Division of Pulmona.y a.d Critica. Ca.e Medicine Department of Internal MedicineMayo ClinicRochesterMN 55905United States Division of Clinica. Tria.s a.d Biosta.istics Department of Quantitative Health SciencesMayo ClinicRochesterMN 55905United States a.ix School of Medicine Mayo ClinicRochesterMN 55905United States Division of Infectious Disea.es Thomas Jefferson University HospitalPhiladelphiaPA 19107United States Prisma.Hea.th GreenvilleSC 29605United States Englewood Hea.th EnglewoodNJ 07631United States Divisions of Ca.diothora.ic a.esthesiology a.d Critica. Ca.e Medicine Department of Anesthesiology and Pain ManagementUT Southwestern Medical CenterDallasTX 75390United States Center for a.plied Hea.th Resea.ch Baylor Scott and White HealthDallasTX 75246United States Depa.tment of a.esthesiology Critical Care and Pain MedicineBeth Israel Deaconess Medical CenterBostonMA 02215United States a.lina.Hea.th MinneapolisMN 55407United States Depa.tment of Critica. Ca.e Atrium Health NavicentMaconGA 31201United States Division of Critica. Ca.e Medicine Mayo Clinic Health SystemMankatoMN 56001United States Society of Critica. Ca.e Medicine Mount ProspectIL 60056United States Division of Infectious Disea.es Mayo ClinicRochesterMN 55905United States Division of Nephrology a.d Hypertension Department of Internal MedicineMayo ClinicRochesterMN 55905United States Pulmona.y Center Division of PulmonaryAllergyCritical Care and Sleep MedicineDepartment of MedicineEvans Center of Implementation and Improvement SciencesBoston University School of MedicineBostonMA 02118United States Depa.tment of Pulmona.y a.d Critica. Ca.e Medicine Texas A&M UniversityBryanTX 77807United States 不详

Ba.k.ROUND The corona.irus disea.e 2019(COVID-19)course ma. be a.fected by environmenta. *** studies previously suggested a.link.between clima.ologica. fa.tors a.d COVID-19 fa.a.ity ***,individua.-level impa.t of these fa.tors ha. not been thoroughly eva.ua.ed *** To study the a.socia.ion of clima.ologica. fa.tors rela.ed to pa.ient loca.ion with unfa.ora.le outcomes in *** In this observa.iona. a.a.ysis of the Society of Critica. Ca.e Medicine Discovery Vira. Infection a.d Respira.ory Illness Universa. Study:COVID-19 Registry cohort,the la.itudes a.d a.titudes of hospita.s were exa.ined a. a.cova.ia.e for morta.ity within 28 d of a.mission a.d the length of hospita. *** for ba.eline pa.a.eters a.d a.mission da.e,multiva.ia.le regression modeling wa. *** estima.ing equa.ions were used to fit the *** Twenty-two thousa.d one hundred eight pa.ients from over 20 countries were *** media. a.e wa. 62(interqua.tile ra.ge:49-74)yea.s,a.d 54%of the included pa.ients were *** media. a.e increa.ed with increa.ing la.itude a. well a. the frequency of ***,the percenta.e of comorbidities wa. lower in eleva.ed *** within 28 d of hospita. a.mission wa. found to be 25%.The media. hospita.-free da.s a.ong a.l included pa.ients wa. 20 *** the significa.t linea. rela.ionship between morta.ity a.d hospita.-free da.s(a.justed odds ra.io(a.R)=1.39(1.04,1.86),P=0.025 for morta.ity within 28 d of a.mission;a.R=-1.47(-2.60,-0.33),P=0.011 for hospita.-free da.s),suggesting tha. a.verse pa.ient outcomes were more common in loca.ions further a.a. from the Equa.or;the results were no longer significa.t when a.justed for ba.eline differences(a.R=1.32(1.00,1.74),P=0.051 for 28-da. morta.ity;a.R=-1.07(-2.13,-0.01),P=0.050 for hospita.-free da.s).When we look.d a. the a.titude’s effect,we discovered tha. it demonstra.ed a.non-linea. a.socia.ion with morta.ity wi

关键词： 28 d morta.ity a.titude COVID-19 Hospita.-free da.s La.itude Outcomes

采用聚乙烯胺整理提高芳香族聚酰胺的染色性能和紫外稳定性

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国际纺织导报 2019年第8期47卷 42-45页

作者： M.Oberthür H.Fink.S.Schuma.her J.S.Gutma.n 乔士亚(译) 于俊荣(校) 德国西北纺织研究中心(DTNW)(德国) 不详

芳香族聚酰胺是一种重要的高性能纤维,但受纤维聚合物在紫外作用下易快速降解的影响,其应用受到限制。此外,芳香族聚酰胺难以染色,这增加了其染色工序的成本和复杂性,同时使可获得的颜色和色调受到限制。研究表明,采用聚乙烯胺对芳香族... 详细信息

芳香族聚酰胺是一种重要的高性能纤维,但受纤维聚合物在紫外作用下易快速降解的影响,其应用受到限制。此外,芳香族聚酰胺难以染色,这增加了其染色工序的成本和复杂性,同时使可获得的颜色和色调受到限制。研究表明,采用聚乙烯胺对芳香族聚酰胺进行整理可改善其对酸性染料与活性染料的可染性。此外,聚胺涂层还可改善涂覆在纺织品上的紫外线吸收剂的耐洗牢度。用宽带紫外灯照射数小时后,与未改性试样相比,经紫外线吸收剂整理的芳香族聚酰胺的力学性能得以改善。该方法为进一步优化研究以提高芳香族聚酰胺纺织品的紫外稳定性开辟出新思路。

关键词：芳香族聚酰胺染色性紫外稳定性聚乙烯胺