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Loss of mdig expression enha.ces DNa.a.d histone methyla.ion a.d meta.ta.is of a.gressive brea.t ca.cer

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signa. Tra.sduction a.d Ta.geted Thera.y 2018年第1期3卷 81-89页

作者： chitra Tha.ur Ba.ling Chen Lingzhi Li Qia. Zha.g Zeng-Qua. Ya.g Fei Chen Depa.tment of Pha.ma.eutica. sciences Eugene Applebaum College of Pharmacy and Health SciencesWayne State UniversityDetroitMI 48201USA synthesis Medchem Corp 425 Changyang StreetSuzhou Industrial ParkSuzhou 215025China City of Hope Institute 1500 E.Duarte RoadDuarteCA 91010USA Depa.tment of Oncology a.d Ba.ba.a.a.n Ka.ma.os Ca.cer Institute Wayne State UniversityDetroitMI 48202USA

We previously reported tha. expression of a. environmenta.ly induced gene,minera. dust-induced gene(mdig),predicts overa.l surviva. in brea.t ca.cer *** the present report,we further demonstra.e the differentia. roles of mdig between ea.lier-a.d la.er-sta.e brea.t *** nonca.cerous brea.t,mdig is a.prolifera.ion fa.tor for cell growth a.d cell *** brea.t ca.cer,however,higher levels of mdig nega.ively regula.e the migra.ion a.d inva.ion of ca.cer *** of globa. DNa.methyla.ion,chroma.in a.cessibility a.d H3K9me3 heterochroma.in signa.ure suggests tha. silencing mdig enha.ces DNa.a.d histone *** immunosta.ning a.d da.a.mining,we found tha. mdig is significa.tly upregula.ed in noninva.ive a.d/or ea.lier-sta.e brea.t *** contra.t,in triple-nega.ive a.d other inva.ive brea.t ca.cers,diminished mdig expression wa. noted,indica.ing tha. the loss of mdig expression could be a. importa.t fea.ure of a.gressive brea.t *** together,our da.a.suggest tha. mdig is a.new bioma.ker tha. likely promotes tumor growth in the ea.ly sta.es of brea.t ca.cer while a.ting a. a.tumor suppressor to inhibit inva.ion a.d meta.ta.is in la.er-sta.e tumors.

关键词： brea.t meta.ta.is inva.ion

Nitrogen Ga. Hea.ing a.d supply system for ssT-1 Toka.a.

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Pla.ma.science a.d Technology 2013年第2期15卷 157-160页

作者： Zia.ddin KHa. Firozkha. Pa.Ha. Yuva.ira. Pa.a.a.TU siju GEORGE Ga.tu Ra.EsH hima BINDU Dilip C. Ra.a. Pra.ha.t THa.KEY Ka.peshDHa.a.I subra.a.PRa.Ha. Institute for Pla.ma.Resea.ch Bhat Gandhinagar-382 428 India

stea.y sta.e Toka.a. （ssT-1） va.uum vessel ba.ing a. well a. ba.ing of the first wa.l components of ssT-1 a.e essentia. to pla.ma.physics experiments. Under a.refurbishment spectrum of ssT-1, the nitrogen ga. hea.ing a.d supply system ha. been fully refurbished. The ssT-1 va.uum vessel consists of ultra.high va.uum （UHV） compa.ible eight modules a.d eight sectors. Recta.gula. ba.ing cha.nels a.e embedded on ea.h of them. simila.ly, the ssT-1 pla.ma.fa.ing components （PFC） a.e comprised of modula. gra.hite diverters a.d mova.le gra.hite ba.ed limiters. The nitrogen ga. hea.ing a.d supply system would ba.e the pla.ma.fa.ing components a. 350 ~C a.d the ssT-1 va.uum vessel a. 150 ~C over a. extended dura.ion so a. to remove wa.er va.our a.d other a.sorbed ga.es. a. efficient PLC ba.ed ba.ing fa.ility ha. been developed a.d implemented for monitoring a.d control purposes. This pa.er presents functiona. a.d opera.iona. a.pects of a.ssT-1 nitrogen ga. hea.ing a.d supply system. some of the experimenta. results obta.ned during the ba.ing of ssT-1 va.uum modules a.d sectors a.e a.so presented here.

关键词： ssT-1 hea.ing a.d supply system gra.hite ba.ed limiters PFC

Merging bound sta.es in the continuum in a. open a.oustic resona.or

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science China.Physics,Mecha.ics & a.tronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Hua.g Bin Jia.a.tem s.Pilipchuk sibo Hua.g Chen shen a.ma. F.sa.reev Yong Li a.drey E.Miroshnichenko school of Physics a.d Electronic sciences East China Normal University Institute of a.oustics Tongji University L.V.Kirensky Institute of Physics Depa.tment of Mecha.ica. Engineering Rowan University school of Engineering a.d Technology University of New South Wales at Canberra

Bound sta.es in the continuum （BICs） a.e perfectly loca.ized resona.ces despite embedding in the continuum ***,a. isola.ed BIC is very sensitive to the structure ***,we report merging a.oustic BICs in a.single open resona.or,robust a.a.nst the structure *** find tha. both symmetry-protected BIC a.d Friedrich-Wintgen BIC a.e susta.ned in a.single coupled wa.eguide-resona.or *** va.ying the height a.d length of the resona.or,these two BICs move towa.d ea.h other a.d merge into a.single one a. a.critica. *** to a. individua. BIC,the merged BIC is robust a.a.nst fa.rica.ion error beca.se its Q-fa.tor is proportiona. to ΔL-4,whereΔL embodies the structure *** essence of this extra.rdina.y phenomenon is perfectly expla.ned by the two-a.d three-level a.proxima.ions of the effective nonHermitia. ***,we present direct experimenta. demonstra.ions of the moving a.d merging of BICs in a.coupled 3D wa.eguide-resona.or,which a.e evidenced by the va.ishing of the linewidth of Fa.o resona.ce in the tra.smission *** results ma. find exciting a.plica.ions in designing high-qua.ity a.oustic sources,sensors a.d filters.

关键词： a.oustic resona.ces bound sta.e in the continuum high-Q resona.ces

Ta.geting ha.mful effects of non-excita.ory a.ino a.ids a. a. a.terna.ive thera.eutic stra.egy to reduce ischemic da.a.e

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Neura. Regenera.ion Resea.ch 2025年第9期20卷 2454-2463页

作者： Victoria.Jiménez Ca.retero IrisÁlva.ez-Merz Jorge Hernández-Ca.pa.o sergei a.Kirov Jesús M.Hernández-Guijo Depa.tment of Pha.ma.ology a.d Thera.eutic School of MedicineUniv.Autónoma de MadridMadridSpain Ra.ón y Ca.a. Institute for Hea.th Resea.ch(IRYCIs) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Depa.tment of Neuroscience a.d Regenera.ive Medicine&Depa.tment of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excita.ory a.ino a.ids gluta.a.e a.d a.pa.ta.e in ce rebra. ischemia.a.d excitotoxicity is ***,the role of non-excita.ory a.ino a.ids in bra.n da.a.e following a.stroke or bra.n tra.ma.rema.ns la.gely *** relea.e of a.ino a.ids by necrotic cells in the ischemic core ma. contribute to the expa.sion of the *** findings indica.ed tha. the reversible loss of field excita.o ry postsyna.tic potentia.s ca.sed by tra.sient hypoxia.beca.e irreversible when exposed to a.mixture of just four non-excita.ory a.ino a.ids(L-a.a.ine,glycine,L-gluta.ine,a.d L-serine)a. their pla.ma.*** a.ino a.ids induce swelling in the soma. of neurons a.d a.trocytes during hypoxia.a.ong with perma.ent dendritic da.a.e media.ed by N-methyl-D-a.pa.ta.e *** N-methyl-D-a.pa.ta.e receptors prevented neurona. da.a.e in the presence of these a.ino a.ids during *** is likely tha. a.troglia. swelling ca.sed by the a.cumula.ion of these a.ino a.ids via.the a.a.ine-serine-cysteine tra.sporter 2 excha.ger a.d system N tra.sporters a.tiva.es volume-regula.ed a.ion cha.nels,lea.ing to the relea.e of excitotoxins a.d subsequent neurona. da.a.e through N-methyl-D-a.pa.ta.e receptor ***,previously unrecognized mecha.isms involving non-excita.ory a.ino a.ids ma. contribute to the progression a.d expa.sion of bra.n injury in neurologica. emergencies such a. stroke a.d tra.ma.ic bra.n *** these pa.hwa.s co uld highlight new thera.eutic ta.gets to mitiga.e bra.n injury.

关键词： cell swelling N-methyl-D-a.pa.ta.e receptor non-excita.ory a.ino a.ids stroke syna.tic tra.smission

Bohm’s a.proa.h to qua.tum mecha.ics: a.terna.ive theory or pra.tica. picture?

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Frontiers of physics 2019年第1期14卷 75-89页

作者： a. s. sa.z Depa.tment of Optics Faculty of Physical Sciences Universidad Complutense de Madrid Pza. Ciencias 1 Ciudad Universitaria E-28040 Madrid Spain

since its inception Bohmia. mecha.ics ha. been genera.ly rega.ded a. a.hidden-va.ia.le theory a.med a. providing a. objective description of qua.tum phenomena. To da.e, this ra.her na.row conception of Bohm’s proposa. ha. ca.sed it more rejection tha. a.cepta.ce. Now, a.ter 65 yea.s of Bohmia. mecha.ics, should still be such a. interpreta.iona. a.pect the preva.ling a.pra.sa.? Why not fa.oring a.more pra.ma.ic view, a. a.legitima.e picture of qua.tum mecha.ics, on equa. footing in a.l respects with a.y other more conventiona. qua.tum picture? These questions a.e used here to introduce a.discussion on a. a.terna.ive wa. to dea. with Bohmia. mecha.ics a. present, enha.cing its a.pect a. a. efficient a.d useful picture or formula.ion to ta.kle, explore, describe a.d expla.n qua.tum phenomena.where pha.e a.d correla.ion (enta.glement) a.e key elements. This discussion is presented through two complementa.y blocks. The first block is a.med a. briefly revisiting the historica. context tha. ga.e rise to the a.pea.a.ce of Bohmia. mecha.ics, a.d how this a.proa.h or a.a.ogous ones ha.e been used in different physica. contexts. This discussion is used to empha.ize a.more pra.ma.ic view to the detriment of the more conventiona. hidden-va.ia.le (ontologica.) a.proa.h tha. ha. been a.leitmotif within the qua.tum founda.ions. The second block focuses on some pa.ticula. forma. a.pects of Bohmia. mecha.ics supporting the view presented here, with specia. empha.is on the physica. mea.ing of the loca. pha.e field a.d the a.socia.ed velocity field encoded within the wa.e function. a. a. illustra.ion, a.simple model of Young’s two-slit experiment is considered. The simplicity of this model a.lows to understa.d in a. ea.y ma.ner how the informa.ion conveyed by the Bohmia. formula.ion rela.es to other more conventiona. concepts in qua.tum mecha.ics. This sort of peda.ogica. a.plica.ion is a.so a.med a. showing the potentia. interest to introduce Bohmia. mecha.ics in undergra.ua.e qua.tum

关键词： Bohmia. mecha.ics qua.tum pha.e velocity field interference Young’s two-slit experiment

Field a.d reverse field solitons in wa.eopera.or nonlinea. schrödinger equa.ion with spa.e-time reverse: Modula.ion insta.ility

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Communica.ions in Theoretica. Physics 2023年第6期75卷 39-50页

作者： H I a.del-Ga.a. Ma.hema.ics Depa.tment Fa.ulty of science Ca.ro University GizaEgypt

The wa.e-opera.or nonlinea. schrödinger equa.ion wa. introduced in the ***,nonloca. spa.e-time reverse complex field equa.ions were a.so recently *** in this a.ea.were focused on employing the inverse sca.tering method a.d Da.boux ***,we present a. a.proa.h to find the solutions of the wa.e-opera.or nonlinea. schrödinger equa.ion with spa.e a.d time reverse(W-O-NLsE-sTR).It is ba.ed on implementing the unified method together with introducing a.conventiona. formula.ion of the ***,a.field a.d a.reverse field ma. be ***,for deriving the solutions of W-O-NLsE-sTR,it is evident to distinguish two ca.es(when the field a.d its reverse a.e intera.tive or not-intera.tive).In the non-intera.tive a.d intera.tive ca.es,exa.t a.d a.proxima.e solutions a.e *** both ca.es,the solutions a.e eva.ua.ed numerica.ly a.d they a.e displa.ed *** is observed tha. the field exhibits solitons propa.a.ing essentia.ly(or ma.nly)on the nega.ive spa.e va.ia.le,while those of the reverse field propa.a.e on the other side(or vice versa..These results a.e completely novel,a.d we think tha. it is a. essentia. beha.ior tha. cha.a.terizes a.complex field system with *** the other ha.d,they ma. exhibit right a.d left ca.le pa.terns(or vice versa..It is found tha. the solutions of the field a.d its reverse exhibit self-pha.e modula.ion by solita.y *** the intera.tive ca.e,the pulses of the field a.d its reverse propa.a.e in the whole *** a.a.ysis of modula.ion sta.ility shows tha.,when the field is sta.le,its reverse is unsta.le or both a.e *** holds whenever the pola.iza.ion of the medium is selfdefocusing.

关键词： wa.e-opera.or nonlinea. schrödinger equa.ion spa.e-time reverse unified method

Utiliza.ion of Ma.well-Ca.ta.eo la. for MHD swirling flow through oscilla.ory disk subject to porous medium

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a.plied Ma.hema.ics a.d Mecha.ics(English Edition) 2019年第6期40卷 837-850页

作者： a. Ra.F Z. a.Ba. s. a. sHEHZa. Depa.tment of Ma.hema.ics The Islamia University of BahawalpurBahawalpur 63100Pakistan Depa.tment of Ma.hema.ics COMSATS University IslamabadSahiwal 57000Pakistan

The present study a.ms to investiga.e the sa.ient fea.ures of incompressible, hydroma.netic, three-dimensiona. flow of viscous fluid subject to the oscilla.ory motion of a.disk. The rota.ing disk is conta.ned in a.porous medium. Furthermore, a.time-inva.ia.t version of the Ma.well-Ca.ta.eo la. is implemented in the energy equa.ion. The flow problem is norma.ized by obta.ning simila.ity va.ia.les. The resulting nonlinea. system is solved numerica.ly using the successive over-rela.a.ion method. The ma.n results a.e discussed through gra.hica. representa.ions a.d ta.les. It is perceived tha. the therma. rela.a.ion time pa.a.eter decrea.es the tempera.ure curves a.d increa.es the hea. tra.s- fer ra.e. The oscilla.ory curves for the velocity field demonstra.e a.decrea.ing tendency with the increa.ing porosity pa.a.eter va.ues. Two- a.d three-dimensiona. flow phenom- ena.a.e a.so shown through gra.hica. results.

关键词： time-dependent flow oscilla.ory disk porous medium ma.netohydrody-na.ic (MHD) Ma.well-Ca.ta.eo la. numerica. solution

Ion-a.oustic shock Wa.es in Nonextensive Electron-Positron-Ion Pla.ma

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Chinese Physics Letters 2015年第1期32卷 95-99页

作者： M. Ferdousi s. Ya.min s. a.hra. a. a. Ma.un Depa.tment of Physics dahangirnagar University Savar Dhaka-1342 Bangladesh Depa.tment of Physics International University of Business Agriculture and Technology Uttara Dhaka Bangladesh

a.rigorous theoretica. investiga.ion is ma.e of ion-a.oustic shock structures in a. unma.netized three-component pla.ma.whose constituents a.e nonextensive electrons, nonextensive positrons, a.d inertia. ions. The Burgers equa.ion is derived by employing the reductive perturba.ion method. The effects of electron a.d positron nonextensivity a.d ion kinema.ic viscosity on the properties of these ion-a.oustic shock wa.es a.e briefly discussed. It is found tha. shock wa.es with positive a.d nega.ive potentia.s a.e obta.ned to depend on the pla.ma.pa.a.eters. The enta.lment of our results ma. be useful to understa.d some a.trophysica. a.d cosmologica. scena.ios including stella. polytropes, ha.ronic ma.ter a.d qua.k-gluon pla.ma. protoneutron sta.s, da.k-ma.ter ha.os, etc., where effects of nonextensivity ca. pla. significa.t roles.

关键词： Ion-a.oustic shock Wa.es in Nonextensive Electron-Positron-Ion Pla.ma

Effect of solid solution supersa.ura.ion on Precipita.ion of γ′ in Ra.idly Quenched Ni-a. Bina.y a.loys

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Journa. of Ma.eria.s science & Technology 2009年第1期25卷 130-134页

作者： a. sa.a.i a. a.dolla.-za.eh s. Behrouzgha.mi s.H. Ra.a.i Depa.tment of Ma.eria.s Engineering Tarbiat Modarres University P.O. Box 14115-143 Tehran Iran Depa.tment of Ma.eria.s a.d Meta.lurgica. Engineering Iran University of Science and Technology (IUST) Narmak#16846 Tehran Iran

The effect of solid solution supersa.ura.ion on the precipita.ion of γ＇ in ra.idly quenched Ni-a. bina.y a.loys conta.ning 11.6, 14.2 a.d 16.5 a.. pct a. wa. investiga.ed. The sa.ples were solutioned a. 1250℃, quenched in iced brine, a.d then a.a.yzed by electron microscopy a.d XRD （X-ra. diffra.tion） techniques. In Ni-11.6 a.. pct a. a.loy, ordering a.d pha.e sepa.a.ion took pla.e simulta.eously, resulting in a.uniform distribution of γ＇. a.tra.sition from uniform to bimoda. γ＇ pha.e distribution occurred in the composition ra.ge between 14.2 a.d 16.5 a.. pct a.. This tra.sition wa. a.compa.ied by cha.ges in the morphology of γ＇ precipita.es. The microstructura. observa.ions were discussed in view of both kinetics a.d crysta.logra.hic considera.ions.

关键词： Ni-a. system Hea. trea.ment γ' precipita.ion La.tice misma.ch