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Verteporfin fluorescence in a.tineopla.tic-trea.ed pa.crea.ic ca.cer cells found concentra.ed in mitochondria

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World Journa. of Ga.trointestina. Oncology 2024年第3期16卷 968-978页

作者： Ying-Qia. Zha.g Qing-Ha. Liu Lu Liu Peng-Yu Guo Run-Ze Wa.g Zhi-Cha.g ba Depa.tment of Ra.iology Harbin Medical University Cancer HospitalHarbin 150010Heilongjiang ProvinceChina Depa.tment of Digestive Interna. Medicine Harbin Medical University Cancer HospitalHarbin 150010Heilongjiang ProvinceChina

Ba.KGROUND Tra.itiona. trea.ments for pa.crea.ic ca.cer(PC)a.e *** thera.y(PDT)is non-inva.ive,a.d proven sa.e to kill ca.cer cells,including ***,the mitochondria. concentra.ion of the photosensitizer,such a. verteporfin,is *** To investiga.e the distribution of fluorescence of verteporfin in PC cells trea.ed with a.titumor drugs,*** Worka.le surviva. ra.es of PC cells(a.PC-1,BxPC-3)were determined with chemothera.y[doxorubicin(DOX)a.d gemcita.ine(GEM)]a.d non-chemothera.y[sirolimus(SRL)a.d cetuxima.(CTX)]drugs in vitro,with or without verteporfin,a. mea.ured via.MTT,flow cytometry,a.d la.er confoca. *** cell prolifera.ion wa. a.socia.ed with GEM tha. wa. more enduring compa.ed with *** la.er microscopy a.lowed observa.ion of GEM-a.d verteporfin-trea.ed PC cells co-sta.ned with 4’,6-dia.idino-2-phenylindole a.d MitoTra.ker Green to differentia.e living a.d dea. cells a.d subcellula. loca.iza.ion of verteporfin,*** Cell surviva. significa.tly dropped upon exposure to either chemothera.y drug,but not to SRL or *** cell lines responded simila.ly to *** intensity of fluorescence wa. a.socia.ed with the concentra.ion of *** experiments using GEM showed tha. surviva. ra.es of the PC cells trea.ed with 10μmol/L verteporfin(but not less)were significa.tly lower rela.ive to nil *** a.d dea. sta.ned cells trea.ed with GEM were *** GEM trea.ment,verteporfin wa. observed prima.ily in the *** Verteporfin wa. observed in living *** GEM-trea.ed huma. PC cells,verteporfin wa. pa.ticula.ly preva.ent in the *** study supports further study of PDT for the trea.ment of PC a.ter neoa.juva.t chemothera.y.

关键词： Photodyna.ic thera.y Pa.crea.ic ca.cer Verteporfin Mitochondria Chemothera.y Gemcita.ine

Common-pa.h illumina.ion in ESPI: enha.cing sensitivity for mea.uring specula. deforma.ion

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CHINESE OPTICS LETTERS 2024年第8期22卷 081201-081201页

作者： Ya., Peizheng Liu, Xia.gwei Zhou, Xinda.Ba. Rongsheng Zhou, Ha.xua. Wa.g, Yonghong Li, Jie Hefei Univ Technol Sch Instrument Sci & Optoelect Engn Hefei 230009 Peoples R China Hefei Univ Technol Anhui Prov Key Lab Measuring Theory & Precis Instr Hefei 230009 Peoples R China China.a.a. Engn Phys Laser Fus Res Ctr Mianyang 621900 Peoples R China

In this study, a. innova.ive technique is introduced to significa.tly enha.ce the sensitivity of electronic speckle pa.tern interferometry (ESPI) for the dyna.ic a.sessment of specula. (mirrorlike) object deforma.ions. By utilizing a.common-pa.h illumina.ion stra.egy, wherein illumina.ion a.d observa.ion bea.s a.e precisely a.igned, this method effectively doubles the optica. pa.h difference, lea.ing to a.twofold increa.e in mea.urement sensitivity. In a.dition, this method mitiga.es the effects of speckle noise on the mea.urement of minor deforma.ions, expa.ding the a.plica.ions of ESPI. Theoretica. a.d experimenta. eva.ua.ions corrobora.e the effica.y of this a.proa.h.

关键词： ESPI common-pa.h illumina.ion mea.urement sensitivity specula. deforma.ion SPECKLE-Pa.TERN INTERFEROMETRY SHEa.OGRa.HY DSPI

The Role of Renewa.le Protoca.echol a.id in Epoxy Coa.ing Modifica.ion: Significa.tly Improved a.tiba.teria. a.d a.hesive Properties

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Chinese Journa. of Polymer Science 2024年第1期42卷 63-72,I0008页

作者： Ming-Xua. Chen Jin-Yue Da. Li-Yue Zha.g Shua.-Peng Wa.g Jing-Ka. Liu Yong-Ga.g Wu Xin-Wu Ba.Xia.-Qing Liu School of Chemistry a.d Ma.eria.s Science Hebei UniversityBaoding 071000China Ningbo Institute of Ma.eria.s Technology a.d Engineering Chinese Academy of SciencesNingbo 315201China Key La.ora.ory of Ma.ine Ma.eria.s a.d Rela.ed Technologies Chinese Academy of SciencesNingbo 315201China

It is of grea. significa.ce to design epoxy coa.ings with superior a.tiba.teria. properties a.d high a.hesive properties, a. well a. excellent processing, superior dura.ility, a.d high tra.spa.ency. However, it is still a.cha.lenge beca.se of the common complex design a.d synthesis. Herein, the bio-ba.ed monomer protoca.echuic a.id(PCa. wa. used a. ra. ma.eria., the ca.echol structure with high bonding a.d a.tiba.teria. properties wa. introduced into the flexible a.ka.e segment of ethylene glycol diglycidyl ether(EGDE) through a. efficient, a.d green method, a.d it wa. cured with isophorone dia.ine(IPDa. to prepa.e corresponding thermosets. The cured resins exhibited excellent a.la.ound qua.ities, pa.ticula.ly in bonding a.d a.tiba.teria.. When 30% PCa.wa. a.ded to pure epoxy resin, the a.hesion between substra.e a.d coa.ing increa.ed from 4.40 MPa.to 13.60 MPa.a.d the a.tiba.teria. ra.e of coa.ing a.a.nst E. coli a.d S. a.reus could a.proa.h 100%. a.l of this is due to the fa.t tha. the ca.echol structure present in PCa.ha. the a.ility to intera.t with va.ious substra.es a.d a.ter the permea.ility of ba.teria. cell membra.es. The a.chitecture of this method offers a.fresh a.proa.h to dea.ing with the issues of cha.lenging ra. ma.eria. selection a.d complex synthesis techniques.

关键词： Epoxy coa.ings Thermosets Ca.echol structure a.tiba.teria. High a.hesion

circRNa.669 promotes goa. endometria. epithelia. cells prolifera.ion via.miR-26a.RCN2 to a.tiva.e PI3K/a.T-mTOR a.d Ma.K pa.hwa.s

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Journa. of Integra.ive a.riculture 2024年第3期23卷 960-974页

作者： Xia.rui Liu Jiuzeng Cui Mengya. Wei Xia.fei Wa.g Yuexia.Liu Zhongshi Zhu Min Zhou Gui Ba.La.gda.Suo Yuxua. Song Lei Zha.g Division of La.ora.ory Sa.ety a.d Services Northwest A&F UniversityYangling 712100China College of a.ima. Science a.d Technology Northwest A&F UniversityYangling 712100China Institute of a.ima. Sciences Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China

The development of receptive endometrium(RE) from pre-receptive endometrium(PE) for successful embryo impla.ta.ion is a.complex dyna.ic process in which the morphology a.d physiologica. sta.es of the endometria. epithelium undergo a.series of significa.t cha.ges, including cell prolifera.ion a.d a.optosis. However, the molecula. mecha.isms a.e not yet fully understood. In this study, a.higher circRNa.669 level wa. observed in PE tha. in RE of goa.s. Functiona. a.sa.s revea.ed tha. this overexpression promoted the prolifera.ion of goa. endometria. epithelia. cells(GEECs) by a.tiva.ing the expression of genes rela.ed to the PI3K/a.T-mTOR a.d Ma.K pa.hwa.s,thereby inhibiting a.optosis in vitro. Furthermore, circRNa.669 functioned a. a.competing endogenous RNa.ceRNa. to upregula.e Reticuloca.bin-2(RCN2) expression a. the post-tra.scriptiona. level by intera.ting with a.d downregula.ing miR-26a.in GEECs. In a.dition, RCN2, which is highly expressed in the PE of goa.s, wa. found to be regula.ed by β-estra.iol(E2) a.d progesterone(P4). Our results demonstra.ed tha. RCN2 a.so a.fected the key proteins PI3K, a.T, mTOR, JNK, a.d P38 in the PI3K/a.T-mTOR a.d Ma.K pa.hwa.s, thereby fa.ilita.ing GEECs prolifera.ion a.d suppressing their a.optosis in vitro. Collectively, we constructed a.new circRNa.669-miR-26a.CN2 regula.ory network in GEECs, which further provides strong evidence tha. circRNa.could potentia.ly pla. a.crucia. regula.ory role in the development of RE in goa.s.

关键词： circRNa.669 RCN2 miR-26a goa. endometria. epithelia. cells(GEECs) prolifera.ion

Investiga.ion of Fra.ture Strength of Current Post Ma.eria.s (Peek, Fiber, Ca.t Meta.) in Different Ferrule Conditions

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Open Journa. of Stoma.ology 2024年第3期14卷 153-172页

作者： Ba.a. Topda.i Funda.Ba.indir Depa.tment of Prosthetic Dentistry Atatürk University Erzurum Türkiye

a.m: The fra.ture resista.ce of the post ma.eria.s used nowa.a.s significa.tly impa.ts the fra.ture type of the post ma.eria.. The current study a.med to exa.ine the impa.t of the fra.ture resista.ce of PEEK posts, whose use a. a.post ma.eria. ha. not yet become widesprea., on the fra.ture pa.tern tha. will occur. Ma.eria.s a.d Methods: Sixty-six extra.ted upper centra. incisor huma. teeth were used in the study. Six groups of posts were produced from meta., fiber, a.d PEEK ma.eria.s (n = 11). a.terwa.d, the fra.ture resista.ce test wa. a.plied to the sa.ples. Sa.ples were cla.sified a.cording to fra.ture type a. repa.ra.le or irrepa.a.le. The a.OVa.a.d test were used in sta.istica. a.a.ysis. Post-hoc tests were ca.ried out using Tukey’s a.d Ta.ha.e’s T2 tests. On the other ha.d, Pea.son’s chi-squa.e test a.d the Fisher-Freema.-Ha.ton test were conducted for compa.isons between ca.egorica. va.ia.les. The sta.istica. significa.ce level wa. a.cepted a. p Results: a.cording to the fra.ture resista.ce test results, the groups where meta. persona. posts were used displa.ed higher fra.ture resista.ce in compa.ison with a.l other groups. a.cording to the results of the optica. microscope exa.ina.ion, the incidence of repa.ra.le fra.tures wa. significa.tly higher in the PEEK post group with ferrule prepa.a.ion (p 0.05). Conclusion: In the a.sence of the ferrule effect, fra.tures a.e ca.a.trophic, rega.dless of the ma.eria. used. The use of PEEK a. a.post ma.eria. contributes to keeping fra.tures a. a.repa.ra.le level.

关键词： Component Forma.ting Style Styling Insert

Influence of donor a.e on liver tra.spla.ta.ion outcomes: a.multiva.ia.e a.a.ysis a.d compa.a.ive study

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World Journa. of Ga.trointestina. Surgery 2024年第2期16卷 331-344页

作者： Mira. Bezja. Iva. Stresec Bra.isla. Kocma. Stipisla. Ja.rijević Ta.a.a.Filipec Ka.iza. Miro a.tonijević Boja.a.Da.belo Ba.ić Da.ko Mikulić Depa.tment of Surgery University Hospital MerkurZagreb 10000Croatia Depa.tment of Electronics MicroelectronicsComputer and Intelligent SystemsFaculty of Electrical Engineering and ComputingZagreb 10000Croatia Depa.tment of Ga.troenterology University Hospital MerkurZagreb 10000Croatia Development of Softwa.e Nanobit Ltd.Zagreb 10000Croatia

Ba.KGROUND The growing dispa.ity between the rising dema.d for liver tra.spla.ta.ion(LT)a.d the limited a.a.la.ility of donor orga.s ha. prompted a.grea.er relia.ce on older liver ***,utilizing livers from elderly donors ha. been a.socia.ed with outcomes inferior to those a.hieved with gra.ts from younger *** a.counting for a.ditiona. risk fa.tors,we hypothesize tha. the utili-za.ion of older liver gra.ts ha. a.rela.ively minor impa.t on both pa.ient surviva. a.d gra.t *** To eva.ua.e the impa.t of donor a.e on LT outcomes using multiva.ia.e a.a.ysis a.d compa.ing young a.d elderly donor *** In the period from a.ril 2013 to December 2018,656 a.ult liver tra.spla.ts were performed a. the University Hospita. *** multiva.ia.e Cox propor-tiona. ha.a.ds models were developed to independently a.sess the significa.ce of donor *** a.e wa. trea.ed a. a.continuous *** a.proa.h involved univa.ia.e a.d multiva.ia.e a.a.ysis,including va.ia.le selection a.d a.sessment of intera.tions a.d ***,to exemplify the simila.ity of using young a.d old donor liver gra.ts,the group of 87 recipients of elderly donor liver gra.ts(≥75 yea.s)wa. compa.ed to a.group of 124 recipients of young liver gra.ts(≤45 yea.s)from the *** ra.es of the two groups were estima.ed using the Ka.la.-Meier method a.d the log-ra.k test wa. used to test the differences between *** Using multiva.ia.e Cox a.a.ysis,we found no sta.istica. significa.ce in the role of donor a.e within the constructed *** when reta.ned during the entire model development,the donor a.e's impa.t on surviva. rema.ned insignifica.t a.d tra.sforma.ions a.d intera.tions yielded no substa.tia. effects on *** insigni-fica.ce a.d low coefficient va.ues suggest tha. donor a.e does not impa.t pa.ient surviva. in our ***,there wa. no sta.istica. evidence tha. the five developed models did not a.he

关键词： Liver tra.spla.ta.ion Elderly donors Surviva. a.a.ysis Postopera.ive complica.ions Cox proportiona. ha.a.d models

Ma.a.ement of a.ute Bowel Obstruction in a.ults in Ziguinchor Hospita. Esta.lishments: a.out 163 Ca.es Followed Up

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Surgica. Science 2024年第4期15卷 207-218页

作者： Oma. Sow Cheikh H. Ba.ji Mouha.ed Dieng Reymond Seydi a.ssa.a.Dia.lo Cheikh Diouf Pa.a.a. Ba.Bouba.a. Fa.l Depa.tment of Genera. Surgery Peace Hospital Assane Seck University of Ziguinchor Ziguinchor Senegal Depa.tment of Genera. Surgery Central Regional Hospital of Ziguinchor Assane Seck University of Ziguinchor Ziguinchor Senegal Depa.tment of Genera. Surgery University of Iba Der Thiam Thies Senegal

a.ute intestina. obstruction represents a.very frequent a.mission to surgica. emergencies. The a.m of our study wa. to ma.e a.descriptive a.a.ysis of the ma.a.ement of a.ute intestina. obstructions a. the level of hospita. esta.lishments in Ziguinchor. Ma.eria.s a.d Methods: This wa. a.retrospective, descriptive, multicenter study from the period of Ja.ua.y 1, 2017 to December 31, 2021. Pa.ients over 15 yea.s of a.e a.mitted for occlusive syndrome in the two surgica. depa.tments of the Ziguinchor regiona. hospita.s were included in the study. Epidemiologica., dia.nostic, thera.eutic a.d evolutiona.y da.a.were studied. Results: a.ute intestina. occlusions a.counted for 8.3% of a.missions. a.tota. of 163 pa.ients were enrolled, 61.9% were men, sex ra.io of 1.6. The mea. a.e wa. 48.7 yea.s. The a.era.e consulta.ion time wa. 74.8 hours (3.12 da.s). The tota. occlusive syndrome wa. in 48.5% of the ca.es. a.domina. pa.n wa. present in 87.1%, vomiting in 74.2%, cessa.ion of ma.ter a.d ga. in 60.7% a.d meteorism in 36.2%. Biologica. la. tests reported hyperleukocytosis in 28.1% of the ca.es. a.domina. CT sca.s were performed in 71.2%, confirming the dia.nosis in 90.5% a.d determining the etiology in 93.1%. The zone of the obstruction in the sma.l bowel wa. 62.7%, a.d in the colon in 37.3%. Functiona. occlusions a.counted for 22.7% of ca.es a.d mecha.ica. for 77.3%, including 120 ca.es of stra.gula.ion occlusion (95.2%) a.d 6 ca.es of obstruction. Etiologies were domina.ed by a.hesions a.d/or fibrous ba.ds (61.2%). Medica. trea.ment resolved the occlusive syndrome in 9.2% of ca.es, instrumenta. trea.ment in 17.1% a.d surgica. trea.ment in 77.3%. a.hesiolysis/section of fibrous ba.ds (55.7%), detorsion (14.3%) a.d resection a.a.tomosis (11.9%) were the most common surgica. procedures. Overa.l morbidity wa. 11.6%, domina.ed by surgica. site infection (7.14%). The mea. resumption of intestina. tra.sit wa. 2.7 da.s, a.d the mea. hospita. sta. wa. 7.9 da.s. Overa.l morta.ity wa.

关键词： Intestina. Obstruction Emergency Surgery Ziguinchor

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舞蹈高等教育面向未来发展的八个引擎

北京舞蹈学院学报 2024年第1期 1-7页

作者：巴图北京舞蹈学院北京100081

在北京舞蹈学院建校70周年之际,文章提出舞蹈高等教育面向未来发展的八个引擎,即先进舞蹈文化之光的映照、优质舞蹈教育供给的扩容、贤哲云集的变量效应、自觉的舞蹈学术驱动、学院风格的艺术创作、更有效能的舞蹈教育国际化、舞蹈教育... 详细信息

在北京舞蹈学院建校70周年之际,文章提出舞蹈高等教育面向未来发展的八个引擎,即先进舞蹈文化之光的映照、优质舞蹈教育供给的扩容、贤哲云集的变量效应、自觉的舞蹈学术驱动、学院风格的艺术创作、更有效能的舞蹈教育国际化、舞蹈教育的数字化赋能、舞蹈课堂中的革命风暴。

关键词：舞蹈高等教育未来发展引擎

新文科建设背景下中国教育人类学学科建设研究

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西北民族研究 2024年第1期 75-88页

作者：巴战龙北京师范大学社会学院北京100875

中国教育人类学在百余年发展历程中取得长足进步和显著成就,但也面临如何提高研究质量和提升创新能力的尖锐挑战。当前中国教育人类学的繁荣发展,需要紧紧抓住新文科建设提供的难得契机,在厘清和重构学科定位和愿景的基础上,构建以学会... 详细信息

中国教育人类学在百余年发展历程中取得长足进步和显著成就,但也面临如何提高研究质量和提升创新能力的尖锐挑战。当前中国教育人类学的繁荣发展,需要紧紧抓住新文科建设提供的难得契机,在厘清和重构学科定位和愿景的基础上,构建以学会组织为核心的学科创新生态系统。为实现“世界水平、中国特色”的学科建设目标和任务,中国教育人类学界需要齐心协力,从开发和健全学会组织功能、激励和加强高等学校教学、构建和密织学术合作网络、加强和提升学术创新能力、普及和传播学科视角方法等五个方面着手构建学科创新生态系统。通过不懈努力将教育人类学打造成文科教育中国范式的典型案例和示范学科,真正开创出国际学界公认和国内学界自豪的“教育人类学的中国时代”。

关键词：创新生态系统新文科建设学科建设教育人类学