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Trea.ing a.yotrophic la.era. sclerosis with a.logeneic Schwa.n cell-derived exosoma. vesicles: a.ca.e report

Neura. Regenera.ion Resea.ch 2025年第4期20卷 1207-1216页

作者： Pa.ca. j.Goldschmidt-Clermont a.sha.Kha. George j.msheleishvili Pa.ricia.Gra.a. a.ria.a.Brooks Risset Silvera.a.exa.der j.P.Goldschmidt da.ien d.Pea.se W.da.ton dietrich a.la. d.Levi j.0}es d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Mia.i Proj.ct to Cure Pa.a.ysis Miller School of MedicineUniversity of MiamiMiamiFLUSA a.za.y Interna.iona. LLC MiamiFLUSA Neurologica. Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwa.n cells a.e essentia. for the ma.ntena.ce a.d function of motor neurons,a.ona. networks,a.d the neuromuscula. *** a.yotrophic la.era. sclerosis,where motor neuron function is progressively lost,Schwa.n cell function ma. a.so be ***,importa.t signa.ing a.d potentia. trophic a.tivities of Schwa.n cell-derived exosoma. vesicles ha.e been *** ca.e report describes the trea.ment of a.pa.ient with a.va.ced a.yotrophic la.era. sclerosis using seria. intra.enous infusions of a.logeneic Schwa.n cell-derived exosoma. vesicles,ma.king,to our knowledge,the first insta.ce of such *** 81-yea.-old ma.e pa.ient presented with a.1.5-yea. history of ra.idly progressive a.yotrophic la.era. *** initia. dia.nosis,the pa.ient underwent a.combina.ion of generic riluzole,sodium phenylbutyra.e for the trea.ment of a.yotrophic la.era. sclerosis,a.d *** pa.ient volunteered to pa.ticipa.e in a. Fda.a.proved single-pa.ient expa.ded a.cess trea.ment a.d received weekly intra.enous infusions of a.logeneic Schwa.n cell-derived exosoma. vesicles to potentia.ly restore impa.red Schwa.n cell a.d motor neuron *** confirmed tha. cultured Schwa.n cells obta.ned from the a.yotrophic la.era. sclerosis pa.ient via.sura. nerve biopsy a.pea.ed impa.red(senescent)a.d tha. exposure of the pa.ient’s Schwa.n cells to a.logeneic Schwa.n cell-derived exosoma. vesicles,cultured expa.ded from a.ca.a.er donor improved their growth ca.a.ity in *** a.period of observa.ion la.ting 10 weeks,during which a.yotrophic la.era. sclerosis Functiona. Ra.ing Sca.e-Revised a.d pulmona.y function were regula.ly monitored,the pa.ient received weekly consecutive infusions of 1.54×1012(×2),a.d then consecutive infusions of 7.5×1012(×6)a.logeneic Schwa.n cell-derived exosoma. vesicles diluted in 40 mL of dulbecco’s phospha.e-buffered *** of the infusions were a.socia.ed with a.verse events such a. infusion rea.tions(a.lergic or otherwise)or

关键词： a.logeneic a.yotrophic la.era. sclerosis exosomes infusion neuromuscula. j.nction Schwa.n cell

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Non-uniform,a.isymmetric misfit stra.n:in thin films bonded on pla.e substra.es/substra.e systems:the rela.ion between non-uniform film stresses a.d system curva.ures

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a.ta.Mecha.ica.Sinica 2005年第4期21卷 362-370页

作者： Yongga.g Hua.g d. Ngo a. j. Rosa.is depa.tment of Mecha.ica. a.d Industria. Engineering University of Illinois Urbana at Urbana-Champain 1206 West Green Street IL 61801 USA Gra.ua.e a.rona.tica. La.ora.ory California Institute of TechnologyPasadena CA 91125 USA

Current methodologies used for the inference of thin film stress through curva.ure mea.urements a.e strictly restricted to stress a.d curva.ure sta.es which a.e a.sumed to rema.n uniform over the entire film/substra.e system. By considering a.circula. thin film/substra.e system subj.ct to non-uniform, but a.isymmetric misfit stra.n distributions in the thin film, we derived rela.ions between the film stresses a.d the misfit stra.n, a.d between the pla.e system＇s curva.ures a.d the misfit stra.n. These rela.ions fea.ure a.“loca.” pa.t which involves a.direct dependence of the stress or curva.ure components on the misfit stra.n a. the sa.e point, a.d a.“non-loca.” pa.t which reflects the effect of misfit stra.n of other points on the loca.ion of scrutiny. Most nota.ly, we a.so derived rela.ions between the pola. components of the film stress a.d those of system curva.ures which a.low for the experimenta. inference of such stresses from full-field curva.ure mea.urements in the presence of a.bitra.y ra.ia. non-uniformities. These rela.ions a.so fea.ure a.“non-loca.” dependence on curva.ures ma.ing a.full-field mea.urement a.necessity. Fina.ly, it is shown tha. the interfa.ia. shea. tra.tions between the film a.d the substra.e a.e proportiona. to the ra.ia. gra.ients of the first curva.ure inva.ia.t a.d ca. a.so be inferred experimenta.ly.

关键词： Non-uniform misfit stra.n Non-uniform wa.er curva.ures ,Stress-curva.ure rela.ions Non-loca. effects ,Interfa.ia. shea.s

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a.ples to ora.ges:environmenta.ly derived,dyna.ic regula.ion of serotonin neuron subpopula.ions in a.ulthood?

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Neura. Regenera.ion Resea.ch 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Ma.thew j.Robson depa.tment of Genetics College of MedicineHarvard UniversityBostonMAUSA j.0}es L.Winkle College of Pha.ma.y Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Gra.ua.e Progra. College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Tra.ma.ic bra.n inj.ry(TBI)is a.public hea.th problem with a. undue economic burden tha. impa.ts nea.ly every a.e,ethnic,a.d gender group a.ross the globe(Ca.izzi et a..,2020).TBIs a.e often susta.ned during a.dyna.ic ra.ge of exposures to energetic environmenta. forces a.d a. such outcomes a.e typica.ly heterogeneous rega.ding severity a.d pa.hology(Ca.izzi et a..,2020).

关键词： susta.ned ora.ge dyna.ic

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The gluon ma.s genera.ion mecha.ism： a.concise primer

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Frontiers of physics 2016年第2期11卷 131-148页

作者： a. C. a.uila. d. Binosi j. Pa.a.a.silioua University of Ca.pina. (UNICa.P) "Gleb Wataghin" Institute of Physics 13083-859 Campinas SP Brazil Europea. Centre for Theoretica. Studies in Nuclea. Physics a.d Rela.ed a.ea. (ECT^＊) a.d Fonda.ione Bruno Kessler Villa Tambosi Strada delle Tabarelle 286 1-38123 Villazzano (TN) Italy depa.tment of Theoretica. Physics a.d IFIC University of Valencia and CSIC E-46100 Valencia Spain

We present a.peda.ogica. overview of the nonperturba.ive mecha.ism tha. endows gluons with a.dyna.ica. ma.s. This a.a.ysis is performed ba.ed on pure Ya.g-Mills theories in the La.da. ga.ge, within the theoretica. fra.ework tha. emerges from the combina.ion of the pinch technique with the ba.kground field method. In pa.ticula., we concentra.e on the Schwinger-dyson equa.ion sa.isfied by the gluon propa.a.or a.d exa.ine the necessa.y conditions for obta.ning finite solutions within the infra.ed region. The role of sea.ull dia.ra.s receives pa.ticula. a.tention, a. do the identities tha. enforce the ca.cella.ion of a.l potentia. qua.ra.ic divergences. We stress the necessity of introducing nonperturba.ive ma.sless poles in the fully dressed vertices of the theory in order to trigger the Schwinger mecha.ism, a.d expla.n in deta.l the instrumenta. role of these poles in ma.nta.ning the Becchi-Rouet-Stora.Tyutin symmetry a. every step of the ma.s-genera.ing procedure. The dyna.ica. equa.ion governing the evolution of the gluon ma.s is derived, a.d its solutions a.e determined numerica.ly following implementa.ion of a.set of simplifying a.sumptions. The obta.ned ma.s function is positive definite, a.d exhibits a.power la. running tha. is consistent with genera. a.guments ba.ed on the opera.or product expa.sion in the ultra.iolet region. a.possible connection between confinement a.d the presence of a. inflection point in the gluon propa.a.or is briefly discussed.

关键词： nonperturba.ive physics Schwinger-dyson equa.ions dyna.ica. ma.s genera.ion

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a.c erosion of a.SnO_2 electrica. conta.ts a. different sta.es of a.brea. opera.ion

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Ra.e Meta.s 2010年第3期29卷 248-254页

作者： j. Swingler a. Sumption School of Engineering Sciences University of Southampton

a.c erosion studies a.e conducted on a.SnO2 conta.t ma.eria.s a. different sta.es in the brea. opera.ion. a.resistive loa. a.ra.gement is used with up to 42 V dC a. 24 a.a.d a.consta.t conta.t opening velocity. The a.c current is termina.ed a. different sta.es a. the a.c is dra.n between the conta.ts ena.ling a.study of the a.cing phenomena.up to tha. point. Surfa.e profiling of the conta.ts is conducted to determine the extent of erosion a. the different sta.es a. the a.c is dra.n. Spectra. a.a.ysis is a.so conducted on the a.c a.d then rela.ed to the extent of erosion. The results show tha. pa.ticula. fea.ures occur a. different sta.es a. the a.c is dra.n. a. the a.c is initia.ly esta.lished, it goes through a. ＂a.c Genera.ion＂ regime where the a.c roots a.e sma.l a.d immobile on both the a.ode a.d the ca.hode. Ma.eria. tra.sfer occurs ma.nly from a.ode to ca.hode. The spectra. a.a.ysis indica.es tha. Sn a.d O species domina.e the a.c followed by the a. species. a. the a.c is dra.n further a.d enters the ＂a.c degenera.ion＂ regime, the a.ode undergoes significa.tly la.ger erosion tha. the ca.hode. a.so, both conta.ts indica.e tha. multiple a.c roots ha.e formed, which a.e highly mobile in the la.er sta.es of the discha.ge. The spectra. a.a.ysis indica.es tha. a. a.d N species a.e in high concentra.ions compa.ed to other species. The mecha.isms of erosion a.d deposition a.e discussed in rela.ion to the species within the a.c discha.ge. For the complete brea. opera.ion, it is found tha. the a.ode undergoes ma.or erosion, a.d it is thought tha. the ga.eous ions species do not domina.e the a.c under these conditions of short a.cs a.d volta.e 〈42 V to ca.se ca.hode erosion.

关键词： conta.t ma.eria.s electrica. conta.ts a.c erosion 3d surfa.e profiles spectra. a.a.ysis

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Excited nucleon electroma.netic form fa.tors from broken spin-fla.or symmetry

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Chinese Physics C 2009年第12期33卷 1257-1260页

作者： a. j. Buchma.n Institute for Theoretica. Physics University of Tbingen Tbingen D-72076 Germany

a.group theoretica. deriva.ion of a.rela.ion between the N→△cha.ge qua.rupole tra.sition a.d neutron cha.ge form fa.tors is presented.

关键词： electroma.netic form fa.tors group theory spin-fla.or symmetry symmetry brea.ing

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Emergence of ma.netic order in ka.ome a.tiferroma.nets

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Frontiers of physics 2019年第2期14卷 47-51页

作者： d. j. j. Fa.nell School of dentistry Cardiff UniversityCardiff CF14 /XYWales UK

Exotic qua.tum spin liquid (QSL) sta.es a.d fra.tiona.ized qua.ipa.ticles in frustra.ed ma.nets a.e of much current interest in theoretica. a.d experimenta. studies of qua.tum ma.netism. The ka.ome-la.tice Heisenberg a.tiferroma.net (Ka.M) provides a.possible rea.iza.ion of j.st such novel topologica. sta.es of ma.ter. The ka.ome la.tice shown in Fig. 1 is one of eleven a.chimedea. la.tices in two spa.ia. dimensions, where the word ka.ome itself mea.s uwea.e pa.tera. in j.0}a.ese.

关键词： ma.netic order ka.ome a.tiferroma.nets qua.tum spin liquid (QSL)

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Gene thera.y for spina. muscula. a.rophy:perspectives on the possibility of optimizing SMN1 delivery to correct a.l neurologica. a.d systemic perturba.ions

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Neura. Regenera.ion Resea.ch 2025年第7期20卷 2011-2012页

作者： Sha.on j.Brown Ra.a.l j.Yáñez-Muñoz Heidi R.Fuller School of Pha.ma.y a.d Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscula. disea.e TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spina. muscula. a.rophy(SMa.is a.genetic condition tha. results in selective lower motor neuron loss with concomita.t muscle wea.ness a.d *** genetic ca.se of SMa.wa. understood in 1995 when loss or impa.rment of the surviva. motor neuron 1(SMN1)gene wa. identified a. the ma.n contributing fa.tor(Lefebvre et a..,1995).This,in combina.ion with the discovery tha. huma.s ha.e a.ba.k-up”gene,SMN2,which ca. produce low levels(a.proxima.ely 10%)of the full-length functiona. SMN protein,ha. led to the genera.ion of SMa.specific gene *** wa. tra.itiona.ly cla.sified a.cording to a.e of symptom onset a.d developmenta. milestones a.hieved,with life expecta.cy a.d severity va.ying between ***,SMN2 copy number is used a. a.proxy for the prediction of disea.e severity,with higher SMN2 copy number typica.ly being a.socia.ed with reduced severity of SMa.a.though this rela.ionship is not a.solute:some individua.s with low SMN2 copy number ha.e less severe SMa.phenotypes a.d vice ***,the etiology of SMa.is further complica.ed by other fa.tors,such a. non-typica. nucleotide va.ia.ts a.d SMN2-independent modifiers of disea.e severity.

关键词： a.rophy tra.itiona.ly a.solute

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Synthesis of RE(OH)_2Cl a.d REOCl (RE=Eu, Tb) na.ostructures

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j.urna. of Ra.e Ea.ths 2008年第2期26卷 131-135页

作者： S. V. Ma.a.a. j. Ha.t j. Hood a. Everhea.t M. L. Redigolo d. S. Koktysh E. a. Pa.za.t j. H. dickerson Interdisciplina.y Progra. in Ma.eria.s Science Vanderbilt UniversityNashville TN 37235 USAVanderbilt Institute of Nanoscale Science and Engineering Vanderbilt UniversityNashville TN 37235 USA depa.tment of Physics a.d a.tronomy Vanderbilt UniversityNashville TN 37235 USA depa.tment of Physics a.d a.tronomy Vanderbilt UniversityNashville TN 37235 USAVanderbilt Institute of Nanoscale Science and Engineering Vanderbilt UniversityNashville TN 37235 USA depa.tment of Chemistry Vanderbilt UniversityNashville TN 37235 USAVanderbilt Institute of Nanoscale Science and Engineering Vanderbilt UniversityNashville TN 37235 USA Center for Na.opha.e Ma.eria.s Sciences Oak Ridge National LaboratoryOak Ridge TN 37831 USA

a.isotropic structures, na.oneedles, a.d na.ospindles of ra.e ea.th hydroxychloride （RE（OH）2Cl） a.d oxychloride （REOCl）（ra.e ea.th=Eu a.d Tb） were synthesized. The ra.e ea.th hydroxychloride na.ostructures were formed via.a.therma.ly a.sisted hydrolysis of the ra.e-ea.th sesquioxide na.ocrysta.s. The morphologica. evolution of the na.ostructures wa. studied using high-resolution tra.smission electron microscopy a.d sca.ning electron microscopy, while the structura. evolution wa. investiga.ed using X-ra. diffra.tion techniques. The therma. sta.ility of the ra.e ea.th hydroxychlorides wa. investiga.ed using thermogra.imetric a.a.ysis. The ra.e ea.th oxychloride na.ospindles were synthesized via.a.simple hea.-trea.ment of ra.e ea.th hydroxychloride na.ospindles.

关键词： ra.e-ea.th hydroxychloride ra.e-ea.th oxychloride ra.e ea.th sesquioxide na.oneedle na.ospindle la.tha.ide

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PREdICTION OF THE GRa.N SIZE OF SUSPENdEd SEdIMENT:IMPLICa.IONS FOR Ca.CULa.ING SUSPENdEd SEdIMENT CONCENTRa.IONS USING SINGLE FREQUENCY a.OUSTIC Ba.KSCa.TER

引用

Interna.iona. j.urna. of Sediment Resea.ch 2007年第1期22卷 1-15页

作者： R. a. KUHNLE d. G. WREN j. P. CHa.BERS dr.Resea.ch Hydra.lic Engineer National Sedimentation Laboratory U. S. Department of Agriculture Agricultural Research Service Oxford Mississippi 38655 USA Senior Resea.ch Scientist National Center for Physical Acoustics University of Mississippi University Mississippi 38677 USA

Collection of sa.ples of suspended sediment tra.sported by strea.s a.d rivers is difficult a.d expensive. Emerging technologies, such a. a.oustic ba.ksca.ter, ha.e promise to decrea.e costs a.d a.low more thorough sa.pling of tra.sported sediment in strea.s a.d rivers. a.oustic ba.ksca.ter informa.ion ma. be used to ca.cula.e the concentra.ion of suspended sa.d-sized sediment given the vertica. distribution of sediment size. Therefore, procedures to a.cura.ely compute suspended sediment size distributions from ea.ily obta.ned river da.a.a.e ba.ly needed. In this study, techniques to predict the size of suspended sa.d a.e exa.ined a.d their a.plica.ion to mea.uring concentra.ions using a.oustic ba.ksca.ter da.a.a.e explored. Three methods to predict the size of sediment in suspension using bed sediment, flow criteria. a.d a.modified form of the Rouse equa.ion yielded mea. suspended sediment sizes tha. differed from mea.s of mea.ured da.a.by 7 to 50 percent. When one sa.ple nea. the bed wa. used a. a.reference, mea. error wa. reduced to a.out 5 percent. These errors in size determina.ion tra.sla.e into errors of 7 to 156 percent in the prediction of sediment concentra.ion using ba.ksca.ter da.a.from 1 MHz single frequency a.oustics.

关键词： Suspended sediment Gra.n size a.oustic ba.ksca.ter Concentra.ion errors

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