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Carbamylated erythropoietin regulates immune responses and promotes long-term kidney allograft survival through activation of PI3K/AKT signaling

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Signal Transduction and Targeted Therapy 2020年第1期5卷 794-805页

作者： Ning Na Daqiang Zhao Jinhua Zhang Jiaqing Wu Bin Miao Heng Li Yingxun Luo zuofu tang Wensheng Zhang Joseph A.Bellanti Song Guo Zheng Department of Kidney Transplantation The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630 GuangdongChina Department of Kidney Transplantation The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000 GuangdongChina Thomas E.Starzl Transplantation Institute University of Pittsburgh School of MedicinePittsburgh 15261 PAUSA Department of Plastic Surgery University of Pittsburgh School of MedicinePittsburgh 15261 PAUSA Department of Pediatrics and Microbiology-Immunology Georgetown University Medical CenterWashingtonDCUSA Department of Internal Medicine The Ohio State University Wexner Medical CenterColumbus 43210 OHUSA United States Army Institute of Surgical Research JBSA Fort Sam HoustonHouston 78234 TXUSA

Modulation of alloimmune responses is critical to improving transplant outcome and promoting long-term graft *** determine mechanisms by which a nonhematopoietic erythropoietin(EPO)derivative,carbamylated EPO(CEPO),regulates innate and adaptive immune cells and affects renal allograft survival,we utilized a rat model of fully MHC-mismatched kidney *** administration markedly extended the survival time of kidney allografts compared with the transplant alone control *** therapeutic effect was inhibited when the recipients were given LY294002,a selective inhibitor of the phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway or anti-EPO receptor(EPOR)antibody,in addition to *** vitro,CEPO inhibited the differentiation and function of dendritic cells and modulated their production of proinflammatory and anti-inflammatory cytokines,along with activating the PI3K/AKT signaling pathway and increasing EPOR mRNA and protein expression by these innate immune ***,after CD4^(+)T cells were exposed to CEPO the Th1/Th2 ratio decreased and the regulatory T cell(Treg)/Th17 ratio *** effects were abolished by LY294002 or anti-EPOR antibody,suggesting that CEPO regulates immune responses and promotes kidney allograft survival by activating the PI3K/AKT signaling pathway in an EPOR-dependent *** immunomodulatory and specific signaling pathway effects of CEPO identified in this study suggest a potential therapeutic approach to promoting kidney transplant survival.

关键词： PI3K/AKT kidney inhibited

A randomized controlled trial to evaluate efficacy and safety of early conversion to a low-dose calcineurin inhibitor combined with sirolimus in renal transplant patients

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Chinese Medical Journal 2022年第13期135卷 1597-1603页

作者： Xiang Zheng Weijie Zhang Hua Zhou Ronghua Cao Zhangfei Shou Shuwei Zhang Ying Cheng Xuchun Chen Chenguang Ding zuofu tang Ning Li Shaohua Shi Qiang Zhou Qiuyuan Chen Gang Chen Zheng Chen Peijun Zhou Xiaopeng Hu Xiaodong Zhang Ning Na Wei Wang Department of Urology Capital Medical University Beijing Chaoyang HospitalBeijing 100020China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430032China Kidney Transplantation Dialysis Center The Second People’s Hospital of Shanxi ProvinceTaiyuanShanxi 030012China Department of Organ Transplantation Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhouGuangdong 510120China Department of Nephrology Shulan(Hangzhou)HospitalHangzhouZhejiang 310000China Department of Urology Ningbo Yinzhou Number.2 HospitalNingboZhejiang 315000China Department of Organ Transplantation The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China Institute of Kidney Transplantation The First Affiliated HospitalMedical College of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Department of Kidney The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Department of Kidney Southwest HospitalThe First Hospital Affiliated to The Third Military Medical University(Army Medical University)Chongqing 400000China Organ Transplant Center The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510260China Kidney Transplantation Center Department of UrologyRuijin HospitalShanghai Jiaotong University School of MedicineShanghai 200000China.

Background:The calcineurin inhibitor(CNI)-based immune maintenance regimen that is commonly used after renal transplantation has greatly improved early graft survival after transplantation;however,the long-term prognosis of grafts has not been significantly *** nephrotoxicity of CNI drugs is one of the main risk factors for the poor long-term prognosis of ***(SRL)has been employed as an immunosuppressant in clinical practice for over 20 years and has been found to have no nephrotoxic effects on ***,the regimen and timing of SRL application after renal transplantation vary,and clinical data are *** prospective randomized controlled studies are particularly *** study aims to investigate the effects of early conversion to a low-dose CNI combined with SRL on the long-term prognosis of renal ***:Patients who receive four weeks of a standard regimen with CNI+mycophenolic acid(MPA)+glucocorticoid after renal transplantation in multiple transplant centers across China will be included in this *** week 5,after the operation,patients in the experimental group will receive an additional administration of SRL,a reduction in the CNI drug doses,withdrawal of MPA medication,and maintenance of *** addition,patients in the control group will receive the maintained standard of *** patients’vital signs,routine blood tests,routine urine tests,blood biochemistry,serum creatinine,BK virus(BKV)/cytomegalovirus(CMV),and trough concentrations of CNI drugs and SRL at the baseline and weeks 12,24,36,48,72,and 104 after conversion will be *** survival,graft survival,and estimated glomerular filtration rate will be calculated,and concomitant medications and adverse events will also be ***:The study data will be utilized to evaluate the efficacy and safety of early conversion to low-dose CNIs combined with SRL in renal transplant patients.

关键词： Calcineurin inhibitor Conversion Rapamycin Renal transplantation Sirolimus

Topologically protected entanglement switching around exceptional points

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Light(Science & Applications) 2024年第8期13卷 1631-1644页

作者： Zan tang Tian Chen Xing tang Xiangdong Zhang Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurements of Ministry of Education Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of Technology100081 BeijingChina

The robust operation of quantum entanglement states is crucial for applications in quantum information,computing,and communications^(1–3).However,it has always been a great challenge to complete such a task because of decoherence and ***,we propose theoretically and demonstrate experimentally an effective scheme to realize robust operation of quantum entanglement states by designing quadruple degeneracy exceptional *** encircling the exceptional points on two overlapping Riemann energy surfaces,we have realized a chiral switch for entangled states with high *** to the topological protection conferred by the Riemann surface structure,this switching of chirality exhibits strong robustness against perturbations in the encircling ***,we have experimentally validated such a scheme on a quantum walk *** work opens up a new way for the application of non-Hermitian physics in the field of quantum information.

关键词： exceptional quantum Riemann

An economic way to achieve all-weather CO2 reduction

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National Science Review 2024年第3期11卷 46-47页

作者： Junwang tang Department of Chemical Engineering University College London

Utilising solar power to convert carbon dioxide（CO2） into hydrocarbon fuels presents an eco-friendly method to address dependence on fossil fuels and contribute to a net-zero CO2emission goal[1,2].

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UAV-assisted data collection for wireless sensor networks with dynamic working modes

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Digital Communications and Networks 2024年第3期10卷 805-812页

作者： Jie Chen Jianhua tang Shien-Ming Wu School of Intelligent Engineering South China University of TechnologyGuangzhou511442China

Wireless Sensor Network(WSN)is a cornerstone of Internet of Things(IoT)and has rich application *** this work,we consider a heterogeneous WSN whose sensor nodes have a diversity in their Residual Energy(RE).In this work,to protect the sensor nodes with low RE,we investigate dynamic working modes for sensor nodes which are determined by their RE and an introduced energy ***,we employ an Unmanned Aerial Vehicle(UAV)to collect the stored data from the heterogeneous *** aim to jointly optimize the cluster head selection,energy threshold and sensor nodes’working mode to minimize the weighted sum of energy con-sumption from the WSN and UAV,subject to the data collection rate *** this end,we propose an efficient search method to search for an optimal energy threshold,and develop a penalty-based successive convex approximation algorithm to select the cluster *** we present a low-complexity iterative approach to solve the joint optimization problem and discuss the implementation *** results justify that our proposed approach is able to reduce the energy consumption of the sensor nodes with low RE significantly and also saves energy for the whole WSN.

关键词： Unmanned aerial vehicle Wireless sensor networks Cluster heads Dynamic working modes

Highly effective design of high GFA alloys with different metalbased and various components by machine learning

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Science China(Technological Sciences) 2024年第5期67卷 1431-1442页

作者： tang YiChuan HE YiFan FAN ZhuoQun WANG ZhongQi tang ChengYing Guangxi Key Laboratory for Informational Materials School of Materials Science and EngineeringGuilin University of Electronic TechnologyGuilin541004China

The glass-forming ability(GFA)is of great significance for the development of novel functional metal-based metallic *** this study,seven popular machine learning(ML)algorithms were employed to design novel M-based(M=Fe,Co,Ni,Ti,Zr,and rare earth metal(RE))and X-component(X=2,3,4,5,6,and>6)alloys with excellent GFA.A GFA containing 6957 data points with structural analysis was *** engineering was used to analyze the importance and correlation of *** algorithms were utilized for GFA prediction,revealing that Xtreme Gradient Boosting Trees exhibited the strongest predictive capability,achieving a high accuracy of 94.0%,a true positive rate of 97.6%,and a root mean squared error of 0.3705 across the entire ***,the GFA of ternary to hexahydroxy alloys based on Fe,Co,Ni,Zr,Ti,and Y was predicted using all possible compositions generated through ***,a series of alloys with good GFA was successfully designed and *** present work suggests that the proposed ML method can be utilized to design novel multiple-M-based amorphous alloys with high GFA.

关键词： machine learning amorphous alloy feature engineering materials design glass forming ability

Nuclear charge radius predictions by kernel ridge regression with odd-even effects

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Nuclear Science and Techniques 2024年第2期35卷 94-102页

作者： Lu tang Zhen-Hua Zhang Mathematics and Physics Department North China Electric Power UniversityBeijing 102206China Hebei Key Laboratory of Physics and Energy Technology North China Electric Power UniversityBaoding 071000China

The extended kernel ridge regression(EKRR)method with odd-even effects was adopted to improve the description of the nuclear charge radius using five commonly used nuclear *** are:(i)the isospin-dependent A^(1∕3) formula,(ii)relativistic continuum Hartree-Bogoliubov(RCHB)theory,(iii)Hartree-Fock-Bogoliubov(HFB)model HFB25,(iv)the Weizsacker-Skyrme(WS)model WS*,and(v)HFB25**** the last two models,the charge radii were calculated using a five-parameter formula with the nuclear shell corrections and deformations obtained from the WS and HFB25 models,*** each model,the resultant root-mean-square deviation for the 1014 nuclei with proton number Z≥8 can be significantly reduced to 0.009-0.013 fm after considering the modification with the EKRR *** best among them was the RCHB model,with a root-mean-square deviation of 0.0092 *** extrapolation abilities of the KRR and EKRR methods for the neutron-rich region were examined,and it was found that after considering the odd-even effects,the extrapolation power was improved compared with that of the original KRR *** strong odd-even staggering of nuclear charge radii of Ca and Cu isotopes and the abrupt kinks across the neutron N=126 and 82 shell closures were also calculated and could be reproduced quite well by calculations using the EKRR method.

关键词： Nuclear charge radius Machine learning Kernel ridge regression method

Controlled synthesis of one-dimensional segmented heteronanostructures

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Science China Materials 2024年第8期67卷 2715-2716页

作者： Zhiyong tang CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China

Telluride materials possess distinctive advantages,including the high theoretical volume capacity and electrical conductivity,rendering them promising candidates for a range of energy storage and optoelectronic applications[1].Heterogeneous compositions and interfaces in heteronanostructures have significant implications on the electron transport,magnetic coupling,and phonon scattering,thereby promoting the performances in photocatalysis,and thermoelectrics[2].

关键词： synthesis rendering thereby

A supramolecular self-assembly material based on cucurbituril and cationic TPE as ultra-sensitive probe of energetic pentazolate salts

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Defence Technology（防务技术） 2024年第5期35卷 69-76页

作者： Boan tang Jingxiang Zhong Shutao Wang Shiyu Zhou Yongxing tang Wei Huang School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China

The successful synthesis of the pentazolate anion(cyclo-N-5)has been a great breakthrough in the field of energetic ***,the detection methods for these energetic materials based on the pentazolate anion are quite ***,two fluorescent probes for cyclo-N-5anion were *** 1(TPE2N)was synthesized with a tetraphenylethylene functionalized by two cationic groups which can generate strong electrostatic interactions with pentazolate anion and result in specific fluorescent *** 2 was designed based on sensor 1 and supramolecular cucurbit[7]uril(CB[7]).The unique structural features of CB[7]provide sites for the interaction between the cations and N-5anion in its cavity,which would generate a platform for the detection and enhance the recognition *** titration calorimetry(ITC)experiment and fluorescence titration experiment indicate the binding molar ratio between sensor 1 with CB[7]is 1:*** sensors display typical aggregation-induced emission(AIE)features and good *** sensors demonstrate excellent sensitivity to pentazole hydrazine salt with high enhancement constant(sensor 1:1.34×10^(6);sensor 2:3.78×10^(6))and low limit of detection(LOD:sensor 1=4.33μM;sensor 2=1.54μM).The formation of an AIE-based supramolecular sensor effectively improves the sensitivity to *** addition,the probes also have good selectivity of N-5anion *** research would shed some light on the design of novel fluorescent sensors to detect pentazolate-based molecules and provides an example of supramolecular chemistry combined with fluorescent probes.

关键词： Pentazolate anion Explosives detection Aggregation-induced emission(AIE) Host-guest interaction