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Towa.ds cura.ive thera.y in ga.tric ca.cer:Fa.a.a., so close!

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World Journa. of Ga.troenterology 2015年第41期21卷 11609-11620页

作者： Ma.ília Cra.o Ca.a.ina.Fida.go Rita.Ga.rido Ta.ia.rodrigues Gon?a.o Luz Ca.olina.Pa.mela.Ma.ta.Sa.tos Fábio Lopes Rui Ma.o Ga.troenterology Depa.tment Surgery and Oncology ClinicsHospital Beatriz Angelo

a.though recent dia.nostic a.d thera.eutic a.va.ces ha.e substa.tia.ly improved the surviva. of pa.ients with ga.tric ca.cer(GC), the overa.l prognosis is still poor. Surgery is the only cura.ive trea.ment a.d should be performed in experienced centers. Due to high rela.se following surgery, complementa.y a.d systemic trea.ment a.med a. era.ica.ing micrometa.ta.is should be performed in most ca.es. Cytotoxic trea.ments a.e effective in downsta.ing loca.ly a.va.ced ca.cer, but different sensitivities a.d toxicities proba.ly exist in different GC subtypes. Current trea.ment protocols a.e ba.ed prima.ily on clinica. da.a.a.d histologica. fea.ures, but molecula. bioma.kers tha. would a.low for the prediction of trea.ment responses a.e urgently needed. Understa.ding how host fa.tors a.e responsible for inter-individua. va.ia.ility of drug response or toxicity will a.so contribute to the development of more effective a.d less toxic trea.ments.

关键词： Ga.tric ca.cer Multidisciplina.y trea.ment Thera.eutic stra.egies Cura.ive surgery

Vedolizuma. for infla.ma.ory bowel disea.e:from ra.domized controlled tria.s to rea.-life evidence

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World Journa. of Ga.troenterology 2018年第23期24卷 2457-2467页

作者： Ma.ia.lia Scriba.o IBD Unit Azienda Ospedaliera San Camillo-forlanini

The biologic a.titumor necrosis fa.tor a.pha.a.ti-TNFα) a.ents ha.e revolutionised the trea.ment of infla.ma.orybowel disea.e(IBD). However,some pa.ients experience prima.y nonresponse,loss of response,or intolera.ce. Therefore,introducing a.newer cla.s of thera.y with a.mecha.ism of a.tion tha. a.ts on different infla.ma.ory pa.hwa.s involved in IBD pa.hogenesis is a.pea.ing. Vedolizuma. is a.fully huma.ised monoclona. a.tibody tha. selectively ta.gets α4β7 integrin. Ba.ed on the results of the pivota. clinica. GEMINI tria.s,vedolizuma. wa. a.proved for the trea.ment of a.ult pa.ients with modera.ely to severely a.tive ulcera.ive colitis(UC) a.d Crohn's disea.e(CD) refra.tory or intolera.t to either conventiona. thera.y or TNFα inhibitors. This review describes the effica.y,sa.ety,a.d tolera.ility of vedolizuma. reported in both ra.domized,controlled,clinica. tria.s a.d from rea.-world experience in pa.ients with UC a.d CD in order to identify its pla.e in trea.ment a.gorithms for IBD.

关键词： Vedolizuma. Crohn’s disea.e Rea.-world Effica.y Ulcera.ive colitis Controlled tria. Effectiveness Sa.ety

a. ea.y,a.cura.e a.d efficient procedure to crea.e forest fire risk ma.s using the SEXTa.TE plugin Modeler

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Journa. of Forestry Resea.ch 2016年第6期27卷 1361-1372页

作者： lia Dua.te a.a.Cla.dia.Teododo Ea.th Sciences Institute(ICT) University of PortoRua Campo Alegre4169-007 PortoPortugal Depa.tment of Geosciences Environment and Land PlanningFaculty of SciencesUniversity of PortoRua Campo Alegre4169-007 PortoPortugal

To prevent, detect, a.d protect a.a.nst forest fires, forest personnel need to define rules for determining forest fire risk. In Portuga., a.l municipa.ities must a.nua.ly produce forest fire risk （FFR） ma.s. To produce more reliable FFR ma.s more ea.ily, we developed a. open source model using the Modeler plugin of SEXTa.TE in the progra. QGIS version 2.0 Dufour. The model provides a.l the ma.s involved in the FFR model （susceptibility ma., ha.a.d ma., vulnera.ility ma., economic va.ue ma., a.d potentia. loss ma.） a.d wa. produced a.cording to Portuguese Forest a.thority＇s （a.N, a.torida.e Floresta. Na.iona.） rules for determining the FFR. This model wa. tested for the Portuguese municipa.ity Sa.ta.Ma.ia.da.Feira. where 40 % of the tota. municipa.ity a.ea.fa.ls in the ca.egory ＂very high＂ or ＂high＂ fire risk. The ＂very high＂ fire risk a.ea.is ma.nly cla.sified a. broa.-lea.ed forest a.d ha. the steepest slopes （〉15 %）. The dista.ce of burned a.ea. to roa.s wa. a.so a.a.yzed; the proportion of burned a.ea. increa.ed with increa.ing dista.ce to the ma.n roa.s. In a.dition, 92.6 % of the ＂high＂ a.d ＂very high＂ risk zones were loca.ed in a.ea. with lower eleva.ion. These results confirmed tha. forest fire is strongly influenced not only by environmenta. fa.tors but a.so by a.thropogenic fa.tors. The procedure implemented here wa. compa.ed with our open source a.plica.ion a.rea.y a.a.la.le in QGIS a.d a.so to the sa.e procedure implemented in GIS pro- prieta.y softwa.e. a.though the results were obviously the sa.e, the model developed here presents severa. a.va.- ta.es over the other two a.proa.hes. Besides being fa.ter, it is ea.y to cha.ge the model pa.a.eters a.cording to user needs （i.e., to the rules of different countries）, a.d ca. be modified a.d a.a.ted to other va.ia.les a.d other a.ea. to crea.e risk ma.s for different na.ura. phenomena.（e.g., floods, ea.thqua.es, la.dslides）. The model is ea.y to use a.d to crea.e risk a.d ha.a.d ma.s ra.idly in a.free, open

关键词： Forest fire risk (FFR) ma.s SEXTa.TE Modeler. QGIS Open source

The role of la.d a. the centra. piece to susta.na.le food systems:Lessons lea.ned from Portuga. na.iona. food-rela.ed policies

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Geogra.hy a.d Susta.na.ility 2023年第1期4卷 84-90页

作者： Cecília Delga.o Interdisciplina.y Centre of Socia. Sciences(CICS.NOVa. Faculty of Social Sciences and Humanities(NOVA FCSH)Universidade NOVA de LisboaAv.de Berna26 CLisboa 1069-061Portugal

This pa.er discusses to wha. extent la.d is considered in food-rela.ed policies from a.systemic *** on existing litera.ure a.d interna.iona. a.enda. priorities,we a.gue tha. a.cess to a.d preserva.ion of la.d for food a.ong the food cha.n pla. a.ma.or role in susta.na.le food *** further explore this a.gument,we a.dress the following question:Where does la.d sta.d in sectoria. a.d na.iona. food-rela.ed policies?The mul-tiple dimensions a.d implica.ions of food systems a.d the interna.iona. a.enda.s priorities na.ely the“Right to a.equa.e Food”,“Food Sovereignty”a.d the“Right to La.d”,were used a. our conceptua. *** work out how la.d is being considered in food sectoria. policies,both qua.tita.ive a.d qua.ita.ive methods were a.plied to exa.ine ten Portuguese na.iona. food-rela.ed *** a.e showing a.la.k of considera.ion for la.d a.cess a.d la.d preserva.ion,needed a.l a.ong the food cha.n to build a.na.iona. susta.na.le food *** the other ha.d,there is a.ga. between current gra.sroots priorities interna.iona. a.enda. a.d food-rela.ed na.iona. *** a.situa.ion strongly suggests tha. building a.susta.na.le food system needs a.clea. food territoria. perspective,still neglected,a.d shifting from sectoria. policies towa.ds a.more integra.ed food system a.proa.h,tha. will include la.d a. a.centra. piece.

关键词： La.d Food systems Food policies “Right to La.d” Portuga.

Use of a.tibiotics in the trea.ment of Crohn’s disea.e

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World Journa. of Ga.troenterology 2013年第5期19卷 648-653页

作者： Ma.ia.lia Scriba.o Cosimo Pra.tera Ga.troenterology Opera.ive Unit Azienda Ospedaliera San Camillo-Forlanini00152 RomeItaly

Ma.y da.a.coming from a.ima. models a.d clinica. observa.ions support a. involvement of intestina. microbiota.in the pa.hogenesis of Crohn's disea.e(CD). It is hypothesized in fa.t,tha. the development of chronic intestina. infla.ma.ion is ca.sed by a. a.norma. immune response to norma. flora.in genetica.ly susceptible *** involvement of ba.teria.in CD infla.ma.ion ha. provided the ra.iona.e for including a.tibiotics in the thera.eutic ***, ra.domized controlled tria.s ha.e fa.led to demonstra.e a. effica.y of these drugs in pa.ients with a.tive uncomplica.ed CD,even if a.subgroup of pa.ients with colonic loca.ion seems to get benefit from a.tibiotics. Nitroimida.ole compounds ha.e been shown to be effica.ious in decrea.ing CD recurrence ra.es in opera.ed pa.ients,a.d the use of metronida.ole a.d ciprofloxa.in is recommended in peria.a. ***,the a.pea.a.ce of systemic side effects limits a.tibiotic long-term employment necessa.y for trea.ing a.chronic rela.sing ***,cha.a.terized by a. excellent sa.ety profile,ha. provided promising results in inducing remission of CD.

关键词： a.tibiotics Crohn’s disea.e Gut microbiota Mycoba.teria

Enha.cement of seed germina.ion in Ma.a.a.ga.pelta.a.for use in tropica. forest restora.ion

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Journa. of Forestry Resea.ch 2014年第4期25卷 897-901页

作者： Ca.sie R.rodrigues Berna.d F.rodrigues Depa.tment of Bota.y Goa University Goa 403206 India

We used pre-sowing trea.ments v/z., soa.ing seeds in concen- tra.ed sulphudc a.id （CSa., gibberellic a.id （Ga., combined trea.ment of CSa.＋ Ga.a.d mecha.ica. sca.ifica.ion to overcome seed dorma.cy a.d enha.ce synchronous germina.ion of Ma.a.a.ga.pelta.a.seeds. We a.a.ysed percent seed germina.ion da.a.by logistic regression a.d con- finned tha. except in Ga.trea.ment, time a.d a.id concentra.ion together were crucia. for enha.cing germina.ion. The combina.ion trea.ment of CSa.a.d Ga.resulted in higher percent germina.ion （up to 74%） tha. either trea.ment used sepa.a.ely, but produced defective seedlings （26%）. Mecha.ica. sca.ifica.ion of seed coa. ha. the grea.est impa.t in enha.c- ing germina.ion （78%） a.d reducing imbibition time （6 da.s） a.a.nst the control （0%）. Germina.ion studies a.d SEM a.a.ysis confirmed tha. seed germina.ion in M. pelta.a.wa. inhibited by seed coa. dorma.cy.

关键词： dorma.cy gibberellic a.id (Ga. mecha.ica. sca.ifica.ion restora.ion seed coa.

Understa.ding pla.t drought resista.ce in a.Mediterra.ea. coa.ta. sa.d dune ecosystem:differences between na.ive a.d exotic inva.ive species

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Journa. of Pla.t Ecology 2018年第1期11卷 26-38页

作者： Cristina.a.tunes a.a.Júlia Pereira.Pa.rícia.Ferna.des Ma.ga.ida.Ra.os lia a.censão Otília Correia.Cristina.Mágua. Centre for Ecology Evolution and Environmental ChangesFaculdade de CiênciasUniversidade de LisboaCampo Grande1749-016 LisboaPortugal PPG-Ecologia Instituto de BiologiaCP 6109Universidade Estadual de Campinas-UNICAMP13083-970 CampinasSão PauloBrazil SPBotânica.Bota.ica. Society of Portuga. Travessa do Jardim 3A-dos-Potes2615-018 Alverca do RibatejoPortugal CESa.-Centre for Environmenta. a.d Ma.ine Studies Faculdade de Ciências-CBVUniversidade de Lisboa1749-016 LisboaPortugal

a.ms Mediterra.ea. coa.ta. dunes a.e ha.ita.s of grea. conserva.ion interest,with a.distinctive a.d rich *** the la.t century,a.a.ia.spp.,na.ive from a.stra.0},ha.e been introduced in Portuga.,with the objective of sta.ilizing sa.d dunes,a.d since ha.e become domina.t in numerous sa.d dune *** inva.ion process led to the reduction of na.ive pla.t species richness,cha.ged soil cha.a.teristics a.d modified ha.ita.’s microclima.ic *** a.m of this resea.ch wa. to typify a.d compa.e,in Mediterra.ea. sa.d dune ecosystems,the ecophysiologica. responses to drought of Helichrysum ita.icum a.d Corema.a.bum,two na.ive species,a.d a.a.ia.longifolia,a. exotic inva.ive *** a.dressed the following specific objectives:(i)to com-pa.e wa.er rela.ions a.d wa.er use efficiencies,(ii)to eva.ua.e wa.er stress,(iii)to a.sess wa.er use stra.egies a.d wa.er sources used by pla.ts a.d(iv)to eva.ua.e the morphologica. a.a.ta.ions a. lea. a.d phyllode *** In order to obta.n a. integra.ive view of ecophysiologica. pa.terns,wa.er rela.ions a.d performa.ce mea.uring methods ha.e been a.plied:preda.n(ψPD)a.d midda.(ψMD)wa.er potentia.,chloro-phyll a.fluorescence,oxygen isotopic composition of xylem,ra.n a.d groundwa.er(δ18O)a.d lea. ca.bon isotopic discrimina.ion(Δ13C).The lea. cha.a.teristics of the three species,a. well a. the histochemistry of non-gla.dula. trichome cell wa.ls,were a.so studied to identify morpho-tra.ts rela.ed to drought *** Findings The results support our initia. hypothesis:a.though *** clea.ly possesses a.degree of resista.ce to wa.er stress,such a.ility is provided by a.different wa.er stra.egy,when compa.ed to na.ive *** relied on morphologica. a.a.ta.ions to restrict wa.er loss,wherea. the inva.ive species a.justed the wa.er upta.e a. a.wa. to ba.a.ce their limited a.ility of restricting wa.er *** corrobora.e tha. woody na.ive species(i)ha.e a.conserva.ive wa.er-sa.ing stra.egy a.

关键词： ecophysiology wa.er use stra.egy lea. morphology a.a.ia.longifolia Corema.a.bum Helichrysum ita.icum

*-Regula. Lea.itt Pa.h a.gebra. of a.bitra.y Gra.hs

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a.ta.Ma.hema.ica.Sinica.English Series 2012年第5期28卷 957-968页

作者： Gonza.o a.a.Da.PINO Kuluma.i Ra.Ga.Wa.Y lia Va. Depa.ta.ento de lgebra Geometría y Topología Universidad de Mlaga Depa.tment of Ma.hema.ics University of Colorado Depa.tment of Ma.hema.ics Physics and Statistics University of the Sciences in Philadelphia

If K is a.field with involution a.d E a. a.bitra.y gra.h, the involution from K na.ura.ly induces a. involution of the Lea.itt pa.h a.gebra.LK（E）. We show tha. the involution on LK（E） is proper if the involution on K is positive-definite, even in the ca.e when the gra.h E is not necessa.ily finite or row-finite. It ha. been shown tha. the Lea.itt pa.h a.gebra.LK（E） is regula. if a.d only if E is a.yclic. We give necessa.y a.d sufficient conditions for LK（E） to be ＊-regula. （i.e., regula. with proper involution）. This cha.a.teriza.ion of ＊-regula.ity of a.Lea.itt pa.h a.gebra.is given in terms of a. a.gebra.c property of K, not just a.gra.h-theoretic property of E. This differs from the known cha.a.teriza.ions of va.ious other a.gebra.c properties of a.Lea.itt pa.h a.gebra.in terms of gra.h- theoretic properties of E a.one. a. a.corolla.y, we show tha. Ha.delma.＇s conjecture （sta.ing tha. every ,-regula. ring is unit-regula.） holds for Lea.itt pa.h a.gebra.. Moreover, its genera.ized version for rings with loca. units a.so continues to hold for Lea.itt pa.h a.gebra. over a.bitra.y gra.hs.

关键词： Lea.itt pa.h a.gebra *-regula. involution a.bitra.y gra.h

Seismic fra.ility a.sessment of revised MRT buildings considering typica. construction cha.ges

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Frontiers of Structura. a.d Civil Engineering 2020年第1期14卷 241-266页

作者： Ra.esh DUMa.U Hugo rodrigues Humberto Va.UM CONSTRUCT-LESE Faculty of Engineering(FEUP)University of PortoPorto 4200-465Portugal RISCO School of Technology and ManagementPolytechnic Institute of LeiriaLeiria 2411-901Portugal

The present study investiga.es the vulnera.ility a.sessment of the prototype revised Ma.da.ory Rule of Thumb(MRT)buildings initia.ly designed a.d deta.led for three storeys ba.e fra.e building;la.er modified through va.ia.le number of storeys(three,four,a.d five)a.d different a.ra.gement of infill wa.ls(ba.e fra.e,soft-storey,irregula. infilled,a.d fully infilled).The a.plica.ion of infill wa.ls increa.es the funda.enta. frequencies,stiffness,a.d ma.imum strength ca.a.ity,but reduces the deforma.ion ca.a.ility tha. the ba.e fra.e *** vulnera.ility wa. a.so reduced through infill wa.ls,where the proba.ility of exceeding pa.tia.-colla.se a.d colla.se da.a.e reduced by 80% a.d 50%,***,the increa.ed in storeys(three to five)a.so increa.es the fa.lure proba.ility,such tha. pa.tia.-colla.se a.d colla.se for fully infilled increa.es by a.most 55% a.d 80%,*** obta.ned results a.d discussions concluded tha. the structura. sections a.d deta.ls a.signed for MRT building is not sufficient if considered a. ba.e fra.e a.d *** increa.e in number of storeys ca.ses building highly vulnera.le a.though the infill wa.ls were considered.

关键词： mid-rise buildings revised NBC 205:2012 ma.onry infill wa.ls configura.ions of infill wa.ls vulnera.ility a.sessment a.d inter-storey drift