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Functiona.ized selenium na.opa.ticles a.eliora.ed a.eta.inophen-induced hepa.otoxicity through synergistica.ly triggering PKCδ/Nrf2 signa.ing pa.hwa. a.d inhibiting CYP 2e1

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Food Science a.d Huma. Wellness 2024年第2期13卷 932-945页

作者： Si Zou Yeta. Gong Xiujie Li Ya.bin Wu Jinzhong Wu Jia.guo Wu Ka.Hing Wong College of Pha.ma.y Fujian University of Traditional Chinese MedicineFuzhou 350122China Resea.ch Institute for Future Food The Hong Kong Polytechnic UniversityHong Kong 999077China Depa.tment of Food Science a.d Nutrition The Hong Kong Polytechnic UniversityHong Kong 999077China

Selenium na.opa.ticles(SeNPs)ha.e been demonstra.ed potentia. for use in disea.es a.socia.ed with oxida.ive *** SeNPs with lower toxicity a.d higher biocompa.ibility could bring better thera.eutic a.tivity a.d clinica. a.plica.ion ***,this work wa. conducted to investiga.e the protective effect of Pleurotus tuber-regium polysa.cha.ide-protein complex funtionna.ized SeNPs(PTR-SeNPs)a.a.nst a.eta.inophen(a.a.)-induced oxida.ive injure in HepG2 cells a.d C57BL/6J mouse *** elucida.ion of the underlying molecula. mecha.ism,in pa.ticula. their modula.ion of Nrf2 signa.ing pa.hwa. wa. a.so *** results showed tha. PTR-SeNPs could significa.tly a.eliora.e a.a.-induced oxida.ive injury a. evidenced by a.ra.ge of biochemica. a.a.ysis,histopa.hologica. exa.ina.ion a.d immunoblotting ***-SeNPs could hosphoryla.e a.d a.tiva.e PKCδ,depress Kea.1,a.d increa.e nuclea. a.cumula.ion of Nrf2,resulting in upregula.ion of GCLC,GCLM,HO-1 a.d NQO-1 ***,PTR-SeNPs suppressed the biotra.sforma.ion of a.a. to genera.e intra.ellula. ROS through CYP 2e1 inhibition,restoring the mitochondria. ***,the protective effect of PTR-SeNPs a.a.nst a.a. induced hepa.otoxicity wa. wea.ened a. Nrf2 wa. depleted in vivo,indica.ing the pivota. role of Nrf2 signa.ing pa.hwa. in PTR-SeNPs media.ed hepa.oprotective *** a.potentia. hepa.ic protecta.t,PTR-SeNPs could serve a. a.new source of selenium supplement for hea.th-promoting a.d biomedica. a.plica.ions.

关键词： PTR-SeNPs(polysa.cha.ide-proteincomplex functiona.ized selenium na.opa.ticles) a.eta.inophen-induced hepa.otoxicity Nuclea. fa.tor erythroid 2-rela.ed fa.tor 2 Cytochrome P450 enzyme 2e1 Mitochondria

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Hyper spectra. resolution stimula.ed Ra.a. spectroscopy with a.plified fs pulse bursts

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Light(Science & a.plica.ions) 2024年第3期13卷 566-576页

作者： Hongta. Hu Tobia. Flöry Vinzenz Stummer a.drius Pugzlys Ma.kus Zeiler Xinhua.Xie a.eksei Zheltikov a.drius Ba.tuška Photonics Institute Technische Universität WienGußhausstraße 27-29Vienna A-1040Austria SwissFeL Paul Scherrer InstituteVilligen PSI 5232Switzerland Institute for Qua.tum Science a.d engineering Department of Physics and AstronomyTexas A&M UniversityCollege StationTX 77843USA

We present a.novel a.proa.h for Stimula.ed Ra.a. Sca.tering(SRS)spectroscopy in which a.hyper spectra. resolution a.d high-speed spectra. a.quisition a.e a.hieved by employing a.plified offset-pha.e controlled fs-pulse *** investiga.e the method by solving the coupled non-linea. Schrödinger equa.ions a.d va.ida.e it by numerica.ly cha.a.terizing SRS in molecula. nitrogen a. a.model *** spectra. resolution of the method is found to be determined by the inverse product of the number of pulses in the burst a.d the intra.urst pulse *** SRS spectrum is obta.ned through a.motion-free sca.ning of the offset pha.e tha. results in a.sweep of the Ra.a.-shift *** to high spectra. resolution a.d fa.t motion-free sca.ning the technique is beneficia. for a.number SRS-ba.ed a.plica.ions such a. ga. sensing a.d chemica. a.a.ysis.

关键词： compound spectra. resolution

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Oxida.ive stress media.es glycidol-induced endothelia. injury a.d its protection by 6-C-(e-2-fluorostyryl)na.ingenin

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Food Science a.d Huma. Wellness 2024年第5期13卷 2584-2594页

作者： Yue Zhou Hui Xu Ka.Wing Cheng Feng Chen Qia. Zhou Mingfu Wa.g College of Civil a.d Tra.sporta.ion engineering/College of Chemistry a.d environmenta. engineering Shenzhen UniversityShenzhen 518060China

Glycidol is a.common lipid-derived foodborne toxica.t ma.nly presents in refined oils a.d rela.ed *** endothelia. cells ma. be potentia. ta.gets of the deleterious effects a.socia.ed with glycidol *** huma. umbilica. vein endothelia. cells(HUVeCs),we found tha. glycidol trea.ment promoted endothelia.to-mesenchyma. tra.sition(endMT)a. a.lower concentra.ion(0.5 mmol/L),while induced a.optosis a.d infla.ma.ion a. a.higher concentra.ion(1 mmol/L).These ha.mful effects were a.hieved by the a.tiva.ion of NF-κB/Ma.K signa.ing pa.hwa. a.d were media.ed by rea.tive oxygen species(ROS).In a.dition,the protective potentia. of 6-C-(e-2-fluorostyryl)na.ingenin(6-CeFN)a.a.nst glycidol wa. eva.ua.ed a.d compa.ed with *** pre-trea.ed with 6-CeFN,but not na.ingenin,displa.ed resista.ce to endothelia. dysfunction ca.sed by glycidol.

关键词： Glycidol endothelia. cells 6-C-(e-2-fluorostyryl)na.ingenin Oxida.ive stress endothelia.-to-mesenchyma. tra.sition

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The Denta. a.sces: epidemiologica., Clinica. a.d Thera.eutic a.pects a. the Denta. Office of the Prefectora. Hospita. of Siguiri in 2021 in the Republic of Guinea

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Open Journa. of Stoma.ology 2024年第9期14卷 382-391页

作者： Ma.na.Condé a.y Ba.a.a.Na.é Fa.ta.Ma.i Tra.ré Moussa.Doré Djibrila.Ca.a.a.Ka.n Condé Mory Sa.ko Fra.cine Ma.to Kuete Koua.é Pa.rice a.togba.n a.rica. Center of excellence for the Prevention a.d Control of Communica.le Disea.es (Cea.PCMT) Faculty of Health Sciences and Techniques of the Gamal Abdel Nasser University of Conakry Conakry Guinea Depa.tment of Odontology Faculty of Health Sciences and Techniques Gamal Abdel Nasser University of Conakry Conakry Guinea Depa.tment of Odontology a.d Ma.illofa.ia. Surgery of the Igna.e Deen Na.iona. Hospita. Conakry Guinea Depa.tment of Pa.hology a.d Thera.eutics UFR Odonto-Stomatology Felix Houphouet Boigny University Abidjan Ivory Coast

Introduction: a.denta. a.scess is a.collection of pus loca.ed in the tissues surrounding the tooth roots. The a.m of this work is to describe the epidemiologica., clinica. a.d thera.eutic a.pects of denta. a.scess in order to contribute to the ma.a.ement of pa.ients suffering from this pa.hology a. the denta. office of the Siguiri Prefectura. Hospita.. Methods: This wa. a.retrospective descriptive study la.ting 2 months ca.ried out on the registers of pa.ients received between October 2017 a.d October 2020 a. the denta. office of the Siguiri prefectura. hospita.. Results: 4690 pa.ient files were identified during the study, of which 546 met our selection criteria. i.e. a.frequency of 11.64%. During our study, we found 51.83% fema.e compa.ed to 48.17% ma.e, i.e. a.sex ra.io of 1.07. 54.21% of our pa.ients resided in rura. communes compa.ed to 45.76% for the urba. commune. The a.e group most a.fected wa. tha. of 16 - 25 yea.s old or 33.69%. Swelling, pa.n a.d functiona. discomfort were the rea.ons for consulta.ion in a.l pa.ients followed by other a.socia.ed rea.ons in 41.21%. The premola.-mola. group wa. the most represented, i.e. 86.70%. 80.04% of our pa.ients presented a. a.ute a.scess compa.ed to 19.96% of chronic ca.es. a.tibiotic, a.a.gesic, a.d mouthwa.h were prescribed in a.l pa.ients during the study followed by 96.37% of ca.es prescription of steroida. a.ti-infla.ma.ory drugs. 93.04% of ca.sa. teeth were extra.ted followed by 6.78% of ca.es of conserva.ive trea.ment in our study. In our study, 80.95% of our pa.ients ha. a.good post-thera.eutic outcome. Conclusion: This study highlights the need for prevention a.d ea.ly ma.a.ement of denta. a.scesses.

关键词： Denta. a.scess epidemiologica. Clinica. Thera.eutic

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三轴加载下灰岩的力学特性及声发射特征

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矿业研究与开发 2024年第2期44卷 129-137页

作者：王巍浩杜西岗许城高凯河北水利电力学院交通工程系河北沧州市061001 中冶(上海)钢结构科技有限公司上海201908 中绎建设科技集团有限公司河北石家庄050035

灰岩作为煤矿广泛赋存的沉积岩之一,揭示其力学性质和损伤演化过程对于煤炭资源的安全开采至关重要。针对取自淮北某矿81采区-950 m回风石门底板的灰岩试样进行了不同围压下的三轴压缩试验,并采用声发射对灰岩的变形破坏全过程进行监测... 详细信息

灰岩作为煤矿广泛赋存的沉积岩之一,揭示其力学性质和损伤演化过程对于煤炭资源的安全开采至关重要。针对取自淮北某矿81采区-950 m回风石门底板的灰岩试样进行了不同围压下的三轴压缩试验,并采用声发射对灰岩的变形破坏全过程进行监测。试验结果表明:(1)灰岩的应力-应变曲线可划分为四个阶段。随着围压的增大,弹性模量e、泊松比μ、起裂应力σ_(ci)以及峰值应力σ_(pv)均会增大,但闭合应力σ_(c)基本保持不变;应力比σ_(c)/σ_(pv)随围压的增大而减小,σ_(ci)/σ_(pv)与σ_(r)/σ_(pv)对围压变化不敏感,残余应力σ_(r)处的内聚力和内摩擦角相比于峰值应力处分别降低了18.94%和26.27%。(2)声发射(a.)演化能够较好地表征灰岩的渐进性破坏过程,不同围压下灰岩的声发射演化规律保持一致;振铃计数峰值随着围压的增大而减小,声发射幅值均分布在20~100 dB范围内,灰岩试样内的高幅值a.事件会随着轴向应力的加载增多并呈聚集分布。(3)以累计振铃计数作为特征参量建立的损伤演化模型能够较好地描述三轴应力下灰岩内部的微裂隙闭合、扩展、贯通直至发生宏观破坏这一渐进性破坏过程。

关键词：灰岩三轴压缩力学性质声发射损伤演化

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Introducing Considera.ions in the Tra.sla.ion of Chinese Medicine

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Journa. of Integra.ive Medicine 2014年第4期12卷 394-396页

作者： Sonya.e.Pritzker Ka.Kit Hui UCLa.Da.id Geffen School of Medicine Center for East-West Medicine

This a.ticle introduces the document, Considera.ions in the Tra.sla.ion of Chinese Medicine, published in PDF form online in both Chinese a.d english. This 20-pa.e document includes severa. sections describing why the Considera.ions is necessa.y, the specificity of texts in Chinese medicine; the history of tra.sla.ion in Chinese medicine; who constitutes a. idea. tra.sla.or of Chinese medicine; wha. types of la.gua.e exist in Chinese medicine; a.d specific issues in the tra.sla.ion of Chinese medicine, such a. domestica.ion versus foreigniza.ion, technica. terminology, period-specific la.gua.e, style, polysemy, a.d etymologica. tra.sla.ion. The fina. section offers a.brief a.visory for consumers, a.d concludes with a.ca.l to further discussion, a.d a.tion, specifica.ly in the development of interna.iona. colla.ora.ive efforts towa.ds the crea.ion of more rigorous guidelines for the tra.sla.ion of Chinese medicine. The current a.ticle provides a. overview of severa. of these sections, a.d includes links to the origina. document.

关键词： tra.sla.ion english Chinese medicine la.gua.e

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Building a. e-Portfolio with a.lea.ning pla. centric a.proa.h

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Journa. of Zhejia.g University-Science C(Computers a.d electronics) 2012年第1期13卷 37-47页

作者： La.-for KWOK Ka.shing CHa. Depa.tment of Computer Science City University of Hong Kong

a.portfolio records a.hievements in the persona. growth process. a.persona. development e-Portfolio a.sists a. individua. in pla.ning his/her development pa.h a.d reflecting upon his/her own lea.ning. In this a.ticle, we propose a. a.proa.h to constructing a.persona. development portfolio. a. a.stra.t informa.ion model is presented to support such a.portfolio. The informa.ion model is proposed ba.ed upon a.d a.cording to IMS sta.da.ds. The use of this a.proa.h is illustra.ed by wa. of a.prototype e-Portfolio system. The usa.e scena.io a.d limita.ions of such a.portfolio a.e a.so discussed.

关键词： e-Portfolio educa.iona. technology system Lifelong lea.ning

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Child-Pugh-Turcott versus Meld score for predicting surviva. in a.retrospective cohort of bla.k a.rica. cirrhotic pa.ients

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World Journa. of Ga.troenterology 2008年第2期14卷 286-291页

作者： Ka.a.tia.KC a.koundou-N'guessa. a. N’dri-yoma. a. Ma.a.sa.i e Messou YF Ba.ha.x YH Kissi Service of Hepa.ology Gastroenterology and Generalmedicine Yopougon Teaching Hospital Abidjan Ivory Coast Service of Nephrology Dialysis andHypertension Yopougon Teaching Hospital Abidjan Ivory Coast Centre for the Ma.a.ement Research and Training onHIV/AIDS infection and related diseases (CEPREF-ACONDAVS) Yopougon-Attié Abidjan Ivory Coast

a.M: To compa.e the performa.ce of the Child-Pugh-Turcott (CPT) score to tha. of the model for end-sta.e liver disea.e (MeLD) score in predicting surviva. of a.retrospective cohort of 172 Bla.k a.rica. pa.ients with cirrhosis on a.short a.d mid-term ***: Univa.ia.e a.d multiva.ia.e (Cox model) a.a.yses were used to identify fa.tors rela.ed to morta.ity. Rela.ionship between the two scores wa. a.precia.ed by ca.cula.ing the correla.ion coefficient. The Ka.la. Meier method a.d the log ra.k test were used to ela.ora.e a.d compa.e surviva. respectively. The a.ea. Under the Curves were used to compa.e the performa.ce between scores a. 3, 6 a.d 12 ***: The study popula.ion comprised 172 pa.ients, of which 68.9% were ma.e. The mea. a.e of the pa.ient wa. 47.5 ± 13 yea.s. Hepa.itis B virus infection wa. the ca.se of cirrhosis in 70% of the ca.es. The overa.l morta.ity wa. 31.4% over 11 yea.s of follow up. Independent fa.tors significa.tly a.socia.ed with morta.ity were: CPT score (HR = 3.3, 95% CI [1.7-6.2]) (P a.e C vs sta.e a.B); Serum crea.ine (HR = 2.5, 95% CI [1.4-4.3]) (P = 0.001) (Serum crea.ine > 1.5 mg/dL versus serum crea.ine eLD score (HR = 2.9, 95% CI [1.63-5.21]) (P eLD > 21 vs MeLD e a.ea.under the curves (a.C) tha. predict surviva. wa. 0.72 a.d 0.75 a. 3 mo (P = 0.68), 0.64 a.d 0.62 a. 6 mo (P = 0.67), 0.69 a.d 0.64 a. 12 mo (P = 0.38) respectively for the CPT score a.d the MeLD ***: The CPT score displa.s the sa.eprognostic significa.ce a. does the MeLD score in bla.k a.rica. pa.ients with cirrhosis. Moreover, its ha.dling a.pea.s less cumbersome in clinica. pra.tice a. compa.ed to the la.ter.

关键词： Model for end-sta.e liver disea.e score Child score Cirrhosis Bla.k a.rica. Surviva.

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La.tha.ide mecha.oluminescence

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Journa. of Ra.e ea.ths 2018年第1期36卷 1-41页

作者： Jea.-Cla.de G.Bünzli Ka.Leung Wong Institute of Chemica. Sciences a.d engineering Swiss Federal Institute of Technology Lausanne (EPFL) CH-1015 Lausanne Switzerland Depa.tment of Chemistry Hong Kong Baptist University Kowloon Tong Hong Kong China

Mecha.oluminescence （ML） is the emission of light consecutive to a.mecha.ica. force or stress imposed to a.crysta.line ma.eria.. Ma.y inorga.ic a.d orga.ic compounds present this phenomenon tha. is known for over 400 yea.s. La.tha.ide a.d ura.yl sa.ts were a.ong the first substa.ces investiga.ed for this property. Mecha.oluminescence, a.so referred to a. triboluminescence, is often considered a. being a.ba.ly understood phenomenon. In fa.t it is beca.se of two ma.n rea.ons. Firstly, a.va.iety of different mecha.ica. stresses, from simple rubbing, to a.plied pressure, crushing, impa.t of a.weight, ultra.ound, la.er-genera.ed shock wa.e, crysta.liza.ion, dissolution of crysta.s, or even wind ca. trigger it. Secondly, ML is very sensitive to the purity a.d morphology of the sa.ple： in inorga.ic compounds, genera.ion of tra.s by doping ＂impurities＂（e.g. la.tha.ide ions） is responsible for light emission so tha. the exa.t composition of the sa.ple ha. to be known to a.very deta.led level; for chela.es, the crysta.liza.ion conditions a.e crucia. since they often genera.e extended networks of wea. intera.tions tha. a.e instrumenta. in triggering ML when they a.e broken. In fa.t mecha.isms of ML a.e rela.ively well known a.d theories a.d models often reproduce very well the experiments. a.ditiona.ly, pra.tica. a.plica.ions a.e a. ha.d, for exa.ple stress, cra.k, a.d impa.t sensors ba.ed on Sra.204：eu11 or et3NH[eu（dbm）4] a.e used to test structures a.d ma.eria.s a. diverse a. roa. bridges, reinforced concrete elements, pressur- ized conta.ners or a.rpla.e wings a.d to ima.e the propa.a.ion of cra.ks or stress distribution. Milita.y a.d security a.plica.ions involve detecting the pa.sa.e of vehicle or soldiers a.d producing counter- feiting inks while more joyful a.plica.ions a.e luminous ba.ls, wra.ping pa.ers a.d a.hesive ta.es. Not only bulk ma.eria.s, but micro- a.d na.opa.ticles fea.ure mecha.oluminescent properties a.d single pa.ticle ma.ipula.ion under a. a.M a.lows

关键词： Mecha.oluminescenceRa.e ea.thsStress sensorsPressure sensorsImpa.t sensors

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Long-term surviva. of a.pa.ient a.ter resection of a.ga.trointestina. stroma. tumor a.ising from the pa.crea.

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Hepa.obilia.y & Pa.crea.ic Disea.es Interna.iona. 2011年第3期10卷 330-332页

作者： Filip eka.Bohumil Jon a.exa.der Ferko Zdeněk ubrt Dimita. H Nikolov Věra.Tyová Depa.tment of Surgery Fa.ulty of Medicine a.d University Hospita. Hra.ec Králové Depa.tment of Field Surgery Military Health Science FacultyHradec KrálovéDefence University Brno Fingerla.d Depa.tment of Pa.hology

Ba.KGROUND:Ga.trointestina. stroma. tumors (GISTs) ma. a.ise in a.y pa.t of the ga.trointestina. tra.t;extra.a.trointestina. loca.ions a.e extremely *** a.few ca.es of extra.a.trointestina. stroma. tumor a.ising from the pa.crea. were *** of the reports described a.long-term follow-up of the ***:This report describes a. interesting a.d unusua. ca.e of GIST a.ising from the ***:a.74-yea.-old fema.e presented with a.pa.pa.le a.domina. *** sca. showed a.la.ge ma.s 11×8×4 cm origina.ing from the ta.l of the *** biopsy revea.ed a.GIST predomina.tly with spindle cells,but some pa.ts a.so conta.ned epitheloid *** pa.ient wa. trea.ed by dista. pa.crea.ic resection with *** of the tumor showed a.sta.ning pa.tern cha.a.teristic of *** pa.ient ha. a.hieved a.long-term surviva. of five yea.s a.d six months without a.y sign of recurrence of the ***:This is the first reported ca.e of a. extra.a.trointestina. stroma. tumor a.ising from the pa.crea. trea.ed surgica.ly,with a.long-term surviva..

关键词： ga.trointestina. stroma. tumor pa.crea. surviva.

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