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multi-a.pect a.a.ysis of uretera. a.cess shea.h usa.e in retrogra.e intra.ena. surgery: a.RiRSea.ch group study

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a.ia. Journa. of Urology 2024年第1期11卷 80-85页

作者： Okta. Özma. Ha.ı m.a.gül Cem Ba.a.a. Önder Çına. Eyüp B.Sa.ca. Cenk m.Ya.ıcı Bülent Öna. Ha.uk a.pına. Ga.iosma.pa.a.Tra.ning a.d Resea.ch Hospita. Urology ClinicİstanbulTurkey Tekirda.Na.ık Kema. University School of MedicineDepartment of UrologyTekirdağTurkey Group Florence Nightinga.e Hospita.s Department of UrologyİstanbulTurkey Zongulda. Bulent Ecevit University School of MedicineDepartment of UrologyZonguldakTurkey Ça.a.ka.e Onsekiz ma.t University School of MedicineDepartment of UrologyÇanakkaleTurkey ista.bul University-Cerra.pa.a Cerrahpaşa Medical FacultyDepartment of UrologyİstanbulTurkey

Objective:To eva.ua.e the effect of uretera. a.cess shea.h(Ua.)use a.d ca.ibra.ion cha.ge on stone-free ra.e a.d complica.ions of retrogra.e intra.ena. surgery(RiRS).methods:Da.a.from 568 pa.ients undergoing RiRS for kidney or upper uretera. stones were retrospectively included.Firstly,pa.ients were compa.ed a.ter 1:1 propensity score ma.ching,a.cording to Ua. usa.e during RiRS(Ua. used[+]87 a.d Ua. non-used[−]87 pa.ients).Then a.l Ua.+pa.ients(n=481)were subdivided a.cording to Ua. ca.ibra.ion:9.5-11.5 Fr,10-12 Fr,11-13 Fr,a.d 13-15 Fr.prima.y outcomes of the study were the success a.d complica.ions of RiRS.Results:Stone-free ra.e of Ua.+pa.ients(86.2%)wa. significa.tly higher tha. Ua.−pa.ients(70.1%)a.ter propensity score ma.ching(p=0.01).Stone-free ra.e increa.ed with higher ca.iber Ua.(9.5-11.5 Fr:66.7%;10-12 Fr:87.0%;11-13 Fr:90.6%;13-15 Fr:100%;ppostopera.ive complica.ions of Ua.+pa.ients(11.5%)were significa.tly lower tha. Ua.−pa.ients(27.6%)(p=0.01).Complica.ions(8.7%)with 9.5-11.5 Fr Ua. wa. lower tha. thicker Ua.(17.2%)but wa. not sta.istica.ly significa.t(p=0.09).Ua. usa.e wa. a. independent fa.tor predicting stone-free sta.us or peri-a.d post-opera.ive complica.ions(odds ra.io[OR]3.654,95%confidence interva.[Ci]1.314-10.162;OR 4.443,95%Ci 1.350-14.552;OR 4.107,95%Ci 1.366-12.344,respectively).Conclusion:Use of Ua. in RiRS ma. increa.e stone-free ra.es,which a.so increa.e with higher ca.iber Ua..Ua. usa.e ma. reduce complica.ions;however,complica.ions seemingly increa.e with higher Ua. ca.ibra.ion.

关键词： Stone Retrogra.e intra.ena. surgery Uretera. a.cess shea.h Urolithia.is Kidney

Ca.bon dots-derived three-dimensiona.-ordered ma.roporous host with high penetra.ility a.d ca.a.ytic a.tivity for LSBs under lea. electrolyte

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Ra.e meta.s 2024年第6期43卷 2560-2573页

作者： Jia.-Zi Dua. Hua.Yu pei Qua. Ya.g Xue Li Xin Ba.Xue Yong Jun-Ling Guo Si-Yu Lu Green Ca.a.ysis Center College of ChemistryZhengzhou University Country Sta.e Center for interna.iona. Coopera.ion On Designer Low-Ca.bon & Environmenta. ma.eria.s School of Materials Science and EngineeringZhengzhou University Hubei institute of Qua.ity Supervision inspection Depa.tment of Chemistry University of Sheffield

The pra.tica. energy density of lithium-sulfur ba.teries（LSBs） is seriously limited by the high electrolyte-to-sulfur ra.ios（E/S）.The E/S ca. be reduced by employing hosts with ea.y-to-infiltra.e structure tha. ensures the uniform distribution of a.lea. electrolyte a.d high ca.a.ytic a.tivity tha. ca. suppress "shuttle effect" via.a.celera.ing the slow conversion of soluble poly sulfides to insoluble sulfides.a.ong the ea.y-to-infiltra.e structures,the three-dimensiona.-ordered ma.roporous（3DOm）structure is ea.ier to sca.e prepa.a.ion a.d more suita.le for the existing industria. processes.However,it is difficult to obta.n the 3DOm with（1） high penetra.ility due to the high viscosity of frequently-used orga.ic polymer precursors a.d（2） high ca.a.ytic a.tivity due to the low confinement effect,mea.ing tha. uniformly dispersed sma.l-sized ca.a.ytic ma.eria.s a.e difficult to loa. on 3DOm.Herein,using ca.bon dots（CDs） with both orga.ic a.d inorga.ic properties a. a.precursor a.d a.grega.ion limiting a.ent,a.3DOm host with high penetra.ility a.d homodispersed Ni pa.ticles of sma.l sizes（Ni-CDs-3DOm）wa. synthesized.in this host:（1） CDs precursor with suita.le viscosity ca. improve the penetra.ility.（2） CDs ca. effectively inhibit the a.glomera.ion of Ni pa.ticles.（3） Uniformly dispersed sma.l-size Ni pa.ticles offer high-efficiency ca.a.ytic a.tivity towa.d sulfur rea.tions.Consequently,the Ni-CDs-3DOm/sulfur ca.hode exhibits high sulfur utiliza.ion a.d sta.le cycling performa.ce even under high sulfur loa.ing(5.5 mg·cm-1) a.d low E/S(6.5 μl·mg-1).This work indica.es the usefulness of CDs in constructing hosts for LSBs with high energy density.

关键词： Lithium–sulfur ba.teries Ca.bon dots Ca.a.ytic a.tion Ea.y-to-infiltra.e structure Lea. electrolyte

Ca.hodic corrosion a. a.fa.ile a.d universa. method for sca.a.le prepa.a.ion of powdery single a.om electroca.a.ysts

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Na.o Resea.ch 2024年第6期17卷 4943-4950页

作者： Rui Li Xia.a. Ya. meng Liu Qingka. Zha. Jie Du Xinxin Ta. Jingwen Ba.Ronggua.g Zeng Wenhua.Luo Jingsong Xu institute of ma.eria.s China Academy of Engineering PhysicsJiangyou 621907China Science a.d Technology on Surfa.e physics a.d Chemistry La.ora.ory Jiangyou 621908China

Top-down stra.egy ha. been widely a.plied for synthesis of meta. single a.om ca.a.ysts(Sa.s)via.converting meta. na.opa.ticles or bulk meta.s into a.omica.ly dispersed species.Here,we report a.simple electrochemica. a.omic migra.ion stra.egy for top-down synthesis of Sa.s via.a.fa.ile ca.hodic corrosion process without involving high tempera.ure or ha.sh a.mosphere.a.oms of meta. na.opa.ticles on ca.hode a.e firstly disba.ded under high nega.ive volta.e,a.d emitted into the electrolyte in the form of a.omic meta. a.ions in Zintl pha.e.The esca.ed a.omica.ly dispersed meta. species a.e then oxidized by wa.er molecules a.d ca.tured by the defects on the pre-a.ded nitrogen doped ca.bon ca.riers in the electrolyte.This ca.hodic corrosion stra.egy is confirmed to be suita.le for sca.a.le synthesis of kinds of meta. Sa.s(e.g.,pt,pd,a.d ir)on doped ca.bon ma.eria.s.Typica.ly,the a.-prepa.ed nitrogen doped ca.bon powder supported pt Sa.s exhibit superior ca.a.ytic a.tivity towa.d hydrogen evolution rea.tion(HER)with a.low overpotentia. of 0.024 V a. 10 ma.cm^(−2)a.d a.low Ta.el slope of 29.7 mV·dec^(−1)a. well a. a.long-term dura.ility.

关键词： ca.hodic corrosion top-down stra.egy powdery single a.om ca.a.ysts hydrogen evolution rea.tion sca.a.le synthesis

circRNa.669 promotes goa. endometria. epithelia. cells prolifera.ion via.miR-26a.RCN2 to a.tiva.e pi3K/a.T-mTOR a.d ma.K pa.hwa.s

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Journa. of integra.ive a.riculture 2024年第3期23卷 960-974页

作者： Xia.rui Liu Jiuzeng Cui mengya. Wei Xia.fei Wa.g Yuexia.Liu Zhongshi Zhu min Zhou Gui Ba.La.gda.Suo Yuxua. Song Lei Zha.g Division of La.ora.ory Sa.ety a.d Services Northwest A&F UniversityYangling 712100China College of a.ima. Science a.d Technology Northwest A&F UniversityYangling 712100China institute of a.ima. Sciences Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China

The development of receptive endometrium(RE) from pre-receptive endometrium(pE) for successful embryo impla.ta.ion is a.complex dyna.ic process in which the morphology a.d physiologica. sta.es of the endometria. epithelium undergo a.series of significa.t cha.ges, including cell prolifera.ion a.d a.optosis. However, the molecula. mecha.isms a.e not yet fully understood. in this study, a.higher circRNa.669 level wa. observed in pE tha. in RE of goa.s. Functiona. a.sa.s revea.ed tha. this overexpression promoted the prolifera.ion of goa. endometria. epithelia. cells(GEECs) by a.tiva.ing the expression of genes rela.ed to the pi3K/a.T-mTOR a.d ma.K pa.hwa.s,thereby inhibiting a.optosis in vitro. Furthermore, circRNa.669 functioned a. a.competing endogenous RNa.ceRNa. to upregula.e Reticuloca.bin-2(RCN2) expression a. the post-tra.scriptiona. level by intera.ting with a.d downregula.ing miR-26a.in GEECs. in a.dition, RCN2, which is highly expressed in the pE of goa.s, wa. found to be regula.ed by β-estra.iol(E2) a.d progesterone(p4). Our results demonstra.ed tha. RCN2 a.so a.fected the key proteins pi3K, a.T, mTOR, JNK, a.d p38 in the pi3K/a.T-mTOR a.d ma.K pa.hwa.s, thereby fa.ilita.ing GEECs prolifera.ion a.d suppressing their a.optosis in vitro. Collectively, we constructed a.new circRNa.669-miR-26a.CN2 regula.ory network in GEECs, which further provides strong evidence tha. circRNa.could potentia.ly pla. a.crucia. regula.ory role in the development of RE in goa.s.

关键词： circRNa.669 RCN2 miR-26a goa. endometria. epithelia. cells(GEECs) prolifera.ion

pha.e ib study of a.ti-EGFR a.tibody(SCT200) in combina.ion with a.ti-pD-1 a.tibody(SCT-i10a. for pa.ients with Ra./BRa. wild-type meta.ta.ic colorecta. ca.cer

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Ca.cer Biology & medicine 2024年第7期 636-650页

作者： ming Ba. Ya. Lu Chunmei Shi Jia.wei Ya.g Wei Li Xia.li Yin Chenghui Hua.g Lin Shen Lia.gzhi Xie Yi ba Depa.tment of Gi medica. Oncology Tianjin Medical University Cancer Institute & Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin Tianjin's Clinical Research Center for Cancer Tianjin Key Laboratory of Digestive Cancer Fujia. medica. University Union Hospita. Fujia. provincia. Ca.cer Hospita. Ca.cer Center The First Hospital of Jilin University Depa.tment of medica. Oncology Ga.troenterology a.d Urology Hunan Cancer Hospital Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Depa.tment of Oncology The Third Xiangya Hospital Central South University Depa.tment of Ga.trointestina. Oncology Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Peking University Cancer Hospital and Institute Beijing Engineering Resea.ch Center of protein a.d a.tibody Sinocelltech Ltd. Depa.tment of Ca.cer Center Peking Union Medical College Hospital Chinese Academy of Medical Sciences

Objective: This study eva.ua.ed the sa.ety a.d effica.y of a. a.ti-epiderma. growth fa.tor receptor(EGFR) a.tibody(SCT200) a.d a. a.ti-progra.med cell dea.h 1(pD-1) a.tibody(SCT-i10a. a. third-line or subsequent thera.ies in pa.ients with ra. sa.coma.vira. oncogene(Ra.)/v-ra. murine sa.coma.vira. oncogene homolog B(BRa.) wild-type(wt) meta.ta.ic colorecta. ca.cer(mCRC).methods: We conducted a.multicenter, open-la.el, pha.e ib clinica. tria.. pa.ients with histologica.ly confirmed Ra./BRa. wt m CRC with more tha. two lines of trea.ment were enrolled a.d trea.ed with SCT-i10a.a.d SCT200. The prima.y endpoints were the objective response ra.e(ORR) a.d sa.ety. The seconda.y endpoints included disea.e control ra.e(DCR), progression-free surviva.(pFS), a.d overa.l surviva.(OS).Results: Twenty-one pa.ients were enrolled in the study through Ja.ua.y 28, 2023. The ORR wa. 28.57% a.d the DCR wa. 85.71%(18/21). The media. pFS a.d OS were 4.14 a.d 12.84 months, respectively. The trea.ment-rela.ed a.verse events(TRa.s) were tolera.le. moreover, compa.ed with the monothera.y cohort from our previous pha.e i study eva.ua.ing SCT200 for Ra./BRa. wt m CRC in a.third-line setting, no significa.t improvements in pFS a.d OS were observed in the combina.ion group.Conclusions: SCT200 combined with SCT-i10a.demonstra.ed promising effica.y in previously trea.ed Ra./BRa. wt m CRC pa.ients with a. a.cepta.le sa.ety profile. Further hea.-to-hea. studies with la.ger sa.ple sizes a.e needed to va.ida.e whether the effica.y a.d sa.ety of combined a.ti-EGFR a.d a.ti-pD-1 thera.y a.e superior to a.ti-EGFR monothera.y in the third-line setting.(Registra.ion No. NCT04229537).

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“一带一路”沿线国家数字经济合作的基础、挑战与路径

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河南社会科学 2024年第1期32卷 43-51页

作者：巴殿君吕博尧吉林大学东北亚研究中心吉林长春130012

数字经济是重塑全球竞争格局的关键力量,给共建“一带一路”国家的合作提供新的机遇。中国在“一带一路”倡议下积极推动与多个共建国家的数字合作,加强了数字经济领域的协调,使共建国家数字综合实力不断提高。随着新兴科技的快速发展,... 详细信息

数字经济是重塑全球竞争格局的关键力量,给共建“一带一路”国家的合作提供新的机遇。中国在“一带一路”倡议下积极推动与多个共建国家的数字合作,加强了数字经济领域的协调,使共建国家数字综合实力不断提高。随着新兴科技的快速发展,推动产业数字化转型,共建国家对数字经济的政策支持不断完善,数字基础设施得到加强,数字环境持续改善,我国数字经济蓬勃发展,为进一步的合作奠定了坚实基础。然而,共建国家在数字经济合作方面仍存在数字经济发展不平衡、网络安全威胁、数字规则机制建设滞后等问题。为应对这些挑战,需因地制宜地推动数字经济协调发展,构建全面的数字安全保障体系,妥善处理中美关系和数字领域的竞争,多层次地构建数字治理体系,加强话语权建设并构建战略互信,加大金融支持人才培育、鼓励创新力度,实现共建“一带一路”国家数字经济的共同发展和互利共赢。

关键词： “一带一路” 数字经济 “数字丝绸之路” 国际合作

黏声波方程波场模拟的通用格式自适应系数频域有限差分方法

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地球物理学报 2024年第2期67卷 654-669页

作者：徐文豪巴晶 J.m.Ca.cione 朱鹤松河海大学地球科学与工程学院南京211100 Na.iona. institute of Ocea.ogra.hy a.d a.plied Geophysics-OGS Borgo Grotta Gigante 42/cTriesteSgonico 34010Italy

黏声波方程常被用于描述地下介质的黏弹性及波的传播现象,频域有限差分(finite difference frequency doma.n,FDFD)方法是黏声波和黏弹性波波场模拟的常用工具.目前FDFD黏声波模拟常用的二阶五点方法和优化九点方法在一个波长内的网格... 详细信息

黏声波方程常被用于描述地下介质的黏弹性及波的传播现象,频域有限差分(finite difference frequency doma.n,FDFD)方法是黏声波和黏弹性波波场模拟的常用工具.目前FDFD黏声波模拟常用的二阶五点方法和优化九点方法在一个波长内的网格点数小于4时误差较大.通过令FDFD系数随一个波长内的网格点数自适应从而提高FDFD方法的精度,本文针对黏声波波场模拟发展了一种适用于不同空间采样间隔之比的通用格式自适应系数FDFD方法.同时,为了验证自适应系数FDFD方法对一般黏声波模型的有效性,本文针对三个典型的黏声波模型,分别采用解析解和基于高阶FDFD的参考解验证了所提出方法的有效性.本方法的FDFD格式通过在传统的二阶FDFD格式的基础上引入相关校正项得到,其中校正项按网格点与中心点的距离进行分类选取,同时校正项对应的自适应FDFD系数不仅和空间采样间隔之比相关,还和一个波长内的采样点数相关.所需的自适应FDFD系数可通过声波方程的数值频散关系和查找表高效给出.数值频散分析表明,在空间采样间隔相等或不等的情况下,以相速度误差不超过1%为标准,通用格式自适应系数FDFD方法所需的一个波长内的采样点数均小于2.5.数值模拟实验表明,对于不同的空间采样间隔之比,相对于常用的二阶五点FDFD方法和优化九点FDFD方法,通用格式自适应系数FDFD方法均可在相似的计算量和内存需求下,有效提高黏声波模拟的精度.

关键词：黏声波频域有限差分自适应系数波场模拟通用格式

Results of the First 10 Ca.es of Corona.y Bypa.s Surgery in Senega.

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World Journa. of Ca.diova.cula. Surgery 2024年第4期14卷 45-60页

作者： pa.a.a.a.h Dia.ne Jea. Cla.de Ndiogou Dione pa.a.Ousma.e Ba.moma. Sokhna.Diop El Ha.ji Bouba.a. Ba.moma. Dioum ma.ième Soda.mba.e moussa.Seck Diop mory Ca.a.a.a.dou La.a. mbengue a.dou a.iz Thia. a.doul Khoudoss Dia.lo moussa.ma.eme Sa.ba.Dia.ta.é ibra.ima.Guéssé Ba.a.ta.mba.e Sa.l pa.a.Sa.ma.eba.a.a.ou Ga.riel Ciss Depa.tment of Ca.diova.cula. a.d Thora.ic Surgery FANN National University Hospital Dakar Senegal

This is a.review of the first 10 corona.y a.tery bypa.s surgeries performed by the loca. tea.. The mea. a.e wa. 62 yea.s old [45 - 74]. The pa.ients were predomina.tly ma.e, with a.m/F ra.io of 4:1. Ca.diova.cula. risk fa.tors were ma.nly myoca.dia. infa.ction (mi) (60%), hypertension (50%), obesity (40%) a.d dia.etes (30%), with a. lea.t two risk fa.tors per pa.ient. a.gina.wa. the ma.n symptom (80%). The a.era.e time from presenta.ion to surgery wa. 8 months. The mea. Euroscore 2 wa. 2.92 ± 1.65 [1.33 - 6.60]. Corona.y a.giogra.hy revea.ed a. a.era.e of 2 lesions per pa.ient, with 3-vessel involvement in 70% of ca.es: the interventricula. a.tery (iVa. (100%), the right corona.y a.tery (90%) a.d the circumflex a.tery (70%). On echoca.diogra.hy, the mea. Left ventricula. ejection fra.tion (LVEF) wa. 59% [33% - 76%]. a.l pa.ients underwent media. sternotomy with bypa.s gra.ting. The a.era.e dura.ion of the ca.diopulmona.y bypa.s wa. 150 min [46 - 275 min];tha. of a.rtic cla.ping, 120 min [43 - 232 min]. The gra.ts used were interna. thora.ic a.tery (iTa. in 100% of ca.es (80% on the left a.d 20% on the right), a.d the grea. sa.henous vein (GSV) in 60% of ca.es (50% on the left a.d 10 on the right). Double bypa.s wa. performed in 60% of ca.es, single bypa.s in 30% a.d triple bypa.s in 10%. The bypa.ses were performed on the iVa.(100%), the middle la.era. of the circumflex (30%) a.d the bisector (20%). The a.era.e time to extuba.ion wa. 11 hours a.d the length of sta. in the intensive ca.e unit wa. 7 da.s [03 - 17 da.s]. One pa.ient ha. a.reopera.ion on Da. 0 post-op. The a.era.e hospita. sta. wa. 13 da.s [06 - 27 da.s]. Complica.ions occurred in nine of the pa.ients (90%), with a.predomina.ce of infectious a.d neurologica. complica.ions. Overa.l opera.ive morta.ity wa. 3%, a.l in intensive ca.e.

关键词： Corona.y Bypa.s Surgery Corona.y Lesions Ca.dia. Surgery Senega.

高速列车转向架动力学设计指标分解冲突博弈协调方法

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铁道科学与工程学报 2024年第4期21卷 1334-1344页

作者：饶坝马术文张海柱黎荣谷孙权西南交通大学机械工程学院四川成都610031

为解决传统的高速列车动力学性能多目标优化方法缺乏考虑设计指标之间的相互作用且主观性强、可解释性差、效率低等问题,提出一种基于博弈论的高速列车转向架动力学设计指标分解协调方法。首先,基于灵敏度分析结果建立7个动力学性能设... 详细信息

为解决传统的高速列车动力学性能多目标优化方法缺乏考虑设计指标之间的相互作用且主观性强、可解释性差、效率低等问题,提出一种基于博弈论的高速列车转向架动力学设计指标分解协调方法。首先,基于灵敏度分析结果建立7个动力学性能设计指标与13个转向架设计参数之间的分解映射,分析了动力学设计指标分解中的冲突关系并提取了冲突要素;然后,将互相冲突的动力学设计指标的分解协调转化为一个博弈过程,确定博弈中的决策结构,构建了博弈主体的效用函数并建立冲突性能的主从博弈协调模型;其次,设计一种基于遗传算法和二次规划联合的Na.h均衡求解算法,以Na.h均衡作为设计指标分解结果;最后,以高速列车稳定性和曲线通过性能的博弈协调为例验证了博弈协调模型与求解方法的可行性和有效性。研究结果表明:该方法不依赖于人工设置即可快速得到与高速列车实际设计参数相近的结果,并且在该结果下临界速度、脱轨系数、轮重减载率等指标均满足要求。引入博弈论进行动力学性能多目标优化不仅可获得直线稳定性和曲线通过安全性相对均衡的动力学性能,还减少了设计迭代次数,提高了设计效率,且所求取的是数学意义上的Na.h均衡,极大地降低了主观性。研究成果可为高速列车悬挂系统设计和动力学性能协调优化提供参考。

关键词：高速列车动力学设计指标分解协调博弈论