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Salivary cytokines and levels in denture stomatitis: An exploratory case-control study

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Open Journal of Stomatology 2012年第4期2卷 326-333页

作者： Silvana P. Barros Sandra Al-Tarawneh Sompop Bencharit zvi loewy Linda Gendreau Steven Offenbacher Department of Periodontology School of Dentistry University of North Carolina Chapel Hill USA Department of Pharmaceutical and Biomedical Sciences Touro College of Pharmacy New York USA Department of Pharmacology School of Medicine University of North Carolina Chapel Hill USA Department of Prosthodontics School of Dentistry University of North Carolina Chapel Hill USA GlaxoSmithKline Consumer Healthcare Parsippany USA

We aimed to evaluate the microbial and inflammatory characteristics associated with Denture Stomatitis (DS) analyzing: l) Levels of salivary cytokines and cultivable C. albicans;2) DNA-DNA checkerboard on biofilm associated with mucosal tissue-bearing denture surfaces, 3) Serum C-reactive protein (CRP) levels. Thirty-two subjects were enrolled in the study with control (n = 17) and DS types II and III (n = 15) subjects. Samples were collected from unstimulated whole saliva, serum and swabs from denture surfaces. Salivary levels of inflammatory mediators and CRP were measured by multiplex. Samples from denture and mucosal surfaces were analyzed by DNA-DNA checkerboard. Saliva from DS subjects showed increase in IL-8 (p = 0.04) and IL-1β (p = 0.04) with trend for increase in IL-1β, TNFα and IL-6 levels. C. albicans higher counts in DS saliva (p = 0.03) showed association with elevated levels of IL-8 (p = 0.03) and IL-1α (p = 0.01). CRP levels were not different among groups (p = 0.74). DNA-DNA checkerboard analyses indicated typical periodontal pathogens below the detection threshold of 104 organisms on both denture and inflamed mucosal surfaces. The data suggest that DS is associated with elevation of salivary IL1 and IL-8 together with increased C. albicans. There was no evidence of systemic inflammation as measured by serum C-reactive protein levels.

关键词： Cytokines Serum C-Reactive Protein Denture C. albicans Stomatitis Salivary

不同清洗方式对义齿白色假丝酵母菌生物膜清除效果的影响

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国际口腔医学杂志 2010年第2期37卷 157-160页

作者：李莉娜 Young Kim 舒毅 Renate Lux 田敏 Prasad Adusumilli zvi loewy 郭宏 Yu Shao 施文元沈嵩黄正蔚田宇朱昞张恺陈谦明王敏吴红崑周学东加利福尼亚大学洛杉矶分校牙科学校加利福尼亚洛杉矶90095 四川大学华西口腔医院四川成都610041 中美史克口腔护理研究开发中心葛兰素史克消费保健品部中国研究开发中心北京100025 葛兰素史克消费者保健中心新泽西帕瑟伯尼07054 北京大学口腔医院北京100101 上海交通大学医学院附属第九人民医院上海200011 第四军医大学口腔医院陕西西安710032 首都医科大学口腔医院北京100050 中山大学光华口腔医学院广东广州510055

目的比较不同清洁方式对义齿白色假丝酵母菌生物膜的清除能力。方法制作并消毒树脂片,在其表面培养白色假丝酵母菌生物膜,分别以化学(浸泡)、机械(刷洗)和复合(浸泡与刷洗并用)等方式处理覆有白色假丝酵母菌生物膜的树脂片,再将其浸入... 详细信息

目的比较不同清洁方式对义齿白色假丝酵母菌生物膜的清除能力。方法制作并消毒树脂片,在其表面培养白色假丝酵母菌生物膜,分别以化学(浸泡)、机械(刷洗)和复合(浸泡与刷洗并用)等方式处理覆有白色假丝酵母菌生物膜的树脂片,再将其浸入新鲜培养液进行残留生物膜的恢复培养,分别在0、6、24h后利用菌落计数进行效果评价。结果机械清除效果与牙膏种类密切相关,单纯的化学处理没有明显的清除作用,保丽净义齿清洁片复合处理清除白色假丝酵母菌生物膜的效果最佳,其处理后的树脂片培养24h仍未检出白色假丝酵母菌。结论不同的义齿清洗方法对附着在义齿表面的白色假丝酵母菌生物膜的清除能力有差异。其中,以保丽净义齿清洁片复合效果最好且能够持续地发挥抑菌作用。

关键词：口腔卫生义齿清洗产品白色假丝酵母菌生物膜义齿性口炎

Neutrophils in the tumor microenvironment-when a company becomes a crowd

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Cellular & Molecular Immunology 2024年第4期21卷 313-314页

作者： zvi G.Fridlender zvi Granot Faculty of Medicine Hebrew University of JerusalemJerusalemIsrael Institute of Pulmonary Medicine Hadassah-Hebrew University Medical Center91120 JerusalemIsrael Department of Developmental Biology and Cancer Research Institute for Medical Research Israel CanadaFaculty of MedicineHebrew University91120 JerusalemIsrael

Traditionally,neutrophils are perceived as terminally differentiated cells with defined functions and limited *** is commonly believed that circulating,marginating and tissue-infiltrating neutrophils belong to the same homogeneous population and are capable of switching between these *** research has stagnated since the early 1980s,maintaining a narrow and simplistic view of their capabilities.

关键词： narrow infiltrating differentiated

Determination of creatinine level in patient blood samples by Fourier NIR spectroscopy and multivariate analysis in comparison with biochemical assay

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Journal of Innovative Optical Health Sciences 2019年第6期12卷 46-55页

作者： zvi Hai Barnea(Burbea) David Abookasis Nephrology Department Edith Wolfson Hospital Holon 5822012Israel Sackler Faculty of Medicine Tel Aviv University Ramat Aviv 6997801Israel Department of Electrical and Electronics Engineering Ariel University Ariel 4070000Israel

In this paper,in vivo spectra from 23 patients'blood samples with various Creatinine(Cr)concentration levels ranging from 0.96 to 12.5 mg/dL were measured using Fourier transform near-infrared spectrometer(FT-NIRS)and spectrum quantitative analysis *** Cr undergoes passive filtration,it serves as a key biomarker of kidneys function via the estimation of glomerular filtration ***,increased blood Cr concentration reflects impaired renal *** spectra pre processing and outlier exclusion,a spectral model was developed based on partial least squares regression(PLSR)method,wherein Cr concentrations correlated with filtered NIR spectra across several peaks,where Cr is know n to absorb NIR *** statistical metrics were applied to estimate the model efficiency during data *** of spectra-derived concentrations to reference Cr measurements by the current gold-standard Jaffe's method held in hospital lab revealed a Cr prediction accuracy of 1.64 mg/dL with good corre-lation of R=***-Altman plots were used to compare between our calculations and ref-erence lab values and reveal minimal bias between the *** finding presented the potential of FT-NIRS coupled with PLSR technique for Cr determination.

关键词： Creatinine Fourier transform near infrared spectroscopy blood samples chemo metrics statistical analysis

The energy transfer mechanism of a perturbed solid-body rotation flow in a rotating pipe

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Acta Mechanica Sinica 2017年第2期33卷 274-283页

作者： Chunjuan Feng Feng Liu zvi Rusak Shixiao Wang School of Aeronautics Northwestern Polytecrhnical University Department of Mechanical and Aerospace Engineering University of California Department of Mechanical Aerospaceand Nuclear EngineeringRensselaer Polytechnic Institute Department of Mathematics University of Auckland

Three-dimensional direct numerical simulations of a solid-body rotation superposed on a uniform axial flow entering a rotating constant-area pipe of finite length are presented. Steady in time profiles of the radial, axial, and circumferential velocities are imposed at the pipe inlet. Convective boundary conditions are imposed at the pipe outlet. The Wang and Rusak (Phys. Fluids 8:1007-1016, 1996.) axisymmetric instability mechanism is retrieved at certain operational conditions in terms of incoming flow swirl levels and the Reynolds number. However, at other operational conditions there exists a dominant, three-dimensional spiral type of instability mode that is consistent with the linear stability theory of Wang et al. (J. Fluid Mech. 797: 284-321, 2016). The growth of this mode leads to a spiral type of flow roll-up that subsequently nonlinearly saturates on a large amplitude rotating spiral wave. The energy transfer mechanism between the bulk of the flow and the perturbations is studied by the Reynolds-Orr equation. The production or loss of the perturbation kinetic energy is combined of three components: the viscous loss, the convective loss at the pipe outlet, and the gain of energy at the outlet through the work done by the pressure perturbation. The energy transfer in the nonlinear stage is shown to be a natural extension of the linear stage with a nonlinear saturated process.

关键词： Vortex instability Incompressible viscous flow Cylindrical coordinates

What If I Told You Camouflage is a Myth? Animal Coloration is Mainly A-biotic and not Biotic (Camouflage)

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Research in Ecology 2024年第1期6卷 14-27页

作者： zvi Sever Formerly Biology Department University of IndianapolisIndiana46227USA

In the present article,the author posits that the perception that animals apparently display a strategy of avoiding detection by means of camouflage—i.e.,by disguising themselves in the natural colours of their environment—is not the actual case in nature but,rather,merely *** coloration is mainly a-biotic(eco-physiological)and not biotic(camouflage).The contention regarding the absence of the phenomenon of camouflage among animals as a common evolutionary response is based on three arguments:(1)that reflecting the natural colours of the environment is linked to ecophysiology;(2)that predator and prey constitute“an evolutionary pair”and,accordingly,they know how to identify one another(in order to survive they employ different strategies,of which camouflage is not one of them);and (3)that the approach of relating animal camouflage to reflecting the colours of the environment is an anthropocentric *** than the accepted biotic-ethological approach(colour camouflage),the present article suggests the recognition of a-biotic and eco-physiological conditions as a distinct research field,whose title“Reflection of environmental colours by animals”,along with this article,calls for eco-physiologists to demonstrate that this approach indeed offers a special contribution to the understanding of colouration in animals.

关键词： A-biotic Anthropocentrism Camouflage Eco-physiology Ethology Evolution Reflection

Capsule endoscopy: Improving transit time and image view

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World Journal of Gastroenterology 2005年第37期11卷 5863-5866页

作者： zvi Fireman D Paz Y Kopelman Department of Gastroenterology Hillel Yaffe Hadera and Bruce Rappaport Faculty of Medicine Technion Haifa Israel

AIM： To evaluate the effect of various methods of small bowel preparation on the transit time and the quality of visualization of the entire small bowel mucosa. METHODS： Ninety-five patients underwent capsule endoscopy （CE） by easily swallowing the capsule. They were divided into three study groups according to the preparation used： group A （n = 26） by polyethylene glycol （PEG） liter or with sodium phosphate （SP） 12 h prior to the CE study; group B （n = 29） by erythromycin 1 h prior to the CE study; and group C （n = 40） without any preparation. Visualization ranged from good to satisfactory to poor. RESULTS： The gastric emptying time in the group prepared with erythromycin was shorter but without statistical significance and the small bowel transit time was unaffected. In elderly subjects prepared by PEG or SP, the gastric emptying time was significantly longer （163.7 rain, P = 0.05）. The transit times of the three sub-groups were not affected by gender or pathology. The grade of cleaning of the entire study group was 3.27±1.1. The erythromycin group presented significantly the worst quality of images （P = 0.05） compared to the other sub-groups. Age, gender, and pathology had no effect on the quality of the cleaning of the small bowel in the sub-groups. One （1.05%） case had no natural excretion. CONCLUSION： Erythromycin markedly reduces gastric emptying time, but has a negative effect on the quality of the image in the small bowel. The preparation of elderly subjects with PEG or SP has a negative effect on the small bowel transit time.

关键词： Capsule endoscopy Gastric emptying time Small bowel transit time View Erythromycin Polyethylene glycol

Peptide self‐assembly as a strategy for facile immobilization of redox enzymes on carbon electrodes

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Carbon Energy 2023年第11期5卷 15-30页

作者： Itzhak Grinberg Oren Ben‐zvi Lihi Adler‐Abramovich Iftach Yacoby Department of Oral Biology The Goldschleger School of Dental MedicineFaculty of MedicineTel Aviv UniversityTel AvivIsrael The Center for Nanoscience and Nanotechnology Tel Aviv UniversityTel AvivIsrael The Center for the Physics and Chemistry of Living Systems Tel Aviv UniversityTel AvivIsrael School of Plant Sciences and Food Security The George S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael

Redox-enzyme‐mediated electrochemical processes such as hydrogen production,nitrogen fixation,and CO_(2) reduction are at the forefront of the green chemistry *** scale up,the inefficient two‐dimensional(2D)immobilization of redox enzymes on working electrodes must be replaced by an efficient dense 3D *** of 3D electrodes was demonstrated by embedding enzymes in polymer ***,several requirements,such as simple immobilization,prolonged stability,and resistance to enzyme leakage,still need to be *** study presented here aims to overcome these gaps by immobilizing enzymes in a supramolecular hydrogel formed by the self‐assembly of the peptide hydrogelator *** the self‐assembly process avoids the need for tedious and potentially harmful chemistry,allowing the rapid loading of enzymes on a 3D electrode under mild *** the[FeFe]hydrogenase enzyme,high enzyme loads,prolonged resistance against electrophoresis,and highly efficient hydrogen production are ***,this enzyme retention is shown to arise from its interaction with the peptide ***,this method is successfully used to retain other redox enzymes,paving the way for a variety of enzyme‐mediated electrochemical applications.

关键词： 3D electrode enzymes encapsulation H2 production hydrogenase peptide hydrogel

Diffuse transmitted spectroscopy in conjunction with spectral peak averaging as a potential tool for noninvasive creatinine screening

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Journal of Innovative Optical Health Sciences 2020年第6期3卷 71-80页

作者： zvi Hai Barnea(Burbea) Shmuel Zimlichman David Abookasis Nephrology Department Edith Wolfson HospitalHolon 5822012Israel Sackler Faculty of Medicine Tel Aviv University P.O.Box 39040Tel Aviv 6997801Israel Department of Electrical and Electronics Engineering Ariel University Ariel 4070000Israel

Creatinine(Cr)is a biochemical waste molecule generated from muscle metabolism and primarily cleared from the bloodstream by the *** kidney function declines,Cr levels in the blood tend to ***,Cr serves as an indicator of kidney *** this work,we present a simple method for the rapid screening for impaired renal function based on the subject's Cr *** our setup,broadband white light is delivered to a finger clamp through a fiber-optic cable to illuminate the patient's *** light is transmitted through the finger and collected by a second optical fiber coupled to a visible-near-infrared(VisNIR)spectrometer which covers the spectral range from 400nm to *** the calibration process,the transmitted spectra acquired from 60 patients were *** average was calculated using the peak level of the transmitted,diffused intensity at three different wavelengths to create a"Cr intensity index".Patients were divided into five groups according to their Cr concentration levels,ranging from 1 mg/dL to 13 mg/*** observations indicated that each group featured a unique spectral ***,we tested the index on 20 patients not included in the cali-bration procedure(unknown samples).We were able to classify patients into groups according to their Cr level with moderate prediction accuracy(R^(2)=0.55)and mean screening error of up to 16%.Future efforts will evaluate the accuracy of this approach with larger patient populations representing a broad range of Cr ***,this preliminary work is an essential step toward developing this useful noninvasive Cr screening platform using NIR light spectroscopy.

关键词： Creatinine near-infrared spectroscopy spectral peak averaging patient finger prediction